R K Andrews

Summary

Publications

  1. ncbi A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory and the Peptide Biology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
    J Biol Chem 276:28092-7. 2001
  2. ncbi Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI
    Robert K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:4219-21. 2002
  3. ncbi Adhesion-dependent signalling and the initiation of haemostasis and thrombosis
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia
    Histol Histopathol 13:837-44. 1998
  4. ncbi Snake venom modulators of platelet adhesion receptors and their ligands
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Toxicon 38:775-91. 2000
  5. ncbi Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, St Kilda Road Central, Melbourne, Victoria, Australia
    Blood 98:681-7. 2001
  6. ncbi Platelet adhesion receptors and (patho)physiological thrombus formation
    R K Andrews
    Hanzel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Histol Histopathol 16:969-80. 2001
  7. ncbi ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 10:1133-41. 2012
  8. ncbi Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
    F T Mu
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Thromb Haemost 8:324-30. 2010
  9. ncbi TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
  10. ncbi Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia, 3181
    Biochemistry 37:638-47. 1998

Collaborators

Detail Information

Publications47

  1. ncbi A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory and the Peptide Biology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
    J Biol Chem 276:28092-7. 2001
    ..Characterization of alborhagin as a GPVI agonist that is structurally distinct from convulxin demonstrates the versatility of snake venom toxins and provides a novel probe for GPVI-dependent platelet activation...
  2. ncbi Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI
    Robert K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:4219-21. 2002
    ..His269-Pro287 is analogous to the calmodulin-binding sequence in GPIbbeta. The novel interaction of GPVI and calmodulin may regulate aspects of GPVI function...
  3. ncbi Adhesion-dependent signalling and the initiation of haemostasis and thrombosis
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia
    Histol Histopathol 13:837-44. 1998
    ..Emerging evidence suggests GP Ib-IX-V-dependent signalling may involve receptor cross-linking and the cytoplasmic signalling protein, 14-3-3 zeta...
  4. ncbi Snake venom modulators of platelet adhesion receptors and their ligands
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Toxicon 38:775-91. 2000
    ....
  5. ncbi Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, St Kilda Road Central, Melbourne, Victoria, Australia
    Blood 98:681-7. 2001
    ..Together, these results suggest separate regions of GPIb-IX-V can directly bind calmodulin, and this novel interaction potentially regulates aspects of GPIb-IX-V-dependent platelet activation. (Blood. 2001;98:681-687)..
  6. ncbi Platelet adhesion receptors and (patho)physiological thrombus formation
    R K Andrews
    Hanzel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Histol Histopathol 16:969-80. 2001
    ..This review will focus on recent advances in understanding structure-activity relationships of GP Ib-IX-V, its role in initiating thrombus formation, and its emerging relationships with other vascular cell adhesion receptors...
  7. ncbi ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 10:1133-41. 2012
    ....
  8. ncbi Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
    F T Mu
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Thromb Haemost 8:324-30. 2010
    ....
  9. ncbi TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
    ....
  10. ncbi Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex
    R K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia, 3181
    Biochemistry 37:638-47. 1998
    ....
  11. ncbi The vascular biology of the glycoprotein Ib-IX-V complex
    M C Berndt
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia
    Thromb Haemost 86:178-88. 2001
    ..This review will focus on recent advances in our understanding of the structure and function of this important platelet receptor, with particular emphasis on insights made within the last two years...
  12. ncbi Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G
    E E Gardiner
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 98:1440-7. 2001
    ..Cathepsin G- or neutrophil elastase-mediated PSGL-1 proteolysis may constitute a potential autocrine mechanism for down-regulation of neutrophil adhesion to P-selectin...
  13. ncbi Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta
    J K Campbell
    Monash University, Department of Medicine, Box Hill Hospital, Nelson Road, Box Hill, Melbourne, Victoria, Australia 3128
    Biochemistry 36:15363-70. 1997
    ..Thus, 14-3-3zeta serves in human platelets to activate the 43 kDa 5-phosphatase and may thereby function to prevent generation of Ins(1,4,5)P3 -mediated calcium release in unstimulated platelets...
  14. ncbi Programmed autologous cleavage of platelet receptors
    M C Berndt
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    J Thromb Haemost 5:212-9. 2007
    ..This review discusses the underlying mechanisms for dual proteolytic pathways of receptor regulation, and the impact of these pathways on thrombus formation and stability in vivo...
  15. ncbi Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura
    E E Gardiner
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    J Thromb Haemost 6:1175-82. 2008
    ..Receptors on platelets that contain immunoreceptor tyrosine-based activation motifs (ITAMs) include collagen receptor glycoprotein (GP) VI, and FcgammaRIIa, a low affinity receptor for immunoglobulin (Ig) G...
  16. ncbi The human 11 beta-hydroxysteroid dehydrogenase type II enzyme: comparisons with other species and localization to the distal nephron
    Z Krozowski
    Laboratory of Molecular Hypertension, Baker Institute of Medical Research, Prahran, Australia
    J Steroid Biochem Mol Biol 55:457-64. 1995
    ..These results support the notion that 11 beta-HSD2 is an autocrine protector of the mineralocorticoid receptor and that it plays an important role in cardiovascular homeostatic mechanisms...
  17. ncbi Calmodulin interacts with the platelet ADP receptor P2Y1
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Biochem J 398:339-43. 2006
    ..These results suggest that the interaction of calmodulin with the P2Y1 C-terminal tail may regulate P2Y1-dependent platelet aggregation...
  18. ncbi Role of calmodulin in platelet receptor function
    Elizabeth E Gardiner
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
    Curr Med Chem Cardiovasc Hematol Agents 3:283-7. 2005
    ..Further studies should define the precise functional role of calmodulin in thrombus formation initiated by GPIb-IX-V or GPVI...
  19. ncbi Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa
    Elizabeth E Gardiner
    Department of Immunology, Monash University, Melbourne, Australia
    Blood 111:165-74. 2008
    ..Activation of both pathways was observed with immunoglobulin from patients with heparin-induced thrombocytopenia (HIT), suggesting novel mechanisms for platelet dysfunction by FcgammaRIIa after immunologic insult...
  20. ncbi Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Thromb Haemost 98:1285-90. 2007
    ....
  21. ncbi The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet target
    Robert K Andrews
    Department of Immunology, Monash University, Melbourne, Australia
    Drug News Perspect 20:285-92. 2007
    ..The unique recognition sequences and arrangement of functional 14-3-3zeta-binding sites found within the cytoplasmic domain of GPIb-IX-V increase the likelihood of selective targeting of this interaction...
  22. ncbi Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Haemost 93:716-23. 2005
    ..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation...
  23. ncbi Platelet physiology and thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Res 114:447-53. 2004
    ..This review will focus on the structure-function of primary platelet adhesion receptors, GPIb-IX-V and GPVI, and how they act together to regulate platelet thrombus formation in pathophysiology...
  24. ncbi Platelet interactions in thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    IUBMB Life 56:13-8. 2004
    ..This arrangement may underlie common mechanisms of initiating thrombus formation in haemostasis or thrombotic disease...
  25. ncbi Platelet physiology: in cold blood
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia
    Curr Biol 13:R282-4. 2003
    ..New evidence suggests that this clearance is mediated in the liver by the Mac-1 integrin on Kupffer cells recognizing clustered GPIb receptor on platelets, leading to platelet phagocytosis...
  26. ncbi Proteolytic cleavage of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is regulated by a calmodulin-binding motif
    Mae Xhum Wong
    Kronheimer Building, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia
    FEBS Lett 568:70-8. 2004
    ..Taken together, these results suggest that this highly charged cluster of amino acids in the PECAM-1 cytoplasmic domain directly interacts with CaM and this novel interaction appears to regulate cleavage of PECAM-1...
  27. ncbi Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
    ..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI...
  28. ncbi Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase
    Elizabeth E Gardiner
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, 3800
    Blood 104:3611-7. 2004
    ..This process may represent a potential mechanism to regulate GPVI-dependent platelet adhesion...
  29. ncbi Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha
    James C Whisstock
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Thromb Haemost 87:329-33. 2002
    ..This provides the basis for relating these genetic lesions to abnormal function of the receptor...
  30. ncbi Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway
    Stuart J Marshall
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 361:297-305. 2002
    ..In contrast, activation of GPIbalpha in washed platelets does not promote functional responses...
  31. ncbi Functional analysis of the C-terminal flanking sequence of platelet glycoprotein Ib alpha using canine-human chimeras
    Yang Shen
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:145-50. 2002
    ....
  32. ncbi Platelet adhesion: a game of catch and release
    Robert K Andrews
    Department of Immunology, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, Victoria, Australia
    J Clin Invest 118:3009-11. 2008
    ..Together, these studies reveal molecular mechanisms regulating GPIbalpha-vWF bond formation and platelet adhesion under shear stress...
  33. ncbi Platelet receptor redox regulation
    Jane F Arthur
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Victoria, Australia
    Platelets 19:1-8. 2008
    ....
  34. ncbi New direction for WE thrombin
    Michael C Berndt
    Arterioscler Thromb Vasc Biol 28:205-7. 2008
  35. ncbi Platelet glycoprotein VI-related clinical defects
    Jane F Arthur
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    Br J Haematol 139:363-72. 2007
    ..Clinical consequences of GPVI-related defects may be uniquely informative about the role of platelet GPVI in health and disease...
  36. ncbi Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
    ..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V...
  37. ncbi Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VI
    Robert K Andrews
    Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton 3168, Australia
    Curr Med Chem Cardiovasc Hematol Agents 1:143-9. 2003
    ..Anti-thrombotics based on snake venom GPIIb-IIIa inhibitors have been investigated clinically, however analogous proteins recognizing GPIb-IX-V or GPVI are yet to be therapeutically exploited...
  38. ncbi Snake venom probes of platelet adhesion receptors and their ligands
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic. 3168, Australia
    Toxicon 45:1051-61. 2005
    ..Whether homologous adhesion/counter-receptors on platelets and other vascular cells are also potential snake venom targets is as yet largely unexplored...
  39. ncbi Primary platelet adhesion receptors
    Jana Yip
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 57:103-8. 2005
    ....
  40. ncbi Snake venom toxins affecting platelet function
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monas University, Clayton, Victoria, Australia
    Methods Mol Biol 273:335-48. 2004
  41. ncbi Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor
    Yang Shen
    Department of Immunology and the Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
    J Biol Chem 281:26419-23. 2006
    ..Together, these data demonstrate that LRR2-4, encompassing a pronounced negative charge patch on human GPIbalpha, is essential for GPIbalpha.VWF-dependent adhesion as hydrodynamic shear increases...
  42. ncbi Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
    Tong Shi
    St. George Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Arthritis Rheum 54:2558-67. 2006
    ..CONCLUSION: Our findings show that inappropriate platelet activation by the anti-beta2GPI antibody-beta2GPI complex via the GPIbalpha receptor may contribute to the prothrombotic tendency associated with APS...
  43. ncbi Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity
    Robert K Andrews
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Australia
    Arterioscler Thromb Vasc Biol 27:1511-20. 2007
    ..In particular, a focus on proteolytic regulation of the platelet collagen receptor, glycoprotein (GP)VI, illustrates many of the key biochemical, cellular, and clinical implications of current research in this area...
  44. ncbi A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway
    Scott Dunkley
    Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Br J Haematol 137:569-77. 2007
    ..A genetic defect in GPVI/Fcgamma signalling compromising platelet function is hypothesised in this family...
  45. ncbi Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
    Jane F Arthur
    Department of Immunology, Monash University, Melbourne 3004, Australia
    J Biol Chem 282:30434-41. 2007
    ....
  46. ncbi Fractionation of snake venom metalloproteinases by metal ion affinity: a purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3008 Victoria, Australia
    Toxicon 50:1064-72. 2007
    ..The combined results support the general concept of using Ni(2+)-agarose to fractionate snake venom metalloproteinases...
  47. ncbi A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
    Fi Tjen Mu
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Blood 111:4580-7. 2008
    ..Together, these data suggest the GPIb alpha C-terminus regulates signaling through independent association of 14-3-3zeta and PI3-kinase...