Affiliation: Centro de Referencia para Lactobacilos
Villena J, Saavedra L, Hébert E, Masumizu Y, Sato N, Humayun Kober A, et al
. Draft Genome Sequence of Lactobacillus plantarum TL2766, a Strain with the Ability To Ferment Wakame. Genome Announc. 2016;4: pubmed publisher
..The reads were assembled into contigs, with a total size of 3,310,195 bp. The genome information will be useful for further specific genetic studies of this strain and for its biotechnological applications. ..
Villena J, Masumizu Y, Iida H, Ikeda Ohtsubo W, Albarracin L, Makino S, et al
. Draft Genome Sequence of the Immunobiotic Strain Lactobacillus jensenii TL2937. Genome Announc. 2017;5: pubmed publisher
..3%, and 1,470 predicted protein-coding sequences. The genome information will be useful for gaining insight into the immunomodulatory properties of the TL2937 strain in the porcine host. ..
Garcia Castillo V, Albarracin L, Kitazawa H, Villena J. Screening and Characterization of Immunobiotic Lactic Acid Bacteria with Porcine Immunoassay Systems. Methods Mol Biol. 2019;1887:131-144 pubmed publisher
Tada A, Zelaya H, Clua P, Salva S, Alvarez S, Kitazawa H, et al
. Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation. Inflamm Res. 2016;65:771-83 pubmed publisher
..It is a step forward in the understanding of the cellular mechanisms involved in the antiviral capabilities of immunobiotic strains. ..
Laiño J, Villena J, Kanmani P, Kitazawa H. Immunoregulatory Effects Triggered by Lactic Acid Bacteria Exopolysaccharides: New Insights into Molecular Interactions with Host Cells. Microorganisms. 2016;4: pubmed publisher
..A detailed molecular understanding should lead to a more rational use of immunobiotics in general, and their EPS in particular, as efficient prevention and therapies for specific immune-related disorders in humans and animals. ..
Villena J, Kitazawa H. Probiotic Microorganisms: A Closer Look. Microorganisms. 2017;5: pubmed publisher
Murofushi Y, Villena J, Morie K, Kanmani P, Tohno M, Shimazu T, et al
. The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14. Mol Immunol. 2015;64:63-75 pubmed publisher
..This work describes for the first time that a Lactobacillus strain and its EPS reduce inflammation in intestinal epithelial cells in a RP105/MD1-dependend manner. ..
Tsukida K, Takahashi T, Iida H, Kanmani P, Suda Y, Nochi T, et al
. Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells. BMC Immunol. 2016;17:21 pubmed publisher
..jensenii TL2937 with porcine APCs that will be crucial for the successful development of functional feeds for the porcine host. This study is a step in that direction. ..
Kanmani P, Albarracin L, Kobayashi H, Iida H, Komatsu R, Humayun Kober A, et al
. Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells. Mol Immunol. 2018;93:253-265 pubmed publisher
..Although further in vivo studies are needed, our results suggest that these EPSs or a yogurt fermented with LDR-1 have potential to improve intestinal innate antiviral response and protect against intestinal viruses. ..