Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regenerationRyan M Anderson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
Dev Biol 334:213-23. 2009
..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate...
Adenosine signaling promotes regeneration of pancreatic β cells in vivoOlov Andersson
Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology and Program in Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Cell Metab 15:885-94. 2012
..With this whole-organism screen, we identified components of the adenosine pathway that could be therapeutically targeted for the treatment of diabetes...
Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studiesSilvia Curado
Department of Biochemistry and Biophysics, Program in Developmental Biology, Liver Center, Diabetes Center and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
Nat Protoc 3:948-54. 2008
..Using this protocol, cell ablation can be achieved in 12-72 h, depending on the transgenic line used, and recovery initiates within the following 24 h...
Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labelingDaniel Hesselson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Liver Center and Diabetes Center, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 106:14896-901. 2009
..g., diabetes mellitus). Our data reveal the existence of distinct populations of beta-cells in vivo and should help develop better strategies to regulate beta-cell differentiation and proliferation...
Suppression of Ptf1a activity induces acinar-to-endocrine conversionDaniel Hesselson
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics, and Human Genetics, Institute for Regeneration Medicine, Liver Center, and Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA
Curr Biol 21:712-7. 2011
..These data indicate that targeted postembryonic disruption of the acinar cell fate can restore the developmental plasticity that is lost during development...
Conditional targeted cell ablation in zebrafish: a new tool for regeneration studiesSilvia Curado
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94158 2324, USA
Dev Dyn 236:1025-35. 2007
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