Subhash C Annedi

Summary

Publications

  1. doi Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 22:2510-3. 2012
  2. doi 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 22:1980-4. 2012
  3. doi Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario, L5K 1B3, Canada
    J Med Chem 54:7408-16. 2011
  4. doi Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario L5K 1B3, Canada
    J Med Chem 55:943-55. 2012
  5. doi First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain
    Gabriela Mladenova
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario L5K 1B3, Canada
    J Med Chem 55:3488-501. 2012
  6. doi Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Eur J Med Chem 55:94-107. 2012
  7. doi 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a p
    Jailall Ramnauth
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario, L5K 1B3, Canada
    J Med Chem 55:2882-93. 2012
  8. doi 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
    Shawn Maddaford
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 21:5234-8. 2011
  9. doi 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
    Paul Renton
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 21:5301-4. 2011
  10. doi Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors
    Jailall Ramnauth
    NeurAxon Inc, Mississauga, Ontario, Canada
    J Med Chem 54:5562-75. 2011

Collaborators

Detail Information

Publications10

  1. doi Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 22:2510-3. 2012
    ....
  2. doi 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 22:1980-4. 2012
    ....
  3. doi Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario, L5K 1B3, Canada
    J Med Chem 54:7408-16. 2011
    ..These results suggest that 16 may be a useful tool for evaluating the potential role of selective nNOS inhibitors in the treatment of pain such as migraine and CTTH...
  4. doi Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario L5K 1B3, Canada
    J Med Chem 55:943-55. 2012
    ..The results presented in this report make cis-45 as an ideal tool for evaluating the potential role of selective nNOS inhibitors in CNS related disorders where excess NO produced by nNOS is thought to play a crucial role...
  5. doi First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain
    Gabriela Mladenova
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario L5K 1B3, Canada
    J Med Chem 55:3488-501. 2012
    ..Overall, the data suggest that cis-(+)-37 is a promising dual action development candidate having therapeutic potential for the treatment of neuropathic pain...
  6. doi Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine
    Subhash C Annedi
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Eur J Med Chem 55:94-107. 2012
    ....
  7. doi 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a p
    Jailall Ramnauth
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, Ontario, L5K 1B3, Canada
    J Med Chem 55:2882-93. 2012
    ..Furthermore, 47 was efficacious in the Chung model of neuropathic pain and has an excellent safety profile, making it a promising preclinical development candidate...
  8. doi 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
    Shawn Maddaford
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 21:5234-8. 2011
    ..One of the compounds, (R)-8 was shown to reduce tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in an in vivo rat model of dural inflammation relevant to migraine pain...
  9. doi 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
    Paul Renton
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 21:5301-4. 2011
    ..The most potent compound of the series for human nNOS (IC(50)=0.02 μM) (S)-12 showed very good selectivity over the eNOS (eNOS/nNOS=96-fold) and iNOS (iNOS/nNOS=850-fold) isoforms...
  10. doi Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors
    Jailall Ramnauth
    NeurAxon Inc, Mississauga, Ontario, Canada
    J Med Chem 54:5562-75. 2011
    ..In addition, this compound reduced tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in a rat model of dural inflammation relevant to migraine pain...