G A Rabinovich

Summary

Country: Argentina

Publications

  1. ncbi request reprint Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease
    G A Rabinovich
    División Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, C1120, Buenos Aires, Argentina
    Parasite Immunol 27:103-14. 2005
  2. pmc Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway
    Pablo N Fernández Larrosa
    National Reference Center for AIDS, Department of Microbiology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Retrovirology 5:19. 2008
  3. pmc Immunosuppressive strategies that are mediated by tumor cells
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Buenos Aires, Argentina
    Annu Rev Immunol 25:267-96. 2007
  4. ncbi request reprint Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Glycoconj J 19:565-73. 2004
  5. ncbi request reprint Role of galectins in inflammatory and immunomodulatory processes
    Gabriel A Rabinovich
    División de Immunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Cordoba 2351, 3er Piso, CP 1120, Buenos Aires, Argentina
    Biochim Biophys Acta 1572:274-84. 2002
  6. ncbi request reprint Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms
    G A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Cell Death Differ 9:661-70. 2002
  7. ncbi request reprint Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, School of Medicine, University of Buenos Aires, Cordoba 2351, 3er Piso C 1120, City of Buenos Aires, Argentina
    J Leukoc Biol 71:741-52. 2002
  8. ncbi request reprint An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer
    G A Rabinovich
    Department of Immunopathology, Institute of Biology and Experimental Medicine IBYME CONICET, Buenos Aires, Argentina
    Scand J Immunol 66:143-58. 2007
  9. pmc Functions of cell surface galectin-glycoprotein lattices
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires, Argentina
    Curr Opin Struct Biol 17:513-20. 2007
  10. doi request reprint Immunology south of the equator in the Americas
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 9:1087-90. 2008

Collaborators

  • A Gruppi
  • L Fainboim
  • C E Sotomayor
  • E M Riley
  • Stefano Iacobelli
  • Wilson Savino
  • Norberto W Zwirner
  • M Hirashima
  • Alexis M Kalergis
  • N A Sanjuan
  • M A Toscano
  • Marta A Toscano
  • German A Bianco
  • J M Ilarregui
  • Juan M Ilarregui
  • E Zuniga
  • N Rubinstein
  • Pablo N Fernández Larrosa
  • Diego O Croci
  • M T Elola
  • M I Gonzalez
  • L Giordanengo
  • J B de Souza
  • J E Tongren
  • F T Liu
  • M C Salamone
  • Diego A Riva
  • Mariel Bibini
  • Renata Luzzi
  • Mónica Saracco
  • Susana E Mersich
  • Liliana Martinez Peralta
  • M F Troncoso
  • Linda G Baum
  • Jorge Correale
  • Joseph D Hernandez
  • Francoise Poirier
  • G R Vasta
  • C Wolfenstein-Todel
  • Natalia Rubinstein
  • M C Sanchez
  • G A Bianco
  • A K Mendiguren
  • M M Iglesias
  • G V Salamone
  • G Barbieri
  • J Hirabayashi
  • K I Kasai
  • S Gea
  • H A Guglielmone
  • M A Vides
  • G A Chiabrando
  • G R Bonacci

Detail Information

Publications32

  1. ncbi request reprint Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease
    G A Rabinovich
    División Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, C1120, Buenos Aires, Argentina
    Parasite Immunol 27:103-14. 2005
    ..Understanding the role of galectin-sugar interactions during the course of microbial infections might contribute to defining novel targets for disease prevention and immune intervention...
  2. pmc Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway
    Pablo N Fernández Larrosa
    National Reference Center for AIDS, Department of Microbiology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Retrovirology 5:19. 2008
    ....
  3. pmc Immunosuppressive strategies that are mediated by tumor cells
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Buenos Aires, Argentina
    Annu Rev Immunol 25:267-96. 2007
    ....
  4. ncbi request reprint Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Glycoconj J 19:565-73. 2004
    ..Moreover, we will discuss the importance of these sugar-binding proteins as therapeutic targets in Th1- and Th2-mediated immune disorders, an exciting area for future research...
  5. ncbi request reprint Role of galectins in inflammatory and immunomodulatory processes
    Gabriel A Rabinovich
    División de Immunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Cordoba 2351, 3er Piso, CP 1120, Buenos Aires, Argentina
    Biochim Biophys Acta 1572:274-84. 2002
    ....
  6. ncbi request reprint Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms
    G A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Cell Death Differ 9:661-70. 2002
    ..The present study sets the basis for a potential use of galectin-1 as a selective immunosuppressive agent to limit T-cell-mediated reactivity during the effector phase of the alloimmune response...
  7. ncbi request reprint Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, School of Medicine, University of Buenos Aires, Cordoba 2351, 3er Piso C 1120, City of Buenos Aires, Argentina
    J Leukoc Biol 71:741-52. 2002
    ..Understanding the intimate mechanisms involved in galectin functions will help to delineate selective and novel strategies for disease intervention and diagnosis...
  8. ncbi request reprint An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer
    G A Rabinovich
    Department of Immunopathology, Institute of Biology and Experimental Medicine IBYME CONICET, Buenos Aires, Argentina
    Scand J Immunol 66:143-58. 2007
    ....
  9. pmc Functions of cell surface galectin-glycoprotein lattices
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires, Argentina
    Curr Opin Struct Biol 17:513-20. 2007
    ....
  10. doi request reprint Immunology south of the equator in the Americas
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 9:1087-90. 2008
    ..Despite a troubled economic and political past, a tradition of fundamental research in immunology and infectious diseases has been fostered in Argentina, Brazil and Chile, as well as in other South American countries...
  11. ncbi request reprint [Galectins: a novel family of proteins involved in the regulation of the immune response. Implications in immunopathological processes]
    G A Rabinovich
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Cordoba 2351, 1120 Buenos Aires, Argentina
    Medicina (B Aires) 61:85-92. 2001
    ..The use of recombinant galectins or their antagonists will have future implications in the diagnosis, prognosis and treatment of these diseases, widening the horizons of molecular immunopathology...
  12. ncbi request reprint Apoptosis as a target for gene therapy in rheumatoid arthritis
    G A Rabinovich
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Cordoba 2351, 3er Piso, 1120 Buenos Aires, Argentina
    Mem Inst Oswaldo Cruz 95:225-33. 2000
    ....
  13. ncbi request reprint Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2
    G A Rabinovich
    Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba, Cordoba, Argentina
    Cell Death Differ 7:747-53. 2000
    ....
  14. doi request reprint Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428, Ciudad de Buenos Aires, Argentina
    Nat Rev Immunol 9:338-52. 2009
    ....
  15. doi request reprint Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Immunol Rev 230:144-59. 2009
    ....
  16. ncbi request reprint Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Buenos Aires, Argentina
    Glycobiology 16:210-20. 2006
    ..Our results suggest that galectin inhibitors with subtle differences in their carbohydrate structures may be potentially used to specifically block different steps of tumor growth and metastasis...
  17. ncbi request reprint The role of galectins in the initiation, amplification and resolution of the inflammatory response
    N Rubinstein
    Department of Microbiology, Hospital de Clinicas Jose de San Martin, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Tissue Antigens 64:1-12. 2004
    ....
  18. ncbi request reprint Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization
    G A Rabinovich
    Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba, Argentina
    J Immunol 160:4831-40. 1998
    ..This effect was quantified by using the terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end-labeling assay and was found to be associated to the specific carbohydrate-binding properties of galectin...
  19. ncbi request reprint Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis
    E Zuniga
    Laboratory of Immunology, Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba, Argentina
    J Leukoc Biol 70:73-9. 2001
    ..Hence, the present study describes a potential mechanism by which B cells can regulate T-cell function and survival...
  20. pmc The coming of age of galectins as immunomodulatory agents: impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders
    J M Ilarregui
    División Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Av Córdoba 2351 3 Piso C1120 Ciudad de Buenos Aires, Argentina
    Ann Rheum Dis 64:iv96-103. 2005
    ....
  21. ncbi request reprint Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis
    M I Gonzalez
    Department of Microbiology, School of Medicine, University of Buenos Aires, Argentina
    Int J Immunopathol Pharmacol 18:615-23. 2005
    ..Since many viruses have evolved mechanisms to counteract the antiviral response raised by the infected host, our results suggest that HSV-1 may use galectin-1 as a weapon to kill activated T cells and evade specific immune responses...
  22. ncbi request reprint Activation-induced expression of CD1d antigen on mature T cells
    M C Salamone
    División Inmunogenética, Hospital de Clinicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Leukoc Biol 69:207-14. 2001
    ..Elucidation of the molecular mechanisms implicated in the activation-dependent expression of this nonclassical antigen will provide new insights into the understanding of antigen presentation and immune regulation...
  23. ncbi request reprint Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival
    M T Elola
    Instituto de Quimica y Fisicoquimica Biologicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C1123, Buenos Aires, Argentina
    Cell Mol Life Sci 64:1679-700. 2007
    ....
  24. pmc Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages: modulation of microbicidal activity and survival
    E Zuniga
    Departmento de Bioquímica Clínica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Infect Immun 69:6804-12. 2001
    ....
  25. pmc Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: differential expression of this beta-galactoside-binding protein in cardiac Chagas' disease
    L Giordanengo
    Immunology, Department of Clinical Biochemistry, Faculty of Chemical Sciences, , , Argentina
    Clin Exp Immunol 124:266-73. 2001
    ..This protein was found to be markedly upregulated in cardiac tissue from patients with severe CCD, compared to cardiac tissue from normal individuals...
  26. pmc Galectin-1 as a potential cancer target
    G A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Br J Cancer 92:1188-92. 2005
    ....
  27. doi request reprint Endogenous galectin-3 controls experimental malaria in a species-specific manner
    M A Toscano
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Parasite Immunol 34:383-7. 2012
    ..Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses...
  28. ncbi request reprint Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy
    G A Rabinovich
    Division of Immunology, Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba, Cordoba, Argentina
    Cell Death Differ 6:711-21. 1999
    ....
  29. ncbi request reprint Interaction of human tissue plasminogen activator (t-PA) with pregnancy zone protein: a comparative study with t-PA-alpha2-macroglobulin interaction
    M C Sanchez
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Biochem 124:274-9. 1998
    ..The present study suggests that PZP, by binding to t-PA, may contribute to the control of the activity of proteinases derived from fibrinolytic systems...
  30. ncbi request reprint [How do protein-glycan interactions regulate T-cell physiology?]
    Marta A Toscano
    División Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 66:357-62. 2006
    ..This article briefly reviews the mechanisms by which protein-carbohydrate interactions modulate immunological processes such as T-cell activation, migration and apoptosis...
  31. ncbi request reprint Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
    German A Bianco
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Autoimmun Rev 5:349-56. 2006
    ....
  32. ncbi request reprint Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
    Marta A Toscano
    División de Immunogenética Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, C1120AAF Buenos Aires, Argentina
    Nat Immunol 8:825-34. 2007
    ..Our findings identify a molecular link among differential glycosylation of T helper cells, susceptibility to cell death and termination of the inflammatory response...