Juanita Bustamante

Summary

Affiliation: Universidad de Buenos Aires
Country: Argentina

Publications

  1. doi request reprint Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Alcohol 46:473-9. 2012
  2. doi request reprint Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy
    J Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Mol Cell Biochem 354:231-40. 2011
  3. ncbi request reprint Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia
    Juanita Bustamante
    Catedra de Fisicoquimica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
    Toxicol Appl Pharmacol 199:44-51. 2004
  4. ncbi request reprint Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis
    J Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Buenos Aires, 1113, Argentina
    Arch Biochem Biophys 376:239-47. 2000
  5. ncbi request reprint Sequential NO production by mitochondria and endoplasmic reticulum during induced apoptosis
    Juanita Bustamante
    Laboratory of Free Radical Biology, Institute of Biochemistry Luis Federico Leloir, School of Natural and Exact Sciences, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Nitric Oxide 6:333-41. 2002
  6. ncbi request reprint Brain nitric oxide synthases and mitochondrial function
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Front Biosci 12:1034-40. 2007
  7. doi request reprint Age related changes from youth to adulthood in rat brain cortex: nitric oxide synthase and mitochondrial respiratory function
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Buenos Aires C1113AAD, Argentina
    Neurochem Res 33:1216-23. 2008
  8. ncbi request reprint Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Biochim Biophys Acta 1757:535-42. 2006
  9. ncbi request reprint Hippocampal mitochondrial dysfunction with decreased mtNOS activity in prehepatic portal hypertensive rats
    Silvia Lores-Arnaiz
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Neurochem Int 47:362-8. 2005
  10. doi request reprint Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes
    Mariela L Paz
    Institute of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Photodermatol Photoimmunol Photomed 24:115-22. 2008

Collaborators

Detail Information

Publications34

  1. doi request reprint Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Alcohol 46:473-9. 2012
    ..We can conclude that a decreased motor performance observed in the hangover group of animals could be associated with brain cortex mitochondrial dysfunction and the resulting impairment of its energetic metabolism...
  2. doi request reprint Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy
    J Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Mol Cell Biochem 354:231-40. 2011
    ..In addition, in vitro studies performed in mitochondria from sham animals showed that mitochondrial permeability transition (MPT) could be a mitochondrial mediator of the apoptotic signaling in the presence of NH(4) (+) and calcium...
  3. ncbi request reprint Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia
    Juanita Bustamante
    Catedra de Fisicoquimica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
    Toxicol Appl Pharmacol 199:44-51. 2004
    ..This is mediated through mitochondrial events, associated with an evident decrease in DeltaPsi(m), cytochrome c release and caspase 3 activation...
  4. ncbi request reprint Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis
    J Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Buenos Aires, 1113, Argentina
    Arch Biochem Biophys 376:239-47. 2000
    ....
  5. ncbi request reprint Sequential NO production by mitochondria and endoplasmic reticulum during induced apoptosis
    Juanita Bustamante
    Laboratory of Free Radical Biology, Institute of Biochemistry Luis Federico Leloir, School of Natural and Exact Sciences, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Nitric Oxide 6:333-41. 2002
    ..Meanwhile, other thymocyte apoptotic pathways, such as those induced by MPS or etoposide, seem to centrally involve mitochondria but not endoplasmic reticulum...
  6. ncbi request reprint Brain nitric oxide synthases and mitochondrial function
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Front Biosci 12:1034-40. 2007
    ..All these results seems to be clearly related with the reversible and concentration-dependent attenuation of the respiratory chain by NO...
  7. doi request reprint Age related changes from youth to adulthood in rat brain cortex: nitric oxide synthase and mitochondrial respiratory function
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Buenos Aires C1113AAD, Argentina
    Neurochem Res 33:1216-23. 2008
    ..During rat growth, the respiratory function seems to be modulated by NO produced by the different NOS enzymes: nNOS, eNOS and mtNOS present in the cytosol and in the mitochondria...
  8. ncbi request reprint Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Biochim Biophys Acta 1757:535-42. 2006
    ..Regulation of mtNOS activity by membrane potential makes mtNOS a regulable enzyme that in turn regulates mitochondrial O2 uptake and H2O2 production...
  9. ncbi request reprint Hippocampal mitochondrial dysfunction with decreased mtNOS activity in prehepatic portal hypertensive rats
    Silvia Lores-Arnaiz
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Neurochem Int 47:362-8. 2005
    ..It is concluded that the moderate increase in plasma ammonia that followed portal hypertension was the potential primary cause of the observed alterations...
  10. doi request reprint Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes
    Mariela L Paz
    Institute of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Photodermatol Photoimmunol Photomed 24:115-22. 2008
    ..However, the loss of keratinocyte mitochondrial function generated by UVB, as well as its kinetics, has not been characterized completely...
  11. ncbi request reprint Dopamine enhances mtNOS activity: implications in mitochondrial function
    Analia Czerniczyniec
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Biochim Biophys Acta 1767:1118-25. 2007
    ..This work provides evidence that in the studied conditions, dopamine modifies mitochondrial function by a nitric oxide-dependent pathway...
  12. pmc Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage
    F Schopfer
    Laboratory of Oxygen Metabolism, University Hospital, School of Medicine, University of Buenos Aires, Cordoba 2351, Buenos Aires, Argentina
    Biochem J 349:35-42. 2000
    ..It may be concluded that the reaction of mitochondrial ubiquinol with peroxynitrite is part of a complex regulatory mechanism with implications for mitochondrial function and integrity...
  13. ncbi request reprint Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine
    Silvia Lores-Arnaiz
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Arch Biochem Biophys 430:170-7. 2004
    ..Results indicate that chlorpromazine inhibits brain mtNOS activity in vitro and can exert the same action in vivo...
  14. ncbi request reprint Pharmacological regulation of mitochondrial nitric oxide synthase
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Methods Enzymol 359:328-39. 2002
  15. doi request reprint Dopamine modifies oxygen consumption and mitochondrial membrane potential in striatal mitochondria
    Analia Czerniczyniec
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Mol Cell Biochem 341:251-7. 2010
    ....
  16. pmc Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation
    N A Riobo
    Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Cordoba 2351, 1120, Buenos Aires, Argentina
    Biochem J 359:139-45. 2001
    ..Inhibition of Complex I activity by peroxynitrite may have critical implications for energy supply in tissues such as the brain, whose mitochondrial function depends largely on the channelling of reducing equivalents through Complex I...
  17. ncbi request reprint Modulation of brain mitochondrial function by deprenyl
    Analia Czerniczyniec
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Neurochem Int 48:235-41. 2006
    ..Our results suggest that in vitro effects of deprenyl on mitochondrial function can occur through two different mechanisms, involving nitric oxide synthase inhibition and decreased hydrogen peroxide production...
  18. ncbi request reprint Kinetic analysis of thapsigargin-induced thymocyte apoptosis
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Free Radic Biol Med 37:1490-8. 2004
    ..Preincubation of thymocytes with NOS inhibitors (NG-methyl-L-arginine and L-Nomega-nitro-L-arginine methylester) halted the whole process through inhibition of mitochondrial and endoplasmic reticulum NOS activities and of DNA laddering...
  19. ncbi request reprint Autonomic regulation of pacemaker activity: role of heart nitric oxide synthases
    Andrea L Fellet
    Department of Physiology, Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Am J Physiol Heart Circ Physiol 291:H1246-54. 2006
    ..The observations suggest that NO-mediated pathways contribute to pacemaker heart activity, likely through the NO steady-state levels in the right atrium and the whole heart...
  20. ncbi request reprint Heart mitochondrial nitric oxide synthase is upregulated in male rats exposed to high altitude (4,340 m)
    Gustavo F Gonzales
    Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Am J Physiol Heart Circ Physiol 288:H2568-73. 2005
    ..We conclude that high altitude triggers a physiological adaptive response that upregulates heart mtNOS activity and is associated in an opposed manner with the serum levels of testosterone and estradiol...
  21. ncbi request reprint Heart mitochondrial nitric oxide synthase. Effects of hypoxia and aging
    Laura B Valdez
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Mol Aspects Med 25:49-59. 2004
    ..Nitric oxide and H(2)O(2) constitute signals for metabolic control that are involved in the regulation of cellular processes, such as proliferation and apoptosis...
  22. ncbi request reprint Hydrogen peroxide induces apoptotic-like cell death in coelomocytes of Themiste petricola (Sipuncula)
    Guillermo A Blanco
    Department of Immunology, IDEHU National Research Council CONICET, Buenos Aires, Argentina
    Biol Bull 209:168-83. 2005
    ....
  23. ncbi request reprint Skin damage and mitochondrial dysfunction after acute ultraviolet B irradiation: relationship with nitric oxide production
    Daniel H Gonzalez Maglio
    Institute of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Photodermatol Photoimmunol Photomed 21:311-7. 2005
    ..The aim of the current study was to investigate the effect of UVB irradiation in hairless mice skin...
  24. ncbi request reprint Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage
    M G Repetto
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, Junin 956, C1113AAD Buenos Aires, Argentina
    Mini Rev Med Chem 10:615-23. 2010
    ..This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content...
  25. ncbi request reprint Free radical chemistry in biological systems
    L B Valdez
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Biol Res 33:65-70. 2000
    ..Mitochondrial aging by oxyradical- and peroxynitrite-induced damage would occur through selective mtDNA damage and protein inactivation, leading to dysfunctional mitochondria unable to keep membrane potential and ATP synthesis...
  26. ncbi request reprint Nitric oxide and superoxide radical production by human mononuclear leukocytes
    L B Valdez
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Antioxid Redox Signal 3:505-13. 2001
    ..It is apparent that NO and O2- production by human mononuclear cells may constitute the basis of intercellular signaling and cell toxicity...
  27. ncbi request reprint Reactions of peroxynitrite in the mitochondrial matrix
    L B Valdez
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University Hospital, School of Medicine, University of Buenos Aires, Argentina
    Free Radic Biol Med 29:349-56. 2000
    ..An intramitochondrial steady state concentration of about 2 nM ONOO- was calculated, taking into account the rate constants and concentrations of ONOO- coreactants...
  28. ncbi request reprint Nitric oxide, superoxide, and hydrogen peroxide production in brain mitochondria after haloperidol treatment
    S L Arnaiz
    School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Nitric Oxide 3:235-43. 1999
    ..This inhibition does not seem to be caused by increased NO or ONOO- formation...
  29. ncbi request reprint Biochemistry of free radicals: from electrons to tissues
    A Boveris
    Laboratorio de Radicales Libres en BiologĂ­a y Medicina, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 58:350-6. 1998
    ..Septic shock and endotoxemia produce muscle dysfunction and oxidative stress due to increased steady state concentrations of reactive oxygen and nitrogen species...
  30. ncbi request reprint Measurement of superoxide radical and hydrogen peroxide production in isolated cells and subcellular organelles
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina
    Methods Enzymol 349:280-7. 2002
  31. ncbi request reprint Active oxygen species in the liver of rats submitted to chronic hypobaric hypoxia
    L E Costa
    Instituto de Investigaciones Cardiologicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Am J Physiol 264:C1395-400. 1993
    ..Results suggest that in chronic hypoxia there is a lower rate of generation of active oxygen species in liver, leading to a decreased steady-state concentration of singlet oxygen...
  32. ncbi request reprint Oxidative stress and mitochondrial damage in coronary artery bypass graft surgery: effects of antioxidant treatments
    J Milei
    , Buenos Aires, Argentina
    Compr Ther 27:108-16. 2001
    ..Those patients who received antioxidant therapy benefited by less oxidative stress and mitochondrial damage...
  33. ncbi request reprint The inhibition of PB125I formation in calf thyroid caused by 14-iodo-15-hydroxy-eicosatrienoic acid is due to decreased H2O2 availability
    L Krawiec
    Depto Aplicaciones Biologicas, Comision Nacional de Energia Atomica, Buenos Aires, Argentina
    Horm Metab Res 20:86-90. 1988
    ..Incubation of slices with 10(-5)M I-HO-A caused a 46% decrease in PB125I formation and addition of actinomycin D or puromycin failed to alter this effect.(ABSTRACT TRUNCATED AT 250 WORDS)..
  34. doi request reprint Time course of regression of the protection conferred by simulated high altitude to rat myocardium: correlation with mtNOS
    Pablo La Padula
    Instituto de Investigaciones Cardiologicas, Marcelo T de Alvear 2270, C1122AAJ Buenos Aires, Argentina
    J Appl Physiol 105:951-7. 2008
    ..Results support the putative role of mtNOS in the mechanism involved...