Migraine life-time prevalence in mental disorders: concurrent comparisons with first-degree relatives and the general populationTrino Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
Invest Clin 53:38-51. 2012
..A high variability was observed in migraine prevalence among the diagnostic categories, but it was particularly high in subjects with affective disorders, mainly in women, who thus deserve special attention from clinicians...
The metabolic syndrome and its constituting variables in atypical antipsychotic-treated subjects: comparison with other drug treatments, drug-free psychiatric patients, first-degree relatives and the general population in VenezuelaTrino Baptista
Department of Physiology, Los Andes University Medical School, and San Juan de Dios Hospital, P O Box 93, Merida, 5101 A, Venezuela
Schizophr Res 126:93-102. 2011
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- Rosiglitazone in the assistance of metabolic control during olanzapine administration in schizophrenia: a pilot double-blind, placebo-controlled, 12-week trial
T Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
Pharmacopsychiatry 42:14-9. 2009
..We assessed the effects of rosiglitazone on BWG, the insulin resistance index (HOMA-IR), lipids, glycated hemoglobin and fibrinogen in olanzapine-treated schizophrenia patients...
- Pharmacological management of atypical antipsychotic-induced weight gain
Trino Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
CNS Drugs 22:477-95. 2008
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- Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study
Trino Baptista
Department of Physiology, Los Andes University Medical School, P O Box 93, Merida, 5101 A, Venezuela
Psychiatry Res 159:250-3. 2008
..Weight loss was similar in both groups: -2.8+/-3.2 kg vs. -1.4+/-2.6 kg. Except for preventing a triglyceride increase, the drug combination lacked efficacy for metabolic control in this clinical population...
- Evolution theory: an overview of its applications in psychiatry
Trino Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
Psychopathology 41:17-27. 2008
..1) Describe the concept, mechanisms and outcome of evolution; (2) review the current topics in research and clinical psychiatry where evolutionary concepts are explicitly applied...
- Similar frequency of abnormal correlation between serum leptin levels and BMI before and after olanzapine treatment in schizophrenia
Trino Baptista
Departments of Physiology, Los Andes University Medical School, Merida, Venezuela
Int Clin Psychopharmacol 22:205-11. 2007
..The impact of olanzapine on leptin regulation appears discrete and limited to a small number of participants. Additional studies must clarify the features that render them to metabolic dysregulation...
- Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric, double-blind, placebo-controlled trial
Trino Baptista
Department of Physiology, Los Andes University Medical School, PO Box 93, Merida, 5101 A, Venezuela
Schizophr Res 93:99-108. 2007
..The primary objective of this study was to assess whether metformin prevents or reverses BWG in patients with schizophrenia or bipolar disorder under olanzapine administration. Secondarily we evaluated diverse metabolic variables...
- Insulin counter-regulatory factors, fibrinogen and C-reactive protein during olanzapine administration: effects of the antidiabetic metformin
Trino Baptista
Department of Physiology, Los Andes University Medical School, San Cristobal, Venezuela
Int Clin Psychopharmacol 22:69-76. 2007
..The trend for leptin to increase after placebo, but not after metformin in spite of similar weight gain suggests a beneficial effect of this antidiabetic agent...
- Metformin for prevention of weight gain and insulin resistance with olanzapine: a double-blind placebo-controlled trial
Trino Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
Can J Psychiatry 51:192-6. 2006
..To assess whether metformin prevents body weight gain (BWG) and metabolic dysfunction in patients with schizophrenia who are treated with olanzapine...
- Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection
Trino Baptista
Department of Physiology, Los Andes University Medical School, P O Box 93, Merida 5101 A, Venezuela
Prog Neuropsychopharmacol Biol Psychiatry 28:1305-11. 2004
..Other diet protocols and lower APD doses must be tested to further characterize the RIS model...
- Drug induced weight gain, an impediment to successful pharmacotherapy: focus on antipsychotics
T Baptista
Department of Physiology, P O Box 93, Los Andes University Medical School, Merida, 5101 A, Venezuela
Curr Drug Targets 5:279-99. 2004
..Notwithstanding this, novel strategies are necessary to treat this side effect in a clinical population particularly prone to poor compliance and under a high risk of negative drug interaction...
- Treatment of the metabolic disturbances caused by antipsychotic drugs: focus on potential drug interactions
Trino Baptista
Department of Physiology, Los Andes University Medical School, Merida, Venezuela
Clin Pharmacokinet 43:1-15. 2004
..After reviewing the literature, the authors provide preliminary guidelines to assist clinicians in drug selection for this complex and fragile clinical population...
- Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance
Trino Baptista
Department of Physiology, Los Andes University Medical School, 5101 A, Merida, Venezuela
Brain Res 957:144-51. 2002
..The animal model of RIS-induced obesity in rats might be improved by testing other doses, route of administration and type of diet...
- Are leptin and cytokines involved in body weight gain during treatment with antipsychotic drugs?
Trino Baptista
Los Andes University Medical School, Department of Physiology, Merida, Venezuela
Can J Psychiatry 47:742-9. 2002
..To critically review published literature on the causal association between leptin, cytokines, and excessive body weight gain (BWG) induced by antipsychotic drugs (APs)...
