Rodolfo A Rey

Summary

Country: Argentina

Publications

  1. ncbi Anti-Müllerian hormone in disorders of sex determination and differentiation
    Rodolfo Rey
    Division de Endocrinologia, Hospital de Ninos Ricardo Gutierrez, Departamento de Histologia, Embriología, Biología Celular y Genética, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Arq Bras Endocrinol Metabol 49:26-36. 2005
  2. doi Normal male sexual differentiation and aetiology of disorders of sex development
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Division de Endocrinologia, Hospital de Niños Dr Ricardo Gutierrez, C1425EFD Buenos Aires, Argentina
    Best Pract Res Clin Endocrinol Metab 25:221-38. 2011
  3. ncbi Mini-puberty and true puberty: differences in testicular function
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas Dr César Bergadá CEDIE, CONICET FEI División de Endocrinología, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, C1425EFD Buenos Aires, Argentina Departamento de Histología, Biologia Celular, Embriologia y Genetica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121ABG Buenos Aires, Argentina Electronic address
    Ann Endocrinol (Paris) 75:58-63. 2014
  4. doi Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach
    R A Rey
    Centro de Investigaciones Endocrinologicas CEDIE, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Andrology 1:3-16. 2013
  5. doi Are Klinefelter boys hypogonadal?
    Rodolfo A Rey
    Centro de Investigaciones Endocrinologicas, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Acta Paediatr 100:830-8. 2011
  6. doi Ontogeny of the androgen receptor expression in the fetal and postnatal testis: its relevance on Sertoli cell maturation and the onset of adult spermatogenesis
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Hospital de Niños R Gutiérrez, C1425EFD Buenos Aires, Argentina
    Microsc Res Tech 72:787-95. 2009
  7. ncbi Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias
    Rodolfo A Rey
    CEDIE, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
    J Clin Endocrinol Metab 90:6035-40. 2005
  8. ncbi How to evaluate gonadal function in the cryptorchid boy. Lessons from new testicular markers
    Rodolfo Rey
    Centro de Investigaciones Endocrinologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 16:357-64. 2003
  9. ncbi AMH/MIS: what we know already about the gene, the protein and its regulation
    Rodolfo Rey
    Centro de Investigaciones Endocrinológicas CONICET, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Mol Cell Endocrinol 211:21-31. 2003
  10. ncbi Regulation of spermatogenesis
    Rodolfo Rey
    Endocrine Research Centre, R Gutierrez Children s Hospital, Buenos Aires, Argentina
    Endocr Dev 5:38-55. 2003

Collaborators

Detail Information

Publications32

  1. ncbi Anti-Müllerian hormone in disorders of sex determination and differentiation
    Rodolfo Rey
    Division de Endocrinologia, Hospital de Ninos Ricardo Gutierrez, Departamento de Histologia, Embriología, Biología Celular y Genética, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Arq Bras Endocrinol Metabol 49:26-36. 2005
    ..Finally, AMH may be normally secreted in intersex patients with defects restricted to androgen synthesis or action, resulting in patients with female or ambiguous external genitalia with no Müllerian derivatives...
  2. doi Normal male sexual differentiation and aetiology of disorders of sex development
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Division de Endocrinologia, Hospital de Niños Dr Ricardo Gutierrez, C1425EFD Buenos Aires, Argentina
    Best Pract Res Clin Endocrinol Metab 25:221-38. 2011
    ..Understanding the pathogenesis is useful for an efficient early diagnosis approach, which is necessary for adequate decision making in the management of DSD...
  3. ncbi Mini-puberty and true puberty: differences in testicular function
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas Dr César Bergadá CEDIE, CONICET FEI División de Endocrinología, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, C1425EFD Buenos Aires, Argentina Departamento de Histología, Biologia Celular, Embriologia y Genetica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121ABG Buenos Aires, Argentina Electronic address
    Ann Endocrinol (Paris) 75:58-63. 2014
    ....
  4. doi Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach
    R A Rey
    Centro de Investigaciones Endocrinologicas CEDIE, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Andrology 1:3-16. 2013
    ..Finally, the lack of elevation of gonadotropins in adolescents or adults with primary gonadal failure is indicative of a combined hypogonadism involving the gonads and the hypothalamic-pituitary axis...
  5. doi Are Klinefelter boys hypogonadal?
    Rodolfo A Rey
    Centro de Investigaciones Endocrinologicas, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Acta Paediatr 100:830-8. 2011
    ..Sertoli cell products AMH and inhibin B are normal in prepubertal boys and only decline during mid- to late puberty...
  6. doi Ontogeny of the androgen receptor expression in the fetal and postnatal testis: its relevance on Sertoli cell maturation and the onset of adult spermatogenesis
    Rodolfo A Rey
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Hospital de Niños R Gutiérrez, C1425EFD Buenos Aires, Argentina
    Microsc Res Tech 72:787-95. 2009
    ..We show that the absence of androgen receptor expression in Sertoli cells underlies a physiological stage of androgen insensitivity within the male gonad in the fetal and early postnatal periods...
  7. ncbi Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias
    Rodolfo A Rey
    CEDIE, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
    J Clin Endocrinol Metab 90:6035-40. 2005
    ..Isolated hypospadias may result from impaired testicular function or androgen end-organ defects or, alternatively, from hormone-independent abnormalities of morphogenetic events responsible for urethral seam...
  8. ncbi How to evaluate gonadal function in the cryptorchid boy. Lessons from new testicular markers
    Rodolfo Rey
    Centro de Investigaciones Endocrinologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 16:357-64. 2003
    ..The determination of testosterone, its precursors and dihydrotestosterone, after hCG stimulation, should be reserved for situations in which Leydig cell function needs to be specifically assessed...
  9. ncbi AMH/MIS: what we know already about the gene, the protein and its regulation
    Rodolfo Rey
    Centro de Investigaciones Endocrinológicas CONICET, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Mol Cell Endocrinol 211:21-31. 2003
    ..Serum AMH determination is useful to study testicular function in boys and in patients with gonadal tumours. AMH levels in seminal and follicular fluid may also be of clinical use...
  10. ncbi Regulation of spermatogenesis
    Rodolfo Rey
    Endocrine Research Centre, R Gutierrez Children s Hospital, Buenos Aires, Argentina
    Endocr Dev 5:38-55. 2003
  11. ncbi Sertoli cell markers in the diagnosis of paediatric male hypogonadism
    Romina P Grinspon
    Centro de Investigaciones Endocrinologicas CEDIE, CONICET, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 25:3-11. 2012
    ..In conclusion, measurement of serum AMH and inhibin B is helpful in assessing testicular function, without need for stimulation tests, and orientates the aetiological diagnosis of paediatric male hypogonadism...
  12. doi Gonadotrophin secretion pattern in anorchid boys from birth to pubertal age: pathophysiological aspects and diagnostic usefulness
    Romina P Grinspon
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Division de Endocrinologia, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 76:698-705. 2012
    ..The biphasic ontogeny of serum gonadotrophins observed in normal children also exists in girls with gonadal dysgenesis, although with higher levels. However, limited data exist in prepubertal boys with anorchia...
  13. doi The prepubertal testis: biomarkers and functions
    Clara Valeri
    Centro de Investigaciones Endocrinologicas CEDIE, Division de Endocrinologia, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Curr Opin Endocrinol Diabetes Obes 20:224-33. 2013
    ..Biomarkers of prepubertal testicular function have become widely available only in recent years. The aim of this review is to update the knowledge on key biomarkers used to assess hypogonadism in boys...
  14. doi Anti-müllerian hormone and sertoli cell function in paediatric male hypogonadism
    Romina P Grinspon
    Centro de Investigaciones Endocrinologicas CEDIE, CONICET, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Horm Res Paediatr 73:81-92. 2010
    ..Furthermore, serum AMH is an excellent marker of FSH and androgen action in the testis...
  15. ncbi Subcellular and molecular mechanisms regulating anti-Müllerian hormone gene expression in mammalian and nonmammalian species
    Celina Lasala
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    DNA Cell Biol 23:572-85. 2004
    ..Particular features are observed in AMH expression in nonmammalian species. In birds, AMH is expressed both in the male and female fetal gonads, and, like in reptiles, its expression is not preceded by that of SOX9...
  16. ncbi Seminiferous tubule function in delayed-onset X-linked adrenal hypoplasia congenita associated with incomplete hypogonadotrophic hypogonadism
    Ignacio Bergada
    Centro de Investigaciones Endocrinológicas and División de Endocrinología, Hospital de Niños R Gutiérrez, C1425EFD Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 68:240-6. 2008
    ..Clinical variants with delayed-onset have been recognized. The objective of this study is to assess Sertoli cell function throughout pubertal development in patients with childhood-onset AHC due to stop mutations in the DAX-1 gene...
  17. doi Physiological androgen insensitivity of the fetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells
    Hector E Chemes
    Centro de Investigaciones Endocrinologicas, Hospital de Niños R Gutiérrez, and Departamento de Histología, Biologia Celular, Embriología, y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Clin Endocrinol Metab 93:4408-12. 2008
    ..We hypothesized that Sertoli cells do not respond to testosterone because they do not express the androgen receptor...
  18. doi SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1
    Celina Lasala
    Centro de Investigaciones Endocrinologicas, Hospital de Niños R Gutiérrez, Gallo, Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 301:E539-47. 2011
    ..SOX9 and SF1 binding to the AMH promoter is essential to increase the activity of the AMH promoter in response to cAMP...
  19. ncbi Basal follicle-stimulating hormone and peak gonadotropin levels after gonadotropin-releasing hormone infusion show high diagnostic accuracy in boys with suspicion of hypogonadotropic hypogonadism
    Romina P Grinspon
    Centro de Investigaciones Endocrinologicas, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
    J Clin Endocrinol Metab 95:2811-8. 2010
    ..Most tests use an acute GnRH stimulus, allowing only the release of previously synthesized gonadotropins. A constant GnRH infusion, inducing de novo gonadotropin synthesis, may allow a better discrimination...
  20. ncbi Time course of the serum gonadotropin surge, inhibins, and anti-Müllerian hormone in normal newborn males during the first month of life
    Ignacio Bergada
    Centro de Investigaciones Endocrinologicas, Division de Endocrinologia, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
    J Clin Endocrinol Metab 91:4092-8. 2006
    ..Newborns with ambiguous genitalia or males with nonpalpable gonads usually require an early assessment of the presence and functional state of testicular tissue...
  21. ncbi New perspectives in the diagnosis of pediatric male hypogonadism: the importance of AMH as a Sertoli cell marker
    Romina P Grinspon
    Centro de Investigaciones Endocrinologicas, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Arq Bras Endocrinol Metabol 55:512-9. 2011
    ..Furthermore, serum AMH is an excellent marker of FSH and androgen action on the testis...
  22. ncbi Altered serum profile of inhibin B, Pro-alphaC and anti-Müllerian hormone in prepubertal and pubertal boys with varicocele
    Romina V Trigo
    Centro de Investigaciones Endocrinologicas CEDIE, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 60:758-64. 2004
    ..The aim of the present study was to assess the functional state of Sertoli cells in order to detect early changes in the testicular function of prepubertal and pubertal patients with untreated grade II or III varicocele...
  23. ncbi Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome
    Rodolfo A Rey
    Centro de Investigaciones Endocrinologicas, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Hum Mol Genet 15:3538-43. 2006
    ..Lack of occurrence of the mutation in Leydig cells may explain why sexual precocity is rarely observed in boys with MAS...
  24. ncbi Establishment of testicular endocrine function impairment during childhood and puberty in boys with Klinefelter syndrome
    María Gabriela Bastida
    División de Endocrinología and Centro de Investigaciones Endocrinológicas, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 67:863-70. 2007
    ..Design Retrospective chart review. Patients A total of 29 boys with Klinefelter syndrome with up to 12.3 years follow-up...
  25. ncbi Follicle-stimulating hormone increases testicular Anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 5'-monophosphate-mediated activation of the AMH Gene
    Céline Lukas-Croisier
    Centro de Investigaciones Endocrinologicas, Hospital de Ninos, Gallo 1330, C1425EFD Buenos Aires, Argentina
    Mol Endocrinol 17:550-61. 2003
    ..We conclude that prepubertal testicular AMH production is increased by FSH stimulation through Sertoli cell proliferation and an enhancement of AMH gene transcription...
  26. pmc Prediction of reproductive outcomes according to different serum anti-Müllerian hormone levels in females undergoing intracystoplasmic sperm injection
    Santiago Brugo Olmedo
    Centro Medico, Seremas, Buenos Aires, Argentina
    PLoS ONE 8:e75685. 2013
    ..However, practical data is scarce for the physician and the patients to predict these outcomes in an individual couple according to serum AMH measured prior to assisted reproduction technology (ART) procedures...
  27. doi Heterozygous IGFALS gene variants in idiopathic short stature and normal children: impact on height and the IGF system
    Horacio M Domene
    Centro de Investigaciones Endocrinológicas Dr César Bergadá CEDIE, CONICET FEI División de Endocrinología, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
    Horm Res Paediatr 80:413-23. 2013
    ..We have characterized IGFALS gene variants in idiopathic short stature (ISS) and in normal children, determining their impact on height and the IGF system...
  28. pmc Clinical Presentation of Klinefelter's Syndrome: Differences According to Age
    Néstor Pacenza
    Servicio de Endocrinología y Metabolismo, Unidad Asistencial Dr César Milstein, Buenos Aires, Argentina
    Int J Endocrinol 2012:324835. 2012
    ..In adults average height and weight are slightly higher than those in the normal population. Bone mineral density is mildly affected, more at the spine than at the femoral neck level, in less than half of cases...
  29. ncbi FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells
    Ariel F Gualtieri
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Int J Androl 32:218-25. 2009
    ..Therefore, protection of germ cells against oxidative stress seems to be regulated by hormones and germ cell-released growth factors capable of influencing the production of Sertoli cell GSH...
  30. doi Origin and evolution of somatic cell testicular tumours in transgenic mice
    Silvina Quintana
    Center for Research in Endocrinology CEDIE CONICET, Buenos Aires Children s Hospital, Gallo 1330, Buenos Aires, Argentina
    J Pathol 221:443-51. 2010
    ....
  31. doi Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood
    Sergio E Recabarren
    Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Medicine, University of Concepcion, Chillan, Chile
    J Clin Endocrinol Metab 93:3318-24. 2008
    ..However, the reproductive phenotypes in first-degree male relatives of PCOS women have been described less often...
  32. ncbi Hormonal profile in women with polycystic ovarian syndrome with or without type 1 diabetes mellitus
    Ethel Codner
    Institute of Maternal and Child Research, School of Medicine, University of Chile, Casilla 226 3, Santiago, Chile
    J Clin Endocrinol Metab 92:4742-6. 2007
    ....