Pablo Iribarren

Summary

Country: Argentina

Publications

  1. pmc Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Neurobiol Dis 27:90-8. 2007
  2. ncbi request reprint Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:3651-9. 2006
  3. ncbi request reprint CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    FASEB J 19:2032-4. 2005
  4. ncbi request reprint IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    J Immunol 175:6100-6. 2005
  5. ncbi request reprint Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 178:1759-66. 2007
  6. ncbi request reprint Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
  7. ncbi request reprint Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Frederick, MD 21702, USA
    Immunol Res 31:165-76. 2005
  8. ncbi request reprint Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
    GuoGuang Ying
    Laboratory of Molecular Immunoregulation and Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 172:7078-85. 2004
  9. ncbi request reprint Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor
    Ronghua Sun
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Immunol 173:428-36. 2004
  10. ncbi request reprint The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes
    Heng Yi Tao
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:50-6. 2004

Collaborators

Detail Information

Publications26

  1. pmc Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Neurobiol Dis 27:90-8. 2007
    ..Our results suggest that IL-10 may affect the pathogenic process of AD by up-regulating mFPR2 and thus favoring the recognition and internalization of Abeta(42) by activated microglial cells...
  2. ncbi request reprint Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:3651-9. 2006
    ..Our results demonstrated a potentially important role for TLR2 in microglial cells of promoting cell responses to chemoattractants produced in lesions of inflammatory and neurodegenerative diseases in the brain...
  3. ncbi request reprint CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    FASEB J 19:2032-4. 2005
    ..Our results suggest that TLR9 may play an important role in promoting microglial recognition of Abeta42, thus affecting the pathogenic process of AD...
  4. ncbi request reprint IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    J Immunol 175:6100-6. 2005
    ....
  5. ncbi request reprint Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 178:1759-66. 2007
    ....
  6. ncbi request reprint Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
    ..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells...
  7. ncbi request reprint Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Frederick, MD 21702, USA
    Immunol Res 31:165-76. 2005
    ..This review discusses recent findings relevant to the function and regulation of FPRL1/FPR2 in mononuclear phagocytes by pro- and antiinflammatory signals and its potential as a therapeutic target in AD...
  8. ncbi request reprint Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
    GuoGuang Ying
    Laboratory of Molecular Immunoregulation and Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 172:7078-85. 2004
    ..We conclude that Humanin shares human FPRL1 and mouse FPR2 with Abeta(42) and suggest that Humanin may exert its neuroprotective effects by competitively inhibiting the access of FPRL1 to Abeta(42)...
  9. ncbi request reprint Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor
    Ronghua Sun
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Immunol 173:428-36. 2004
    ..Thus, our studies identify CaG as a novel, host-derived chemotactic agonist for FPR and expand the functional scope of this receptor in inflammatory and immune responses...
  10. ncbi request reprint The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes
    Heng Yi Tao
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:50-6. 2004
    ..Thus, RV may be therapeutically promising for diseases in which activation of formylpeptide receptors contributes to the pathogenic processes...
  11. ncbi request reprint Toll-like receptors in inflammation, infection and cancer
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Int Immunopharmacol 7:1271-85. 2007
    ..We hope to provide new insight into the pathogenesis and progression of diseases and more importantly, into the potential for TLRs as targets of therapeutics...
  12. ncbi request reprint TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 173:962-8. 2004
    ..Thus, TGF-beta1 may exert a protective role in CNS diseases characterized by microglial cell activation by proinflammatory stimulants...
  13. ncbi request reprint Silencing the formylpeptide receptor FPR by short-interfering RNA
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Room 31 40, MD 21702 1201, USA
    Mol Pharmacol 66:1022-8. 2004
    ....
  14. pmc Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity
    Maria Cecilia Rodriguez-Galan
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 183:740-8. 2009
    ..These data could highly contribute to the design of more efficient/less toxic protocols for the treatment of cancer...
  15. ncbi request reprint Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
    FEBS J 272:769-78. 2005
    ..Considering the potential importance of FPRL1 in inflammation and neurodegenerative diseases, the identification of functional domains in this receptor will provide valuable information for the design of specific receptor antagonists...
  16. ncbi request reprint Chemokines and chemokine receptors: their manifold roles in homeostasis and disease
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:95-104. 2004
    ..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases...
  17. ncbi request reprint The role of chemokine receptors in the promotion of viral infections
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
    Contrib Microbiol 10:210-31. 2003
  18. pmc Activation of macrophages by silicones: phenotype and production of oxidant metabolites
    Pablo Iribarren
    Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000, Cordoba, Argentina
    BMC Immunol 3:6. 2002
    ..p.) injection of dimethylpolysiloxane (DMPS) (silicone). We studied the expression of adhesion and co-stimulatory molecules and both the spontaneous and the stimulated production of reactive oxygen intermediates and nitric oxide (NO)...
  19. ncbi request reprint Cytokines and the immune-neuroendocrine network: What did we learn from infection and autoimmunity?
    Silvia G Correa
    Immunology, Department of Biochemical Chemistry, CIBICI CONICET, Faculty of Chemical Sciences, National University of Cordoba, Haya de la Torre y Medina Allende, 5000 Cordoba, Argentina
    Cytokine Growth Factor Rev 18:125-34. 2007
    ..Clearly, organisms are not well adapted to that disregulated condition yet, suggesting that additional partners within neuroendocrine-immune interactions might emerge from the evolutionary road...
  20. ncbi request reprint The role of dendritic cells in neurodegenerative diseases
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 40, Frederick, MD 21702, USA
    Arch Immunol Ther Exp (Warsz) 50:187-96. 2002
    ..This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states...
  21. ncbi request reprint Manipulating chemoattractant and receptor genes
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    In Vivo 16:1-23. 2002
    ....
  22. ncbi request reprint IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Lanzhou Military Medical University, Lanzhou, People s Republic of China
    J Immunol 171:5482-8. 2003
    ..These results suggest that IL-4 may play an important role in the maintenance of homeostasis of CNS and in the regulation of the disease process characterized by microglial activation in response to proinflammatory stimulants...
  23. ncbi request reprint Interaction of bacterial toxin with leukocytes measured by flow cytometry
    Maria Gabriela Paraje
    Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Haya de la Torre y Medina Allende 5000 Córdoba, Argentina
    Curr Microbiol 45:171-4. 2002
    ..The interaction of toxin with leukocytes was evident even after 100 degrees C treatment of toxin during 5 min. The incubation with 2-mercaptoethanol was not necessary for toxin binding...
  24. ncbi request reprint Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:1896-906. 2004
    ....
  25. ncbi request reprint Determination of human sperm calcium uptake mediated by progesterone may be useful for evaluating unexplained sterility
    Laura Cecilia Giojalas
    Center for Cellular and Molecular Biology, Faculty of Sciences, University of Cordoba, Cordoba, Argentina
    Fertil Steril 82:738-40. 2004
    ..The evaluation of the P-mediated intracellular calcium increase by flow cytometry may be a fast and objective tool for the diagnosis of human sperm samples, especially in cases of unexplained sterility...
  26. ncbi request reprint Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells
    Jian Hong Chen
    Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Biochem Biophys Res Commun 342:1368-74. 2006
    ..Our results suggest that Nordy was capable of reducing the level of malignancy of glioma cells...