Meric A Altinoz



  1. Elmaci I, Ozpinar A, Ozpinar A, Perez J, Altinoz M. From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM. Metab Brain Dis. 2019;: pubmed publisher
  2. Altinoz M, Ozpinar A. PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism. Int Immunopharmacol. 2019;69:245-256 pubmed publisher
    ..In this review, we shed light on the potential theraputic role of EA in MS and AD by blocking neural cell death, mitigating neuroinflammation and/or inducing myelination. ..
  3. Elmaci I, Ozpinar A, Bilir A, Altinoz M. Medroxyprogesterone effects on colony growth, autophagy and mitochondria of C6 glioma cells are augmented with tibolone and temozolomide: Cell kinetic and electron microscopical studies with a broad review of the literature. Clin Neurol Neurosurg. 2019;177:77-85 pubmed publisher
    ..MPA and tibolone shall be studied in further experimental models of glioblastoma in vitro and in vivo. ..
  4. Altinoz M, Bilir A, Elmaci I. Erucic acid, a component of Lorenzo's oil and PPAR-? ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis. Chem Biol Interact. 2018;294:107-117 pubmed publisher
    ..Combining systemic EA with intrathecal DOX-chemotherapy via Ommaya reservoirs may reduce DOX concentrations in systemic circulation, hinder toxic interactions with EA and induce selective kill of glioma cells. ..
  5. Altinoz M, Nalbantoglu J, Ozpinar A, Emin Ozcan M, Del Maestro R, Elmaci I. From epidemiology and neurodevelopment to antineoplasticity. Medroxyprogesterone reduces human glial tumor growth in vitro and C6 glioma in rat brain in vivo. Clin Neurol Neurosurg. 2018;173:20-30 pubmed publisher
    ..Lastly, MPA suppressed growth of C6 glioma implanted into rat brain. Progesterone analogues deserve to be studied in future experimental models of high grade glial brain tumors. ..
  6. Elmaci I, Altinoz M. Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma. Crit Rev Oncol Hematol. 2018;128:96-109 pubmed publisher
  7. Altinoz M, Elmaci I, Cengiz S, Emekli Alturfan E, Ozpinar A. From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid. Chem Biol Interact. 2018;291:29-39 pubmed publisher
    ..Lastly, doxorubicin-induced cardiac myofibrillary and endothelial damage and hyalinization necrosis were attenuated with GA treatment. GA highly merits to be studied in further animal models as an anticancer and chemoprotective drug. ..
  8. request reprint
    Altinoz M, Bilir A, Del Maestro R, Tuna S, Ozcan E, Gedikoglu G. Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro. Surg Neurol. 2006;65:478-84; discussion 485 pubmed
    ..Both D and N suppressed this increase via myelinosis and autophagy. Noscapine and D should be further tested in animal models because of their potential and already-present clinical applicability. ..
  9. Altinoz M, Tunalı N. Trinucleotide repeat expansions in human breast cancer-susceptibility genes: relevant targets for aspirin chemoprevention?. Clin Transl Oncol. 2016;18:9-17 pubmed publisher
    ..We hypothesize that aspirin reduction of trinucleotide repeat expansions in breast cancer-susceptibility genes may be one of the relevant mechanisms of its chemopreventive effects. ..

More Information


  1. request reprint
    Altinoz M, Ozdilli K, Carin M, Gedikoglu G. Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. Med Hypotheses. 2007;68:1342-7 pubmed
  2. Altinoz M, Ozpinar A, Elmaci I. Reproductive epidemiology of glial tumors may reveal novel treatments: high-dose progestins or progesterone antagonists as endocrino-immune modifiers against glioma. Neurosurg Rev. 2018;: pubmed publisher
    ..We propose that progestins strongly deserve to be investigated in experimental models of glioblastoma alone and in combination with immunostimulating agents. ..
  3. Altinoz M, Guloksuz S, Elmaci I. Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected potential. Clin Transl Oncol. 2017;19:785-792 pubmed publisher
    ..If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic. ..
  4. Elmaci I, Altinoz M. Thymoquinone: An edible redox-active quinone for the pharmacotherapy of neurodegenerative conditions and glial brain tumors. A short review. Biomed Pharmacother. 2016;83:635-640 pubmed publisher
    ..A simple and easily available agent may be a promising adjunctive treatment option in neurological and neurosurgical practice. ..
  5. Elmaci I, Altinoz M. A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme. Biochem Genet. 2016;54:573-618 pubmed publisher
    ..Recent studies revealed anti-invasive potential of L in GBM cell lines. Here, we propose that a triple-agent regime including drugs already in clinical usage may provide a metabolic adjuvant therapy for PC and GBM. ..
  6. Altinoz M, Ozcan E, Ince B, Guloksuz S. Hemoglobins as new players in multiple sclerosis: metabolic and immune aspects. Metab Brain Dis. 2016;31:983-92 pubmed publisher
    ..Alternatively, such genetic variants may perturb the metabolism of anti-inflammatory hemorphins produced via cleavage of Hbs. ..
  7. Altinoz M, Elmaci I. Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones. Nitric Oxide. 2018;79:68-83 pubmed publisher
    ..We assume that nitromemantines may be more beneficial concomitant with chemo-radiotherapy while nitrones alone may act useful in suppressing basal tumor growth and angiogenesis. ..
  8. Elmaci I, Altınöz M, Sav A, Bölükbaşı F, Onoz M, Baskan O, et al. Whorling-sclerosing meningioma. A review on the histological features of a rare tumor including an illustrative case. Clin Neurol Neurosurg. 2017;162:85-90 pubmed publisher
    ..This rare meningioma variant should be kept in mind among differential diagnoses to avoid overtreatment that might endanger patients' outcome. ..
  9. Altinoz M, Ince B. Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects. Int J Dev Neurosci. 2017;61:73-85 pubmed publisher
    ..We ascribe a protective role to HbA2 and a maladaptive detrimental role to HbF in psychopathology. We believe that future studies on hemoglobins may pave to discover novel pathogenesis mechanisms in mental disorders. ..
  10. Elmaci Ä, Altinoz M. Recrudescence of herpes virus infections following resection of schwannomas. An antiviral role of merlin?. Med Hypotheses. 2017;102:128-129 pubmed publisher
    ..Understanding the viral etiology - molecular merlin interactions in schwannoma tissues may also help to develop strategies against delayed fascial palsy seen following schwannoma resection. ..