Ali A Alshatwi

Summary

Publications

  1. pmc Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes
    Ali A Alshatwi
    Molecular Cancer Biology Research Laboratory MCBRL, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, P O Box 2460, Riyadh 11451, Saudi Arabia
    Evid Based Complement Alternat Med 2012:103026. 2012
  2. pmc Predicting the possibility of two newly isolated phenetheren ring containing compounds from Aristolochia manshuriensis as CDK2 inhibitors
    Ali Abdullah Alshatwi
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia
    Bioinformation 7:334-8. 2011
  3. ncbi request reprint Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change
    Ali Abdullah Alshatwi
    Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia E mail
    Asian Pac J Cancer Prev 14:5783-8. 2013
  4. ncbi request reprint Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area
    Tarique Noorul Hasan
    Molecular Cancer Biology Research Lab MCBRL, Depatment of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia E mail
    Asian Pac J Cancer Prev 14:5671-4. 2013
  5. pmc Identification of functional SNPs in BARD1 gene and in silico analysis of damaging SNPs: based on data procured from dbSNP database
    Ali A Alshatwi
    Molecular Cancer Biology Research Laboratory, Department of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 7:e43939. 2012
  6. doi request reprint A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab MCBRL, Depatment of Food Science and Nutrition, King Saud University, 11451 Riyadh, Saudi Arabia
    Fundam Clin Pharmacol 26:438-43. 2012
  7. pmc Differential expression profile and genetic variants of microRNAs sequences in breast cancer patients
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab MCBRL, Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 7:e30049. 2012
  8. ncbi request reprint Single nucleotide polymorphisms in the p21 and bcl2 cancer susceptibility genes and breast cancer risk in Saudi Arabia
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia
    Asian Pac J Cancer Prev 12:2607-10. 2011
  9. ncbi request reprint Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 12:1555-9. 2011
  10. pmc Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Dept, of Food Science and Nutrition, College of Agriculture and Food Sciences, King Saud University, Saudi Arabia
    J Exp Clin Cancer Res 29:167. 2010

Collaborators

  • E Ramesh
  • Anjana Munshi
  • Anees A Ansari
  • Tarique N Hasan
  • Gowhar Shafi
  • Jegan Athinarayanan
  • Abdullah H Al-Assaf
  • Mohammed A Alsaif
  • Naveed A Syed
  • Amal A Al-Hazzani
  • Vaiyapuri Subbarayan Periasamy
  • Vaiyapuri S Periasamy
  • Tarique Noorul Hasan
  • Abdulaziz A Alsaif
  • Naveed Ahmed Syed
  • Pandurangan Subash-Babu
  • Kholoud K Khoja
  • Abdulrahman A Al-Warthan
  • Abdulaziz Abdullah Alsaif
  • Mohammed Abdullah Alsaif
  • Ali M Alqahtani
  • Kai Y Lei
  • Muhammad A Alfawaz
  • Gowhar Shaf
  • Leena Grace B
  • Abdrohman S Al-Khalifa

Detail Information

Publications29

  1. pmc Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes
    Ali A Alshatwi
    Molecular Cancer Biology Research Laboratory MCBRL, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, P O Box 2460, Riyadh 11451, Saudi Arabia
    Evid Based Complement Alternat Med 2012:103026. 2012
    ..Our data suggest the presence of bioactive compound(s) in walnut green husks that are capable of killing prostate carcinoma cells by inducing apoptosis and that the husks are a candidate source of anticancer drugs...
  2. pmc Predicting the possibility of two newly isolated phenetheren ring containing compounds from Aristolochia manshuriensis as CDK2 inhibitors
    Ali Abdullah Alshatwi
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia
    Bioinformation 7:334-8. 2011
    ..ABBREVIATIONS: CDK2 - cyclin-dependent kinase 2, OLO - Olomoucine, NW1 - Cyclohexylmethyloxy-5-Nitroso-Pyrimidine- 2, 4-Diamine, CMG - 6-O-Cyclohexylmethyl Guanine...
  3. ncbi request reprint Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change
    Ali Abdullah Alshatwi
    Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia E mail
    Asian Pac J Cancer Prev 14:5783-8. 2013
    ..In summary, these data demonstrate that at least 90% of FME induced apoptosis in breast cell is mediated by Fas receptor-independently of either FADD, Caspase 8 or 3, as well as p53 interdependently. ..
  4. ncbi request reprint Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area
    Tarique Noorul Hasan
    Molecular Cancer Biology Research Lab MCBRL, Depatment of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia E mail
    Asian Pac J Cancer Prev 14:5671-4. 2013
    ..The differences could be due to exposure to particular environmental carcinogens; different lifestyle, reproductive pattern; dietary or cultural practices of Saudi Arabian women that need further investigations. ..
  5. pmc Identification of functional SNPs in BARD1 gene and in silico analysis of damaging SNPs: based on data procured from dbSNP database
    Ali A Alshatwi
    Molecular Cancer Biology Research Laboratory, Department of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 7:e43939. 2012
    ..To the best of our knowledge, until now there has been no such study on record for the BARD1 gene. Therefore, this study was undertaken to find the functional nsSNPs in BARD1...
  6. doi request reprint A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab MCBRL, Depatment of Food Science and Nutrition, King Saud University, 11451 Riyadh, Saudi Arabia
    Fundam Clin Pharmacol 26:438-43. 2012
    ..71, 95% CI = 3.49-17.54). These findings suggest that polymorphisms of MDM2 and TP53 genes may be a genetic modifier for developing breast cancer in this ethnic population in the Arab world...
  7. pmc Differential expression profile and genetic variants of microRNAs sequences in breast cancer patients
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab MCBRL, Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 7:e30049. 2012
    ..In summary, the study demonstrates that peripheral blood miRNAs and their expression and genotypic profiles can be developed as biomarkers for early diagnosis and prognosis of breast cancer...
  8. ncbi request reprint Single nucleotide polymorphisms in the p21 and bcl2 cancer susceptibility genes and breast cancer risk in Saudi Arabia
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia
    Asian Pac J Cancer Prev 12:2607-10. 2011
    ..68) in patients than in healthy women. AA vs. AG+GG genotype [OR=3.56 (1.24-10.68); P=0.008] was the dominant genotype. It is likely that these genes conferring measurably increased risks of breast cancer in our study population...
  9. ncbi request reprint Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 12:1555-9. 2011
    ..This study provides experimental data that are relevant to the possible future clinical use of LE to treat breast cancer...
  10. pmc Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Dept, of Food Science and Nutrition, College of Agriculture and Food Sciences, King Saud University, Saudi Arabia
    J Exp Clin Cancer Res 29:167. 2010
    ..In summary, the induction of apoptosis by CH is affected by its ability to increase the expression of pro-apoptotic genes such as caspase-3, -8, and -9 and TP53...
  11. doi request reprint Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR)single nucleotide polymorphisms
    Ali A Alshatwi
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, King Saud University, Saudi Arabia
    Food Chem Toxicol 48:1881-5. 2010
    ..34-3.51), and 2.51 (1.37-4.60) for subjects who hadCC,CT, andTTgenotypes (Pfor interaction, 0.05). Results of this study suggest that theMTHFR C677T polymorphism may modify the association between dietary intake and breast cancer risk...
  12. ncbi request reprint Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis
    Tarique N Hasan
    Molecular Cancer Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia
    Nat Prod Commun 8:213-6. 2013
    ..Thus, NS was concluded to induce apoptosis in SiHa cell through both p53 and caspases activation. NS could potentially be an alternative source of medicine for cervical cancer therapy...
  13. ncbi request reprint Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway
    Kholoud K Khoja
    Dept of Food Sciences and Nutrition, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 12:3299-304. 2011
    ..In summary, the induction of apoptosis by FCE is effected by its ability to increase the expression of pro-apoptotic genes and the spice holds promise for consideration in complementary therapy for breast cancer patients...
  14. doi request reprint Aluminium oxide nanoparticles induce mitochondrial-mediated oxidative stress and alter the expression of antioxidant enzymes in human mesenchymal stem cells
    Ali A Alshatwi
    Nanobiotechnology and Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, Riyadh, Saudi Arabia
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 30:1-10. 2013
    ..The results of this study clearly demonstrate the nanotoxicological effects of ANPs on hMSCs, which will be useful for nanotoxicological indexing...
  15. doi request reprint Black and green tea improves lipid profile and lipid peroxidation parameters in Wistar rats fed a high-cholesterol diet
    Ali A Alshatwi
    Department of Food and Nutrition Science, College of Food and Agricultural Sciences, King Saud University, P O Box 2460, Riyadh 11451, Saudi Arabia
    J Physiol Biochem 67:95-104. 2011
    ..These results suggest that supplementation of BT and GT may protect against the serum and hepatic abnormalities in hypercholesterolemic rats...
  16. ncbi request reprint Association of multiple drug resistance-1 gene polymorphism with multiple drug resistance in breast cancer patients from an ethnic Saudi Arabian population
    Abdulaziz A Alsaif
    Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Cancer Epidemiol 37:762-6. 2013
    ..001). These findings demonstrate, for the first time, that the polymorphisms in (exon 12) 1236 codon of the MDR1 gene greatly influence the drug response in patients from the Arab population of Saudi Arabia...
  17. doi request reprint Tea polyphenols modulate antioxidant redox system on cisplatin-induced reactive oxygen species generation in a human breast cancer cell
    Vaiyapuri S Periasamy
    Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Basic Clin Pharmacol Toxicol 112:374-84. 2013
    ..This suggests that TPP plus CP may be used as an efficient antioxidant-based combination therapy for estrogen receptor (ER)-positive and p53-positive breast cancer...
  18. doi request reprint Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells
    Amal A Al-Hazzani
    Dept of Botany and Microbiology, King Saud University, Saudi Arabia
    Food Chem Toxicol 49:3281-6. 2011
    ..Further study may increase our understanding of the mechanism by which CH has an effect on cervical cancer therapy...
  19. doi request reprint Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells
    E Ramesh
    Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 51:97-105. 2013
    ..These results suggest that the induction of apoptosis by naringin is through both death-receptor and mitochondrial pathways. Taken together, our results suggest that naringin might be an effective agent to treat human cervical cancer...
  20. ncbi request reprint The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways
    Ali A Alshatwi
    Department of Food Science and Nutrition, King Saud University, Riyadh, 11451, Saudi Arabia
    Fundam Clin Pharmacol 27:581-92. 2013
    ..Altogether, these data sustain our contention that hesperetin has anticancer properties and merits further investigation as a potential therapeutic agent...
  21. doi request reprint Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3
    Abdullah H Al-Assaf
    Molecular Cancer Biology Research Lab MCBRL, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia
    Environ Toxicol Pharmacol 36:1033-9. 2013
    ..Moreover, based upon our findings, the role of Fas in Cd induced apoptosis is also undeniable. Hence further investigations are required to understand the different mechanism involved into apoptosis of lymphocytes due to Cd exposure...
  22. ncbi request reprint Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. (RBJR) on MDA-MB-231 human breast cancer cells: role of Bcl-2/Bax, caspases and Tp53
    Tarique N Hasan
    R and D Center, Dept of Biotechnology, Bharathiar University, Coimbatore, India
    Asian Pac J Cancer Prev 12:525-30. 2011
    ..In summary, our data suggest the presence of bioactive compound(s) in WNRB capable of killing breast carcinoma cells through induction of apoptosis, and therefore a candidate source of anticancer drugs...
  23. ncbi request reprint In-vitro cyto-toxicity, geno-toxicity, and bio-imaging evaluation of one-pot synthesized luminescent functionalized mesoporous SiO2@Eu(OH)3 core-shell microspheres
    Anees A Ansari
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Saudi Arabia Electronic address
    Nanomedicine 9:1328-35. 2013
    ....
  24. doi request reprint CYP1A and POR gene mediated mitochondrial membrane damage induced by carbon nanoparticle in human mesenchymal stem cells
    Ali A Alshatwi
    Nanobiotechnology and Molecular Biology Research Lab, Dept of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia
    Environ Toxicol Pharmacol 36:215-22. 2013
    ..In conclusion, routine and high exposure of CNPs to hMSCs increased oxidative stress and mitochondrial membrane damage...
  25. doi request reprint Al₂O₃ nanoparticles induce mitochondria-mediated cell death and upregulate the expression of signaling genes in human mesenchymal stem cells
    Ali A Alshatwi
    Nanobiotechnology and Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia
    J Biochem Mol Toxicol 26:469-76. 2012
    ..Although they provide great advantages in food and agricultural products, the chronic and acute toxicity of ANPs still needs to be assessed carefully...
  26. ncbi request reprint Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells
    Jegan Athinarayanan
    Nanobiotechnology and Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P O Box 2460, Riyadh, 11451, Kingdom of Saudi Arabia
    Cell Biol Toxicol 30:89-100. 2014
    ..Treatment with a high concentration of E551 caused significant cytotoxic effects on WI-38 cells. These findings have implications for the use of these nanoparticles in the food industry. ..
  27. ncbi request reprint Biogenic silica-metal phosphate (metal = Ca, Fe or Zn) nanocomposites: fabrication from rice husk and their biomedical applications
    Jegan Athinarayanan
    Department of Food Science and Nutrition, Nanobiotechnology and Molecular Biology Research Lab, College of Food Sciences and Agriculture, King Saud University, P O Box 2460, Riyadh, 11451, Saudi Arabia
    J Mater Sci Mater Med 25:1637-44. 2014
    ..Our results revealed that these nanocomposites can be used in bone tissue engineering. ..
  28. doi request reprint Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis
    Pandurangan Subash-Babu
    Molecular Biology Research Lab, Department of Food and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 26:291-300. 2012
    ..AE significantly inhibited hMSCs proliferation and preadipocyte differentiation within the first 2 days of treatment, indicating that the antiadipogenic effect...
  29. doi request reprint Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats
    Ali A Alshatwi
    Department of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia
    Nutr Res 30:66-73. 2010
    ..Thus, TP appeared to be more protective because of its additional ability to prevent the H(2)O(2)-induced rise in serum MDA and seemed to lower liver triglycerides more than LB treatment...