Susan E Appt

Summary

Publications

  1. pmc Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis
    Susan E Appt
    Wake Forest Primate Center and Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1353-9. 2012
  2. pmc The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:741-8. 2010
  3. ncbi request reprint Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
  4. pmc Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013
  5. pmc Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1242-52. 2012
  6. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
  7. pmc Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys
    Thomas B Clarkson
    Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:274-81. 2013
  8. pmc Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
    Comp Med 60:380-8. 2010
  9. pmc Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes
    F Salih Muhammad
    Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Comp Med 59:46-59. 2009
  10. pmc Serum antimüllerian hormone predicts ovarian reserve in a monkey model
    Susan E Appt
    Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:597-601. 2009

Collaborators

Detail Information

Publications27

  1. pmc Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis
    Susan E Appt
    Wake Forest Primate Center and Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1353-9. 2012
    ..The aim of this study was to determine if premenopausal ovarian reserve is associated with susceptibility for atherosclerosis...
  2. pmc The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:741-8. 2010
    ..The aim of this study was to determine the relationships among dietary protein source, cardiovascular risk, reproductive hormones, and ovarian aging...
  3. ncbi request reprint Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
    ..05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast...
  4. pmc Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013
    ..The primary aim of this study was to evaluate the endometrial profile of bazedoxifene acetate (BZA), a third-generation SERM, alone and in combination with conjugated equine estrogens (CEE) in a postmenopausal primate model...
  5. pmc Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1242-52. 2012
    ....
  6. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
    ..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model...
  7. pmc Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys
    Thomas B Clarkson
    Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:274-81. 2013
    ....
  8. pmc Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
    Comp Med 60:380-8. 2010
    ..These data indicate that VCD treatment markedly reduced primordial follicles while preserving larger estradiol- and testosterone-producing follicles and ovarian stroma, a condition that mimics ROR in women...
  9. pmc Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes
    F Salih Muhammad
    Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Comp Med 59:46-59. 2009
    ..However, because adult rats were more sensitive to the irritant properties of VCD, the use of a lower dose should be considered...
  10. pmc Serum antimüllerian hormone predicts ovarian reserve in a monkey model
    Susan E Appt
    Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:597-601. 2009
    ..Here, we describe the relationship between AMH and ovarian reserve in cynomolgus monkeys (Macaca fascicularis) estimated to be 12 to 15 years of age (approximately 36-45 y in women)...
  11. doi request reprint Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause
    Areepan Sophonsritsuk
    Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:540-7. 2013
    ..The aim of this study was to determine the effects of estrogen therapy (ET) on carotid artery inflammation when initiated early and late relative to surgical menopause...
  12. pmc Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Lab Invest 88:938-48. 2008
    ....
  13. ncbi request reprint Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Biol Reprod 75:477-86. 2006
    ..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model...
  14. ncbi request reprint Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 86:1210-6. 2006
    ....
  15. pmc Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Comp Med 61:462-6. 2011
    ....
  16. doi request reprint Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression
    Giselle C Melendez
    From the 1Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC and 2University of Hawaii Cancer Center, Honolulu, HI
    Menopause 22:289-96. 2015
    ....
  17. ncbi request reprint Usefulness of the monkey model to investigate the role soy in postmenopausal women's health
    Susan E Appt
    Department of Comparative Medicine, Comparative Medicine Clinical Research Center, Wake Forest University, School of Medicine, Winston Salem, NC, USA
    ILAR J 45:200-11. 2004
    ..Nevertheless, important attributes of soy have been identified, and it may have potential as a complementary component to hormone therapy...
  18. pmc Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women
    Susan E Appt
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Maturitas 60:216-22. 2008
    ..To determine whether co-administration of soy during tibolone treatment would prevent tibolone-induced dyslipoproteinemia in postmenopausal monkeys and women...
  19. pmc Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys
    Thomas B Clarkson
    From the Departments of 1Pathology Comparative Medicine and 2Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Menopause 21:8-14. 2014
    ....
  20. doi request reprint Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future
    Thomas B Clarkson
    Center for Comparative Medicine and Research, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 20:342-53. 2013
    ....
  21. ncbi request reprint Controversies about HRT--lessons from monkey models
    Thomas B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Maturitas 51:64-74. 2005
    ..The results of monkey studies suggest little or no effects of estrogen only treatment; whereas, estrogen+progestin clearly increases breast cancer risk...
  22. ncbi request reprint Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis)
    Robert M Blair
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Nutr 133:2262-7. 2003
    ..In conclusion, treatment with antibiotics resulted in a marked reduction in plasma equol concentrations and altered plasma isoflavonoid patterns in cynomolgus monkeys...
  23. pmc Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis)
    Marnie G Silverstein
    From the 1Integrative Physiology and Pharmacology Graduate Program, Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC and 2Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC
    Menopause 21:1136-42. 2014
    ..The aim of this study was to examine the effects of soy protein and isoflavones on thyroid function and the relationship between thyroid function and ovarian function...
  24. doi request reprint Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates
    Carol A Shively
    From the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    Psychosom Med 77:267-78. 2015
    ..We determined the effects of an SSRI on coronary artery atherosclerosis (CAA) in an established nonhuman primate model used to clarify the association between depression and CAA...
  25. pmc Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates
    Susan E Appt
    Wake Forest University School of Medicine, Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, NC 27157 1040, USA
    Maturitas 67:7-14. 2010
    ....
  26. ncbi request reprint MPA and postmenopausal coronary artery atherosclerosis revisited
    Thomas B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Steroids 68:941-51. 2003
    ..In conclusion, it is evident that the current experimental, clinical, and observational data do not provide evidence that progestins attenuate estrogen's cardiovascular benefits...
  27. ncbi request reprint Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamsters
    Robert M Blair
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:3585-91. 2002
    ....