Meric A Altinoz
Elmaci I, Ozpinar A, Ozpinar A, Perez J, Altinoz M. From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM. Metab Brain Dis. 2019;: pubmed publisher
Altinoz M, Ozpinar A. PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism. Int Immunopharmacol. 2019;69:245-256 pubmed publisher
..In this review, we shed light on the potential theraputic role of EA in MS and AD by blocking neural cell death, mitigating neuroinflammation and/or inducing myelination. ..
Elmaci I, Ozpinar A, Bilir A, Altinoz M. Medroxyprogesterone effects on colony growth, autophagy and mitochondria of C6 glioma cells are augmented with tibolone and temozolomide: Cell kinetic and electron microscopical studies with a broad review of the literature. Clin Neurol Neurosurg. 2019;177:77-85 pubmed publisher
..MPA and tibolone shall be studied in further experimental models of glioblastoma in vitro and in vivo. ..
Altinoz M, Bilir A, Elmaci I. Erucic acid, a component of Lorenzo's oil and PPAR-? ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis. Chem Biol Interact. 2018;294:107-117 pubmed publisher
..Combining systemic EA with intrathecal DOX-chemotherapy via Ommaya reservoirs may reduce DOX concentrations in systemic circulation, hinder toxic interactions with EA and induce selective kill of glioma cells. ..
Altinoz M, Nalbantoglu J, Ozpinar A, Emin Ozcan M, Del Maestro R, Elmaci I. From epidemiology and neurodevelopment to antineoplasticity. Medroxyprogesterone reduces human glial tumor growth in vitro and C6 glioma in rat brain in vivo. Clin Neurol Neurosurg. 2018;173:20-30 pubmed publisher
..Lastly, MPA suppressed growth of C6 glioma implanted into rat brain. Progesterone analogues deserve to be studied in future experimental models of high grade glial brain tumors. ..
Elmaci I, Altinoz M. Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma. Crit Rev Oncol Hematol. 2018;128:96-109 pubmed publisher
Altinoz M, Elmaci I, Cengiz S, Emekli Alturfan E, Ozpinar A. From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid. Chem Biol Interact. 2018;291:29-39 pubmed publisher
..Lastly, doxorubicin-induced cardiac myofibrillary and endothelial damage and hyalinization necrosis were attenuated with GA treatment. GA highly merits to be studied in further animal models as an anticancer and chemoprotective drug. ..
Altinoz M, Bilir A, Del Maestro R, Tuna S, Ozcan E, Gedikoglu G. Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro. Surg Neurol. 2006;65:478-84; discussion 485 pubmed
..Both D and N suppressed this increase via myelinosis and autophagy. Noscapine and D should be further tested in animal models because of their potential and already-present clinical applicability. ..
Altinoz M, TunalÄ± N. Trinucleotide repeat expansions in human breast cancer-susceptibility genes: relevant targets for aspirin chemoprevention?. Clin Transl Oncol. 2016;18:9-17 pubmed publisher
..We hypothesize that aspirin reduction of trinucleotide repeat expansions in breast cancer-susceptibility genes may be one of the relevant mechanisms of its chemopreventive effects. ..