M Saeed Arayne

..The method was validated as per ICH guidelines and USP requirements and found advantageous for the routine analysis of the drug in pharmaceutical formulations and in pharmaceutical investigations involving permethrin...

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..As a result, the availability of captopril was affected by the concurrent administration of H2-receptor antagonists. Accordingly coadministration of both the drugs should be avoided...

..4 and 9. The result showed that availability of ofloxacin slightly changed in presence of all metals in all these dissolution mediums...

..3 to 100.7 The association constants and free energy changes using Benesi-Hildebrand plots are also studied...

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..The proposed method shows high efficiency, allowing the separation of the main component piracetam from other impurities...

..217, 0.352, 0.405, and 0.368 μg/mL for Metf, Cimt, Famt, and Rant, respectively. The applicability of the method was demonstrated by determining the drug content in pharmaceutical formulations, where it exhibited good performance...

..The results in three different media revealed that, hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium...

..Thus, the proposed method is suitable for the simultaneous analysis of active ingredients in tablet dosage forms and human serum...

..The suggested procedures were successfully applied to the determination of these compounds in synthetic mixtures and in pharmaceutical preparations, with high percentage of recovery, good accuracy and precision...

..Moreover, these studies indicated that cephradine was strongly adsorbed on antacids; magnesium trisilicate and simeco tablets (powdered) exhibited relatively higher adsorption capacities...

..These studies were carried out in simulated gastric and intestinal juices for three hours at 37 degrees C. The availability of ciprofloxacin was found to be markedly retarded in presence of all the antacids studied...

..The proposed method is rapid, accurate, economical and selective and it may be used for the quantitative analysis of metformin in Neodipar tablets because of its sensitivity and reproducibility...

..The validation results, together with statistical treatment of the data, demonstrated the reliability of this method...

..0-100.0% with an inter and intra day CV <3%. The method does not require more than 8 minutes for analysis with good peak resolution and low LOD 0.1 microg/ml and LOQ 0.3 microg/ml...

..These complexes were characterized by their physical characteristics, 1H-NMR, IR and Atomic absorption studies...

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..2 %. Validation parameters as specificity, accuracy and robustness were also determined. The method can conveniently be used for analysis of levofloxacin pharmacokinetic levels in human serum and pharmaceutical formulations...

..The synthesized compounds showed diverse antimicrobial profiles. Among them, a few compounds possessed a comparable or better activity in comparison to the reference drug...

..e., antimicrobial activity of complexes of erythromycin increases with respect to parent erythromycin drug and MIC of drug metal complexes decreased...

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..0184 microg/ml and the quantitation limit was about 0.056 microg/ml and therefore could be employed as a more convenient and efficient option for the analysis of diltiazem and its related compounds in drug substance and formulations...

..Present study clearly indicated that most of the NSAID's studied bind to DTZ forming charge transfer complexes, evident from the high availability of DTZ. Hence, concurrent administration of NSAID's with DTZ is not recommended...

..This confirms that the desired level of cleanliness is achieved using the current cleaning procedures, which were consequently validated...

..There were no interfering peaks due to the excipients present in the pharmaceutical tablets. Thus, the proposed method is simple and suitable for the simultaneous analysis of active ingredients in dosage forms and human serum...

..The developed method, after being validated in terms of precision, robustness, recovery, LOD, and LOQ, was successively applied to the analysis of pharmaceutical formulations and human serum...

..Calibration techniques (used in the calibration step) differ in determining coefficient values for the preceding or similar equations...

..4 and 9. This high availability of one drug in presence of other is attributed to the formation of a charge-transfer complex, which was stable at elevated temperatures, except at 60 degrees C in pH 1...

..It is the most widely used drug in Homeopathic system of medicine for kidney pain and for removal of kidney stones. In this article, we present countless blessings of nature encountered through this herb which are worthy of recording...

..It was possible to determine both phloroglucinol and trimethylphloroglucinol in the concentration range of 5 nano gram to 30 nano grams. The detection limit of both phloroglucinol and trimethylphloroglucinol were 0.4 nano gram...

..The established HPLC method is rapid, accurate, and selective, because of its sensitivity and reproducibility. The order of complexation was ferric>chromium>copper>nickel>cadmium>zinc>magnesium>manganese>calcium>cobalt...

..The former two techniques are mostly used to fabricate porous nanoparticles. Present paper reviews these techniques so as to give an idea to those planning to start with the fabrication of nanoparticles in a particular area of interest...

..It was possible to determine all of them in the concentration range of 5-30 nano grams. The detection limit of mebeverine hydrochloride was 0.4-nano gram...

..Among the newly developed nanomedicine and nanodevices such as quantum dots, nanowires, nanotubes, nanocantilevers, and nanopores, nanoshells and nanoparticles are the most promising applications for various cancer treatments...

..The effect of dissolution mediums, simulating various body environments with respect to pH and the influence of temperature on these interactions has been examined in order to elucidate the mechanism of these interactions...

..Accordingly coadministration of both the drugs should be avoided...

..07 to 100.34. The proposed method was validated for selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of buclizine hydrochloride in bulk drug as well as in human serum...

..27 % to 100.06 %. Piroxicam was used as an internal standard. The proposed method is rapid, accurate and selective; it may be used for the quantitative analysis of meloxicam from raw materials, in bulk drugs and other dosage formulations...

..e., Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Bacillus fragilis and Streptococcus pneumonia by disc diffusion method to measure the inhibitory zone and MIC were determined by tube dilution method...

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..Also how nanocarriers are improving molecular imaging to help improve diagnosis and treatment of cardiovascular disease is focused in this article...

..On the other hand, increase in metformin concentration may result in hypoglycemic effects...

..A recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans (Guo et al., 2000)...

..Our investigations reveal that formation of complexes results in decrease in antibacterial activity of cephradine and MIC values are increased...

..These complexes were characterized through physical characteristics, IR, H(1)-NMR, and atomic absorption spectroscopic studies...

..This article will highlight rational approaches in design and surface engineering of nanoscale vehicles and entities for site-specific drug delivery. Potential pitfalls or side effects associated with nanoparticles are also discussed...

..Magaldrate and calcium carbonate in simulated gastric juice exhibited relatively higher adsorption capacities, as did magnesium trisilicate and calcium hydroxide in simulated intestinal juice...

..The results in three different media revealed that, hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium...

..The method was valid was for the determination in raw materials, bulk drug and formulations. The limit of quantification was 5-30 nano grams, while the limit of detection was 0.4 nano grams...