K E Andersson

Summary

Publications

  1. ncbi Pharmacology of erectile function and dysfunction
    K E Andersson
    Department of Clinical Pharmacology, University of Lund, Lund, Sweden
    Urol Clin North Am 28:233-47. 2001
  2. pmc Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation
    V Werkstrom
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:1599-604. 1995
  3. ncbi Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I
    K Persson
    Department of Clinical Pharmacology, University of Lund, S 221 85 Lund, Sweden
    Am J Physiol Regul Integr Comp Physiol 279:R1112-20. 2000
  4. pmc Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I
    L Ny
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Br J Pharmacol 129:395-401. 2000
  5. pmc Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum
    P Hedlund
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:2258-66. 1995
  6. pmc Nitric oxide and relaxation of pig lower urinary tract
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 106:416-22. 1992
  7. pmc NANC neurotransmission in lamina propria of the rabbit urethra: regulation by different subsets of calcium channels
    P K Zygmunt
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 115:1020-6. 1995
  8. ncbi Actions of the new antimuscarinic compound Lu 25-109 on isolated human and pig detrusor
    K Waldeck
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Neurourol Urodyn 21:92-8. 2002
  9. ncbi Characterization of contraction-mediating prostanoid receptors in human penile erectile tissues
    H Hedlund
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    J Urol 141:182-6. 1989
  10. ncbi Detailed organization of nitric oxide synthase, vasopressin and oxytocin immunoreactive cell bodies in the supraoptic nucleus of the female rat
    A Nylen
    Department of Clinical Pharmacology, University Hospital of Lund, Sweden
    Anat Embryol (Berl) 203:309-21. 2001

Collaborators

Detail Information

Publications39

  1. ncbi Pharmacology of erectile function and dysfunction
    K E Andersson
    Department of Clinical Pharmacology, University of Lund, Lund, Sweden
    Urol Clin North Am 28:233-47. 2001
    ..Increased knowledge of the changes in penile tissues associated with erectile dysfunction may explain the pathogenetic mechanisms and help to prevent the disorder...
  2. pmc Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation
    V Werkstrom
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:1599-604. 1995
    ..The release of this mediator seems to involve the N-type VOCC, since the relaxation was markedly reduced or abolished by omega-conotoxin GVIA...
  3. ncbi Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I
    K Persson
    Department of Clinical Pharmacology, University of Lund, S 221 85 Lund, Sweden
    Am J Physiol Regul Integr Comp Physiol 279:R1112-20. 2000
    ..Loss of cGKI abolishes NO-cGMP-dependent relaxations of urethral smooth muscle and results in hyperactive voiding. These data suggest that certain voiding disturbances may be associated with impaired NO-cGKI signaling...
  4. pmc Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I
    L Ny
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Br J Pharmacol 129:395-401. 2000
    ..Relaxant agents acting via the cyclic AMP-pathway can exert their effects independently of cGKI...
  5. pmc Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum
    P Hedlund
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:2258-66. 1995
    ..The role of the investigated peptides for penile erection remains to be established.Keywords: Non-adrenergic, non-cholinergic; relaxation; immunohistochemistry, confocal microscopy, radioimmunoassay; cyclic AMP..
  6. pmc Nitric oxide and relaxation of pig lower urinary tract
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 106:416-22. 1992
    ..The importance of this pathway for lower urinary tract physiology and pathophysiology remains to be established...
  7. pmc NANC neurotransmission in lamina propria of the rabbit urethra: regulation by different subsets of calcium channels
    P K Zygmunt
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 115:1020-6. 1995
    ..With high frequences of stimulation, another mechanism, possibly calcium-independent, appears to become operational...
  8. ncbi Actions of the new antimuscarinic compound Lu 25-109 on isolated human and pig detrusor
    K Waldeck
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Neurourol Urodyn 21:92-8. 2002
    ..Even if Lu 25-109 were less potent than oxybutynin, it has an effect profile that makes it of interest to test its ability to counteract bladder overactivity in humans...
  9. ncbi Characterization of contraction-mediating prostanoid receptors in human penile erectile tissues
    H Hedlund
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    J Urol 141:182-6. 1989
    ..However, the presence of more than one contraction-mediating prostanoid receptor cannot be excluded...
  10. ncbi Detailed organization of nitric oxide synthase, vasopressin and oxytocin immunoreactive cell bodies in the supraoptic nucleus of the female rat
    A Nylen
    Department of Clinical Pharmacology, University Hospital of Lund, Sweden
    Anat Embryol (Berl) 203:309-21. 2001
    ..This is important to take into consideration when performing, and evaluating experimental investigations concerned with neurochemical changes in SON...
  11. pmc Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 107:178-84. 1992
    ..They also suggest that the site of action of L-NAME for inducing bladder hyperactivity in the rat is the outlet region rather than the detrusor muscle...
  12. ncbi Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat
    H Mizusawa
    Department of Clinical Pharmacology, University of Lund, Sweden
    J Urol 167:2276-81. 2002
    ..We studied whether YC-1 modulates erectile responses in the rat...
  13. pmc Morphological and functional in vitro and in vivo characterization of the mouse corpus cavernosum
    H Mizusawa
    Department of Clinical Pharmacology, University of Lund, Sweden
    Br J Pharmacol 132:1333-41. 2001
    ..8. It is concluded that the mouse is a suitable model for studies of erectile mechanisms in vitro and in vivo...
  14. ncbi Capsaicin-induced bladder overactivity and nociceptive behaviour in conscious rats: involvement of spinal nitric oxide
    R K Pandita
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    J Auton Nerv Syst 67:184-91. 1997
    ..The results suggest that NO is not involved in the spinal regulation of the volume- or capsaicin-induced micturition. In contrast, the nociceptive behaviour evoked by intravesical capsaicin seems to involve spinal NO...
  15. ncbi Expression of nitric oxide synthase in bladder smooth muscle cells: regulation by cytokines and L-arginine
    R K Johansson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    J Urol 168:2280-5. 2002
    ..Therefore, the expression and regulation of NOS were studied in rat bladder smooth muscle cells after stimulation with cytokines, lipopolysaccharide and L-arginine...
  16. ncbi The concept of uroselectivity
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Eur Urol 33:7-11. 1998
    ..A clinically meaningful definition of uroselectivity can only be made in man and considers desired effects on obstruction and lower urinary tract symptoms relative to adverse effects...
  17. ncbi Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography
    L O Eriksson
    Department of Clinical Pharmacology, University Hospital of Lund, Sweden
    Acta Physiol Scand 139:393-404. 1990
    ..In contrast, no specific [3H]PGE2 binding could be found on the proximal tubule, glomeruli or on blood vessels. This distribution is in accordance with the assumed site of action for the salt and water regulatory function of PGE2...
  18. ncbi Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts
    L Ny
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    J Auton Nerv Syst 65:49-56. 1997
    ..These results demonstrate the presence of HO isoenzymes in nerves and other structures of the canine and feline gastrointestinal tracts and support the view that CO may have a role as a messenger molecule in the enteric nervous system...
  19. ncbi Nocturia and associated morbidity in a community-dwelling elderly population
    A Rembratt
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    BJU Int 92:726-30. 2003
    ..To investigate the association between nocturia and selected concomitant diseases and medications in a community-dwelling elderly population...
  20. ncbi What is nocturnal polyuria?
    A Rembratt
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    BJU Int 90:18-20. 2002
  21. ncbi Differences between nocturics and non-nocturics in voiding patterns: an analysis of frequency-volume charts from community-dwelling elderly
    A Rembratt
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    BJU Int 91:45-50. 2003
    ..To evaluate differences between elderly people with and without nocturia (waking up in the night to void) in terms of voiding habits, urine production and voided volumes...
  22. ncbi Nitric oxide synthase in the hypothalamic paraventricular nucleus of the female rat; organization of spinal projections and coexistence with oxytocin or vasopressin
    A Nylen
    Department of Clinical Pharmacology, Lund University Hospital, S 221 85, Lund, Sweden
    Brain Res 908:10-24. 2001
    ..The results suggest that NO is an important messenger in the paraventriculo-spinal pathway that may in part act in concert with OT...
  23. ncbi Changes in bladder tone during filling: pharmacological aspects
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Scand J Urol Nephrol Suppl 201:67-72; discussion 76-99. 1999
    ..Whether any of these mechanisms is of importance for bladder relaxation during filling, or whether they can be targets for pharmacological therapeutic interventions, remains to be established...
  24. ncbi Penile erectile function: recommendations for future research
    K E Andersson
    Department of Clinical Pharmacology, University of Lund, Lund, Sweden
    Int J Impot Res 12:S163-7. 2000
    ..Intracavernosal somatic gene therapy is promising, and new molecular targets for drug treatments should be identified and explored. International Journal of Impotence Research (2000) 12, Suppl 4, S163-S167...
  25. ncbi Neurotransmitters: central and peripheral mechanisms
    K E Andersson
    Department of Clinical Pharmacology, University of Lund, Lund, Sweden
    Int J Impot Res 12:S26-33. 2000
    ..The role of other mediators, released from nerves or endothelium has not been definitely established. International Journal of Impotence Research (2000) 12, Suppl 4, S26-S33...
  26. ncbi The importance of the cholinergic system in neurourology
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Eur Urol 34:6-9. 1998
    ..To discuss the parasympathetic cholinergic innervation of the bladder, urethra, prostate and penile erectile tissues, and its functional importance...
  27. ncbi Pre- and postjunctional effects of some prostanoids in human isolated vas deferens
    F Holmquist
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Am J Physiol 260:R792-7. 1991
    ..In addition, the pre- and post-junctional effect profiles of U-44069 and BM 13505 suggest that there may be more than one thromboxane receptor...
  28. pmc Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor
    P M Zygmunt
    Department of Clinical Pharmacology, University of Lund, Sweden
    Br J Pharmacol 110:1285-90. 1993
    ..This raises the question whether VOCCs of a type other than L, T, and N is involved in the mediation of this response...
  29. ncbi The pharmacological treatment of nocturia
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    BJU Int 90:25-7. 2002
  30. ncbi Neurophysiology/pharmacology of erection
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Int J Impot Res 13:S8-S17. 2001
    ..Further research in this area may be rewarding...
  31. ncbi Pharmacology of penile erection
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, S 22185 Lund, Sweden
    Pharmacol Rev 53:417-50. 2001
    ..Dopamine receptors in central nervous centers participating in the initiation of erection have been targeted for the treatment of ED. Apomorphine, administered sublingually, is the first of such drugs...
  32. ncbi Antimuscarinics and the overactive detrusor--which is the main mechanism of action?
    K E Andersson
    Department of Clinical Pharmacology, Institute for Laboratory Medicine, Lund University Hospital, S 221 85 Lund, Sweden
    Eur Urol 43:1-5. 2003
    ..It is suggested that this release, which is increased by stretching the muscle and in the aging bladder, contributes to detrusor overactivity and OAB by eventually increasing bladder afferent activity during storage...
  33. ncbi Ejaculatory dysfunction: why all alpha-blockers are not equal
    K E Andersson
    Department of Clinical Pharmacology, Lund, Sweden
    BJU Int 92:876-7. 2003
  34. ncbi New directions for erectile dysfunction therapies
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, S 22185, Lund, Sweden
    Int J Impot Res 14:S82-92. 2002
    ..The final direction is prevention strategies. Strategies to prevent cavernosal degeneration and/or to restore cavernosal function will be one of the most exciting challenges for future research...
  35. ncbi Oxybutynin and the overactive bladder
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    World J Urol 19:319-23. 2001
    ..A controlled-release preparation has recently been introduced. Oxybutynin has a well-documented efficacy in the treatment of detrusor overactivity, and is a drug of first choice in patients with this disorder...
  36. ncbi Oral alpha adrenoceptor blockade as a treatment of erectile dysfunction
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    World J Urol 19:9-13. 2001
    ..It is still unclear what profile (alpha1 vs alpha2 ARs; selectivity for alpha1 and/or alpha2 AR subtypes) is the most advantageous for an alpha AR antagonist in the treatment of ED...
  37. ncbi Desmopressin in elderly patients with nocturia: short-term safety and effects on urine output, sleep and voiding patterns
    A Rembratt
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    BJU Int 91:642-6. 2003
    ..To investigate the short-term safety of desmopressin in elderly patients with nocturia, with special focus on the risk of hyponatraemia, and to assess the short-term effects on urine output, sleep and voiding patterns...
  38. pmc Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice
    P Hedlund
    Department of Clinical Pharmacology, University of Lund, S 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 97:2349-54. 2000
    ..Altogether, these data identify cGKI as the downstream target of cGMP in erectile tissue and provide evidence that cAMP signaling cannot compensate for the absence of the cGMP/cGKI signaling cascade in vivo...
  39. ncbi The basis for drug treatment of the overactive bladder
    K E Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    World J Urol 19:294-8. 2001
    ..Several CNS transmitters can modulate voiding, but few drugs with a defined CNS site of action have been demonstrated to be clinically useful. Traditionally, drugs for treatment o..