Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasisM Ananthanarayanan
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
Am J Physiol Gastrointest Liver Physiol 300:G771-81. 2011
..Taken together, these data show that the "H3K4me3" epigenetic mark is essential to activation of BSEP, NTCP, and MRP2 genes by nuclear receptors and is downregulated in cholestasis...
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptorM Ananthanarayanan
Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, The Mount Sinai Medical Center, New York, New York 10029, USA
J Biol Chem 276:28857-65. 2001
..These results demonstrate a mechanism by which bile acids transcriptionally regulate the activity of the bile salt excretory pump, a critical component involved in the enterohepatic circulation of bile acids...
- Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity
Frank Chen
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
Gastroenterology 126:756-64. 2004
..The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown...
- Bile salt excretory pump: biology and pathobiology
Frederick J Suchy
Laboratory of Molecular and Developmental Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
J Pediatr Gastroenterol Nutr 43:S10-6. 2006
..This defect leads to enhanced ileal bile salt uptake and impaired canalicular bile salt secretion by BSEP. In PFIC1, an increased load of bile acids is retained in the liver leading to cholestasis and progressive liver injury...
- Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
D Q Shih
Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
Nat Genet 27:375-82. 2001
..Our studies demonstrate that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism...
- Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
Frank Chen
Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:19909-16. 2003
..In summary cell line- and species-specific negative feedback regulation of ASBT by bile acids is mediated by farnesoid X receptor via small heterodimer partner-dependent repression of LRH-1 activation of the ASBT promoter...
- Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development
N Balasubramaniyan
Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
Am J Physiol Gastrointest Liver Physiol 288:G251-60. 2005
..We conclude that expression of NRs during rat liver development is primarily regulated by transcriptional mechanisms, which in turn, control the regulation of bile acid and cholesterol metabolic pathways...
- Cloning and characterization of a novel peptidase from rat and human ileum
B L Shneider
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 272:31006-15. 1997
..Future invesitgations will need to determine the exact substrate specificity of this novel peptidase...
- Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter
S J Karpen
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 271:15211-21. 1996
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