Nicholas J Anthis

Summary

Publications

  1. pmc The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO J 28:3623-32. 2009
  2. pmc Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3DR, United Kingdom
    J Biol Chem 284:36700-10. 2009
  3. ncbi request reprint An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding
    Camilla L Oxley
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 283:5420-6. 2008
  4. pmc The structure of an interdomain complex that regulates talin activity
    Benjamin T Goult
    Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    J Biol Chem 284:15097-106. 2009
  5. pmc The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation
    Benjamin T Goult
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    J Mol Biol 394:944-56. 2009
  6. pmc The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study
    Antreas C Kalli
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Structure 18:1280-8. 2010
  7. pmc Structural diversity in integrin/talin interactions
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX13DR, UK
    Structure 18:1654-66. 2010

Collaborators

Detail Information

Publications7

  1. pmc The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO J 28:3623-32. 2009
    ..These results show key structural features that explain the ability of talin to mediate inside-out TM signalling...
  2. pmc Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3DR, United Kingdom
    J Biol Chem 284:36700-10. 2009
    ..Together, these results indicate that tyrosine phosphorylation is a common mechanism for regulating integrin activation, despite subtle differences in how these integrins interact with their binding proteins...
  3. ncbi request reprint An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding
    Camilla L Oxley
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 283:5420-6. 2008
    ..This switch may represent an in vivo mechanism for control of integrin receptor activation. These results have implications for the control of integrin signaling by proteins containing phosphotyrosine binding domains...
  4. pmc The structure of an interdomain complex that regulates talin activity
    Benjamin T Goult
    Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    J Biol Chem 284:15097-106. 2009
    ..The rod domain competes with beta3-integrin tails for binding to F3, and the structure of the complex suggests that the rod is also likely to sterically inhibit binding of the FERM domain to the membrane...
  5. pmc The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation
    Benjamin T Goult
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    J Mol Biol 394:944-56. 2009
    ..We also demonstrate that F0 is required for the ability of kindlin-1 to support talin-induced alphaIIbbeta3 integrin activation and for the localization of kindlin-1 to focal adhesions...
  6. pmc The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study
    Antreas C Kalli
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Structure 18:1280-8. 2010
    ..Our studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions...
  7. pmc Structural diversity in integrin/talin interactions
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX13DR, UK
    Structure 18:1654-66. 2010
    ..Together, these studies illustrate how the integrin/talin interaction has been fine-tuned to meet varying biological requirements...