Jorge Eduardo Toblli

Summary

Country: Argentina

Publications

  1. doi request reprint Comparison of the renal, cardiovascular and hepatic toxicity data of original intravenous iron compounds
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Nephrol Dial Transplant 25:3631-40. 2010
  2. pmc Understanding the mechanisms of proteinuria: therapeutic implications
    Jorge E Toblli
    Laboratorio de Medicina Experimental, Hospital Aleman, Facultad de Medicina, University of Buenos Aires, Avenida Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Int J Nephrol 2012:546039. 2012
  3. ncbi request reprint Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon, 1640, 1118 Buenos Aires, Argentina
    Inflamm Allergy Drug Targets 12:190-8. 2013
  4. pmc Nebivolol: impact on cardiac and endothelial function and clinical utility
    Jorge Eduardo Toblli
    Hospital Aleman, Universidad de Buenos Aires, Buenos Aires, Argentina
    Vasc Health Risk Manag 8:151-60. 2012
  5. doi request reprint Comparison of early gastrointestinal tract and liver toxicity of the originator iron polymaltose complex (IPC) and an IPC similar preparation in non-anemic rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Argentina
    Int J Clin Pharmacol Ther 50:573-83. 2012
  6. doi request reprint Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome
    J E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Placenta 33:81-7. 2012
  7. pmc Comparison of oxidative stress and inflammation induced by different intravenous iron sucrose similar preparations in a rat model
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Inflamm Allergy Drug Targets 11:66-78. 2012
  8. ncbi request reprint Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    Jorge Eduardo Toblli
    Hospital Aleman, Buenos Aires, Argentina
    J Am Coll Cardiol 50:1657-65. 2007
  9. ncbi request reprint Comparative study of gastrointestinal tract and liver toxicity of ferrous sulfate, iron amino chelate and iron polymaltose complex in normal rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Pharmacology 82:127-37. 2008
  10. doi request reprint Differences between original intravenous iron sucrose and iron sucrose similar preparations
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Arzneimittelforschung 59:176-90. 2009

Collaborators

  • Felipe Inserra
  • Leon Ferder
  • Elsa Zotta
  • Fernando P Dominici
  • Monica G Ferrini
  • Nestor F Gonzalez-Cadavid
  • Susana Gorzalczany
  • María Inés Rosón
  • Gabriel Cao
  • María I Rosón
  • Marcela Pandolfo
  • Belisario E Fernandez
  • Silvana Lorena Della Penna
  • Marina C Muñoz
  • Silvana Della Penna
  • Silvana L Della Penna
  • Osvaldo Néstor Mazza
  • Elena M V de Cavanagh
  • Daniel Turyn
  • Marcelo P Coba
  • Federico P Di Gennaro
  • Santiago Perez-Lloret
  • Natalia Lucía Rukavina Mikusic
  • Alicia Correa
  • Belisario Enrique Fernández
  • Andrea Carranza
  • Carolina Susana Cerrudo
  • Verónica Trida
  • Cecilia Medici
  • Edgardo Becher
  • Ines Stella
  • Barbara Piotrkowski
  • Margarita Angerosa
  • Danila P Argentino
  • Susana Cavallero
  • Daniel P Cardinali
  • Oscar H Cingolani
  • Alejandro F Abbate
  • Clara Peña
  • Antonio Vilches
  • Andrzej Bartke
  • Alejandro García Aguirre

Detail Information

Publications43

  1. doi request reprint Comparison of the renal, cardiovascular and hepatic toxicity data of original intravenous iron compounds
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Nephrol Dial Transplant 25:3631-40. 2010
    ..v.) iron is essential for managing haemoglobin levels in haemodialysis patients. However, i.v. iron may cause variable degrees of toxicity. This is mainly related to the pharmacological characteristics of any given i.v. iron compound...
  2. pmc Understanding the mechanisms of proteinuria: therapeutic implications
    Jorge E Toblli
    Laboratorio de Medicina Experimental, Hospital Aleman, Facultad de Medicina, University of Buenos Aires, Avenida Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Int J Nephrol 2012:546039. 2012
    ..In addition, current antiproteinuric therapeutic approaches are briefly commented...
  3. ncbi request reprint Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon, 1640, 1118 Buenos Aires, Argentina
    Inflamm Allergy Drug Targets 12:190-8. 2013
    ..Pregnancy outcome of FFand FS-treated animals was worse than that of IPC-treated animals. ..
  4. pmc Nebivolol: impact on cardiac and endothelial function and clinical utility
    Jorge Eduardo Toblli
    Hospital Aleman, Universidad de Buenos Aires, Buenos Aires, Argentina
    Vasc Health Risk Manag 8:151-60. 2012
    ....
  5. doi request reprint Comparison of early gastrointestinal tract and liver toxicity of the originator iron polymaltose complex (IPC) and an IPC similar preparation in non-anemic rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Argentina
    Int J Clin Pharmacol Ther 50:573-83. 2012
    ..In this study, the median lethal dose, the GI tract and liver toxicity of an IPC similar (Vitalix®, IPCSVITA, Laboratorios Roemmers, Buenos Aires, Argentina) were compared with those of IPC in healthy rats...
  6. doi request reprint Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome
    J E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Placenta 33:81-7. 2012
    ..In this study, the effects of IDA and its treatment with iron polymaltose complex/folic acid (IPC/FA) were examined in anemic pregnant rats, their fetuses and placentas...
  7. pmc Comparison of oxidative stress and inflammation induced by different intravenous iron sucrose similar preparations in a rat model
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Inflamm Allergy Drug Targets 11:66-78. 2012
    ..Therefore, before widespread use of these products it would be prudent to evaluate additional non-clinical and/or clinical data proving the safety, therapeutic equivalence and interchangeability of ISSs with IS(ORIG)...
  8. ncbi request reprint Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    Jorge Eduardo Toblli
    Hospital Aleman, Buenos Aires, Argentina
    J Am Coll Cardiol 50:1657-65. 2007
    ....
  9. ncbi request reprint Comparative study of gastrointestinal tract and liver toxicity of ferrous sulfate, iron amino chelate and iron polymaltose complex in normal rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Pharmacology 82:127-37. 2008
    ....
  10. doi request reprint Differences between original intravenous iron sucrose and iron sucrose similar preparations
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Arzneimittelforschung 59:176-90. 2009
    ..A possible explanation for these observations could be the stability of the iron complex...
  11. doi request reprint ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 16:770-6. 2008
    ....
  12. ncbi request reprint Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    Jorge Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Argentina
    J Hypertens 28:1007-19. 2010
    ..Although effective in reducing blood pressure, therapy with a first-generation [beta]-blocker is currently controversial in metabolic syndrome due to its negative impact on carbohydrate and lipid metabolism...
  13. doi request reprint Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    J Hypertens 29:1613-23. 2011
    ..Accordingly, this study evaluated the renal effects of nebivolol, a third-generation β-blocker with additional vasodilating activity, versus those of atenolol in an animal model of diabetic nephropathy...
  14. doi request reprint Assessment of the extent of oxidative stress induced by intravenous ferumoxytol, ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Arzneimittelforschung 61:399-410. 2011
    ..Only low molecular weight iron dextran induced oxidative stress and inflammation in the heart...
  15. doi request reprint Evaluation of toxicity and oxidative stress induced by intravenous iron isomaltoside 1000 in a nonclinical model
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Arzneimittelforschung 61:553-65. 2011
    ..These findings indicate that IIM has a less favorable safety profile than IS in healthy rats, adversely affecting iron deposition, oxidative stress and inflammatory responses, with impaired liver and renal function...
  16. doi request reprint Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Nephrology (Carlton) 13:636-45. 2008
    ..In this study, we evaluated the relationship between iron metabolism, hepcidin and inflammation focusing on left ventricular (LV) function, in a remnant kidney rat model...
  17. ncbi request reprint In vivo and in vitro effects of nebivolol on penile structures in hypertensive rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Am J Hypertens 19:1226-32. 2006
    ..The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats...
  18. ncbi request reprint Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires
    J Sex Med 4:1291-303. 2007
    ..Phosphodiesterase type 5 (PDE5) inhibitors and angiotensin II receptor blockers (ARB) are both common and efficient therapy in patients with ED and arterial hypertension, respectively...
  19. ncbi request reprint Differences between Candesartan and Hydralazine in the protection of penile structures in spontaneously hypertensive rats
    Osvaldo Néstor Mazza
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    J Sex Med 3:604-11. 2006
    ..However, at present there is no substantial information concerning the functional aspect of this class of antihypertensive drugs...
  20. ncbi request reprint ACE inhibitor and angiotensin type I receptor antagonist in combination reduce renal damage in obese Zucker rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Buenos Aires, Argentina
    Kidney Int 65:2343-59. 2004
    ....
  21. ncbi request reprint Different effect of losartan and amlodipine on penile structures in male spontaneously hypertensive rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Am J Nephrol 24:614-23. 2004
    ....
  22. ncbi request reprint Angiotensin-converting enzyme inhibition reduces lipid deposits in myocardium and improves left ventricular function of obese zucker rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Obesity (Silver Spring) 14:1586-95. 2006
    ..The present study examined whether angiotensin-converting enzyme inhibition could ameliorate lipid deposition and ventricular function in the myocardium of obese Zucker rats (OZRs)...
  23. ncbi request reprint NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Urol Res 33:358-67. 2005
    ..This pathway seems to be mediated not only by AT1 but also by AT2 receptors of angiotensin II...
  24. ncbi request reprint Irbesartan restores the in-vivo insulin signaling pathway leading to Akt activation in obese Zucker rats
    Marina C Muñoz
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    J Hypertens 24:1607-17. 2006
    ....
  25. ncbi request reprint Effects of angiotensin II subtype 1 receptor blockade by losartan on tubulointerstitial lesions caused by hyperoxaluria
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Alemán and Instituto de Investigaciones Cardiológicas, Buenos Aires, Argentina
    J Urol 168:1550-5. 2002
    ..We evaluated whether angiotensin II type 1 receptor blockade prevents oxalate renal lesions...
  26. ncbi request reprint Angiotensin-converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Am J Hypertens 17:172-80. 2004
    ....
  27. ncbi request reprint Cardiovascular protective role of a low-dose antihypertensive combination in obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    J Hypertens 21:611-20. 2003
    ....
  28. doi request reprint Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload
    María I Rosón
    School of Pharmacy and Biochemistry, Department of Pathophysiology, Pharmacology and Clinical Biochemistry, University of Buenos Aires, INFIBIOC, CONICET, Buenos Aires, Argentina
    J Cell Physiol 224:41-8. 2010
    ..The protective role of tempol, but not of losartan, in the inflammatory response may be associated with its greater antioxidant effects...
  29. ncbi request reprint Enalapril prevents fatty liver in nephrotic rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    J Nephrol 15:358-67. 2002
    ..The purpose of the present study was to evaluate the possible protective action of an ACE inhibitor, enalapril (E), on fatty liver in adriamicyn-induced nephrotic rats (NR)...
  30. pmc Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Nephrol Dial Transplant 24:2384-91. 2009
    ....
  31. ncbi request reprint Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats
    Marcelo P Coba
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Junin 956, C1113 AAD, Buenos Aires, Argentina
    J Endocrinol 182:433-44. 2004
    ..Our results suggest that Ser 994 is a novel in vivo IR phosphorylation site that might be involved in the regulation of the IRK in some states of insulin resistance...
  32. ncbi request reprint Effects of ACE inhibition and beta-blockade on plasminogen activator inhibitor-1 and transforming growth factor-beta1 in carotid glomus and autonomic ganglia in hypertensive rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Am J Hypertens 20:326-34. 2007
    ....
  33. ncbi request reprint Renal overexpression of atrial natriuretic peptide and hypoxia inducible factor-1α as adaptive response to a high salt diet
    Silvana Lorena Della Penna
    Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, INFIBIOC CONICET, Argentina Cátedra de Fisiopatología, Facultad de Farmacia y Bioquimica, UBA, Junin 956, Piso 5, 1113 Buenos Aires, Argentina
    Biomed Res Int 2014:936978. 2014
    ....
  34. ncbi request reprint Iron(III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis
    Jorge E Toblli
    Hospital Aleman, Laboratory of Experimental Medicine, Department of Internal Medicine, Buenos Aires, Argentina
    Arzneimittelforschung 57:431-8. 2007
    ..This probably reflects a better risk/benefit ratio of IPC in adults. Properly conducted randomized controlled trials, particularly in pediatrics, are needed...
  35. ncbi request reprint The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    J Nephrol 19:419-28. 2006
    ....
  36. ncbi request reprint [Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril]
    Jorge E Toblli
    Sección Hipertensión Arterial, Hospital Aleman, Av Pueyrredon 1640, 1118 Buenos Aires, Argentina
    Medicina (B Aires) 62:544-50. 2002
    ..These results suggest the existence of a real link between UAE and AC in non-smoking patients with arterial hypertension, and that ACE inhibition can similarly modify these two parameters...
  37. doi request reprint Angiotensin II increases intrarenal transforming growth factor-beta1 in rats submitted to sodium overload independently of blood pressure
    María I Rosón
    Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Hypertens Res 31:707-15. 2008
    ..In conclusion, the interaction of Ang II with acute-sodium overload exacerbated intrarenal TGF-beta1, alpha-SMA and NF-kappaB expression, independently from changes in blood pressure levels, in normal rats...
  38. ncbi request reprint Effects of ACE inhibition and beta-blockade on female genital structures in spontaneously hypertensive rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    J Sex Med 4:1593-603. 2007
    ..This study evaluated the possible differences between an angiotensin converting enzyme (ACE) inhibitor and a beta-blocker concerning their potential protective role on female external genitalia in spontaneously hypertensive rats (SHR)...
  39. ncbi request reprint Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine
    Elena M V de Cavanagh
    Physical Chemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Helguera 2365, Buenos Aires 1417, Argentina
    Am J Physiol Regul Integr Comp Physiol 290:R1616-25. 2006
    ..The mitochondrial-antioxidant actions of losartan may be an additional or alternative way to explain some of the beneficial effects of AT1-receptor antagonists...
  40. ncbi request reprint Disruption of ultradian and circadian rhythms of blood pressure in nondipper hypertensive patients
    Santiago Perez-Lloret
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
    Hypertension 44:311-5. 2004
    ..Ultradian and 24-hour rhythms in HR did not differ among the 3 groups examined. Results indicate that in nondippers, blunted ultradian and 24-hour rhythm amplitude in BP was accompanied by a loss of rhythm integrity...
  41. ncbi request reprint [High doses of aspirin reduce natriuresis in hypertensive patients treated with enalapril]
    Federico P Di Gennaro
    Departamento de Medicina Interna, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina
    Medicina (B Aires) 64:301-5. 2004
    ..These results suggest that in essential hypertensive individuals treated with enalapril and two ASA doses, low doses of ASA are associated with better blood pressure control and higher natriuresis...
  42. doi request reprint Sodium load combined with low doses of exogenous angiotensin II upregulate intrarenal angiotensin II
    María Inés Rosón
    Department of Pathophysiology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, INFIBIOC CONICET, Buenos Aires, Argentina
    Kidney Blood Press Res 32:334-41. 2009
    ..The present study was designed to evaluate the effects of a salt load combined with exogenous low nonhypertensive angiotensin II (Ang II) doses on Ang II intrarenal regulation...
  43. ncbi request reprint Renal protective role of atrial natriuretic peptide in acute sodium overload-induced inflammatory response
    María Inés Rosón
    Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Am J Nephrol 26:590-601. 2006
    ..The present study was performed to explore the effect of exogenous infusions of atrial natriuretic peptide (ANP) on the early inflammatory response during acute sodium overload in normal rats...