Yoshio Araki

Summary

Publications

  1. ncbi The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats
    Yoshio Araki
    Ace Bio Product Co, Chiyoda ku, Tokyo, Japan
    Int J Mol Med 12:121-4. 2003
  2. ncbi Hepatocellular carcinoma treated by percutaneous hot saline injection
    Yoshio Araki
    Division of Gastroenterology and Hematology, Shiga University of Medical Science, Seta Tukinowa, Otsu City 520 2192, Shiga, Japan
    Oncol Rep 12:569-71. 2004
  3. ncbi Elevated circulating platelet-derived microparticles in patients with active inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Am J Gastroenterol 100:2042-8. 2005
  4. ncbi The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and Caco-2
    Yoshio Araki
    Otsu City 520 2101, Shiga, Japan
    Oncol Rep 10:1931-6. 2003
  5. ncbi The analysis of pyridylamino-dextran sulfate oligomers by high-performance liquid chromatography and a novel detection system for sulfated polysaccharides
    Yoshio Araki
    Department of Internal Medicine, Nagahama Red Cross Hospital, Japan
    Oncol Rep 12:363-7. 2004
  6. ncbi The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats
    Yoshio Araki
    Ace Bio Product Co, Chiyoda ku, Tokyo, Japan
    Int J Mol Med 12:125-9. 2003
  7. ncbi Budd-Chiari syndrome: a case with a combination of hepatic vein and superior vena cava occlusion
    Yoshio Araki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu City, Shiga, Japan
    World J Gastroenterol 11:3797-9. 2005
  8. ncbi Dietary bile acids inhibit potentially elemental diet-induced small intestinal atrophy in rats
    Yoshio Araki
    Ace Bio Product Co, Tokyo, Japan
    Int J Mol Med 10:623-6. 2002
  9. ncbi The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice
    Yoshio Araki
    Department of Internal Medicine, Biwako Youikuin Hospital, Otsu 520 2144, Japan
    Int J Mol Med 17:331-4. 2006
  10. ncbi Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line
    Yoshio Araki
    Department of Internal Medicine, Biwako Youikuin Hospital, 7 7 2 Ohgaya, Otsu 520 2144 Shiga, Japan
    Free Radic Biol Med 39:769-80. 2005

Collaborators

Detail Information

Publications57

  1. ncbi The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats
    Yoshio Araki
    Ace Bio Product Co, Chiyoda ku, Tokyo, Japan
    Int J Mol Med 12:121-4. 2003
    ..A clinical effect for edaravone against acute pancreatitis is strongly expected...
  2. ncbi Hepatocellular carcinoma treated by percutaneous hot saline injection
    Yoshio Araki
    Division of Gastroenterology and Hematology, Shiga University of Medical Science, Seta Tukinowa, Otsu City 520 2192, Shiga, Japan
    Oncol Rep 12:569-71. 2004
    ..In conclusion, PHoT shows good anti-tumor effects despite a small number of punctures and holds promise as a curative local treatment method for small HCCs...
  3. ncbi Elevated circulating platelet-derived microparticles in patients with active inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Am J Gastroenterol 100:2042-8. 2005
    ..60, p < 0.01, n = 122). CONCLUSION: Elevated circulating PDMPs in active IBD patients suggest a role for platelets in the pathogenesis of IBD...
  4. ncbi The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and Caco-2
    Yoshio Araki
    Otsu City 520 2101, Shiga, Japan
    Oncol Rep 10:1931-6. 2003
    ..It is possible that the cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids under certain conditions. The understanding of the precise mechanism of this phenomenon remains to be determined...
  5. ncbi The analysis of pyridylamino-dextran sulfate oligomers by high-performance liquid chromatography and a novel detection system for sulfated polysaccharides
    Yoshio Araki
    Department of Internal Medicine, Nagahama Red Cross Hospital, Japan
    Oncol Rep 12:363-7. 2004
    ..This novel detection system may be specific and may potentially provide useful information in the analyses of sulfated polysaccharides, which are present in environmental and biological materials...
  6. ncbi The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats
    Yoshio Araki
    Ace Bio Product Co, Chiyoda ku, Tokyo, Japan
    Int J Mol Med 12:125-9. 2003
    ..These results strongly support the involvement of ROS in the pathogenesis of DSS-induced colitis. A clinical effect for edaravone against IBD patients is strongly expected...
  7. ncbi Budd-Chiari syndrome: a case with a combination of hepatic vein and superior vena cava occlusion
    Yoshio Araki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu City, Shiga, Japan
    World J Gastroenterol 11:3797-9. 2005
    ..If deteriorating liver function or intractable ascites occur again, a liver transplantation may be anticipated. This is the first case report of Budd-Chiari syndrome associated with a superior vena cava occlusion...
  8. ncbi Dietary bile acids inhibit potentially elemental diet-induced small intestinal atrophy in rats
    Yoshio Araki
    Ace Bio Product Co, Tokyo, Japan
    Int J Mol Med 10:623-6. 2002
    ..Oral bile acid administration may prevent this atrophy and the elevations in mucosal DAO and ALP activities, which may lead to new therapeutic strategies in patients managed with ED...
  9. ncbi The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice
    Yoshio Araki
    Department of Internal Medicine, Biwako Youikuin Hospital, Otsu 520 2144, Japan
    Int J Mol Med 17:331-4. 2006
    ..These results strongly support the involvement of ROS in the pathogenesis of DSS-induced colitis. A clinical effect for edaravone and tempol in IBD patients is strongly expected...
  10. ncbi Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line
    Yoshio Araki
    Department of Internal Medicine, Biwako Youikuin Hospital, 7 7 2 Ohgaya, Otsu 520 2144 Shiga, Japan
    Free Radic Biol Med 39:769-80. 2005
    ..In addition, PLA2, COX, PKC, NADH dehydrogenase, and XO are located upstream of the ROS generation, but ERK 1/2, PI 3 K, p38 MAPK, and MLCK are downstream during the signaling of CA-induced TEER alterations...
  11. ncbi Chemical depolymerization of dextran sulfate sodium - the application of size-exclusion or ion-pair liquid chromatography
    Yoshio Araki
    First Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Shiga, Japan
    Biomed Chromatogr 21:335-7. 2007
    ..Fluorometric analyses using SEC and UV analyses using IPLC allow for the detection of DSS, reactants and sulfate...
  12. ncbi Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: the role of mast cells
    Yoshio Araki
    First Department of Pathology, Shiga University of Medical Science, 6 13 20 Aoyama, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 19:257-62. 2007
    ..These effects may be closely associated with its inhibitory effects on mucosal mast cells, and the destruction of the mucosal connective tissues...
  13. ncbi In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis
    Yoshio Araki
    First Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Shiga, Japan
    Oncol Rep 16:1357-62. 2006
    ..The cell cycle arrest and reduced intracellular generation of ROS may be involved during initiation or throughout the early stages of DSS-induced colitis...
  14. ncbi Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Biochim Biophys Acta 1591:69-74. 2002
    ..This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha...
  15. ncbi IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts
    Kazunori Hata
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G1035-44. 2002
    ..This was dependent on the enhancement of IL-6 mRNA stability. In conclusion, human SEMFs secreted IL-6, IL-8, and MCP-1 in response to IL-17. These responses might play an important role in the pathogenesis of gut inflammation...
  16. ncbi Inhibitory effects of somatostatin on tumor necrosis factor-alpha-induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 10:89-93. 2002
    ..These findings suggest that some of the therapeutic actions of somatostatin on acute pancreatitis might be mediated by reducing local IL-6 secretion in the pancreas...
  17. ncbi Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan
    J Gastroenterol 40:802-10. 2005
    ..CONCLUSIONS: IL-17 augments TNF-alpha-induced G- and GM-CSF release via transcriptional and posttranscriptional mechanisms...
  18. ncbi Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis
    Yasuyuki Deguchi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 52:2993-8. 2007
    ..In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients...
  19. ncbi Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats
    Yoshio Araki
    Otsu 520-2101, Shiga, Japan
    Int J Mol Med 13:577-80. 2004
    ..The potential clinical efficacy of the Clostridium butyricum derivative in IBD patients is also discussed...
  20. ncbi IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    J Immunol 169:1683-7. 2002
    ..Because cooperation between NF-kappaB and IRF-1 is important in the TNF-alpha-induced RANTES gene expression, the major mechanism mediating the inhibitory effect of IL-17 may be achieved by the inhibition of IRF-1 DNA-binding activity...
  21. ncbi Mast cells may not play a crucial role in the pathogenesis of experimental closed duodenal loop-induced pancreatitis in rats
    Yoshio Araki
    Department of Internal Medicine, Nagahama Red Cross Hospital, Nagahama, Shiga, Japan
    Pancreas 24:298-302. 2002
    ..CONCLUSION: These results indicate that mast cells may not be crucial for the development of CDL-induced pancreatitis...
  22. ncbi Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 25:203-8. 2010
    ..These findings give insight into the mechanisms responsible for DSS-induced colitis, especially with respect to the molecular mass of DSS...
  23. ncbi Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 10:631-4. 2002
    ..In conclusion, IL-4, in particular IL-4 plus IL-17, induced IL-6 secretion in human colonic myofibroblasts. Th2 immune responses might play an important role in the pathogenesis of gut inflammation...
  24. ncbi Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Gastroenterology 129:969-84. 2005
    ..We investigated IL-22 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and analyzed its biologic activities in human colonic subepithelial myofibroblasts (SEMFs)...
  25. ncbi Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17
    Shigeki Bamba
    Division of Gastroenterology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan
    J Gastroenterol 38:548-54. 2003
    ..CONCLUSIONS: Colonic SEMFs actively secreted MMP-3 in response to IL-17, IL-1beta, and TNF-alpha. This was coupled with TIMP-1 secretion. Colonic SEMFs may play an important role in ECM turnover via MMP secretion...
  26. ncbi The long-term oral administration of a product derived from a probiotic, Clostridium butyricum induced no pathological effects in rats
    Yoshio Araki
    Ace Bio Product Co, Chiyoda-ku, 101-0047 Tokyo, Japan
    Int J Mol Med 12:571-5. 2003
    ..No pathological abnormalities were found in the hemocyte count, the biochemical and electrolyte analyses, or the macroscopic and microscopic findings...
  27. ncbi Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5
    Yasuyuki Deguchi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Int J Mol Med 16:605-8. 2005
    ..The development of DSS colitis was aggravated in genetically C5-deficient DBA2/J mice. These findings suggest that the complement system might play a protective role in the development of DSS-induced experimental colitis...
  28. ncbi Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Oncol Rep 28:1597-605. 2012
    ..Therefore, the molecular mass distribution of the DSS differed between each part in the lumen. As an early stage event, DSS induced colitis through cell cycle arrest and apoptosis according to its molecular mass...
  29. ncbi Short-term oral administration of a product derived from a probiotic, Clostridium butyricum induced no pathological effects in rats
    Yoshio Araki
    Ace Bio Product Co, Tokyo, Japan
    Int J Mol Med 9:173-7. 2002
    ..It is possible that this novel product with the additive exerts therapeutic effects on some gastrointestinal disorders...
  30. ncbi High serum bile acids cause hyperthyroidism and goiter
    Ken Ichi Mukaisho
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga, Japan
    Dig Dis Sci 53:1411-6. 2008
    ..In the duodenal content reflux model of rats, we noted an elevation of serum bile acid and swelling of the thyroid gland. This study was designed to elucidate whether bile acids (BAs) also enhance thyroid function...
  31. ncbi Detection of N-nitroso-bile acids at 285 nm in reverse-phase HPLC
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Shiga, Japan
    J Sep Sci 31:2827-30. 2008
    ..96 h), but remained fairly stable under acidic (pH 2) (t(1/2) = 12.8 h) and neutral (pH 7) (t(1/2) = 7.8 h) conditions. This study is the first report, which simply and specifically analyzes N-nitroso-bile acids using an RP-HPLC system...
  32. ncbi Effects of the soluble fibre pectin on intestinal cell proliferation, fecal short chain fatty acid production and microbial population
    Tetsuya Fukunaga
    Division of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Shiga, Japan
    Digestion 67:42-9. 2003
    ..This study aimed to evaluate the effects of pectin on rat intestinal cell proliferation and the intraluminal environment...
  33. ncbi N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 12:721-5. 2003
    ..The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Our data suggest that n-3 fatty acid-rich diet may be applicable for enteral nutrition in the treatment of IBD patients...
  34. ncbi Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    Atsuhiro Ogawa
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Clin Immunol 110:55-62. 2004
    ..Blocking of IL-17 activity in vivo using the anti-IL-17 mAb enhanced the development of DSS-colitis in mice. This suggests an inhibitory role for IL-17 in the development of DSS-colitis...
  35. ncbi Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Cancer Immunol Immunother 50:663-72. 2002
    ..These observations indicate that both a down-regulation of DAF expression and the induction of susceptibility to complement attack contribute to the anti-tumor effects of butyrate in colonic cancer...
  36. ncbi Elevated serum anti-carbonic anhydrase II antibodies in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 9:499-502. 2002
    ..These results suggest that autoimmune responses against CA II may be involved in the pathogenesis of UC, and similar mechanism may participate in the development of pancreatic lesions in UC patients...
  37. ncbi Inflixmab as a possible treatment for the hemorrhagic type of Crohn's disease
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Gastroenterol 39:284-7. 2004
    ..We suggest that infliximab therapy should be tried to stop acute gastrointestinal bleeding in CD before there is a surgical emergency...
  38. ncbi Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma
    Zhi qiang Ling
    Department of Pathology, Shiga University of Medical Science, Shiga, Japan
    Cancer Sci 101:624-30. 2010
    ..Ezrin probably influences the growth and invasiveness of ESCC cells, and phosphorylation is only required in metastatic behavior of tumor cells at the leading edge and invasive front...
  39. ncbi Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Oncol Rep 24:869-74. 2010
    ..In conclusion, the increased apoptosis and decreased proliferation might lead to a breakdown of the epithelial barrier function, and thus facilitate the mucosal invasion of intraluminal microorganisms in DSS-induced colitis...
  40. ncbi Modification of intestinal flora in the treatment of inflammatory bowel disease
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 10 1 2 Shinkawa Chuo ku, Tokyo, 104 8288, Japan
    Curr Pharm Des 9:333-46. 2003
    ..The use of antibiotics continues to be of interest. Although these strategies hold great promise and appear to be useful in some settings, more clinical study is needed to firmly establish the relevance of these therapies...
  41. ncbi Operative indications for patients with refractory or severe ulcerative colitis
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Shiga, Japan
    Hepatogastroenterology 52:1470-3. 2005
    ..Since new treatments using cyclosporin A and leukocytapheresis have been developed, we analyzed historical changes in the operative indications for UC...
  42. ncbi In vitro alterations in fecal short chain fatty acids and organic anions induced by the destruction of intestinal microflora under hypotonic and aerobic conditions
    Yoshio Araki
    Ace Bio Product Co, Uchikanda 1-18-11-506, Chiyoda-ku 101-0047, Tokyo, Japan
    Int J Mol Med 9:627-31. 2002
    ..These alterations may influence the pathogenesis and progression of IBD...
  43. ncbi High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model
    Kuan Hao Chen
    Department of Pathology and Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Shiga 520 2192, USA
    Cancer Sci 98:1683-8. 2007
    ..High dietary animal fat changed the bile-acid composition and increased the concentration of taurine conjugates in the bile juice. These increased bile acids promoted the development of BE and Barrett's dysplasia leading to EAC...
  44. ncbi The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range
    Shigeki Bamba
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520 2192, Japan
    Dig Dis Sci 57:327-34. 2012
    ..To test this, we used three DSS preparations of similar molecular weights but with different sulfur contents...
  45. ncbi Histological examination of the relationship between respiratory disorders and repetitive microaspiration using a rat gastro-duodenal contents reflux model
    Keisuke Oue
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Exp Anim 60:141-50. 2011
    ..The reflux model is a good tool for examining the causal relationships between GER and respiratory disorders...
  46. ncbi IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    Mitsue Shimada
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Immunol 168:861-8. 2002
    ..In conclusion, pancreatic periacinar myofibroblasts secreted a large amount of IL-6 in response to proinflammatory cytokines. These cells might play an important role in the pathogenesis of acute pancreatitis via IL-6 secretion...
  47. ncbi Decomposition of dextran sulfate sodium under alkaline, acidic, high temperature and high pressure conditions
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu 520 2192, Shiga, Japan
    Oncol Rep 20:147-9. 2008
    ..Therefore, these Mr 2500 or 1800 DSS molecules may be useful in investigating the mechanisms of DSS-induced colitis...
  48. ncbi Suppressive effects of a new anti-inflammatory agent, IS-741, on dextran sulfate sodium-induced experimental colitis in rats
    Jin Makino
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan
    Int J Mol Med 9:391-6. 2002
    ..The findings in this study suggest that IS-741 may be a useful new therapeutic agent for inflammatory bowel disease...
  49. ncbi Oral administration of a product derived from Clostridium butyricum in rats
    Yoshio Araki
    Ace Bio Product Co, Uchikanda, Tokyo, Japan
    Int J Mol Med 9:53-7. 2002
    ..The rats grew normally for the duration of the experimental period. It is possible that this novel product with the additive exerts therapeutic effects on some gastointestinal disorders...
  50. ncbi Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan
    J Gastroenterol 38:134-41. 2003
    ..These effects may be brought about by an increase of butyrate production and adsorption of bile acids...
  51. ncbi Germinated barley foodstuff prolongs remission in patients with ulcerative colitis
    Hiroyuki Hanai
    Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
    Int J Mol Med 13:643-7. 2004
    ..No side effects related to GBF were observed. GBF appeared to be effective and safe as a maintenance therapy to taper steroid dose and prolong remission in patients with UC...
  52. ncbi Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, Tokyo 104 8288, Japan
    Int J Mol Med 12:701-4. 2003
    ..Nutraceutical GBF therapy may have a place in long-term management of UC, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder...
  53. ncbi Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA
    Tadashi Okada
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Int J Oncol 25:1383-8. 2004
    ..The PP1Cdelta-depleted cells were enlarged, and appeared flat and rich in lamellipodia. These data suggested that each PP1C isoform has non-redundant function in vivo...
  54. ncbi Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability
    Yoshio Araki
    Research Institute for Microbial Diseases, Graduate School of Science, Osaka University, 3 1 Yamada oka, Suita, Osaka, Japan
    Genes Cells 8:465-80. 2003
    ..Genetic analysis showed that MCM10 interacts with components of the elongation machinery such as Pol delta and Pol epsilon, suggesting that it may play a role in elongation replication...
  55. ncbi Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment
    Masanobu Fukuda
    Pharmaceutical Division, Kirin Brewery Co. Ltd, Shibuya-ku, Tokyo 150-8011, Japan
    Int J Mol Med 9:65-70. 2002
    ..These data suggest that modification of the intestinal microflora by prebiotics, including GBF, may serve as a useful adjunct in the treatment of ulcerative colitis as well as antibiotic treatment...
  56. ncbi Do mast cells play any role in the pathogenesis of experimental pancreatic fibrosis in rats?
    Yoshio Araki
    Pancreas 25:415-7. 2002
  57. ncbi Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway
    Hiroshi Kitagaki
    National Research Institute of Brewing, 3 7 1 Kagamiyama, Higashi Hiroshima City, Hiroshima 739 0046, Japan
    FEBS Lett 581:2935-42. 2007
    ....