A Alpar

Summary

Publications

  1. ncbi request reprint Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    Neuroreport 18:1247-50. 2007
  2. doi request reprint Deprivation-induced dendritic shrinkage might be oppositely affected by the expression of wild-type and mutated human amyloid precursor protein
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    J Neurosci Res 87:1813-22. 2009
  3. ncbi request reprint Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450, Budapest, Hungary
    Brain Res 1120:13-22. 2006
  4. ncbi request reprint Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    Brain Res 1099:189-98. 2006
  5. doi request reprint Constitutively enhanced p21Ras activity amplifies dendritic remodeling of hippocampal neurons during physical activity
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Int J Dev Neurosci 27:407-11. 2009
  6. doi request reprint Activity-induced dendrite and dendritic spine development in human amyloid precursor protein transgenic mice
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Int J Dev Neurosci 29:107-14. 2011
  7. ncbi request reprint Constitutive expression of p21H-ras(Val12) in pyramidal neurons results in reorganization of mouse neocortical afferents
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurobiol 60:263-74. 2004
  8. ncbi request reprint Adaptive morphological changes of neocortical interneurons in response to enlarged and more complex pyramidal cells in p21H-Ras(Val12) transgenic mice
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Brain Res Bull 62:335-43. 2004
  9. ncbi request reprint Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institut for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 467:119-33. 2003
  10. doi request reprint Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice
    A Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Eur J Neurosci 27:3083-94. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    Neuroreport 18:1247-50. 2007
    ..9 mice but decreased in Tg2576 mice. Furthermore, perisomatic inhibition of pyramidal neurons was found to be reduced in Tg2576 mice. Findings suggest different effects of wild-type and mutant hAPP on neuronal connectivity...
  2. doi request reprint Deprivation-induced dendritic shrinkage might be oppositely affected by the expression of wild-type and mutated human amyloid precursor protein
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    J Neurosci Res 87:1813-22. 2009
    ..Degradation of apical arbors was especially pronounced. Results demonstrate for the first time opposite effects of the expression of wild-type and mutated human APP on deprivation-induced dendritic restructuring in vivo...
  3. ncbi request reprint Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450, Budapest, Hungary
    Brain Res 1120:13-22. 2006
    ..Rather a functional heterogeneity of the pyramidal cell population contributing to specific intra-or subcortical projections is suggested...
  4. ncbi request reprint Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    Brain Res 1099:189-98. 2006
    ..The findings suggest that Abeta-related pathology induces morphological aberrations in basal and apical arbors to different degrees which are unrelated to direct plaque-associated changes...
  5. doi request reprint Constitutively enhanced p21Ras activity amplifies dendritic remodeling of hippocampal neurons during physical activity
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Int J Dev Neurosci 27:407-11. 2009
    ..Since Ras is crucially involved in signaling and cascades of neurotrophins that are elevated after physical activity, these results strongly suggest an important role of Ras in dendritic dynamics during induced neuronal remodeling...
  6. doi request reprint Activity-induced dendrite and dendritic spine development in human amyloid precursor protein transgenic mice
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Int J Dev Neurosci 29:107-14. 2011
    ..The results suggest that enhanced levels of wild-type hAPP do not result in degenerative changes of neuronal morphology, but rather promote dendritic growth...
  7. ncbi request reprint Constitutive expression of p21H-ras(Val12) in pyramidal neurons results in reorganization of mouse neocortical afferents
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurobiol 60:263-74. 2004
    ..Moreover, expression of p21H-ras(Val12) in pyramidal cells induces an enhanced establishment of efferent boutons...
  8. ncbi request reprint Adaptive morphological changes of neocortical interneurons in response to enlarged and more complex pyramidal cells in p21H-Ras(Val12) transgenic mice
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Brain Res Bull 62:335-43. 2004
    ..The findings of the present study demonstrate the morphogenetic capacity of interneurons for adapting to morphological alterations of principal neurons in the cerebral cortex...
  9. ncbi request reprint Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institut for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 467:119-33. 2003
    ..The data presented here suggest an important role of p21Ras-dependent signaling in the final differentiation and maintenance of dendritic morphology...
  10. doi request reprint Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice
    A Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Eur J Neurosci 27:3083-94. 2008
    ..The results provide the first evidence for a role of Ras in preserving neuronal structure after functional deprivation in vivo...
  11. doi request reprint Perineuronal and perisynaptic extracellular matrix in the human spinal cord
    C Jager
    Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Neuroscience 238:168-84. 2013
    ..The detailed description of ECM distribution in the human spinal cord shall support clinical approaches in injury and regenerative therapy...
  12. ncbi request reprint Topographical organisation of projections from the nucleus isthmi magnocellularis to the optic tectum of the chick brain
    T Tömböl
    Department of Anatomy Histology and Embryology, Semmelweis University, Tuzolto u 58, 1094, Budapest, Hungary
    Anat Embryol (Berl) 211:119-28. 2006
    ..The projections observed appeared to be topographically organised, and furthermore appeared to be parallel with and complimentary to previously described projections of the parvocellular isthmic nucleus...
  13. ncbi request reprint A golgi and a combined Golgi/GABA immunogold study of local circuit neurons in the homing pigeon hippocampus
    T Tömböl
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Anat Embryol (Berl) 201:181-96. 2000
    ....
  14. doi request reprint Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets
    D Lendvai
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Budapest, Hungary
    J Neurosci Res 90:376-87. 2012
    ....
  15. ncbi request reprint The axon arbourisation of nuclei isthmi neurons in the optic tectum of the chick and pigeon. A Golgi and anterograde tracer-study
    T Tömböl
    Department of Anatomy, Histology and Embryology, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
    Anat Embryol (Berl) 209:371-80. 2005
    ..Controlling for size, there was no significant difference between chicks and pigeons. The significance of these afferents in the optic tectum is discussed...
  16. ncbi request reprint Chondroitin sulphate proteoglycan-based perineuronal net establishment is largely activity-independent in chick visual system
    G Gati
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    J Chem Neuroanat 40:243-7. 2010
    ..Results suggest that establishment of extracellular matrix and perineuronal nets are largely activity-independent in the investigated precocial bird...
  17. ncbi request reprint Scaling properties of pyramidal neurons in mice neocortex
    Andreas Schierwagen
    Institute for Computer Science, University of Leipzig, 04109 Leipzig, Germany
    Math Biosci 207:352-64. 2007
    ..In conclusion, our results suggest only a minor impact of the Ras protein on dendritic electroanatomy, with non-significant changes of most regions of the corresponding METs...
  18. doi request reprint Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs
    Alan Alpar
    Paul Flechsig Institute for Brain Research, Faculty of Medicine, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Brain Res 1330:9-19. 2010
    ..g., of neurogenesis) or slow degenerative processes, particularly due to the at least doubled longevity of tenrecs in comparison to mice and rats...
  19. doi request reprint Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain
    Markus Morawski
    Paul Flechsig Institute of Brain Research, Faculty of Medicine, University of Leipzig, Germany
    Brain Res 1275:10-23. 2009
    ..The early appearance of perineuronal nets in the precocial birds' brain is probably due to the rapid establishment of neuronal morphology and function which is required for the immediate functional and behavioural performance of chicken...