Research Topics
Genomes and Genes | Pablo IribarrenSummaryCountry: Argentina Publications
Research Grants
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Publications
Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microgliaPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Neurobiol Dis 27:90-8. 2007..Our results suggest that IL-10 may affect the pathogenic process of AD by up-regulating mFPR2 and thus favoring the recognition and internalization of Abeta(42) by activated microglial cells...
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptideKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 281:3651-9. 2006..Our results demonstrated a potentially important role for TLR2 in microglial cells of promoting cell responses to chemoattractants produced in lesions of inflammatory and neurodegenerative diseases in the brain...- CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2Pablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
FASEB J 19:2032-4. 2005..Our results suggest that TLR9 may play an important role in promoting microglial recognition of Abeta42, thus affecting the pathogenic process of AD... - IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microgliaPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
J Immunol 175:6100-6. 2005.... - Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligandKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Immunol 178:1759-66. 2007.... - Formylpeptide receptor FPR and the rapid growth of malignant human gliomasYe Zhou
Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
J Natl Cancer Inst 97:823-35. 2005..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells... - Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer diseasePablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg. 560, Frederick, MD 21702, USA
Immunol Res 31:165-76. 2005..This review discusses recent findings relevant to the function and regulation of FPRL1/FPR2 in mononuclear phagocytes by pro- and antiinflammatory signals and its potential as a therapeutic target in AD... - Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptorGuoGuang Ying
Laboratory of Molecular Immunoregulation and. Basic Research Program, SAIC-Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 172:7078-85. 2004..We conclude that Humanin shares human FPRL1 and mouse FPR2 with Abeta(42) and suggest that Humanin may exert its neuroprotective effects by competitively inhibiting the access of FPRL1 to Abeta(42)... - Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptorRonghua Sun
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
J Immunol 173:428-36. 2004..Thus, our studies identify CaG as a novel, host-derived chemotactic agonist for FPR and expand the functional scope of this receptor in inflammatory and immune responses... - The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytesHeng Yi Tao
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Cell Mol Immunol 1:50-6. 2004..Thus, RV may be therapeutically promising for diseases in which activation of formylpeptide receptors contributes to the pathogenic processes... - Toll-like receptors in inflammation, infection and cancerKeqiang Chen
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
Int Immunopharmacol 7:1271-85. 2007..We hope to provide new insight into the pathogenesis and progression of diseases and more importantly, into the potential for TLRs as targets of therapeutics... - TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathwaysYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA
J Immunol 173:962-8. 2004..Thus, TGF-beta1 may exert a protective role in CNS diseases characterized by microglial cell activation by proinflammatory stimulants... - Silencing the formylpeptide receptor FPR by short-interfering RNAYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Room 31 40, MD 21702 1201, USA
Mol Pharmacol 66:1022-8. 2004.... - Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacityMaria Cecilia Rodriguez-Galan
Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 183:740-8. 2009..These data could highly contribute to the design of more efficient/less toxic protocols for the treatment of cancer... - Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxisYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
FEBS J 272:769-78. 2005..Considering the potential importance of FPRL1 in inflammation and neurodegenerative diseases, the identification of functional domains in this receptor will provide valuable information for the design of specific receptor antagonists... - Chemokines and chemokine receptors: their manifold roles in homeostasis and diseaseYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Cell Mol Immunol 1:95-104. 2004..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases... - The role of chemokine receptors in the promotion of viral infectionsYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
Contrib Microbiol 10:210-31. 2003 - Activation of macrophages by silicones: phenotype and production of oxidant metabolitesPablo Iribarren
Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000, Cordoba, Argentina
BMC Immunol 3:6. 2002..p.) injection of dimethylpolysiloxane (DMPS) (silicone). We studied the expression of adhesion and co-stimulatory molecules and both the spontaneous and the stimulated production of reactive oxygen intermediates and nitric oxide (NO)... - Cytokines and the immune-neuroendocrine network: What did we learn from infection and autoimmunity?Silvia G Correa
Immunology, Department of Biochemical Chemistry, CIBICI CONICET, Faculty of Chemical Sciences, National University of Cordoba, Haya de la Torre y Medina Allende, 5000 Cordoba, Argentina
Cytokine Growth Factor Rev 18:125-34. 2007..Clearly, organisms are not well adapted to that disregulated condition yet, suggesting that additional partners within neuroendocrine-immune interactions might emerge from the evolutionary road... - The role of dendritic cells in neurodegenerative diseasesPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 40, Frederick, MD 21702, USA
Arch Immunol Ther Exp (Warsz) 50:187-96. 2002..This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states... - Manipulating chemoattractant and receptor genesYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
In Vivo 16:1-23. 2002.... - IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinasesPablo Iribarren
Laboratory of Molecular Immunoregulation, Lanzhou Military Medical University, Lanzhou, People s Republic of China
J Immunol 171:5482-8. 2003..These results suggest that IL-4 may play an important role in the maintenance of homeostasis of CNS and in the regulation of the disease process characterized by microglial activation in response to proinflammatory stimulants... - Interaction of bacterial toxin with leukocytes measured by flow cytometryMaria Gabriela Paraje
Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Haya de la Torre y Medina Allende 5000 Córdoba, Argentina
Curr Microbiol 45:171-4. 2002..The interaction of toxin with leukocytes was evident even after 100 degrees C treatment of toxin during 5 min. The incubation with 2-mercaptoethanol was not necessary for toxin binding... - Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP riboseSantiago Partida-Sanchez
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 172:1896-906. 2004.... - Determination of human sperm calcium uptake mediated by progesterone may be useful for evaluating unexplained sterilityLaura Cecilia Giojalas
Center for Cellular and Molecular Biology, Faculty of Sciences, University of Cordoba, Cordoba, Argentina
Fertil Steril 82:738-40. 2004..The evaluation of the P-mediated intracellular calcium increase by flow cytometry may be a fast and objective tool for the diagnosis of human sperm samples, especially in cases of unexplained sterility... - Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cellsJian Hong Chen
Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Biochem Biophys Res Commun 342:1368-74. 2006..Our results suggest that Nordy was capable of reducing the level of malignancy of glioma cells...
Research Grants
- The role of chemoattractant receptors in central nervous system diseasesPablo Iribarren; Fiscal Year: 2009....
- The role of chemoattractant receptors in central nervous system diseasesPablo Iribarren; Fiscal Year: 2010....