P R J Ames

Summary

Publications

  1. doi request reprint Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus
    Paul R J Ames
    Queen Mary University of London, William Harvey Research Institute, Centre for Sports and Exercise Medicine, Mile End Hospital, London, UK
    Thromb Res 130:350-4. 2012
  2. doi request reprint Atherosclerosis in thrombotic primary antiphospholipid syndrome
    P R J Ames
    Immunoclot Ltd, Leeds, UK
    J Thromb Haemost 7:537-42. 2009
  3. doi request reprint Recurrent abdominal thrombosis despite heparin thromboprophylaxis in a patient with transient eosinophilia
    P R J Ames
    Department of Haematology, Royal Preston Hospital, Lancashire, United Kingdom
    Clin Appl Thromb Hemost 17:229-31. 2011
  4. doi request reprint Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview
    Paul R J Ames
    Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom
    Clin Appl Thromb Hemost 16:628-36. 2010
  5. doi request reprint Eosinophilia and thrombosis in parasitic diseases: an overview
    Paul R J Ames
    Haematology and Rheumatology Department, Airedale General Hospital, Sutton, United Kingdom
    Clin Appl Thromb Hemost 17:33-8. 2011
  6. doi request reprint High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome
    P R J Ames
    Rheumatology and Haematology, Airedale District General Hospital, Steeton, UK
    Lupus 19:711-6. 2010
  7. ncbi request reprint Atherosclerosis in primary antiphospholipid syndrome
    Paul Rj Ames
    Immunoclot Ltd, Leeds, UK
    Expert Rev Clin Immunol 4:53-60. 2008
  8. doi request reprint Clinical relevance of nitric oxide metabolites and nitrative stress in thrombotic primary antiphospholipid syndrome
    Paul R J Ames
    Department of Rheumatology, Airedale General Hospital, Steeton, UK
    J Rheumatol 37:2523-30. 2010
  9. doi request reprint Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome
    Paul R J Ames
    Haematology and Rheumatology Departments, Airedale Hospital, Steeton, UK
    Thromb Res 127:595-9. 2011
  10. doi request reprint Antiphospholipid antibodies and atherosclerosis: insights from systemic lupus erythematosus and primary antiphospholipid syndrome
    Paul R J Ames
    Department of Haematology, Royal Preston Hospital, Preston, UK
    Clin Rev Allergy Immunol 37:29-35. 2009

Detail Information

Publications20

  1. doi request reprint Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus
    Paul R J Ames
    Queen Mary University of London, William Harvey Research Institute, Centre for Sports and Exercise Medicine, Mile End Hospital, London, UK
    Thromb Res 130:350-4. 2012
    ..The effect of ASA ingestion on platelet activation, thromboxane generation, oxidative stress and anti-oxidant biomarkers was studied in type 2 diabetes mellitus (DM)...
  2. doi request reprint Atherosclerosis in thrombotic primary antiphospholipid syndrome
    P R J Ames
    Immunoclot Ltd, Leeds, UK
    J Thromb Haemost 7:537-42. 2009
    ..The issue of early atherosclerosis, as evaluated by measuring carotid intima media thickness (IMT), associated with aPL, has been limitedly explored in PAPS...
  3. doi request reprint Recurrent abdominal thrombosis despite heparin thromboprophylaxis in a patient with transient eosinophilia
    P R J Ames
    Department of Haematology, Royal Preston Hospital, Lancashire, United Kingdom
    Clin Appl Thromb Hemost 17:229-31. 2011
    ..The role of transient eosinophilia in thrombosis is discussed in the light of other similar rare cases...
  4. doi request reprint Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview
    Paul R J Ames
    Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom
    Clin Appl Thromb Hemost 16:628-36. 2010
    ..In addition, antineutrophil cytoplasmic antibodies may shift the endothelial lining to proadhesive and prothrombotic surface. It is hoped that the review will represent a basis to foster novel research on this topic...
  5. doi request reprint Eosinophilia and thrombosis in parasitic diseases: an overview
    Paul R J Ames
    Haematology and Rheumatology Department, Airedale General Hospital, Sutton, United Kingdom
    Clin Appl Thromb Hemost 17:33-8. 2011
    ..It is hoped that this review contributes to the awareness of the link between PBE and thrombosis in parasitic disorders to foster research in this area...
  6. doi request reprint High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome
    P R J Ames
    Rheumatology and Haematology, Airedale District General Hospital, Steeton, UK
    Lupus 19:711-6. 2010
    ..HDL and ApoA-I correlated negatively with CRP (p = 0.001 and p = 0.007, respectively). IgG anti-HDL may hamper the antioxidant and anti-inflammatory effect of HDL favoring low-grade inflammation and enhanced oxidation in thrombotic PAPS...
  7. ncbi request reprint Atherosclerosis in primary antiphospholipid syndrome
    Paul Rj Ames
    Immunoclot Ltd, Leeds, UK
    Expert Rev Clin Immunol 4:53-60. 2008
    ..Their effect on the coagulation system, the vessel wall and on the antioxidant/oxidant balance impairs vascular homeostasis, leading to premature arterial thickening...
  8. doi request reprint Clinical relevance of nitric oxide metabolites and nitrative stress in thrombotic primary antiphospholipid syndrome
    Paul R J Ames
    Department of Rheumatology, Airedale General Hospital, Steeton, UK
    J Rheumatol 37:2523-30. 2010
    ..To assess the role of nitrite (NO(2)(-)), nitrate (NO(3)(-)), and nitrative stress in thrombotic primary antiphospholipid syndrome (PAPS)...
  9. doi request reprint Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome
    Paul R J Ames
    Haematology and Rheumatology Departments, Airedale Hospital, Steeton, UK
    Thromb Res 127:595-9. 2011
    ..Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR)...
  10. doi request reprint Antiphospholipid antibodies and atherosclerosis: insights from systemic lupus erythematosus and primary antiphospholipid syndrome
    Paul R J Ames
    Department of Haematology, Royal Preston Hospital, Preston, UK
    Clin Rev Allergy Immunol 37:29-35. 2009
    ..The available data is reviewed in the light of the most recent atherogenic pathways that may differentially account for premature vascular disease in SLE and primary APS...
  11. doi request reprint Primary antiphospholipid syndrome: a low-grade auto-inflammatory disease?
    P R J Ames
    Immunoclot Ltd, Leeds LS6 4QT, UK
    Rheumatology (Oxford) 47:1832-7. 2008
    ..To test the inflammation and immune activation hypothesis in primary thrombotic APS (PAPS) and to identify clinical and laboratory factors related to inflammation and immune activation...
  12. ncbi request reprint Anticardiolipin antibody titre and plasma homocysteine level independently predict intima media thickness of carotid arteries in subjects with idiopathic antiphospholipid antibodies
    P R J Ames
    Lupus Research Unit, St Thomas Hospital, London, UK
    Lupus 11:208-14. 2002
    ..Measurement of plasma HC and FNG may help define aPL subjects at higher vascular risk who may require lowering of HC and FNG by vitamin and/or pharmacologic intervention...
  13. pmc Premature atherosclerosis in primary antiphospholipid syndrome: preliminary data
    P R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 64:315-7. 2005
    ..To investigate the atherosclerosis hypothesis in primary antiphospholipid syndrome (PAPS)...
  14. ncbi request reprint Bleeding and re-thrombosis in primary antiphospholipid syndrome on oral anticoagulation: an 8-year longitudinal comparison with mitral valve replacement and inherited thrombophilia
    Paul R J Ames
    Leeds University Teaching Hospitals, Rheumatology, Leeds, UK
    Thromb Haemost 93:694-9. 2005
    ..Male sex and elevated baseline IgG aCL predicted rethrombosis in PAPS that is 13-fold more re-thrombogenic than IT...
  15. ncbi request reprint Factor XIII in primary antiphospholipid syndrome
    Paul R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
    J Rheumatol 32:1058-62. 2005
    ..To evaluate the clinical significance of factor XIII (FXIII) in primary antiphospholipid syndrome (APS)...
  16. ncbi request reprint Lymphocyte subpopulations and intima media thickness in primary antiphospholipd syndrome
    P R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
    Lupus 14:809-13. 2005
    ..009). The relation between IgG anti-beta2GPI-oxLig1 and IMT of carotid arteries with memory CD45RO + T lymphocytes suggests a role for the latter in PAPS related atherogenesis...
  17. pmc Antibodies against beta2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome
    P R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
    Clin Dev Immunol 13:1-9. 2006
    ..03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMT of B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti-beta2GPI-oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity...
  18. pmc Pleural mesothelioma and venous thrombosis: the eosinophilia link
    Paul Richard Julian Ames
    Department of Haematology, West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, IP33 2QZ, UK
    Thromb J 6:3. 2008
    ..We discuss the genesis of peripheral blood eosinophilia and thrombosis in pleural mesothelioma...
  19. doi request reprint Multi-organ failure in adult onset Still's disease: a septic disguise
    Paul R J Ames
    Departments of Haematology, Rheumatology and Intensive Care, Inverclyde Royal Hospital, Greenock, PA16 0XN, UK
    Clin Rheumatol 28:S3-6. 2009
    ....
  20. ncbi request reprint Impact of plasma homocysteine and prothrombin G20210 A on primary antiphospholipid syndrome
    P R Ames
    Lupus Research Unit, St Thomas Hospital, London, UK
    Blood Coagul Fibrinolysis 12:699-704. 2001
    ..Measurement of plasma HC in aPL subjects may identify patients at increased thrombotic risk requiring HC lowering...