J Correale

Summary

Country: Argentina

Publications

  1. ncbi request reprint Oligoclonal bands and antibody responses in multiple sclerosis
    Jorge Correale
    Departmento de Neurologia, Instituto de Investigaciones Neurológicas, Dr Raúl Carrea, Buenos Aires, Argentina
    J Neurol 249:375-89. 2002
  2. ncbi request reprint Monocyte-derived dendritic cells in multiple sclerosis: the effect of bacterial infection
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Montaneses 2325, Buenos Aires, Argentina
    J Neuroimmunol 190:177-89. 2007
  3. ncbi request reprint The risk of relapses in multiple sclerosis during systemic infections
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Neurology 67:652-9. 2006
  4. ncbi request reprint Association between parasite infection and immune responses in multiple sclerosis
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Ann Neurol 61:97-108. 2007
  5. doi request reprint Management of relapsing-remitting multiple sclerosis in Latin America: Practical recommendations for treatment optimization
    Jorge Correale
    Institute for Neurological Research Dr Raúl Carrea FLENI, Buenos Aires, Argentina Electronic address
    J Neurol Sci 339:196-206. 2014
  6. doi request reprint Role of prolactin in B cell regulation in multiple sclerosis
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina Electronic address
    J Neuroimmunol 269:76-86. 2014
  7. doi request reprint Sex-specific environmental influences affecting MS development
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Montañeses 2325 1428, Buenos Aires, Argentina Electronic address
    Clin Immunol 149:176-81. 2013
  8. doi request reprint Modulation of multiple sclerosis by sunlight exposure: role of cis-urocanic acid
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina
    J Neuroimmunol 261:134-40. 2013
  9. pmc Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI Buenos Aires, Argentina
    Front Cell Infect Microbiol 2:112. 2012
  10. doi request reprint Increase in multiple sclerosis activity after assisted reproduction technology
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, Foundation Against Neurological Disease in childhood FLENI, Buenos Aires, Argentina
    Ann Neurol 72:682-94. 2012

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Oligoclonal bands and antibody responses in multiple sclerosis
    Jorge Correale
    Departmento de Neurologia, Instituto de Investigaciones Neurológicas, Dr Raúl Carrea, Buenos Aires, Argentina
    J Neurol 249:375-89. 2002
    ..The elucidation of the mechanisms and target(s) responsible for the onset of MS has obvious implications for the further development of specific therapies...
  2. ncbi request reprint Monocyte-derived dendritic cells in multiple sclerosis: the effect of bacterial infection
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Montaneses 2325, Buenos Aires, Argentina
    J Neuroimmunol 190:177-89. 2007
    ....
  3. ncbi request reprint The risk of relapses in multiple sclerosis during systemic infections
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Neurology 67:652-9. 2006
    ..To assess the risk of multiple sclerosis (MS) relapses, MRI activity, and T cell responses during systemic infections (SI) in patients with MS...
  4. ncbi request reprint Association between parasite infection and immune responses in multiple sclerosis
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Ann Neurol 61:97-108. 2007
    ..To assess whether parasite infection is correlated with a reduced number of exacerbations and altered immune reactivity in multiple sclerosis (MS)...
  5. doi request reprint Management of relapsing-remitting multiple sclerosis in Latin America: Practical recommendations for treatment optimization
    Jorge Correale
    Institute for Neurological Research Dr Raúl Carrea FLENI, Buenos Aires, Argentina Electronic address
    J Neurol Sci 339:196-206. 2014
    ..These recommendations are intended to assist clinicians in Latin America in developing a rational approach to treatment selection and sequencing for their RRMS patients. ..
  6. doi request reprint Role of prolactin in B cell regulation in multiple sclerosis
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina Electronic address
    J Neuroimmunol 269:76-86. 2014
    ..Additionally, prolactin decreased B cell receptor-mediated activation threshold, and induced CD40 expression in B cells. These findings suggest that prolactin promotes B cell autoreactivity in MS through different mechanisms. ..
  7. doi request reprint Sex-specific environmental influences affecting MS development
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Montañeses 2325 1428, Buenos Aires, Argentina Electronic address
    Clin Immunol 149:176-81. 2013
    ....
  8. doi request reprint Modulation of multiple sclerosis by sunlight exposure: role of cis-urocanic acid
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina
    J Neuroimmunol 261:134-40. 2013
    ..Finally, cis-UCA activated the 5-HT2A receptor, inducing the increase in phosphorylated forms of ERK 1/2 and JNK2. Thus, in addition to vitamin D, cis-UCA also appears to be an additional UV-mediated immunomodulator. ..
  9. pmc Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI Buenos Aires, Argentina
    Front Cell Infect Microbiol 2:112. 2012
    ..Overall, the data described indicate that helminth molecules exert potent regulatory effects on both DCs and B cells from MS patients through TLR2 regulation...
  10. doi request reprint Increase in multiple sclerosis activity after assisted reproduction technology
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, Foundation Against Neurological Disease in childhood FLENI, Buenos Aires, Argentina
    Ann Neurol 72:682-94. 2012
    ..Our objective was to evaluate risk of exacerbations in multiple sclerosis (MS) patients undergoing assisted reproduction technology (ART) infertility treatment...
  11. doi request reprint Benign multiple sclerosis: does it exist?
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina
    Curr Neurol Neurosci Rep 12:601-9. 2012
    ..Clearly, the definition of BMS currently applied in clinical practice requires reassessment...
  12. doi request reprint Benign multiple sclerosis: a new definition of this entity is needed
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Raúl Carrea, FLENI, Buenos Aires, Argentina
    Mult Scler 18:210-8. 2012
    ..To study a cohort of benign multiple sclerosis (BMS) patients beyond physical disability, including the evaluation of cognitive and social function, as well as fatigue, pain and MRI studies...
  13. ncbi request reprint Vaccines for multiple sclerosis: progress to date
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina
    CNS Drugs 22:175-98. 2008
    ..Overall, vaccines for MS represent promising approaches for the treatment of this devastating disease, as well as other autoimmune diseases...
  14. doi request reprint Helminth infections associated with multiple sclerosis induce regulatory B cells
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Ann Neurol 64:187-99. 2008
    ..To assess the importance of B-cell control during parasite infections in multiple sclerosis (MS) patients...
  15. doi request reprint Immunomodulatory effects of Vitamin D in multiple sclerosis
    Jorge Correale
    Raul Carrea Institute for Neurological Research, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    Brain 132:1146-60. 2009
    ..Collectively, these data suggest that 1,25(OH)(2)D(3) plays an important role in T cell homeostasis during the course of multiple sclerosis, thus making correction of its deficiency may be useful during treatment of the disease...
  16. ncbi request reprint BHT-3009, a myelin basic protein-encoding plasmid for the treatment of multiple sclerosis
    Jorge Correale
    Raul Carrea Institute for Neurological Research FLENI, Department of Neurology, Buenos Aires, Argentina
    Curr Opin Mol Ther 11:463-70. 2009
    ..BHT-3009 appears to be a promising new approach for the treatment of MS, although further clinical trials are warranted to confirm the early findings...
  17. doi request reprint Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms
    Jorge Correale
    Dr Raul Carrea Institute for Neurological Research, Foundation for the Fight against Childhood Neurological Diseases FLENI, Department of Neurology, Buenos Aires, Argentina
    J Immunol 183:5999-6012. 2009
    ..This knowledge could prove critical in developing novel therapeutic approaches for the treatment of autoimmune diseases such as MS...
  18. doi request reprint Cellular elements of the blood-brain barrier
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    Neurochem Res 34:2067-77. 2009
    ..Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain...
  19. doi request reprint Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina
    Ann Neurol 67:625-38. 2010
    ..The objective of this study was to investigate the role of CD8+ CD25+ FoxP3+ cells during the course of multiple sclerosis (MS)...
  20. doi request reprint Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina
    J Immunol 185:4948-58. 2010
    ..Collectively, these results demonstrate estrogen-promoted differences in vitamin D(3) metabolism, suggesting a greater protective effect of vitamin D(3)-based therapeutic strategies in women...
  21. doi request reprint Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
    Mult Scler 17:521-31. 2011
    ..Recent studies conducted in arthritis, asthma, and inflammatory bowel disease suggest that chitinases are important in inflammatory processes and tissue remodeling...
  22. doi request reprint The impact of parasite infections on the course of multiple sclerosis
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    J Neuroimmunol 233:6-11. 2011
    ..These new observations on parasite infections associated to MS indicate that parasite regulation of host immunity can alter the course of MS...
  23. doi request reprint Vitamin D-mediated immune regulation in multiple sclerosis
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Buenos Aires, Argentina
    J Neurol Sci 311:23-31. 2011
    ..Collectively, these findings suggest that 1,25(OH)(2) VitaminD plays an important role in T cell homeostasis during the course of MS, suggesting correction of its deficiency may be useful during treatment of the disease...
  24. doi request reprint The impact of environmental infections (parasites) on MS activity
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, FLENI, Argentina
    Mult Scler 17:1162-9. 2011
    ..Better understanding of host-parasite interactions caused by specific parasite molecules with immunomodulatory effects will help combat allergies and autoimmune disease without the price of untoward infection as a side-effect...
  25. doi request reprint Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    J Neuroimmunol 195:121-34. 2008
    ..Moreover, IL-15 and IFN-gamma significantly increased CD94 and NKG2A expression. These data provide evidence that CD94/NKG2A receptors play an important role in regulating T cell activity during the course of MS...
  26. ncbi request reprint Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-beta
    Jorge Correale
    Department of Neurology Raúl Carrea Institute for Neurological Research, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    J Neuroimmunol 162:173-83. 2005
    ..We conclude that brief courses of MX may provide a safe treatment alternative for RR MS patients who experience rapid and severe worsening of their disease despite IFN-beta treatment...
  27. ncbi request reprint Activation of humoral immunity and eosinophils in neuromyelitis optica
    Jorge Correale
    Raul Carrea Institute for Neurological Research, FLENI, Montañeses 2325 1428, Buenos Aires, Argentina
    Neurology 63:2363-70. 2004
    ..To study immunologic alterations in patients with neuromyelitis optica (NMO)...
  28. ncbi request reprint The neuroprotective role of inflammation in nervous system injuries
    Jorge Correale
    Raul Carrea Institute for Neurological Research, FLENI, Montaneses 2325, 1428, Buenos Aires, Argentina
    J Neurol 251:1304-16. 2004
    ..Therefore, the design of more effective therapies depends on a clear delineation of the beneficial and detrimental effects of inflammation...
  29. ncbi request reprint Temporal variations of adhesion molecules and matrix metalloproteinases in the course of MS
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Montañeses 2325 1428, Buenos Aires, Argentina
    J Neuroimmunol 140:198-209. 2003
    ..These data suggest that VLA-4, LFA-1alpha and MMP-9 play a leading role in the evolution of inflammatory demyelinating lesions in patients with CIS who develop CDMS...
  30. ncbi request reprint Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Montaneses 2325, Buenos Aires 1428, Argentina
    J Neuroimmunol 136:162-71. 2003
    ..These data raise important issues for the pathogenesis and treatment of multiple sclerosis (MS)...
  31. ncbi request reprint [Current concepts on the use of some immunomodulatory drugs in the treatment of multiple sclerosis]
    J Correale
    Departamento de Neurologia, Instituto de Investigaciones Neurológicas Dr Raúl Carrea, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina
    Medicina (B Aires) 61:470-80. 2001
    ..Several ongoing and planned clinical trials in various stages of disease will help to define further the role of these agents in the treatment of multiple sclerosis...
  32. ncbi request reprint [Immunological mechanisms involved in the pathogenesis of multiple sclerosis]
    J Correale
    Departamento de Neurologia, Instituto de Investigaciones Neurologicas Dr Raul Carrea FLENI, Buenos Aires, Argentina
    Rev Neurol 31:471-6. 2000
    ..To summarize current knowledge of the immunological mechanisms involved in the pathogenesis of multiple sclerosis and its implications in the development of new therapeutic options...
  33. ncbi request reprint Resistance to glucocorticoid-induced apoptosis in PLP peptide-specific T cell clones from patients with progressive MS
    J Correale
    Department of Neurology, University of Southern California, School of Medicine, 1333 San Pablo Street, MCK 142, Los Angeles, CA 90033, USA
    J Neuroimmunol 109:197-210. 2000
    ..Thus, failure to respond to GC treatment may reflect defect in apoptosis that develop during the progressive stages of chronic inflammatory disease...
  34. ncbi request reprint T cell vaccination in secondary progressive multiple sclerosis
    J Correale
    Department of Neurology, USC School of Medicine, 1333 San Pablo Street, MCK 142, Los Angeles, CA 90033, USA
    J Neuroimmunol 107:130-9. 2000
    ..The data obtained indicated that TCV using autologous irradiated bovine myelin-reactive T cells promotes an effective depletion of T cells reactive against different myelin antigens...
  35. ncbi request reprint Myelin basic protein and myelin oligodendrocyte glycoprotein T-cell repertoire in childhood and juvenile multiple sclerosis
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Montañeses 2325 1428, Buenos Aires, Argentina
    Mult Scler 12:412-20. 2006
    ....
  36. ncbi request reprint [Neuronal injury in multiple sclerosis]
    Jorge Correale
    Departamento de Neurologia, Instituto de Investigaciones Neurologicas Dr Raul Carrea FLENI, Facultad de Ciencias Biomédicas Universidad Austral, Buenos Aires, Argentina
    Medicina (B Aires) 66:472-85. 2006
    ..Recognition that MS is in part a neurodegenerative disease should trigger critical rethinking on the pathogenic mechanisms of this disease and provides new targets for a rational treatment...
  37. ncbi request reprint The blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targeting
    Jorge Correale
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, Montañeses 2325 1428, Buenos Aires, Argentina
    Autoimmunity 40:148-60. 2007
    ....
  38. ncbi request reprint Antigen presentation by autoreactive proteolipid protein peptide-specific T cell clones from chronic progressive multiple sclerosis patients: roles of co-stimulatory B7 molecules and IL-12
    J Correale
    Department of Neurology, USC School of Medicine, Los Angeles 90033, USA
    J Neuroimmunol 72:27-43. 1997
    ..Together, these observations suggest that Ag presentation by T cells might amplify and perpetuate an autoimmune response previously initiated by professional APCs. These properties may account for progression of MS into a CP phase...
  39. ncbi request reprint Preliminary studies of cytokine secretion patterns associated with pregnancy in MS patients
    Wendy Gilmore
    Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA
    J Neurol Sci 224:69-76. 2004
    ....
  40. doi request reprint Impaired hypothalamic-pituitary-adrenal axis activity in patients with multiple sclerosis
    María C Ysrraelit
    Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
    Neurology 71:1948-54. 2008
    ..To investigate hypothalamic-pituitary-adrenal axis activity in well-defined multiple sclerosis (MS) patient subgroups...
  41. doi request reprint The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review
    E Cristiano
    Department of Neurology, MS Clinic, Hospital Italiano de Buenos Aires, Argentina
    Mult Scler 19:844-54. 2013
    ..This study showed low frequency for MS in LAC compared with North American and European countries. The role of environmental and genetic factors should be well studied, providing new insights about its etiology...
  42. doi request reprint Prevalence of multiple sclerosis in Buenos Aires, Argentina using the capture-recapture method
    E Cristiano
    MS Section, Hospital Italiano, Buenos Aires, Argentina
    Eur J Neurol 16:183-7. 2009
    ..The objective of the study is to determine the prevalence of MS in a high populated area from Argentina (Greater Buenos Aires Metropolitan area) using the capture-recapture methodology...
  43. ncbi request reprint Focal stiff-person syndrome
    M Fiol
    Department of Neurology, , Buenos Aires, Argentina
    Neurologia 16:89-91. 2001
    ..Definition of the range of clinical expression and immunological profiles could be important for the clinical management of these patients...
  44. doi request reprint Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts
    M Roca
    Department of Neurology, Dr Raúl Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Mult Scler 14:364-9. 2008
    ..In this series, test failures observed correlated with changes in fronto-subcortical fiber tracts...
  45. ncbi request reprint [Recommendations for optimising the treatment of multiple sclerosis in Latin America]
    E Cristiano
    Hospital Italiano, Buenos Aires, Argentina
    Rev Neurol 44:494-8. 2007
    ..In recent years the development of new drugs that have been shown to modify the natural history of MS have had a substantial impact on the treatment of the disease...
  46. doi request reprint Yellow fever vaccination and increased relapse rate in travelers with multiple sclerosis
    Mauricio F Farez
    Department of Neurology, Institute for Neurological Research Dr Raúl Carrea, Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina
    Arch Neurol 68:1267-71. 2011
    ..To investigate the effect of yellow fever (YF) immunization on the subsequent multiple sclerosis (MS) relapse risk...
  47. ncbi request reprint Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
    Marta A Toscano
    División de Immunogenética Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, C1120AAF Buenos Aires, Argentina
    Nat Immunol 8:825-34. 2007
    ..Our findings identify a molecular link among differential glycosylation of T helper cells, susceptibility to cell death and termination of the inflammatory response...
  48. ncbi request reprint [Multiple sclerosis. Old observations, new hypotheses, future perspectives]
    Jorge Correale
    Medicina (B Aires) 65:175-80. 2005