Rami I Aqeilan
Khawaled S, Suh S, Abdeen S, Monin J, Distefano R, Nigita G, et al
. WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs. Cancer Res. 2019;79:1784-1798 pubmed publisher
..SIGNIFICANCE: These findings highlight the mechanism by which the tumor suppressor WWOX regulates metastasis of triple-negative breast cancer.See related commentary by Sharma, p. 1746. ..
Abu Remaileh M, Abu Remaileh M, Akkawi R, Knani I, Udi S, Pacold M, et al
. WWOX somatic ablation in skeletal muscles alters glucose metabolism. Mol Metab. 2019;22:132-140 pubmed publisher
..Genetics, Metabolic Syndrome, Diabetes. ..
Abdeen S, Ben David U, Shweiki A, Maly B, Aqeilan R. Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer. Cell Death Dis. 2018;9:832 pubmed publisher
..Altogether, our data uncover an essential role for WWOX as a bona fide breast cancer tumor suppressor through the maintenance of p53 stability. ..
Abu Remaileh M, Khalaileh A, Pikarsky E, Aqeilan R. WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. Cell Death Dis. 2018;9:511 pubmed publisher
..Our work suggests that WWOX inactivation has a central role in promoting HCC through rewiring of cellular metabolism and modulating proliferation. ..
Abu Remaileh M, Joy Dodson E, Schueler Furman O, Aqeilan R. Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells. J Biol Chem. 2015;290:30728-35 pubmed publisher
..Here we present a short overview of the various approaches taken to study this dynamic gene, emphasizing the most recent findings regarding WWOX's metabolic- and CNS-associated functions and their underlying molecular basis. ..
Abu Remaileh M, Aqeilan R. The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. Exp Biol Med (Maywood). 2015;240:345-50 pubmed publisher
..In this review, we discuss these evolving functions for WWOX and how its deletion affects cellular metabolism and neoplastic progression. ..