Daniel P Cardinali

Summary

Affiliation: Universidad de Buenos Aires
Country: Argentina

Publications

  1. ncbi request reprint Melatonin and the immune system in aging
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuroimmunomodulation 15:272-8. 2008
  2. ncbi request reprint Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Ann N Y Acad Sci 1057:327-36. 2005
  3. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep-wake cycle
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina
    Cancer Causes Control 17:601-9. 2006
  4. ncbi request reprint [Melatonin. Physiology and clinical applications]
    Daniel P Cardinali
    Departamento de Fisiología Facultad de Medicina, Universidad de Buenos Aires
    Vertex 18:288-93. 2007
  5. ncbi request reprint Effect of melatonin on vascular responses in aortic rings of aging rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina
    Exp Gerontol 42:337-42. 2007
  6. doi request reprint Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
    Mariana N Castro
    Departments of Neurology and Psychiatry, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 109:134-40. 2009
  7. ncbi request reprint Antioxidants restore aortic ring relaxation in pancreatectomized rats
    Carlos F Reyes-Toso
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 7, 1121 Buenos Aires, Argentina
    Life Sci 81:1467-72. 2007
  8. ncbi request reprint Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 39:386-91. 2005
  9. ncbi request reprint Effect of melatonin on vascular reactivity in pancreatectomized rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos, Aires, Paraguay 2155, 1121 Buenos Aires, Argentina
    Life Sci 74:3085-92. 2004
  10. ncbi request reprint Heart rate variability response to mental arithmetic stress in patients with schizophrenia: autonomic response to stress in schizophrenia
    Mariana N Castro
    Department of Neurology, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 99:294-303. 2008

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Melatonin and the immune system in aging
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuroimmunomodulation 15:272-8. 2008
    ..The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals...
  2. ncbi request reprint Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Ann N Y Acad Sci 1057:327-36. 2005
    ..By its combined chronobiotic and cytoprotective properties melatonin provides an innovative neuroprotective strategy to reduce the cost of lifetime treatment of some neuropsychiatric disorders...
  3. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep-wake cycle
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina
    Cancer Causes Control 17:601-9. 2006
    ..Both in aged subjects having very minimal sleep disorders as well as in demented patients with a very severe disorganization of the sleep-wake cycle, melatonin treatment reduced the variability of sleep onset and restored sleep...
  4. ncbi request reprint [Melatonin. Physiology and clinical applications]
    Daniel P Cardinali
    Departamento de Fisiología Facultad de Medicina, Universidad de Buenos Aires
    Vertex 18:288-93. 2007
    ..A MT1/MT2 receptor analog of melatonin (ramelteon) has recently been introduced as a new type of hypnotics with no evidence of abuse or dependence...
  5. ncbi request reprint Effect of melatonin on vascular responses in aortic rings of aging rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina
    Exp Gerontol 42:337-42. 2007
    ..Aging did not affect the relaxant response of intact or endothelium-denuded rings to sodium nitroprusside. The results support the improvement by melatonin of vascular response in aging rats, presumably via its antioxidant activity...
  6. doi request reprint Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
    Mariana N Castro
    Departments of Neurology and Psychiatry, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 109:134-40. 2009
    ..Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives...
  7. ncbi request reprint Antioxidants restore aortic ring relaxation in pancreatectomized rats
    Carlos F Reyes-Toso
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 7, 1121 Buenos Aires, Argentina
    Life Sci 81:1467-72. 2007
    ..The results support the evidence about the ability of antioxidants to restore altered vascular reactivity of aortic rings in PPx rats, probably through the scavenging property of superoxide anion accumulation...
  8. ncbi request reprint Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 39:386-91. 2005
    ..The results further support the improvement by melatonin of the endothelial-mediated relaxation in blood vessels of diabetic rats...
  9. ncbi request reprint Effect of melatonin on vascular reactivity in pancreatectomized rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos, Aires, Paraguay 2155, 1121 Buenos Aires, Argentina
    Life Sci 74:3085-92. 2004
    ..The results further support the improvement by melatonin of endothelial-mediated relaxation in blood vessels of diabetic rats...
  10. ncbi request reprint Heart rate variability response to mental arithmetic stress in patients with schizophrenia: autonomic response to stress in schizophrenia
    Mariana N Castro
    Department of Neurology, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 99:294-303. 2008
    ..The vulnerability-stress hypothesis is an established model of schizophrenia symptom formation. We sought to characterise the pattern of the cardiac autonomic response to mental arithmetic stress in patients with stable schizophrenia...
  11. doi request reprint Gender differences in age-related increase of asleep blood pressure
    Santiago Perez-Lloret
    Instituto de Investigaciones Cardiologicas, Prof Dr Alberto C Taquini, Facultad de Medicina, Universidad de Buenos Aires CONICET Marcelo T de Alvear 2270, C1122AAJ Ciudad Autónoma de Buenos Aires, Argentina
    Arch Gerontol Geriatr 50:319-22. 2010
    ....
  12. doi request reprint Cardiac autonomic activity predicts dominance in verbal over spatial reasoning tasks: results from a preliminary study
    Juan I Solernó
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Auton Neurosci 167:78-80. 2012
    ..The results showed that a better relative performance in verbal over spatial reasoning tasks was associated with vagal prevalence in normal subjects...
  13. ncbi request reprint Nonlinear analysis of heart rate variability in patients with eating disorders
    Daniel E Vigo
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia FLENI, Buenos Aires, Argentina
    World J Biol Psychiatry 9:183-9. 2008
    ..Low-frequency heart rate variability was decreased in patients with anorexia. In conclusion, these results are compatible with the view that a more severe alteration of cardiac autonomic function is present in anorexia than in bulimia...
  14. doi request reprint Mood, Th-1/Th-2 cytokine profile, and autonomic activity in older adults with acute/decompensated heart failure: preliminary observations
    Salvador M Guinjoan
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina
    World J Biol Psychiatry 10:913-8. 2009
    ....
  15. ncbi request reprint Cerebroventricular administration of interferon-gamma modifies locomotor activity in the golden hamster
    Verónica I Boggio
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 12:89-94. 2003
    ..One explanation could be the presence of IFN-gamma receptor in the rat suprachiasmatic nucleus, supporting a direct effect on the central oscillator. However, another hypothesis could not be ruled out...
  16. ncbi request reprint Age-related changes in 24-hour rhythms of norepinephrine content and serotonin turnover in rat pineal gland: effect of melatonin treatment
    David Pazo
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 11:81-7. 2002
    ..Impairment of pineal melatonin synthesizing capacity and intrapineal responses to melatonin may underlie pineal aging in rats...
  17. ncbi request reprint Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei
    Analía M Furio
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Cell Mol Neurobiol 22:699-709. 2002
    ..8. The results support the existence of a neuroprotective effect of melatonin on beta amyloid-induced circadian changes in hamsters...
  18. doi request reprint Nonlinear analysis of heart rate variability within independent frequency components during the sleep-wake cycle
    Daniel E Vigo
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Auton Neurosci 154:84-8. 2010
    ..19+/-0.03, REM: 0.14+/-0.03, p<0.001) at SWS. REM was similar to wake status regarding nonlinear HRV. We propose nonlinear HRV is a useful index of the autonomic activity that characterizes the different sleep-wake cycle stages...
  19. ncbi request reprint Infradian awake and asleep systolic and diastolic blood pressure rhythms in humans
    Santiago Perez-Lloret
    Instituto de Investigaciones Cardiologicas, Prof Dr Alberto C Taquini, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Hypertens 24:1273-9. 2006
    ..Blood pressure shows 24-h rhythms with a significant seasonal fluctuation...
  20. ncbi request reprint Melatonin increases oestradiol-induced bone formation in ovariectomized rats
    Marta G Ladizesky
    Seccion Osteopatias Medicas, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Pineal Res 34:143-51. 2003
    ..The melatonin doses employed were pharmacological in terms of circulating melatonin levels but not necessarily for some other fluids or tissues...
  21. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Recent Pat Endocr Metab Immune Drug Discov 5:80-90. 2011
    ..The analysis of published evidence and patents indicates that melatonin can be a useful ad-on therapeutic tool in the early phases of AD...
  22. doi request reprint Sleep habits, alertness, cortisol levels, and cardiac autonomic activity in short-distance bus drivers: differences between morning and afternoon shifts
    Joaquín J Diez
    Departamento de Fisiologia, Universidad Austral, Buenos Aires, Argentina
    J Occup Environ Med 53:806-11. 2011
    ..To evaluate sleep, alertness, salivary cortisol levels, and autonomic activity in the afternoon and morning shifts of a sample of short-distance bus drivers...
  23. ncbi request reprint Melatonin treatment counteracts the hyperthermic effect of lipopolysaccharide injection in the Syrian hamster
    Verónica A Bruno
    Departamento de Fisiologia, Facultad de Medicina, UBA, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina
    Neurosci Lett 389:169-72. 2005
    ..This effect was suppressed by MT administration. The results demonstrate that MT prevents body temperature increase after LPS at ZT 0...
  24. doi request reprint Activity-rest rhythm abnormalities in Parkinson's disease patients are related to dopaminergic therapy
    Santiago Perez-Lloret
    Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
    Int J Neurosci 120:11-6. 2010
    ..e., dopaminergic therapy or DT) with "de novo" patients and healthy controls and to correlate these parameters with self-reported sleep disturbances...
  25. ncbi request reprint Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuro Endocrinol Lett 32:588-606. 2011
    ..In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS...
  26. ncbi request reprint Melatonin role in experimental arthritis
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Curr Drug Targets Immune Endocr Metabol Disord 4:1-10. 2004
    ....
  27. ncbi request reprint Melatonin in sleep disorders and jet-lag
    Daniel P Cardinali
    Departament of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:9-13. 2002
    ..The effect of melatonin on sleep is probably the consequence of increasing sleep propensity (by inducing a fall in body temperature) and of a synchronizing effect on the circadian clock (chronobiotic effect)...
  28. ncbi request reprint In vitro effect of melatonin on oxygen consumption in liver mitochondria of rats
    Carlos F Reyes-Toso
    Departamento de Fisiologia and Hospital de Clinicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuro Endocrinol Lett 24:341-4. 2003
    ..To examine the in vitro effect of melatonin on rat mitochondrial liver respiration...
  29. doi request reprint Heart rate nonlinear dynamics during sudden hypoxia at 8230 m simulated altitude
    Daniel E Vigo
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Wilderness Environ Med 21:4-10. 2010
    ..Although changes in nonlinear HRV can be associated with physiologic stress and are relevant predictors of fatal arrhythmias in ischemic heart disease, to what extent these components vary in sudden hypobaric hypoxia is not known...
  30. pmc A multi-step pathway connecting short sleep duration to daytime somnolence, reduced attention, and poor academic performance: an exploratory cross-sectional study in teenagers
    Santiago Perez-Lloret
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Universidad Catolica Argentina, Buenos Aires, Argentina
    J Clin Sleep Med 9:469-73. 2013
    ..However this hypothesis has never been explored...
  31. ncbi request reprint Autonomic neural signals in bone: physiological implications for mandible and dental growth
    Verónica Boggio
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 1121 Buenos Aires, Argentina
    Life Sci 75:383-95. 2004
    ..These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism...
  32. doi request reprint Melatonin and its analogs in insomnia and depression
    Daniel P Cardinali
    Departmento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    J Pineal Res 52:365-75. 2012
    ..Hence, clinical trials employing melatonin doses in the range of 50-100mg/day are warranted before the relative merits of the melatonin analogs versus melatonin can be settled...
  33. ncbi request reprint Depressive symptoms are related to decreased low-frequency heart rate variability in older adults with decompensated heart failure
    Salvador M Guinjoan
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuropsychobiology 55:219-24. 2007
    ..Depression is often found to result in autonomic dysfunction which, if present in heart failure, might help explain worsened outcomes...
  34. doi request reprint Higher autonomic activation predicts better performance in iowa gambling task
    Lucas Javier Drucaroff
    Instituto de Investigaciones Neurológicas Raúl Carrea F L E N I, Universidad de Buenos Aires, Argentina
    Cogn Behav Neurol 24:93-8. 2011
    ..To evaluate the relationship between the autonomic nervous system basal state and performance in decision-making tasks...
  35. ncbi request reprint Melatonin effect on bone metabolism in rats treated with methylprednisolone
    Marta G Ladizesky
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 40:297-304. 2006
    ..The results are compatible with the view that low doses of methylprednisolone or melatonin decrease bone resorption and have a bone-protecting effect...
  36. doi request reprint Blunting of circadian rhythms and increased acrophase variability in sleep-time hypertensive subjects
    Santiago Perez-Lloret
    Physiology Department, School of Medicine, University of Buenos Aires, Argentina
    Chronobiol Int 25:99-113. 2008
    ..Altogether, the findings suggest a disorganization of the BP circadian rhythm in sleep-time hypertensives that results in reduced 24 h rhythm amplitude and integrity that could be related to cardiovascular risk...
  37. doi request reprint Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuroendocrinology 93:133-42. 2011
    ....
  38. ncbi request reprint Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals
    Hugo L Fideleff
    Departmento de Endocrinologia, Hospital T Alvarez, Buenos Aires, Argentina
    J Pineal Res 40:214-8. 2006
    ..To what extent this increase in melatonin production contributes to a delayed puberty in some pubertal obese males remains to be established...
  39. ncbi request reprint Nighttime changes in norepinephrine and melatonin content and serotonin turnover in pineal glands of young and old rats injected with Freund's adjuvant
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:49-53. 2002
    ..This study was performed to search for changes in rat pineal function attributed to age and immunization with Freund's adjuvant...
  40. ncbi request reprint Circadian disorganization in experimental arthritis
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 12:267-82. 2003
    ..Some pinealectomy-induced immune changes in arthritic rats were also prevented by physiological concentrations of melatonin. Melatonin may play the role of an 'internal synchronizer' for the immune system...
  41. ncbi request reprint The use of melatonin in Alzheimer's disease
    Daniel P Cardinali
    Departament of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:20-3. 2002
    ..Melatonin treatment seems to constitute a selection therapy to ameliorate sundowning and to slow evolution of cognitive impairment in AD patients...
  42. doi request reprint Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis
    Ruth E Rosenstein
    Department of Human Biochemistry, School of Medicine, CEFYBO, University of Buenos Aires, CONICET, Buenos Aires, Argentina
    J Pineal Res 49:1-13. 2010
    ....
  43. ncbi request reprint Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure
    Luis Girotti
    Division Cardiologia, Hospital Ramos Mejia, Buenos Aires, Argentina
    Endocrine 22:245-8. 2003
    ..To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF)...
  44. ncbi request reprint Wavelet transform shows age-related changes of heart rate variability within independent frequency components
    Daniel E Vigo
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay, Argentina
    Auton Neurosci 123:94-100. 2005
    ..Potential applications of this method include the study of heart rate regulation during sleep in which a complex interaction between the sympathetic and the parasympathetic activity takes place...
  45. ncbi request reprint Effect of unilateral superior cervical ganglionectomy on mandibular bone in rats
    Marta Ladizesky
    Seccion Osteopatias Medicas, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Neuro Endocrinol Lett 24:314-20. 2003
    ..To assess the effect of local sympathectomy on mandibular bone during tooth eruption in rats...
  46. ncbi request reprint Brief review: diurnal rhythms, obesity and educational achievement in South american cultures
    Daniel Perez-Chada
    Pulmonary Division and Internal Medicine Department, Hospital Universitario Austral, Buenos Aires, Argentina
    Int J Neurosci 119:1091-104. 2009
    ..The theoretical basis of this relationship is discussed. Several studies investigating the relationships between obesity, sleep disturbance, and a number of important negative outcomes are reviewed...
  47. ncbi request reprint In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary
    Ariel H B Poliandri
    Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Bueno Aires, Argentina
    J Pineal Res 41:238-46. 2006
    ..Melatonin treatment was effective reducing all examined effects of Cd, documenting its effectiveness to protect the rat hypothalamic-pituitary axis from the toxic metal effects...
  48. ncbi request reprint Vascular reactivity in diabetic rats: effect of melatonin
    Carlos F Reyes-Toso
    Departmento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 33:81-6. 2002
    ....
  49. ncbi request reprint Cardiac parasympathetic dysfunction related to depression in older adults with acute coronary syndromes
    Salvador M Guinjoan
    Department of Mental Health and Coronary Care Unit, Hospital de Clinicas Jose de San Martin, University of Buenos Aires School of Medicine, Buenos Aires, Argentina
    J Psychosom Res 56:83-8. 2004
    ..To determine whether depression is associated with cardiac autonomic alterations in elderly patients with recent acute coronary syndromes (ACSs)...
  50. ncbi request reprint Worsening of depressive symptoms 6 months after an acute coronary event in older adults is associated with impairment of cardiac autonomic function
    M Soledad Ladrón de Guevara
    Dept de Salud Mental, Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Ave Córdoba 2351 5 degrees Piso, Buenos Aires 1120, Argentina
    J Affect Disord 80:257-62. 2004
    ..Depression increases mortality of coronary patients, and autonomic dysfunction has been proposed as an explanation for this association...
  51. ncbi request reprint A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 32:41-6. 2002
    ..The results indicate that the combination of melatonin treatment, an appropriate environmental light schedule and timely applied physical exercise can be useful to help elite athletes to overcome the consequences of jet lag...
  52. ncbi request reprint A double blind-placebo controlled study on melatonin efficacy to reduce anxiolytic benzodiazepine use in the elderly
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:55-60. 2002
    ..The possible correlation of urinary excretion of 6-sulphatoxymelatonin (aMT6s) before starting treatment and outcome of treatment was also examined...
  53. ncbi request reprint Melatonin effects on bone: experimental facts and clinical perspectives
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Pineal Res 34:81-7. 2003
    ..Whether melatonin can be used as a novel mode of therapy for augmenting bone mass in diseases deserves to be studied...
  54. pmc Attitudes towards treatment among patients suffering from sleep disorders. A Latin American survey
    Margarita Blanco
    Neurofisiología Clínica y Medicina del Sueño, Centro Neurologico, Hospital Frances, Buenos Aires, Argentina
    BMC Fam Pract 4:17. 2003
    ..Although sleep disorders are common, they frequently remain unnoticed by the general practitioner. Few data are available about the willingness and reasons of patients with sleep disturbances to seek for medical assistance...
  55. pmc Clinical aspects of melatonin intervention in Alzheimer's disease progression
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Curr Neuropharmacol 8:218-27. 2010
    ..In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated...
  56. ncbi request reprint Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining
    Hugo E Castagnino
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:391-5. 2002
    ..To examine the cytoprotective effect of melatonin or recombinant human growth hormone (hGH) on the early phase of a running myocardial infarction in rats by using the Feulgen staining...
  57. ncbi request reprint Disruption of ultradian and circadian rhythms of blood pressure in nondipper hypertensive patients
    Santiago Perez-Lloret
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Hypertension 44:311-5. 2004
    ..Ultradian and 24-hour rhythms in HR did not differ among the 3 groups examined. Results indicate that in nondippers, blunted ultradian and 24-hour rhythm amplitude in BP was accompanied by a loss of rhythm integrity...
  58. ncbi request reprint Relation of depression to heart rate nonlinear dynamics in patients > or =60 years of age with recent unstable angina pectoris or acute myocardial infarction
    Daniel E Vigo
    Department of Physiology, University of Buenos Aires School of Medicine, Buenos Aires, Argentina
    Am J Cardiol 93:756-60. 2004
    ..In our sample, depression was associated with increased correlation and decreased complexity of the interbeat interval time series in older adults who had recently developed an acute coronary syndrome...
  59. ncbi request reprint Twenty-four-hour rhythms of mitogenic responses, lymphocyte subset populations and amino acid content in submaxillary lymph nodes of growing male rats subjected to calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Neuroimmunol 156:66-73. 2004
    ..Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of immune responsiveness in growing rats...
  60. ncbi request reprint Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1-11. 2007
    ..DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment...
  61. ncbi request reprint Melatonin in mood disorders
    Venkataramanujan Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan
    World J Biol Psychiatry 7:138-51. 2006
    ..Bright light treatment, that suppresses melatonin production, is effective in treating bipolar affective disorder and SAD, winter type. This review discusses the role of melatonin in the pathophysiology of bipolar disorder and SAD...
  62. ncbi request reprint 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
    Fernando Chacon
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Chronobiol Int 22:253-65. 2005
    ..The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage...
  63. ncbi request reprint Cadmium-induced changes in Per 1 and Per 2 gene expression in rat hypothalamus and anterior pituitary: effect of melatonin
    Pilar Cano
    Department of Biochemistry and Molecular Biology III, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    Toxicol Lett 172:131-6. 2007
    ..The results indicate that Cd administered chronically in the drinking water to rats affected expression of clock genes in the hypothalamic-pituitary unit, an effect prevented by melatonin...
  64. doi request reprint Effect of aging on 24-hour pattern of stress hormones and leptin in rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Life Sci 83:142-8. 2008
    ..Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release...
  65. doi request reprint Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, 28040, Spain
    Endocrine 33:118-25. 2008
    ..The amplitude of the nocturnal pineal melatonin peak decreased significantly in high-fat fed rats. The results underlie the significant effects that obesity has on circadian organization of hormone secretion...
  66. doi request reprint Jet lag: therapeutic use of melatonin and possible application of melatonin analogs
    Venkataramanujan Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan Malaysia
    Travel Med Infect Dis 6:17-28. 2008
    ....
  67. ncbi request reprint Effect of social isolation on 24-h pattern of stress hormones and leptin in rats
    Mario Perello
    Neuroendocrine Unit, Multidisciplinary Institute on Cell Biology CONICET CICPBA, La Plata, Argentina
    Life Sci 78:1857-62. 2006
    ..These changes can be attributed to an effect of mild stress on the endogenous clock that modulates the circadian hormone release...
  68. ncbi request reprint Role of the melatonin system in the control of sleep: therapeutic implications
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mt Sinai School of Medicine, New York, New York 10029, USA
    CNS Drugs 21:995-1018. 2007
    ....
  69. ncbi request reprint Effect of aging on 24-hour changes in dopamine and serotonin turnover and amino acid and somatostatin contents of rat corpus striatum
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Neurosignals 11:336-44. 2002
    ..Some of the circadian modifications of motor function seen in aging rats could be related to the striatal transmitter changes reported herein...
  70. doi request reprint 24-hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or alpha-ketoglutarate
    Perumal Subramanian
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
    Redox Rep 13:78-86. 2008
    ..The results indicate that melatonin and alpha-KG are effective in protecting from NDEA-induced perturbation of 24-h rhythms in oxidative stress. Melatonin augmented antioxidant defense in rats...
  71. ncbi request reprint Circadian periodicity of heart rate variability in hospitalized angor patients
    Carlos E D'Negri
    Instituto de Investigaciones, Médicas Alfredo Lanari, Laboratorio de Neumonología, Combatientes de Malvinas 3150, 1427 Buenos Aires, Argentina
    Clin Auton Res 15:223-32. 2005
    ..A phase delay of 2.5 h in SDNN acrophase was found in severely affected patients when compared to moderate. The results indicate that severity of unstable angor correlates with desynchronization of parasympathetic control of heart rate...
  72. pmc Effect of rabbit doe-litter separation on 24-hour changes of luteinizing hormone, follicle stimulating hormone and prolactin release in female and male suckling pups
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Reprod Biol Endocrinol 3:50. 2005
    ..e., 48 h) doe-litter separation...
  73. ncbi request reprint Future of melatonin as a therapeutic agent
    Michal Karasek
    Clinic of Endocrinology, Polish Mother s Memorial Hospital Research Institute, Lodz, Poland
    Neuro Endocrinol Lett 23:118-21. 2002
    ..All aspects of the possible therapeutic use of melatonin as well as its safety, dosage, side effects and contraindications are discussed herein based on the round table conference and they are presented in this paper...
  74. ncbi request reprint Melatonin
    Rudiger Hardeland
    Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, D 37073 Goettingen, Germany
    Int J Biochem Cell Biol 38:313-6. 2006
    ..Findings are encouraging to use melatonin as a sleep promoter and in preventing progression of neurodegenerative diseases...
  75. ncbi request reprint Effect of chronic ethanol feeding on 24-hour rhythms of mitogenic responses and lymphocyte subset populations in thymus and spleen of peripubertal male rats
    Vanessa Jimenez
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Neuroimmunomodulation 12:357-65. 2005
    ..Chronic ethanol administration presumably affects the endogenous clock that modulates the circadian variation of immune responsiveness in growing rats...
  76. ncbi request reprint Effect of interferon-gamma treatment on 24-hour variations in plasma ACTH, growth hormone, prolactin, luteinizing hormone and follicle-stimulating hormone of male rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Espana
    Neuroimmunomodulation 12:146-51. 2005
    ..In this study we measured the circadian pattern of plasma ACTH, growth hormone (GH), prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at 6 different time points within a 24-hour cycle in adult male Wistar rats...
  77. pmc Immune response after experimental allergic encephalomyelitis in rats subjected to calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Neuroinflammation 4:6. 2007
    ..The results are compatible with the view that the acute phase of EAE can be curtailed by severe calorie restriction, presumably through impaired IFN-gamma production...
  78. ncbi request reprint 24-hour changes in circulating prolactin, follicle-stimulating hormone, luteinizing hormone, and testosterone in young male rats subjected to calorie restriction
    Fernando Chacon
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Chronobiol Int 21:393-404. 2004
    ..Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of the pituitary-gonadal axis in growing male rats...
  79. ncbi request reprint Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain
    Endocrine 32:1-19. 2007
    ..In every case the experimental manipulation used perturbed the temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself...
  80. ncbi request reprint Effect of ethanol on 24-hour hormonal changes in peripubertal male rats
    Vanessa Jimenez
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Avda Complutense s n, 28040 Madrid, Spain
    Alcohol 34:127-32. 2004
    ..Chronic ethanol administration presumably affects the endogenous clock that modulates the circadian variation of the pituitary-gonadal axis and thyrotropin release in growing male rats...
  81. ncbi request reprint 24-Hour rhythm in gene expression of nitric oxide synthase and heme-peroxidase in anterior pituitary of ethanol-fed rats
    Vanesa Jimenez-Ortega
    Department of Biochemistry and Molecular Biology III, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain
    Neurosci Lett 425:69-72. 2007
    ..One of the mechanisms by which ethanol augments oxidative damage in the adenohypophysis may include overproduction of nitric oxide and carbon monoxide...
  82. ncbi request reprint 24-hour pattern of circulating prolactin and growth hormone levels and submaxillary lymph node immune responses in growing male rats subjected to social isolation
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Endocrine 25:41-8. 2004
    ..Modifications in mean value and 24-h rhythmicity of plasma prolactin and GH levels are presumably involved in the effect of social isolation on immune responsiveness...
  83. ncbi request reprint Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine
    Perumal Subramanian
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
    J Pineal Res 43:305-12. 2007
    ..Melatonin administration significantly curtailed tumor development and counteracted all the biochemical effects...
  84. ncbi request reprint Nocturnal hypertension defined by fixed cut-off limits is a better predictor of left ventricular hypertrophy than non-dipping
    Santiago Perez-Lloret
    Int J Cardiol 127:387-9. 2008
    ..4, 95%CI=0.4-5.5). No interaction was detected (p<.3). These results suggest that the definition of nocturnal hypertension based on fixed cut-off values is a better predictor of left ventricular hypertrophy than non-dipping...
  85. ncbi request reprint Effect of ethanol on 24-h hormonal changes in prolactin release mechanisms in growing male rats
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Endocrine 30:269-78. 2006
    ..Ethanol augmented pituitary levels of DOPAC and 5-HIAA. The results indicate that chronic ethanol administration affects the mechanisms that modulate the circadian variation of prolactin release in growing male rats...
  86. doi request reprint Melatonergic drugs in clinical practice
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Universityof Göttingen, Gottingen, Germany
    Arzneimittelforschung 58:1-10. 2008
    ..g., on reproductive functions. According to current data, both compounds seem to be safe during short-term treatment..