M Ananthanarayanan

Summary

Publications

  1. pmc Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis
    M Ananthanarayanan
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 300:G771-81. 2011
  2. ncbi request reprint Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    M Ananthanarayanan
    Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, The Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 276:28857-65. 2001
  3. ncbi request reprint Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity
    Frank Chen
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gastroenterology 126:756-64. 2004
  4. ncbi request reprint Bile salt excretory pump: biology and pathobiology
    Frederick J Suchy
    Laboratory of Molecular and Developmental Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Pediatr Gastroenterol Nutr 43:S10-6. 2006
  5. ncbi request reprint Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
  6. ncbi request reprint Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    Frank Chen
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:19909-16. 2003
  7. ncbi request reprint Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development
    N Balasubramaniyan
    Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 288:G251-60. 2005
  8. ncbi request reprint Cloning and characterization of a novel peptidase from rat and human ileum
    B L Shneider
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 272:31006-15. 1997
  9. ncbi request reprint Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter
    S J Karpen
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 271:15211-21. 1996

Collaborators

Detail Information

Publications9

  1. pmc Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis
    M Ananthanarayanan
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 300:G771-81. 2011
    ..Taken together, these data show that the "H3K4me3" epigenetic mark is essential to activation of BSEP, NTCP, and MRP2 genes by nuclear receptors and is downregulated in cholestasis...
  2. ncbi request reprint Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    M Ananthanarayanan
    Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, The Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 276:28857-65. 2001
    ..These results demonstrate a mechanism by which bile acids transcriptionally regulate the activity of the bile salt excretory pump, a critical component involved in the enterohepatic circulation of bile acids...
  3. ncbi request reprint Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity
    Frank Chen
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gastroenterology 126:756-64. 2004
    ..The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown...
  4. ncbi request reprint Bile salt excretory pump: biology and pathobiology
    Frederick J Suchy
    Laboratory of Molecular and Developmental Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Pediatr Gastroenterol Nutr 43:S10-6. 2006
    ..This defect leads to enhanced ileal bile salt uptake and impaired canalicular bile salt secretion by BSEP. In PFIC1, an increased load of bile acids is retained in the liver leading to cholestasis and progressive liver injury...
  5. ncbi request reprint Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
    ..Our studies demonstrate that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism...
  6. ncbi request reprint Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    Frank Chen
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:19909-16. 2003
    ..In summary cell line- and species-specific negative feedback regulation of ASBT by bile acids is mediated by farnesoid X receptor via small heterodimer partner-dependent repression of LRH-1 activation of the ASBT promoter...
  7. ncbi request reprint Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development
    N Balasubramaniyan
    Laboratory of Developmental and Molecular Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 288:G251-60. 2005
    ..We conclude that expression of NRs during rat liver development is primarily regulated by transcriptional mechanisms, which in turn, control the regulation of bile acid and cholesterol metabolic pathways...
  8. ncbi request reprint Cloning and characterization of a novel peptidase from rat and human ileum
    B L Shneider
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 272:31006-15. 1997
    ..Future invesitgations will need to determine the exact substrate specificity of this novel peptidase...
  9. ncbi request reprint Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter
    S J Karpen
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 271:15211-21. 1996
    ....