Mirta Schattner

Summary

Affiliation: Academia Nacional de Medicina
Country: Argentina

Publications

  1. doi Poly (I:C) downregulates platelet production and function through type I interferon
    Leonardo Rivadeneyra
    Mirta Schattner, Institute of Experimental Medicine, Pacheco de Melo 3081, Buenos Aires 1425, Argentina, Tel 5411 48073926, Fax 5411 48050712, Email
    Thromb Haemost 114:982-93. 2015
  2. doi Functional responses and molecular mechanisms involved in histone-mediated platelet activation
    A Carestia
    Mirta Schattner, Instituto de Medicina Experimental, CONICET ANM, Pacheco de Melo 3081, Buenos Aires 1425, Argentina, Tel 54 11 4805 5759 ext 301, Fax 54 11 4805 0712, E mail
    Thromb Haemost 110:1035-45. 2013
  3. pmc Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
    Mirta Schattner
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET, National Academy of Medicine Pacheco de Melo 3081 1425, Buenos Aires, Argentina
    Viruses 5:340-51. 2013
  4. pmc Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling
    Roberto G Pozner
    Department of Thrombosis and Hemostasis, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    PLoS Pathog 6:e1000847. 2010
  5. doi Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs
    Maria Jose Lapponi
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET National Academy of Medicine, Buenos Aires, Argentina
    J Pharmacol Exp Ther 345:430-7. 2013
  6. doi Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets
    Julia Etulain
    Thrombosis I Laboratory, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Thromb Haemost 107:99-110. 2012
  7. doi Paracrine regulation of megakaryo/thrombopoiesis by macrophages
    Lina Paola D'Atri
    Thrombosis I Laboratory, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Exp Hematol 39:763-72. 2011
  8. doi Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis
    Maria A Romaniuk
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX, National Academy of Medicine, Buenos Aires, Argentina
    FASEB J 26:2788-98. 2012
  9. doi The low viability of human CD34+ cells under acidic conditions is improved by exposure to thrombopoietin, stem cell factor, interleukin-3, or increased cyclic adenosine monophosphate levels
    Lina Paola D'Atri
    Thrombosis I Laboratory, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Transfusion 51:1784-95. 2011
  10. pmc Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis
    Roberto Gabriel Pozner
    Department of Thrombosis and Haemostasis, Hematological Research Institute, National Academy of Medicine, National Research Council CONICET, Pacheco de Melo 3081 1425, Buenos Aires, Argentina
    Br J Pharmacol 145:283-92. 2005

Collaborators

  • Ricardo M Gomez
  • Gabriel A Rabinovich
  • Maria Virginia Tribulatti
  • Ana Marisa Chudzinski-Tavassi
  • Denisa D Wagner
  • C Fondevila
  • Marina V Atzingen
  • Ricardo Drut
  • Soledad Negrotto
  • Julia Etulain
  • Roberto G Pozner
  • Lina Paola D'Atri
  • Roberto Gabriel Pozner
  • Maria Albertina Romaniuk
  • Leonardo Rivadeneyra
  • Agostina Carestia
  • Oscar Campetella
  • Maria A Romaniuk
  • Maria Jose Lapponi
  • Hebe A Mena
  • Gabriela Pretre
  • Valentina Cattaneo
  • Carolina Jaquenod de Giusti
  • Agustín E Ure
  • Oscar Torres
  • Natalia Pacienza
  • Emilia Scharrig
  • Julieta Carabelli
  • A Carestia
  • Verónica Inés Landoni
  • Diego O Croci
  • Victor Romanowski
  • Lina P D'Atri
  • Elisa Malaver
  • Maria Angela Lazzari
  • Mathieu Picardeau
  • Roberto Meiss
  • Mariela Bollati-Fogolin
  • Maia Cédola
  • Stephen M Cifuni
  • Elba M Vermeulen
  • Maria F Ferrer
  • Siu Ling Wong
  • Kimberly Martinod
  • Diego Omar Croci
  • Blandine Dizier
  • Liliana S Voto
  • Sergio E Strier
  • Anna Lokajczyk
  • Catherine Boisson-Vidal
  • M A Romaniuk
  • Ana L T O Nascimento
  • L Rivadeneyra
  • S Negrotto
  • Giannoula Lakka Klement
  • María J Lapponi
  • Francoise Poirier
  • Karen Amelia Nahmod
  • Martín Isturiz
  • Joseph E Italiano
  • Felisa Concepcion Molinas
  • Marina E Biedma
  • German A Bianco
  • Soledad Collado
  • Mónica Lidia Kotler
  • Maria I Berria

Detail Information

Publications30

  1. doi Poly (I:C) downregulates platelet production and function through type I interferon
    Leonardo Rivadeneyra
    Mirta Schattner, Institute of Experimental Medicine, Pacheco de Melo 3081, Buenos Aires 1425, Argentina, Tel 5411 48073926, Fax 5411 48050712, Email
    Thromb Haemost 114:982-93. 2015
    ..These data provide new evidence for the role of IFN I in megakaryocyte distribution in the bone marrow niches and its influence on thrombopoiesis and haemostasis. ..
  2. doi Functional responses and molecular mechanisms involved in histone-mediated platelet activation
    A Carestia
    Mirta Schattner, Instituto de Medicina Experimental, CONICET ANM, Pacheco de Melo 3081, Buenos Aires 1425, Argentina, Tel 54 11 4805 5759 ext 301, Fax 54 11 4805 0712, E mail
    Thromb Haemost 110:1035-45. 2013
    ..Our data identify histones as important triggers of haemostatic and proinflammatory platelet responses, and only haemostatic responses are partially inhibited by anti-inflammatory drugs. ..
  3. pmc Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
    Mirta Schattner
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET, National Academy of Medicine Pacheco de Melo 3081 1425, Buenos Aires, Argentina
    Viruses 5:340-51. 2013
    ..In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms...
  4. pmc Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling
    Roberto G Pozner
    Department of Thrombosis and Hemostasis, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    PLoS Pathog 6:e1000847. 2010
    ..Our study introduces a potential mechanism for thrombocytopenia in VHF and other diseases associated with increased bone marrow type I IFN levels...
  5. doi Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs
    Maria Jose Lapponi
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET National Academy of Medicine, Buenos Aires, Argentina
    J Pharmacol Exp Ther 345:430-7. 2013
    ..Our results show that NETs have an important role in the local control of infection and that ASA and NF-κB blockade could be useful therapies to avoid undesired effect of persistent neutrophil activation...
  6. doi Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets
    Julia Etulain
    Thrombosis I Laboratory, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Thromb Haemost 107:99-110. 2012
    ..In conclusion, our results indicate that extracellular acidosis downregulates most of the haemostatic platelet functions, and promotes those involved in amplifying the neutrophil-mediated inflammatory response...
  7. doi Paracrine regulation of megakaryo/thrombopoiesis by macrophages
    Lina Paola D'Atri
    Thrombosis I Laboratory, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Exp Hematol 39:763-72. 2011
    ....
  8. doi Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis
    Maria A Romaniuk
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX, National Academy of Medicine, Buenos Aires, Argentina
    FASEB J 26:2788-98. 2012
    ..This study identifies a noncanonical mechanism, based on galectin-integrin interactions, for regulating platelet activation...
  9. doi The low viability of human CD34+ cells under acidic conditions is improved by exposure to thrombopoietin, stem cell factor, interleukin-3, or increased cyclic adenosine monophosphate levels
    Lina Paola D'Atri
    Thrombosis I Laboratory, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Transfusion 51:1784-95. 2011
    ..Because extracellular acidosis is a common feature of injured tissues or the tumor microenvironment and is a critical regulator of cell survival and activation, we evaluated the impact of acidosis on CD34+ cell biology...
  10. pmc Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis
    Roberto Gabriel Pozner
    Department of Thrombosis and Haemostasis, Hematological Research Institute, National Academy of Medicine, National Research Council CONICET, Pacheco de Melo 3081 1425, Buenos Aires, Argentina
    Br J Pharmacol 145:283-92. 2005
    ....
  11. doi Astrocyte response to Junín virus infection
    Roberto G Pozner
    Thrombosis 1 Laboratory, Haematological Research Institute, National Academy of Medicine, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina
    Neurosci Lett 445:31-5. 2008
    ....
  12. ncbi Activation of cyclic AMP pathway prevents CD34(+) cell apoptosis
    Soledad Negrotto
    Hematological Research Institute, National Academy of Medicine, National Research Council CONICET, Buenos Aires, Argentina
    Exp Hematol 34:1420-8. 2006
    ..We have recently demonstrated that in CD34(+)-derived megakaryocytes, cAMP-related agents prevent apoptosis. In this study we addressed the question of whether cAMP also regulates survival of their precursors, CD34(+) cells...
  13. pmc Control of angiogenesis by galectins involves the release of platelet-derived proangiogenic factors
    Julia Etulain
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET National Academy of Medicine, Buenos Aires, Argentina
    PLoS ONE 9:e96402. 2014
    ....
  14. ncbi The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation
    Natalia Pacienza
    Hematological Research Institute, National Academy of Medicine, Buenos Aires, Argentina
    FASEB J 22:1113-23. 2008
    ..Our study reveals a novel unrecognized role for galectin-1 in the control of platelet physiology with potential implications in thrombosis, inflammation, and metastasis...
  15. doi Identification of galectins as novel regulators of platelet signaling and function
    Maria Albertina Romaniuk
    Thrombosis I Laboratory, National Academy of Medicine, CONICET, Argentina
    IUBMB Life 63:521-7. 2011
    ..We also offer new hypotheses and some speculations about the role of platelet-galectin interactions not only in hemostasis and thrombosis but also in inflammation and related diseases such as atherosclerosis and cancer...
  16. doi Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB
    Leonardo Rivadeneyra
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine CONICET, National Academy of Medicine, Buenos Aires, Argentina
    Thromb Res 133:235-43. 2014
    ..The aim of this study was to determine whether NF-κB activation is a downstream signal involved in TLR2 and 4-mediated platelet responses...
  17. doi Galectin-8 elicits pro-inflammatory activities in the endothelium
    Valentina Cattaneo
    Laboratorio de Inmunología Molecular, Instituto de Investigaciones Biotecnologicas Instituto Tecnologico de Chascomus IIB INTECH, Universidad Nacional de San Martín Consejo Nacional de Investigaciones Científicas y Técnicas UNSAM CONICET, San Martín B1650HMP, Buenos Aires, Argentina
    Glycobiology 24:966-73. 2014
    ....
  18. doi Galectins: new agonists of platelet activation
    Mirta Schattner
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX CONICET, National Academy of Medicine, C1425, Buenos Aires, Argentina
    Biol Chem 394:857-63. 2013
    ..We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer...
  19. ncbi Differential astrocyte response to Theiler's murine encephalomyelitis virus infection
    Roberto G Pozner
    Department of Thrombosis and Haemostasis, Hematological Research Institute, National Academy of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Intervirology 48:279-84. 2005
    ..In addition, we investigated whether L*-1-infected astrocytes were able to selectively express molecules whose effects would play a role as pathogenic factors...
  20. pmc Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains
    Soledad Negrotto
    Instituto de Medicina Experimental, CONICET Academia Nacional de Medicina, Buenos Aires, Argentina
    J Virol 89:7409-13. 2015
    ..However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains. ..
  21. ncbi Decreased beta-adrenoceptor chronotropic response in selenium-deficient mice: negative crosstalk between iNOS activity and cAMP accumulation
    Ricardo M Gomez
    Catedra de Farmacologia, Facultad de Odontologia, Universidad de Buenos Aires, Buenos Aires, 1122, Argentina
    Biol Trace Elem Res 117:127-38. 2007
    ....
  22. doi Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira
    Emilia Scharrig
    Laboratory of Animal Viruses, Institute of Biotechnology and Molecular Biology, CCT La Plata, CONICET UNLP, Buenos Aires, Argentina
    PLoS Negl Trop Dis 9:e0003927. 2015
    ..Taken together, these data suggest that LIC triggers NETs, and that the intravascular formation of these DNA traps appears to be critical not only to prevent early leptospiral dissemination but also to preclude further bacterial burden. ..
  23. ncbi The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells
    Mirta Schattner
    Department of Thrombosis and Hemostasis, National Academy of Medicine, National Research Council CONICET, 1425 Buenos Aires, Argentina
    Biol Chem 386:369-74. 2005
    ..Although structurally related, berythractivase and jararhagin induce a dissimilar generation and release of endothelial molecules that may account for their different hemorrhagic activity...
  24. doi Characterization of LIC11207, a novel leptospiral protein that is recognized by human convalescent sera and prevents apoptosis of polymorphonuclear leukocytes
    Gabriela Pretre
    Instituto de Biotecnologia y Biologia Molecular, CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
    Microb Pathog 56:21-8. 2013
    ..Interestingly, rLIC11207 delayed apoptosis of PMNs suggesting a possible role of this protein during the infection...
  25. ncbi Endothelial cell function alteration after Junin virus infection
    Ricardo Martin Gomez
    Department of Microbiology, Faculty of Medicine, University of Buenos Aires, CONICET, Argentina
    Thromb Haemost 90:326-33. 2003
    ..These data demonstrate that endothelial cell responses are triggered subsequently by JV infection, suggesting that such alterations play a major role in the pathogenesis of AHF and perhaps in other viral-induced hemorrhagic diseases...
  26. doi Galectins in the regulation of platelet biology
    Maria A Romaniuk
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX CONICET, National Academy of Medicine, Pacheco de Melo 3081, Buenos Aires, 1425, Argentina
    Methods Mol Biol 1207:269-83. 2015
    ..The present article details the various protocols and reagents currently used in our laboratory to study the role of galectins in human platelet function. ..
  27. doi Human platelets express and are activated by galectin-8
    Maria Albertina Romaniuk
    Thrombosis I Laboratory, Hematological Research Institute, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    Biochem J 432:535-47. 2010
    ..These findings reveal Gal-8 as a potent platelet activator, supporting a role for this lectin in thrombosis and inflammation...
  28. doi Glycobiology of platelet-endothelial cell interactions
    Julia Etulain
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET National Academy of Medicine, Pacheco de Melo 3081, Buenos Aires 1425, Argentina
    Glycobiology 24:1252-9. 2014
    ..The present review outlines the current knowledge regarding glycan-mediated interactions between platelets and endothelial cells and their role in physiopathological processes. ..
  29. doi Acidic preconditioning improves the proangiogenic responses of endothelial colony forming cells
    Hebe A Mena
    Experimental Thrombosis Laboratory, Institute of Experimental Medicine IMEX, National Academy of Medicine CONICET, Pacheco de Melo 3081, 1425, Buenos Aires, Argentina
    Angiogenesis 17:867-79. 2014
    ..Considering that endothelial colony-forming cells (ECFC) are a subpopulation of CD34+ cells and key players in vasculogenesis, in the present study we investigated the effect of acidosis on the survival and functionality of ECFC...
  30. pmc P-selectin promotes neutrophil extracellular trap formation in mice
    Julia Etulain
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, National Scientific and Technical Research Council, National Academy of Medicine, Buenos Aires, Argentina Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA
    Blood 126:242-6. 2015
    ..In summary, P-selectin, cellular or soluble, through binding to PSGL-1, promotes NETosis, suggesting that this pathway is a potential therapeutic target for NET-related diseases. ..