Todd J Anderson

Summary

Publications

  1. doi request reprint 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult
    Todd J Anderson
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 29:151-67. 2013
  2. doi request reprint Microvascular function predicts cardiovascular events in primary prevention: long-term results from the Firefighters and Their Endothelium (FATE) study
    Todd J Anderson
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, 1403 29th St NW, Calgary, AB, Canada
    Circulation 123:163-9. 2011
  3. doi request reprint The optimal measure of microvascular function with velocity time integral for cardiovascular risk prediction
    Vincent Lee
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Vasc Med 17:287-93. 2012
  4. ncbi request reprint Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries
    Matthew I Worthley
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary AB, Canada
    Cardiovasc Res 76:539-46. 2007
  5. ncbi request reprint The effect of iron status on vascular health
    Leanne M Yunker
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Vasc Med 11:85-91. 2006
  6. ncbi request reprint A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice
    Andrew G Howarth
    Smooth Muscle Research Group, Rm 82A, HMRB, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaT2N 4N1
    J Pharmacol Exp Ther 316:364-70. 2006
  7. doi request reprint Comparison of new measures of vascular function to flow mediated dilatation as a measure of cardiovascular risk factors
    Andrew C Philpott
    Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiol 103:1610-5. 2009
  8. doi request reprint The relationship between anthropometric indexes of adiposity and vascular function in the FATE cohort
    Billie Jean Martin
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Obesity (Silver Spring) 21:266-73. 2013
  9. pmc Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention
    Jaroslav Hubacek
    Department of Cardiovascular Sciences and Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta
    Can J Cardiol 25:e42-7. 2009
  10. ncbi request reprint Relation of Basal coronary nitric oxide activity to the burden of atherosclerosis
    Todd J Anderson
    Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiol 95:1170-4. 2005

Collaborators

Detail Information

Publications41

  1. doi request reprint 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult
    Todd J Anderson
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 29:151-67. 2013
    ..The goal is to increase the appropriate use of evidence-based cardiovascular disease event risk assessment in the management of dyslipidemia as a fundamental means of reducing global risk in the Canadian population...
  2. doi request reprint Microvascular function predicts cardiovascular events in primary prevention: long-term results from the Firefighters and Their Endothelium (FATE) study
    Todd J Anderson
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, 1403 29th St NW, Calgary, AB, Canada
    Circulation 123:163-9. 2011
    ..The purpose of the study was to determine the prognostic significance of endothelial function and other vascular markers in apparently healthy men...
  3. doi request reprint The optimal measure of microvascular function with velocity time integral for cardiovascular risk prediction
    Vincent Lee
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Vasc Med 17:287-93. 2012
    ..090 to 0.102). Age, systolic blood pressure, and BMI were predictors of the three VTI end points (p < 0.05). In conclusion, the first beat of reactive hyperaemia remains the suitable measure of microvascular function...
  4. ncbi request reprint Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries
    Matthew I Worthley
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary AB, Canada
    Cardiovasc Res 76:539-46. 2007
    ..This study was designed to evaluate the effects of intracoronary BH4 in human coronary arteries with non-critical coronary artery disease or following percutaneous coronary intervention (PCI)...
  5. ncbi request reprint The effect of iron status on vascular health
    Leanne M Yunker
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Vasc Med 11:85-91. 2006
    ..The present study does not support the hypothesis that mild to moderately increased iron stores are associated with enhanced atherosclerosis risk...
  6. ncbi request reprint A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice
    Andrew G Howarth
    Smooth Muscle Research Group, Rm 82A, HMRB, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaT2N 4N1
    J Pharmacol Exp Ther 316:364-70. 2006
    ..In contrast, nonhyperglycemic ob/ob mice exhibited normal vasodilatory responses to acetylcholine and, consequently, COOH treatment had no effect on endothelial function...
  7. doi request reprint Comparison of new measures of vascular function to flow mediated dilatation as a measure of cardiovascular risk factors
    Andrew C Philpott
    Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiol 103:1610-5. 2009
    ..This may reflect greater sensitivity of these measures to detect early abnormalities associated with risk factors in a relatively young and healthy population...
  8. doi request reprint The relationship between anthropometric indexes of adiposity and vascular function in the FATE cohort
    Billie Jean Martin
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Obesity (Silver Spring) 21:266-73. 2013
    ..However, the correlation of these indexes with measures of vascular health remain poorly defined. This study investigated which measure of adiposity is most strongly associated with endothelial function...
  9. pmc Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention
    Jaroslav Hubacek
    Department of Cardiovascular Sciences and Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta
    Can J Cardiol 25:e42-7. 2009
    ..In addition, the long-term significance of TnT rise following PCI is not clear...
  10. ncbi request reprint Relation of Basal coronary nitric oxide activity to the burden of atherosclerosis
    Todd J Anderson
    Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiol 95:1170-4. 2005
    ..This is in contradistinction to the impairment of stimulated NO activity in the coronary circulation that characterizes atherosclerosis...
  11. pmc Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery
    Anthie Ellis
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    Br J Pharmacol 140:1193-200. 2003
    ..6. Although the data from this study show that H2O2 dilates vessels, they do not support the notion that H2O2 mediates endothelium-dependent relaxations to ACh in either aorta or SMA from mice...
  12. ncbi request reprint The fate of endothelial function testing: rationale and design of the Firefighters And Their Endothelium (FATE) study
    Todd J Anderson
    Cardiovascular Division, Department of Medicine, University of Calgary, Alberta
    Can J Cardiol 19:61-6. 2003
    ..Quantitative B-mode ultrasound will be employed to assess endothelial function and subclinical atherosclerosis. This research is designed to redefine the approach to the primary prevention of atherosclerosis...
  13. ncbi request reprint Modulation of arterial reactivity using amlodipine and atorvastatin measured by ultrasound examination (MARGAUX)
    Francois Charbonneau
    Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada
    Atherosclerosis 197:420-7. 2008
    ..To evaluate the effect of the calcium channel blocker amlodipine on endothelial function in normotensive patients with coronary disease taking concomitant atorvastatin therapy...
  14. ncbi request reprint The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes
    Chris R Triggle
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada
    Mol Cell Biochem 263:21-7. 2004
    ..Here we briefly review the current status of EDHF and the link between EDHF and endothelial dysfunction associated with diabetes...
  15. ncbi request reprint Rationale and design of the Glitazones and the Endothelium (GATE) study: evaluation of rosiglitazone on endothelial function in patients with diabetes
    Jaroslav Hubacek
    University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 20:1449-53. 2004
    ....
  16. ncbi request reprint Registry data evaluating the effectiveness of drug-eluting stents for the treatment of symptomatic in-stent restenosis
    Matthew I Worthley
    Foothills Interventional Cardiology Service, Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada
    Heart Lung Circ 15:300-5. 2006
    ..The objective of this registry database was to evaluate the 'real-world' effectiveness of DES for the treatment of symptomatic bare-metal stent ISR...
  17. ncbi request reprint Prognostic implication of hyperglycemia in myocardial infarction and primary angioplasty
    Matthew I Worthley
    Foothills Interventional Cardiology Service, Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, Calgary, Alberta
    Am J Med 120:643.e1-7. 2007
    ..The study assessed the relationship of admission blood glucose level to in-hospital mortality in patients presenting with an ST-segment elevation myocardial infarction and treated with primary angioplasty...
  18. ncbi request reprint Effects of folinic acid on forearm blood flow in patients with end-stage renal disease
    Todd J Anderson
    Department of Cardiovascular Sciences, Lubin Cardiovascular Institute of Alberta, University of Calgary, Canada
    Nephrol Dial Transplant 21:1927-33. 2006
    ..While folates can improve endothelial function, their role in ESRD has not been fully studied. The objective was to determine the acute and 12 week-effect of folinic acid on endothelium-dependent vasodilation in subjects with ESRD...
  19. ncbi request reprint The relationship between peripheral arterial tonometry and classic measures of endothelial function
    Billie Jean Martin
    Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
    Vasc Med 18:13-8. 2013
    ..Further studies are required to determine if this can be used clinically as a tool for cardiac risk stratification and prediction of CAD...
  20. ncbi request reprint Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction
    Todd J Anderson
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Heart Fail Rev 8:71-86. 2003
    ..The review will focus on the role of nitric oxide in atherosclerosis and the clinical relevance of these findings...
  21. pmc Contrast echocardiography accurately predicts myocardial perfusion before angiography during acute myocardial infarction
    Gregory B Schnell
    Department of Cardiac Sciences and Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
    Can J Cardiol 23:1043-8. 2007
    ..To determine whether myocardial contrast echocardiography (MCE) can quickly and accurately assess myocardial perfusion and infarct-related artery (IRA) patency before emergency angiography during acute myocardial infarction (AMI)...
  22. ncbi request reprint Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function
    Mathew Eric Hyndman
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 282:H2167-72. 2002
    ..superoxide) production and improve endothelial function. 5-Methyltetrahydrofolate may represent an important strategy for intervention aimed at improving tetrahydrobiopterin bioavailability...
  23. ncbi request reprint Coronary flow velocity reserve does not correlate with TIMI frame count in patients undergoing non-emergency percutaneous coronary intervention
    Sanjay K Chugh
    Department of Cardiovascular Sciences, University of Calgary, Calgary, Canada
    J Am Coll Cardiol 44:778-82. 2004
    ..The purpose of this research was to compare the Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) with coronary flow velocity reserve (CFVR) in patients undergoing percutaneous coronary intervention (PCI)...
  24. pmc Risk prediction in cardiovascular disease: the prognostic significance of endothelial dysfunction
    Billie Jean Martin
    Department of Cardiac Sciences and Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta
    Can J Cardiol 25:15A-20A. 2009
    ..However, while it has demonstrated some utility in risk prediction, its use in daily clinical practice is yet to be clearly defined. The present review assesses the prognostic significance of measures of endothelial function...
  25. ncbi request reprint Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy
    Todd J Anderson
    Faculty of Medicine, University of Calgary and Calgary Health Region, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    J Am Coll Cardiol 41:420-5. 2003
    ..The purpose of this study was to evaluate the effect of chelation therapy with ethylenediamine tetraacetic acid (EDTA) on endothelium-dependent vasomotor responses in patients with documented coronary artery disease (CAD)...
  26. ncbi request reprint New markers of inflammation and endothelial cell activation: Part I
    Paul E Szmitko
    Division of Cardiology, University of Calgary, Calgary, Alberta, Canada
    Circulation 108:1917-23. 2003
  27. ncbi request reprint Effect of percutaneous coronary intervention of nonacute total coronary artery occlusions on QT dispersion
    David M Goodhart
    Department of Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Am Heart J 151:529.e1-529.e6. 2006
    ..We sought to assess the effect of percutaneous revascularization (PCI) of TCO on QTd and the relationship between QTd and long-term vessel patency...
  28. pmc Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability
    Malarvannan Pannirselvam
    Department of Pharmacology and Therapeutics and Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Br J Pharmacol 136:255-63. 2002
    ..8. These data suggest that increased production of superoxide anions and decreased availability of BH(4) result in an 'uncoupling' of nitric oxide synthase and endothelial dysfunction in SMA from db/db -/- mice...
  29. ncbi request reprint No cardioprotective benefit of ischemic postconditioning in patients with ST-segment elevation myocardial infarction
    Nathan B Dwyer
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Interv Cardiol 26:482-90. 2013
    ..Postconditioning is a potential cardioprotective strategy that has demonstrated conflicting and variable reductions in infarct size in human trials...
  30. doi request reprint Obesity is associated with impaired human coronary endothelial function
    Matthew I Worthley
    Department of Cardiac Sciences and the Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada Electronic
    Obes Res Clin Pract 3:1-52. 2009
    ..Conclusions: In a cohort of subjects with coronary artery disease, patients with a high BMI had associated impaired microvascular coronary endothelial dependent function. ..
  31. ncbi request reprint Effects of left ventricular contractility and coronary vascular resistance on coronary dynamics
    Yi Hui Sun
    Department of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 286:H1590-5. 2004
    ..I(W-) was proportional to the CSFI. We conclude that contractility and coronary resistance change CSFI by modulating the backward-going compression wave...
  32. ncbi request reprint The endothelium in health and disease--a target for therapeutic intervention
    Chris R Triggle
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada T2N 4N1
    J Smooth Muscle Res 39:249-67. 2003
    ....
  33. doi request reprint Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner
    Stephen B Wilton
    Libin Cardiovascular Institute, University of Calgary, Alberta, Canada
    Heart Rhythm 5:694-700. 2008
    ..The purpose of this study was to use a candidate gene approach to identify common polymorphisms that are associated with resting sinus heart rate in a population without overt cardiovascular disease...
  34. ncbi request reprint Differential sensitivities of cerebral and brachial blood flow to hypercapnia in humans
    Jimmy S Vantanajal
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    J Appl Physiol 102:87-93. 2007
    ..2 +/- 1%/Torr; P < 0.05). Our findings confirm that Vp has a greater sensitivity than BBF in response to hypercapnia and show an adaptive response of BBF that is not evident in Vp...
  35. ncbi request reprint Sedentary lifestyle and antecedents of cardiovascular disease in young adults
    Jonathan M McGavock
    Division of Endocrinology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Hypertens 19:701-7. 2006
    ..The aim of this study was to determine whether sedentary young individuals are characterized by reductions in determinants of vascular health and insulin sensitivity relative to their physically active, age-matched peers...
  36. ncbi request reprint Abciximab attenuates coronary microvascular endothelial dysfunction after coronary stenting
    Eve D Aymong
    Cardiovascular Division, Department of Medicine, University of Calgary, Alberta, Canada
    Circulation 105:2981-5. 2002
    ..The present study was designed to assess endothelium-dependent vasomotion after coronary stenting and to determine if abciximab alters this response...
  37. ncbi request reprint The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension
    Matthew E Hyndman
    University of Calgary Department of Medicine, Calgary, Alberta, Canada
    Hypertension 39:919-22. 2002
    ..16(95% confidence interval, 1.3 to 3.7) more likely to be hypertensive. Therefore, the -786 C/C genotype in NO synthase is a significant contributing factor for increasing the risk of essential hypertension...
  38. doi request reprint Evidence of endothelial dysfunction in patients with inflammatory bowel disease
    Idan Roifman
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Gastroenterol Hepatol 7:175-82. 2009
    ..The purpose of our study was to assess endothelial function in patients with IBD...
  39. ncbi request reprint The effect of ischemia-reperfusion injury on measures of vascular function
    Wesam Alhejily
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada
    Clin Hemorheol Microcirc 56:265-71. 2014
    ..The objective of our study was to assess the effect of ischemia-reperfusion injury on microvascular function including peripheral arterial tonometry (PAT) hyperemic index...
  40. pmc The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
    Amanda V Tyndall
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    BMC Geriatr 13:21. 2013
    ....
  41. ncbi request reprint Fundamentals of endothelial function for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, University of Calgary, Canada
    Circulation 105:546-9. 2002