Pogrmic Majkic K, Samardzija D, Fa S, Hrubik J, Glisic B, Kaisarevic S, et al
. Atrazine enhances progesterone production through activation of multiple signaling pathways in FSH-stimulated rat granulosa cells: evidence for premature luteinization. Biol Reprod. 2014;91:124 pubmed publisher
..Overall, this study showed that ATR acts as a FSH sensitizer leading to enhanced cAMP, AKT, and CEBPB signaling and progesterone biosynthesis, which promotes premature luteinization phenotype in GC. ..
Fa S, Pogrmic Majkic K, Samardzija D, Hrubik J, Glisic B, Kovacevic R, et al
. HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells. Toxicol Appl Pharmacol. 2015;282:20-9 pubmed publisher
..In summary, our data showed that HBCDD inhibits ATP supply, most likely through a decrease in Î”Î¨m, and targets multiple sites in the steroidogenic pathway in Leydig cells. ..
Pogrmic Majkic K, Fa S, Samardzija D, Hrubik J, Kaisarevic S, Andric N. Atrazine activates multiple signaling pathways enhancing the rapid hCG-induced androgenesis in rat Leydig cells. Toxicology. 2016;368-369:37-45 pubmed publisher
..Collectively, these data suggest that exposure to ATR caused perturbations in multiple signaling pathways, thus enhancing the rapid hCG-dependent androgen biosynthesis in peripubertal Leydig cells. ..
Hrubik J, Glisic B, Fa S, Pogrmic Majkic K, Andric N. Erk-Creb pathway suppresses glutathione-S-transferase pi expression under basal and oxidative stress conditions in zebrafish embryos. Toxicol Lett. 2016;240:81-92 pubmed publisher
..This study also provides a novel link between Erk and gstp1-2 expression, setting apart a possible differential regulation of gstp1-2 in adult and embryonic cells. ..
Samardzija D, Pogrmic Majkic K, Fa S, Glisic B, Stanic B, Andric N. Atrazine blocks ovulation via suppression of Lhr and Cyp19a1 mRNA and estradiol secretion in immature gonadotropin-treated rats. Reprod Toxicol. 2016;61:10-8 pubmed publisher
..Collectively, these data indicate that under in vivo conditions, ATR may act directly on granulosa cells by decreasing E2 levels and Lhr mRNA, thus leading to inhibition of ovulation. ..
Hrubik J, Glisic B, Samardzija D, Stanic B, Pogrmic Majkic K, Fa S, et al
. Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2016;190:24-31 pubmed publisher
..These data suggest that direct over-activation of Pkc during early embryogenesis of zebrafish is associated with apoptosis and decreased survival rate of the embryos. ..
Samardzija D, Pogrmic Majkic K, Fa S, Stanic B, Jasnic J, Andric N. Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. Mol Cell Endocrinol. 2018;461:55-63 pubmed publisher
..These results indicate that exposure to BPA disrupts cholesterol homeostasis leading to decreased progesterone production in immature rat granulosa cells. ..