Arany I, Fulop T, Dixit M. Chronic Nicotine Exposure Reduces Antioxidant Function of Simvastatin in Renal Proximal Tubule Cells. In Vivo. 2018;32:1033-1037 pubmed publisher
..Overexpression of CREB or knockdown of p66shc restored simvastatin-dependent induction of HO1 and MnSOD in the presence of nicotine. Antioxidant efficiency of simvastatin might be significantly lessened in smokers/E-cigarette users. ..
Arany I, Clark J, Ember I, Juncos L. Epigenetic modifiers exert renal toxicity through induction of p66shc. Anticancer Res. 2011;31:3267-71 pubmed
..Knockdown or mutation of the cytochrome c binding site of p66shc attenuated ROS production and cell injury. Therapeutic means that interfere with induction of p66shc may ameliorate renal toxicity of those epigenetic modifiers. ..
Reed D, Arany I. Sex hormones differentially modulate STAT3-dependent antioxidant responses during oxidative stress in renal proximal tubule cells. In Vivo. 2014;28:1097-100 pubmed
..Consequently, DHT augmented while E2 attenuated ROS production. Effects of dnSTAT3 were similar to DHT. Sex hormones may influence renal oxidative stress through differential regulation of STAT3-dependent antioxidant responses. ..
Ojeda N, Hall S, Lasley C, Rudsenske B, Dixit M, Arany I. Prenatal Nicotine Exposure Augments Renal Oxidative Stress in Embryos of Pregnant Rats with Reduced Uterine Perfusion Pressure. In Vivo. 2016;30:219-24 pubmed
..NIC also enhanced RUPP-induced reduction in fetal and fetal kidney weight. Prenatal NIC exposure augments the existing renal risk in the growth-restricted fetus, which may contribute to worsening in fetal programming of renal disease. ..
Clark J, Carter A, Dixit M, Arany I. Simvastatin Inhibits Epithelial-to-Mesenchymal Transition Through Induction of HO-1 in Cultured Renal Proximal Tubule Cells. In Vivo. 2016;30:407-11 pubmed
..SIM, via HO-1, suppresses TGF?1-dependent ROS production and, hence, EMT. Further evaluation of the anti-fibrotic nature of SIM in the kidney would be useful in the treatment of chronic kidney disease. ..
Arany I, Hall S, Reed D, Reed C, Dixit M. Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney. Nicotine Tob Res. 2016;18:1628-34 pubmed publisher
..Also, our study may help to develop strategies that mitigate adverse effects of NIC on the obese kidney. ..
Arany I, Carter A, Hall S, Fulop T, Dixit M. Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66shc-dependent antioxidant responses. Apoptosis. 2017;22:220-228 pubmed publisher
Arany I, Hall S, Faisal A, Dixit M. Nicotine Exposure Augments Renal Toxicity of 5-aza-cytidine Through p66shc: Prevention by Resveratrol. Anticancer Res. 2017;37:4075-4079 pubmed
..RES protected cells via the cytoplasmic p66shc/Nrf2/heme oxygenase-1 (HO-1) axis. RES can protect the kidney from adverse effects of NIC in patients undergoing anticancer therapy. ..
Hall S, Dixit M, Arany I. Resveratrol Attenuates Nicotine-mediated Oxidative Injury by Inducing Manganese Superoxide Dismutase in Renal Proximal Tubule Cells. In Vivo. 2017;31:551-555 pubmed
..Silencing of MnSOD abolished the protective effects of RES on NIC-associated oxidative injury. RES may provide protection to the kidney from the adverse effects of NIC in smokers. ..