Arnaldo Dubin

Summary

Affiliation: Universidad Nacional de La Plata
Country: Argentina

Publications

  1. ncbi request reprint End-tidal CO2 pressure determinants during hemorrhagic shock
    A Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Intensive Care Med 26:1619-23. 2000
  2. ncbi request reprint Effects of hemorrhage on gastrointestinal oxygenation
    A Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calle 42 No 577, 1900 La Plata, Argentina
    Intensive Care Med 27:1931-6. 2001
  3. ncbi request reprint Impact of positive end-expiratory pressure on the definition of acute respiratory distress syndrome
    Elisa Estenssoro
    Servicio de Terapia Intensiva, Hospital Interzonal General de Agudos General San Martín, 1900, La Plata, Argentina
    Intensive Care Med 29:1936-42. 2003
  4. pmc Lack of agreement between tonometric and gastric juice partial carbon dioxide tension
    A Dubin
    Clinica Bazterrica, Capital Federal, Argentina
    Crit Care 4:249-254. 2000
  5. pmc Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Crit Care 6:514-20. 2002
  6. ncbi request reprint Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 42 No 577, 1900, La Plata, Argentina
    Intensive Care Med 33:485-94. 2007
  7. doi request reprint Systemic and microcirculatory responses to progressive hemorrhage
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Cátedra de Farmacología Aplicada, Universidad Nacional de La Plata, La Plata, Argentina
    Intensive Care Med 35:556-64. 2009
  8. doi request reprint Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Crit Care Med 36:535-42. 2008
  9. doi request reprint Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Azcuenaga 870, Buenos Aires C1115AAB, Argentina
    J Crit Care 25:659.e1-8. 2010
  10. pmc Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires C1115AAB, Argentina
    Crit Care 13:R92. 2009

Collaborators

  • Elisa Estenssoro
  • Can Ince
  • S Rossi
  • Enrique Piacentini
  • Vanina S Kanoore Edul
  • Carolina Enrico
  • Mario O Pozo
  • Graciela Tuhay
  • Alejandro Risso Vazquez
  • María C Pein
  • Gonzalo Ferrara
  • Vanina Kanoore Edul
  • Fabio D Masevicius
  • Ricardo A Pérez de la Hoz
  • Bruno Laviolle
  • Carlos Canullén
  • Enrique Martins
  • Gastón Murias
  • Héctor S Canales
  • Elizabeth Ventrice
  • Luis P Maskin
  • María Carolina Pein
  • Fabio Daniel Masevicius
  • Daniela Olmos Kutscherauer

Detail Information

Publications24

  1. ncbi request reprint End-tidal CO2 pressure determinants during hemorrhagic shock
    A Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Intensive Care Med 26:1619-23. 2000
    ..To examine the relationship between end-tidal CO2 (PETCO2) and its physiological determinants, pulmonary blood flow (cardiac output, CO) and CO2 production (VCO2), in a model of hemorrhagic shock during fixed minute ventilation...
  2. ncbi request reprint Effects of hemorrhage on gastrointestinal oxygenation
    A Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calle 42 No 577, 1900 La Plata, Argentina
    Intensive Care Med 27:1931-6. 2001
    ..1) To demonstrate that metabolic parameters are better indicators of tissue hypoxia than regional and whole oxygen consumption (VO(2)). (2) To compare intramucosal pH (pHi) in different gastrointestinal segments...
  3. ncbi request reprint Impact of positive end-expiratory pressure on the definition of acute respiratory distress syndrome
    Elisa Estenssoro
    Servicio de Terapia Intensiva, Hospital Interzonal General de Agudos General San Martín, 1900, La Plata, Argentina
    Intensive Care Med 29:1936-42. 2003
    ..We examined whether PEEP during the first hours of ARDS can induce such a change in oxygenation that could mask fulfillment of the AECC criteria of a PaO(2)/FIO(2) </= 200 essential for ARDS diagnosis...
  4. pmc Lack of agreement between tonometric and gastric juice partial carbon dioxide tension
    A Dubin
    Clinica Bazterrica, Capital Federal, Argentina
    Crit Care 4:249-254. 2000
    ..The 95% limits of agreement were 315 mmHg and the dispersion increased as the values of PCO2 increased. Tonometric and gastric juice PCO2 cannot be used interchangeably. Gastric juice PCO2 measurement should be interpreted with caution...
  5. pmc Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Crit Care 6:514-20. 2002
    ..An elevation in intramucosal-arterial PCO2 gradient (DeltaPCO2) could be determined either by tissue hypoxia or by reduced blood flow. Our hypothesis was that in hypoxic hypoxia with preserved blood flow, DeltaPCO2 should not be altered...
  6. ncbi request reprint Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 42 No 577, 1900, La Plata, Argentina
    Intensive Care Med 33:485-94. 2007
    ..To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock...
  7. doi request reprint Systemic and microcirculatory responses to progressive hemorrhage
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Cátedra de Farmacología Aplicada, Universidad Nacional de La Plata, La Plata, Argentina
    Intensive Care Med 35:556-64. 2009
    ..To compare systemic hemodynamics with microcirculatory changes at different vascular beds during progressive hemorrhage...
  8. doi request reprint Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Crit Care Med 36:535-42. 2008
    ..To test the hypothesis that persistent villi hypoperfusion explains intramucosal acidosis after endotoxemic shock resuscitation...
  9. doi request reprint Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Azcuenaga 870, Buenos Aires C1115AAB, Argentina
    J Crit Care 25:659.e1-8. 2010
    ..The aim of this study was to show that 6% hydroxyethyl starch (HES) 130/0.4 achieves a better resuscitation of the microcirculation than normal saline solution (SS), during early goal-directed therapy (EGDT) in septic patients...
  10. pmc Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires C1115AAB, Argentina
    Crit Care 13:R92. 2009
    ..Our goal was to assess the effects of titration of a norepinephrine infusion to increasing levels of mean arterial pressure (MAP) on sublingual microcirculation...
  11. ncbi request reprint Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep
    Vanina S Kanoore Edul
    Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Crit Care Resusc 13:252-61. 2011
    ..To evaluate the effects of nitroglycerin (glyceryl trinitrate) on intestinal microcirculation during endotoxaemic shock...
  12. doi request reprint Systemic and microcirculatory effects of dobutamine in patients with septic shock
    Carolina Enrico
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    J Crit Care 27:630-8. 2012
    ..Our hypotheses were that dobutamine mainly produces tachycardia and vasodilation and fails to improve the microcirculation of patients with septic shock...
  13. ncbi request reprint Intramucosal-arterial Pco2 gradient does not reflect intestinal dysoxia in anemic hypoxia
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    J Trauma 57:1211-7. 2004
    ..An increase in intramucosal-arterial Pco2 gradient (DeltaPco2) might be caused by tissue hypoxia or by diminished blood flow. Our hypothesis was that DeltaPco2 should not be altered in anemic hypoxia with preserved blood flow...
  14. pmc Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches
    Graciela Tuhay
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care 12:R66. 2008
    ..The goal of the present study was therefore to quantify these disorders using both Stewart and conventional approaches...
  15. pmc The distinct clinical profile of chronically critically ill patients: a cohort study
    Elisa Estenssoro
    Servicio de Terapia Intensiva, Hospital Interzonal General San Martín, La Plata, Buenos Aires, Argentina
    Crit Care 10:R89. 2006
    ..Our goal was to describe the epidemiology, clinical profiles, outcomes, and factors that might predict progression of critically ill patients to chronically critically ill (CCI) patients, a still poorly characterized subgroup...
  16. ncbi request reprint Shock on admission day is the best predictor of prolonged mechanical ventilation in the ICU
    Elisa Estenssoro
    Servicio de Terapia Investiva, Hospital Interzonal General de Agudos San Martín, 1900 La Plata, Buenos Aires, Argentina
    Chest 127:598-603. 2005
    ..To determine the incidence of prolonged mechanical ventilation (PMV), which is associated with increased health-care costs and risks of adverse events, and to identify its early predictors...
  17. doi request reprint Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
    Vanina S Kanoore Edul
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 40:1443-8. 2012
    ..Our hypotheses were that 1) hyperdynamic blood flow is absent in septic shock; 2) nonsurvivors show more severe alterations than survivors; and 3) quantitative and semiquantitative microcirculatory parameters have a similar performance...
  18. ncbi request reprint Comparison of three different methods of evaluation of metabolic acid-base disorders
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 35:1264-70. 2007
    ....
  19. ncbi request reprint Alterations in urinary strong ion difference in critically ill patients with metabolic acidosis: a prospective observational study
    Fabio D Masevicius
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Resusc 12:248-54. 2010
    ..Our hypothesis was that the failure to decrease the [SID](urinary) is frequently present and leads to a more severe metabolic acidosis...
  20. ncbi request reprint Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 42 No 577, 1900 La Plata, Argentina
    Resuscitation 69:277-86. 2006
    ..Pretreatment with levosimendan in experimental hypodynamic septic shock in pigs has shown valuable effects in oxygen transport. Our goal was to assess the effects of levosimendan in a normodynamic model of endotoxaemia...
  21. ncbi request reprint Microcirculatory dysfunction in sepsis
    Vanina Kanoore Edul
    Cátedra de Farmacología Aplicada, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Endocr Metab Immune Disord Drug Targets 10:235-46. 2010
    ....
  22. ncbi request reprint Mechanisms of tissue hypercarbia in sepsis
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Universidad Nacional de La Plata and Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Front Biosci 13:1340-51. 2008
    ..In summary, experimental results support the hypothesis that increases in tissue and venous CO2 are insensitive markers of tissue dysoxia, and merely reflect vascular hypoperfusion...
  23. pmc Comparison of different methods for the calculation of the microvascular flow index
    Mario O Pozo
    Servicio de Terapia Intensiva, Clinica Bazterrica, Juncal 3002, C1425AYN Buenos Aires, Argentina
    Crit Care Res Pract 2012:102483. 2012
    ..Although the different methods for the calculation of MFI reflect microvascular perfusion, they are not interchangeable and MFI(vessel by vessel) might be better...
  24. ncbi request reprint Effects of recruitment manoeuvres on haemodynamics, oxygen exchange and oxygen delivery in patients with acute lung injury and acute respiratory distress syndrome
    Vanina S Kanoore Edul
    Cátedra de Farmacología Aplicada, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Crit Care Resusc 12:143-8. 2010
    ..To evaluate the impact of a recruitment manoeuvre (RM) on haemodynamics, gas exchange, and oxygen transport in patients with acute lung injury (ALI) an acute respiratory distress syndrome (ARDS) under mechanical ventilation...