Hugo J F Maccioni

Summary

Country: Argentina

Publications

  1. doi request reprint Content of endoplasmic reticulum and Golgi complex membranes positively correlates with the proliferative status of brain cells
    David C Silvestre
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Neurosci Res 87:857-65. 2009
  2. doi request reprint Organization of the synthesis of glycolipid oligosaccharides in the Golgi complex
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    FEBS Lett 585:1691-8. 2011
  3. doi request reprint Cellular and molecular biology of glycosphingolipid glycosylation
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Neurochem 117:589-602. 2011
  4. ncbi request reprint Glycosylation of glycolipids in the Golgi complex
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Cordoba, Argentina
    J Neurochem 103:81-90. 2007
  5. pmc Identification of a site in Sar1 involved in the interaction with the cytoplasmic tail of glycolipid glycosyltransferases
    Cristián A Quintero
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Centro de Investigaciones en Quimica Biologica de Cordoba, X5000HUA Córdoba, Argentina
    J Biol Chem 285:30340-6. 2010
  6. ncbi request reprint Modulation of GalT1 and SialT1 sub-Golgi localization by SialT2 expression reveals an organellar level of glycolipid synthesis control
    Andrea S Uliana
    , UNC CONICET, , , , Ciudad Universitaria, , Argentina
    J Biol Chem 281:32852-60. 2006
  7. doi request reprint Glycosyltransferase complexes improve glycolipid synthesis
    Waldo Spessott
    Centro de Investigaciones en Química Biológica de Córdoba CIQUIBIC, UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000 HUA Córdoba, Argentina
    FEBS Lett 586:2346-50. 2012
  8. pmc c-Fos activates glucosylceramide synthase and glycolipid synthesis in PC12 cells
    Pilar M Crespo
    Centro de Investigaciones en Quimica Biologica de Cordoba, Universidad Nacional de Cordoba, Ciudad Universitaria, Córdoba X5000HUA, Argentina
    J Biol Chem 283:31163-71. 2008
  9. doi request reprint Spatial organization and stoichiometry of N-terminal domain-mediated glycosyltransferase complexes in Golgi membranes determined by fret microscopy
    Mariana L Ferrari
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    Neurochem Res 37:1325-34. 2012
  10. pmc Cog2 null mutant CHO cells show defective sphingomyelin synthesis
    Waldo Spessott
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000 HUA Córdoba, Argentina
    J Biol Chem 285:41472-82. 2010

Collaborators

  • Claudio G Giraudo
  • Jose L Daniotti
  • Javier Valdez-Taubas
  • Waldo Spessott
  • Pilar M Crespo
  • Cristián A Quintero
  • Andrea S Uliana
  • Mariana L Ferrari
  • David C Silvestre
  • Andrea Uliana
  • Ayelén González Montoro
  • Beatriz L Caputto
  • Lina P Raimondi
  • Guillermo A Gomez
  • Guillermo Montich
  • Marcos Villarreal
  • Javier Valdez Taubas
  • Rodrigo Quiroga
  • Sergio D Haedo
  • Germán A Gil
  • Jose A Martina
  • Adolfo R Zurita

Detail Information

Publications19

  1. doi request reprint Content of endoplasmic reticulum and Golgi complex membranes positively correlates with the proliferative status of brain cells
    David C Silvestre
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Neurosci Res 87:857-65. 2009
    ..Results suggest that the amount of endomembranes and the concentration of constituent functional proteins diminish as cells decline in their proliferative activity...
  2. doi request reprint Organization of the synthesis of glycolipid oligosaccharides in the Golgi complex
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    FEBS Lett 585:1691-8. 2011
    ....
  3. doi request reprint Cellular and molecular biology of glycosphingolipid glycosylation
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Neurochem 117:589-602. 2011
    ....
  4. ncbi request reprint Glycosylation of glycolipids in the Golgi complex
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Cordoba, Argentina
    J Neurochem 103:81-90. 2007
    ..I will also discuss how the organization of the glycosylating machinery in the Golgi may adapt to events controlling glycolipid expression...
  5. pmc Identification of a site in Sar1 involved in the interaction with the cytoplasmic tail of glycolipid glycosyltransferases
    Cristián A Quintero
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Centro de Investigaciones en Quimica Biologica de Cordoba, X5000HUA Córdoba, Argentina
    J Biol Chem 285:30340-6. 2010
    ..The results indicate that amino acids in site A of Sar1 are involved in the interaction with the CT of GGT for concentration at ER exiting sites...
  6. ncbi request reprint Modulation of GalT1 and SialT1 sub-Golgi localization by SialT2 expression reveals an organellar level of glycolipid synthesis control
    Andrea S Uliana
    , UNC CONICET, , , , Ciudad Universitaria, , Argentina
    J Biol Chem 281:32852-60. 2006
    ....
  7. doi request reprint Glycosyltransferase complexes improve glycolipid synthesis
    Waldo Spessott
    Centro de Investigaciones en Química Biológica de Córdoba CIQUIBIC, UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000 HUA Córdoba, Argentina
    FEBS Lett 586:2346-50. 2012
    ....
  8. pmc c-Fos activates glucosylceramide synthase and glycolipid synthesis in PC12 cells
    Pilar M Crespo
    Centro de Investigaciones en Quimica Biologica de Cordoba, Universidad Nacional de Cordoba, Ciudad Universitaria, Córdoba X5000HUA, Argentina
    J Biol Chem 283:31163-71. 2008
    ..This strict regulation assures that lipid metabolism activation will occur as a response to cell requirements thus pointing to c-Fos as an important regulator of key membrane metabolisms in membrane biogenesis-demanding processes...
  9. doi request reprint Spatial organization and stoichiometry of N-terminal domain-mediated glycosyltransferase complexes in Golgi membranes determined by fret microscopy
    Mariana L Ferrari
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    Neurochem Res 37:1325-34. 2012
    ..These results reveals that particular topological organization of GTs may have functional implications in determining the composition of glycolipids in cellular membranes...
  10. pmc Cog2 null mutant CHO cells show defective sphingomyelin synthesis
    Waldo Spessott
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000 HUA Córdoba, Argentina
    J Biol Chem 285:41472-82. 2010
    ....
  11. doi request reprint Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase
    Cristián A Quintero
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina
    Biochem J 412:19-26. 2008
    ..These combined in vivo and in vitro results suggest that CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases...
  12. doi request reprint Defective GM3 synthesis in Cog2 null mutant CHO cells associates to mislocalization of lactosylceramide sialyltransferase in the Golgi complex
    Waldo Spessott
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC, UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    Neurochem Res 35:2161-7. 2010
    ....
  13. ncbi request reprint Cytoplasmic tails of SialT2 and GalNAcT impose their respective proximal and distal Golgi localization
    Andrea S Uliana
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    Traffic 7:604-12. 2006
    ..Exchanging the transmembrane region and the cts of SialT2 and GalNAcT indicates that information for proximal or distal Golgi concentration is associated with the cts...
  14. pmc Ganglioside glycosyltransferases and newly synthesized gangliosides are excluded from detergent-insoluble complexes of Golgi membranes
    Pilar M Crespo
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC, Departamento de Quimica Biologica, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    Biochem J 377:561-8. 2004
    ..This latter event could have taken place shortly after synthesis in the Golgi cisternae, along the secretory pathway and/or at the cell surface...
  15. ncbi request reprint ETS-1 transcription factor activates the expression of mouse UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase gene
    Lina P Raimondi
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    FEBS Lett 576:487-91. 2004
    ..Mutagenesis, competition experiments and functional assays showed that the Ets-1 transcription factor is involved in the activation of the Gal-T2 promoter...
  16. pmc Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with Sar1
    Claudio G Giraudo
    Centro de Investigaciones en Química Biológica de Córdoba CIQUIBIC, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    Mol Biol Cell 14:3753-66. 2003
    ..Collectively, the present data suggest that interaction of the dibasic motif with Sar1 participates in early steps of selection of Golgi resident glycosyltransferases for transport in COPII vesicles...
  17. doi request reprint A novel motif at the C-terminus of palmitoyltransferases is essential for Swf1 and Pfa3 function in vivo
    Ayelén González Montoro
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina
    Biochem J 419:301-8. 2009
    ..The motif is conserved in 70% of PATs from all eukaryotic organisms analysed, and may have once been present in all PATs. We have named this motif PaCCT ('Palmitoyltransferase Conserved C-Terminus')...
  18. ncbi request reprint Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells
    Claudio G Giraudo
    CIQUIBIC, Universidad Nacional de Cordoba Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Argentina
    J Biol Chem 278:40262-71. 2003
    ....
  19. ncbi request reprint Understanding the stepwise synthesis of glycolipids
    Hugo J F Maccioni
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    Neurochem Res 27:629-36. 2002
    ..It is envisaged that the machinery for synthesis in the Golgi complex, and its dynamics, constitute a potential target for fine tuning of the control of glycolipid expression according to cell demands...