H M M Arafa

Summary

Publications

  1. doi request reprint Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance
    H M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Toxicol Ind Health 25:417-27. 2009
  2. doi request reprint Carnitine deficiency aggravates carboplatin nephropathy through deterioration of energy status, oxidant/anti-oxidant balance, and inflammatory endocoids
    Hossam M M Arafa
    Department of Pharmacol and Toxicol, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Toxicology 254:51-60. 2008
  3. doi request reprint Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Arch Toxicol 83:139-50. 2009
  4. doi request reprint Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 105:30-6. 2009
  5. doi request reprint Uroprotective effects of curcumin in cyclophosphamide-induced haemorrhagic cystitis paradigm
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 104:393-9. 2009
  6. ncbi request reprint Anti-fibrotic effect of meloxicam in a murine lung fibrosis model
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Eur J Pharmacol 564:181-9. 2007
  7. ncbi request reprint Enhancement by dexamethasone of the therapeutic benefits of cisplatin via regulation of tumor angiogenesis and cell cycle kinetics in a murine tumor paradigm
    Hossam M M Arafa
    Dept of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Egypt
    Toxicology 222:103-13. 2006
  8. doi request reprint Possible contribution of beta-glycosidases and caspases in the cytotoxicity of novel glycoconjugates in colon cancer cells
    Hossam M M Arafa
    Department of Pharmacol and Toxicol, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Invest New Drugs 28:306-17. 2010
  9. ncbi request reprint Curcumin attenuates diet-induced hypercholesterolemia in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Med Sci Monit 11:BR228-234. 2005
  10. doi request reprint Possible contribution of beta-glucosidase and caspases in the cytotoxicity of glufosfamide in colon cancer cells
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Eur J Pharmacol 616:58-63. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance
    H M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Toxicol Ind Health 25:417-27. 2009
    ..In conclusion, HDN has proven protective effects in BaP-induced testicular toxicity paradigm, and this protection resides, at least in part, on its antioxidant properties...
  2. doi request reprint Carnitine deficiency aggravates carboplatin nephropathy through deterioration of energy status, oxidant/anti-oxidant balance, and inflammatory endocoids
    Hossam M M Arafa
    Department of Pharmacol and Toxicol, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Toxicology 254:51-60. 2008
    ..Thus, one could conclude that carnitine deficiency, whether being a causative clue or a sequela, might represent a risk factor in carboplatin nephropathy...
  3. doi request reprint Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Arch Toxicol 83:139-50. 2009
    ..Data obtained so far would suggest that carnitine deficiency could possibly be a sequela as well as a causative clue for paracetamol hepatotoxicity...
  4. doi request reprint Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 105:30-6. 2009
    ....
  5. doi request reprint Uroprotective effects of curcumin in cyclophosphamide-induced haemorrhagic cystitis paradigm
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 104:393-9. 2009
    ....
  6. ncbi request reprint Anti-fibrotic effect of meloxicam in a murine lung fibrosis model
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Eur J Pharmacol 564:181-9. 2007
    ..Apart from its well-known anti-inflammatory potential, this anti-fibrotic action of meloxicam resides most probably, at least partly, in its anti-oxidant and angiostatic effects...
  7. ncbi request reprint Enhancement by dexamethasone of the therapeutic benefits of cisplatin via regulation of tumor angiogenesis and cell cycle kinetics in a murine tumor paradigm
    Hossam M M Arafa
    Dept of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Egypt
    Toxicology 222:103-13. 2006
    ..Also, dexamethasone did not alter cisplatin-induced nephrotoxicity, thus demonstrating an improved therapeutic potential...
  8. doi request reprint Possible contribution of beta-glycosidases and caspases in the cytotoxicity of novel glycoconjugates in colon cancer cells
    Hossam M M Arafa
    Department of Pharmacol and Toxicol, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Invest New Drugs 28:306-17. 2010
    ..Also, initiation and activation of apoptosis in tumor cells may contribute, at least partly, for the cytotoxicity of these sugar conjugates...
  9. ncbi request reprint Curcumin attenuates diet-induced hypercholesterolemia in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Med Sci Monit 11:BR228-234. 2005
    ..Curcumin (a component of turmeric) has long been used as a spice and food-coloring agent. In experimental animals, curcumin has shown anti-diabetic, anti-inflammatory, cytotoxic and anti-oxidant properties...
  10. doi request reprint Possible contribution of beta-glucosidase and caspases in the cytotoxicity of glufosfamide in colon cancer cells
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Eur J Pharmacol 616:58-63. 2009
    ..In conclusion, the current data could possibly unravel the mechanistic role of beta-glucosidase and apoptotic caspases in the bioactivation and cytotoxicity of glufosfamide within colon cancer cells...
  11. doi request reprint Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo 11231, Egypt
    Food Chem Toxicol 47:1311-7. 2009
    ....
  12. ncbi request reprint Protective role of carnitine esters against alcohol-induced gastric lesions in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pharmacol Res 48:285-90. 2003
    ....
  13. ncbi request reprint Potential protective effect of melatonin against dibromoacetonitrile-induced oxidative stress in mouse stomach
    Mohamed H Abdel-Wahab
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pharmacol Res 46:287-93. 2002
    ..Melatonin could mitigate DBAN-induced oxidative stress in mouse stomach as it did almost normalize both the enzymatic and nonenzymatic antioxidant parameters...
  14. ncbi request reprint Immunomodulatory effects of L-carnitine and q10 in mouse spleen exposed to low-frequency high-intensity magnetic field
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Toxicology 187:171-81. 2003
    ..L-carnitine, but not Q10 could ameliorate the adverse effects of EMF on the vast majority of the immune parameters tested, suggesting a possible immunoprotective role of L-carnitine under the current experimental conditions...
  15. ncbi request reprint Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype
    Mariane G Tadros
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Pharmacol Biochem Behav 82:574-82. 2005
    ..Taken together, one may conclude that taurine has neuroprotective role in the current HD paradigm due, at least partly, to its indirect antioxidant effect and GABA agonistic action...
  16. doi request reprint Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice
    Memy H Hassan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 199:156.e1-8. 2008
    ..This study was undertaken to develop a representative murine model for human leiomyoma...
  17. ncbi request reprint Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression
    Memy H Hassan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0587, USA
    J Clin Endocrinol Metab 92:3949-57. 2007
    ....