Christine B Ambrosone

Summary

Publications

  1. ncbi request reprint New developments in the epidemiology of cancer prognosis: traditional and molecular predictors of treatment response and survival
    Christine B Ambrosone
    Department of Epidemiology Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:2042-6. 2006
  2. pmc Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer and Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 124:433-9. 2010
  3. doi request reprint Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
  4. pmc DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, 270 Farber Hall, University at Buffalo, Buffalo, NY 14214, USA
    Cancer Epidemiol Biomarkers Prev 18:998-1002. 2009
  5. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
  6. pmc Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:964-70. 2008
  7. pmc Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 16:6169-76. 2010
  8. ncbi request reprint Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer
    Chi Chen Hong
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1784-94. 2007
  9. pmc Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
    Susan E McCann
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 122:229-35. 2010
  10. pmc Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    BMC Cancer 10:162. 2010

Collaborators

Detail Information

Publications63

  1. ncbi request reprint New developments in the epidemiology of cancer prognosis: traditional and molecular predictors of treatment response and survival
    Christine B Ambrosone
    Department of Epidemiology Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:2042-6. 2006
  2. pmc Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer and Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 124:433-9. 2010
    ....
  3. doi request reprint Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..77, 95% CI = 1.05-2.99, P-interaction = 0.006). Our results support the hypothesis that there are joint effects of endogenous and exogenous antioxidants...
  4. pmc DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, 270 Farber Hall, University at Buffalo, Buffalo, NY 14214, USA
    Cancer Epidemiol Biomarkers Prev 18:998-1002. 2009
    ..Overall, we found no evidence that these common polymorphisms of the MTHFR and MTR genes are associated with promoter methylation of E-cadherin, p16, and RAR-beta2 genes in breast cancer...
  5. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
    ....
  6. pmc Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:964-70. 2008
    ..These findings suggest that higher iron intake may be associated with risk of clinically aggressive prostate cancer, and that endogenous antioxidant capabilities may modify these associations...
  7. pmc Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 16:6169-76. 2010
    ..In an ancillary study to a SWOG (Southwest Oncology Group) trial (S8897), we investigated functional polymorphisms in 4 genes in CP pharmacokinetic pathways in relation to hematologic toxicity and disease-free survival (DFS)...
  8. ncbi request reprint Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer
    Chi Chen Hong
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1784-94. 2007
    ....
  9. pmc Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
    Susan E McCann
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 122:229-35. 2010
    ..In summary, our results suggest that higher lignan intakes may be associated with improved survival among postmenopausal women with breast cancer...
  10. pmc Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    BMC Cancer 10:162. 2010
    ..Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed...
  11. pmc Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 32:1500-6. 2011
    ....
  12. pmc Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer
    Jie Shen
    Department of Cancer Prevention and Controls, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 33:604-12. 2012
    ..Further characterization of significant associations between microRNAs and risk alleles could facilitate the understanding of the functions of these GWAS discovered risk alleles in the genetic etiology of ovarian cancer...
  13. pmc Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Cancer Causes Control 22:965-75. 2011
    ..28, 95% CI: 1.04-1.57), as well as luminal A or B breast cancers. These findings support the hypothesis of heterogeneous etiologies of breast cancer subtypes and that aspirin and ibuprofen vary in their effects...
  14. pmc Genetic variants in microRNAs and breast cancer risk in African American and European American women
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Breast Cancer Res Treat 141:447-59. 2013
    ..Future studies are needed to validate our findings and to explore the underlying mechanisms. ..
  15. pmc Association between global DNA hypomethylation in leukocytes and risk of breast cancer
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:1889-97. 2009
    ..Global DNA hypomethylation may result in chromosomal instability and oncogene activation, and as a surrogate of systemic methylation activity, may be associated with breast cancer risk...
  16. pmc Pilot intervention outcomes of an educational program for biospecimen research participation
    Marc T Kiviniemi
    School of Public Health and Health Professions, State University of New York, Buffalo, NY, USA
    J Cancer Educ 28:52-9. 2013
    ..Accurate information and improved knowledge can reduce individual anxiety and concerns that serve as barriers to research participation...
  17. pmc Innate immunity pathways and breast cancer Risk in African American and European-American women in the Women's Circle of Health Study (WCHS)
    Zhihong Gong
    Roswell Park Cancer Institute, Buffalo, New York, USA
    PLoS ONE 8:e72619. 2013
    ..These results suggest that immune adaptations suited to ancestral environments may differentially influence breast cancer risk among EA and AA women. ..
  18. pmc Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Breast Cancer Res Treat 126:157-65. 2011
    ..Better understanding of the role of COX-2 genetic variation and interaction with NSAID use in breast carcinogenesis has potential to inform prevention strategies...
  19. pmc Supplement use during an intergroup clinical trial for breast cancer (S0221)
    Gary R Zirpoli
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 137:903-13. 2013
    ..Upon followup from the clinical trial, findings regarding supplement use and survival outcomes will better inform physician recommendations for patients on adjuvant chemotherapy...
  20. pmc Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study
    Michelle R Roberts
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Carcinogenesis 32:1223-30. 2011
    ..These results indicate that some of the variants in BER and NER genes may influence risk of postmenopausal breast cancer...
  21. pmc Intake of cruciferous vegetables modifies bladder cancer survival
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House Rm 365, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 19:1806-11. 2010
    ..Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer...
  22. pmc Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York Exposures and Breast Cancer (WEB) Study
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Cancer Causes Control 21:1503-12. 2010
    ..Results of studies of non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer have been inconsistent. Timing of exposure and analysis of individual NSAIDs should be considered...
  23. pmc Use of nonsteroidal anti-inflammatory drugs and survival following breast cancer diagnosis
    Yanli Li
    Department of Social and Preventive Medicine, State University of New York at Buffalo, 265 Farber Hall, Buffalo, NY 14214, USA
    Cancer Epidemiol Biomarkers Prev 21:239-42. 2012
    ..While there is accumulating evidence that use of nonsteroidal anti-inflammatory drugs (NSAID) decreases breast cancer risk, little is known about the impact of NSAIDs on survival after breast cancer diagnosis...
  24. pmc Case-only analyses of the associations between polymorphisms in the metastasis-modifying genes BRMS1 and SIPA1 and breast tumor characteristics, lymph node metastasis, and survival
    Michelle R Roberts
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 139:873-85. 2013
    ..Future evaluation of metastasis-modifying gene variants is necessary to better understand the biology of metastasis. ..
  25. pmc Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 15:5258-66. 2009
    ..We examined relationships between DFS and variants in NOS3, as well as NQO1, NQO2, and CBR3, among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial (S8897)...
  26. doi request reprint Mitochondrial copy number and risk of breast cancer: a pilot study
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mitochondrion 10:62-8. 2010
    ..These results suggest the mtDNA copy number could be associated with risk of breast cancer, perhaps through an oxidative stress mechanism...
  27. doi request reprint Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:15-26. 2008
    ..Because slow NAT2 genotypes are present in 50% to 60% of Caucasian populations, smoking is likely to play an important role in breast cancer etiology...
  28. pmc Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study
    Chunqiao Tian
    Gynecologic Oncology Group Statistical and Data Center, Buffalo, NY 14263, USA
    Gynecol Oncol 124:575-81. 2012
    ..This study examined associations between functional variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes in patients with epithelial ovarian/primary peritoneal cancer (EOC/PPC) following platinum and taxane-based chemotherapy...
  29. pmc OSAT: a tool for sample-to-batch allocations in genomics experiments
    Li Yan
    Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    BMC Genomics 13:689. 2012
    ..Therefore, it is necessary to develop effective and handy tool to assign collected samples across batches in an appropriate way in order to minimize the impact of batch effects...
  30. pmc Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res 14:R58. 2012
    ..We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may contribute, in part, to the differences in tumor characteristics...
  31. pmc Dietary intakes of total and specific lignans are associated with clinical breast tumor characteristics
    Susan E McCann
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 142:91-8. 2012
    ..Future investigations are warranted to explore the strong associations observed with ER(-) cancer in premenopausal women...
  32. pmc Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk
    Mary E Platek
    Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Cancer Epidemiol Biomarkers Prev 18:2453-9. 2009
    ..80; 95% CI, 1.03-3.28) compared with nondrinkers who were homozygote CC. Our findings indicate that among postmenopausal women, increased breast cancer risk with alcohol consumption may be as a result of effects on one-carbon metabolism...
  33. doi request reprint A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 29:1963-6. 2008
    ....
  34. ncbi request reprint DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
    Breast Cancer Res Treat 114:559-68. 2009
    ..51; 95% CI, 1.01-2.32). Hypermethylation of RAR-beta(2) gene was inversely associated with histological and nuclear grade of breast cancer...
  35. pmc Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY, 14263, USA
    Cancer Causes Control 25:259-65. 2014
    ..We evaluated these associations in a case-control study among African-American women in New York City and New Jersey...
  36. pmc Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221)
    Lara E Sucheston
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 130:993-1002. 2011
    ..If replicated, women with these genotypes should be closely monitored for toxicities and could be targeted for preventive measures or alternative therapeutic approaches...
  37. doi request reprint Associations between vitamin D deficiency and risk of aggressive breast cancer in African-American women
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States
    J Steroid Biochem Mol Biol 136:337-41. 2013
    ..The relationship of vitamin D with breast cancer risk may be subtype-specific, with emerging evidence of stronger effects of vitamin D for more aggressive breast cancer, particularly in women of African ancestry...
  38. doi request reprint Novel genetic variants in microRNA genes and familial breast cancer
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 124:1178-82. 2009
    ..Our findings suggest that functional genetic variants in miRNA genes can potentially alter the regulation of key breast cancer genes. Whether they confer genetic susceptibility to breast cancer remains to be determined...
  39. pmc Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers
    Chi Chen Hong
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 139:477-88. 2013
    ..19, 95 % CI 0.07-0.56). These findings indicate that immune function is associated with ER(-) and TNBC and may be most relevant among younger women, who are likely to be diagnosed with these aggressive phenotypes...
  40. pmc Community-based partnership to identify keys to biospecimen research participation
    Deborah O Erwin
    Roswell Park Cancer Institute, Cancer Prevention and Population Sciences, Buffalo, NY, USA
    J Cancer Educ 28:43-51. 2013
    ..Research participation and biospecimen donation may be influenced by who is sponsoring a study. Monetary incentives for study participation may be more important for African American than White participants...
  41. doi request reprint Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:938-44. 2008
    ..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...
  42. ncbi request reprint Establishing a cancer center data bank and biorepository for multidisciplinary research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1575-7. 2006
    ..In this report, we present an approach to developing a Data Bank and Biorepository at our own institution, with discussion of elements to be considered when establishing such a bank...
  43. pmc IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data
    Dan Wang
    Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Bioinformatics 28:729-30. 2012
    ..The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions...
  44. doi request reprint Molecular epidemiology to better predict lung cancer risk
    Mary E Reid
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Lung Cancer 9:149-53. 2008
    ..It is likely that, by incorporating biomarkers of susceptibility, exposure, and effect, molecular epidemiologic approaches might better define factors that explain some of the variability in lung cancer risk...
  45. doi request reprint A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation
    Theresa Hahn
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Blood Marrow Transplant 16:801-8. 2010
    ..034) and mucositis (74% versus 55%, P = .006). GSTM1 and/or GSTT1 deletion polymorphisms were not associated with toxicity after allogeneic BMT. Future studies may allow for individualized genetic risk stratification...
  46. pmc Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control study
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Causes Control 22:1121-31. 2011
    ..Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer risk is unknown...
  47. ncbi request reprint Genetic predictors of long-term toxicities after radiation therapy for breast cancer
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 122:1333-9. 2008
    ..The application of genomics to outcomes following radiation therapy holds the promise of radiation dose adjustment to improve both cosmetic outcomes and quality of life for breast cancer patients...
  48. pmc Length heteroplasmies in human mitochondrial DNA control regions and breast cancer risk
    Hua Zhao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute Buffalo, NY 14263, USA
    Int J Mol Epidemiol Genet 1:184-92. 2010
    ..These results suggest that the length heteroplasmy in the HV regions of mtDNA could be associated with a risk of breast cancer, perhaps through affecting the copy number of mtDNA...
  49. pmc The promise and limitations of genome-wide association studies to elucidate the causes of breast cancer
    Christine B Ambrosone
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res 9:114. 2007
    ....
  50. doi request reprint Breast cancer racial disparities: unanswered questions
    Foluso O Ademuyiwa
    Department of Medicine, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 71:640-4. 2011
    ..In addition, we make research recommendations by discussing some of the remaining gaps in knowledge that may lead to further understanding of disparities and consequently improved outcomes for all women with breast cancer...
  51. ncbi request reprint Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1115-20. 2007
    ....
  52. ncbi request reprint Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
    Christine B Ambrosone
    Division of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Arch Biochem Biophys 464:169-75. 2007
    ..2, 95% CI=1.1-109.2) but not tobacco usage. These data indicate that women are exposed to several classes of dietary and environmental carcinogens and that metabolic genotype can be a susceptibility factor...
  53. ncbi request reprint Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer
    Jun Yang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1247-53. 2007
    ....
  54. ncbi request reprint Sample collection, processing, and storage for large-scale studies: biorepositories to support cancer research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1574. 2006
  55. ncbi request reprint Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia
    Joli R Weiss
    Department of Epidemiology and Cancer Prevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1038-41. 2007
    ..Based on these data, genotypes derived from archived AML bone marrow samples were not likely to differ from those from genomic DNA, and archived bone marrow samples may be useful for the conduct of retrospective pharmacogenetic studies...
  56. ncbi request reprint Breast cancer in African-American women: differences in tumor biology from European-American women
    Kandace Amend
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 66:8327-30. 2006
    ..An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology...
  57. ncbi request reprint SNPs, haplotypes, and cancer: applications in molecular epidemiology
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, School of Medicine, Abramson Cancer Center, University of Pennsylvania, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 13:681-7. 2004
  58. ncbi request reprint Gene-nutrient interactions in cancer etiology
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Elm Street, Buffalo, NY 14263, USA
    Nutr Rev 62:427-38. 2004
    ..The role of consumption of fruits and vegetables, as well as the role of genetic variants in oxidative stress genes, in the risk of breast cancer are also discussed...
  59. ncbi request reprint Common genetic polymorphisms in the 5'-flanking region of the SULT1A1 gene: haplotypes and their association with platelet enzymatic activity
    Baitang Ning
    Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arizona, USA
    Pharmacogenet Genomics 15:465-73. 2005
    ..These studies indicate that variation in the promoter region of the SULT1A1 gene exerts a significant influence on enzymatic activity...
  60. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  61. ncbi request reprint Associations between catalase phenotype and genotype: modification by epidemiologic factors
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1217-22. 2006
    ..Associations between genotype and phenotype were modified by dietary factors, illustrating the biochemical complexity of studies of genetic polymorphisms and disease risk...
  62. ncbi request reprint Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians
    Susan Nowell
    University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, Arkansas, USA
    Cancer Epidemiol Biomarkers Prev 13:270-6. 2004
    ..These results indicate that variations in SULT1A1 activity contributes to prostate cancer risk and the magnitude of the association may differ by ethnicity and be modified by meat consumption...
  63. ncbi request reprint Re: Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium
    Christine B Ambrosone
    J Natl Cancer Inst 99:487; author reply 488-9. 2007