Kristian Almstrup

Summary

Affiliation: Growth and Reproduction, Rigshospitalet
Location: Copenhagen, Denmark

Publications

  1. pmc Gene expression profiles of mouse spermatogenesis during recovery from irradiation
    Fozia J Shah
    University Department of Growth and Reproduction GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Reprod Biol Endocrinol 7:130. 2009
  2. ncbi request reprint A fast method for measurement of branching enzyme activity using a thin-layer chromatography-based phosphorylase a stimulation assay
    K Almstrup
    Danisco Cultor Innovation Copenhagen, Langebrogade 1, Copenhagen, DK 1001, Denmark
    Anal Biochem 286:297-300. 2000
  3. ncbi request reprint CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
  4. ncbi request reprint Improved gene expression signature of testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Androl 30:292-302; discussion 303. 2007
  5. ncbi request reprint Current approaches for detection of carcinoma in situ testis
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:398-404; discussion 404-5. 2007
  6. doi request reprint Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development
    David Møbjerg Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cell Endocrinol 288:111-8. 2008
  7. ncbi request reprint Re: Niels J. van Casteren, Hans Stoop, Gert R. Dohle, Ronald de Wit, J. Wolter Oosterhuis, Leendert H.J. Looijenga. Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. Eur Urol 2008;54:153-60
    Christina E Hoei-Hansen
    Eur Urol 55:e67-8. 2009
  8. pmc Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte
    Si Brask Sonne
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Res 69:5241-50. 2009
  9. doi request reprint Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:e207-15. 2010
  10. pmc Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
    K Almstrup
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Br J Cancer 103:1269-76. 2010

Detail Information

Publications29

  1. pmc Gene expression profiles of mouse spermatogenesis during recovery from irradiation
    Fozia J Shah
    University Department of Growth and Reproduction GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Reprod Biol Endocrinol 7:130. 2009
    ....
  2. ncbi request reprint A fast method for measurement of branching enzyme activity using a thin-layer chromatography-based phosphorylase a stimulation assay
    K Almstrup
    Danisco Cultor Innovation Copenhagen, Langebrogade 1, Copenhagen, DK 1001, Denmark
    Anal Biochem 286:297-300. 2000
  3. ncbi request reprint CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
    ..In conclusion, despite high mRNA levels, the CDH1 protein is not expressed in CIS, suggesting translational suppression of CDH1 protein expression. CDH1 serum levels may be a serological marker for staging of TGCT patients...
  4. ncbi request reprint Improved gene expression signature of testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Androl 30:292-302; discussion 303. 2007
    ..The merged CIS data from two different microarray platforms, to our knowledge, provide the most precise CIS gene expression signature to date...
  5. ncbi request reprint Current approaches for detection of carcinoma in situ testis
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:398-404; discussion 404-5. 2007
    ..In conclusion, one difficulty is to determine in which males CIS should be suspected; secondly, there does not as yet exist an optimal noninvasive method of diagnosis that is more acceptable than an open surgical biopsy...
  6. doi request reprint Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development
    David Møbjerg Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cell Endocrinol 288:111-8. 2008
    ....
  7. ncbi request reprint Re: Niels J. van Casteren, Hans Stoop, Gert R. Dohle, Ronald de Wit, J. Wolter Oosterhuis, Leendert H.J. Looijenga. Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. Eur Urol 2008;54:153-60
    Christina E Hoei-Hansen
    Eur Urol 55:e67-8. 2009
  8. pmc Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte
    Si Brask Sonne
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Res 69:5241-50. 2009
    ..The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells...
  9. doi request reprint Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:e207-15. 2010
    ..A high expression of EL and abundance of lipid in tubules with CIS may have a diagnostic value...
  10. pmc Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
    K Almstrup
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Br J Cancer 103:1269-76. 2010
    ..The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells...
  11. doi request reprint Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:793-806. 2011
    ..We aimed at describing the phenotypic characteristics throughout life from clinical follow-up of our large cohort of patients with KS...
  12. doi request reprint A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Andrologia 44:78-85. 2012
    ..Combining the immunohistochemical nuclear markers with a rapid cytochemical alkaline phosphatase reaction for detection of CIS cells in ejaculates may provide a more reliable diagnostic method...
  13. ncbi request reprint Estrogenic effect of soy isoflavones on mammary gland morphogenesis and gene expression profile
    Anni R Thomsen
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Sci 93:357-68. 2006
    ..e., more and larger TEBs and ducts. The results suggest an estrogenic response of physiological doses of isoflavones on mammary gland development at both the morphological and molecular level, which resembled that induced by puberty...
  14. ncbi request reprint Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    ..Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells...
  15. ncbi request reprint Identification and expression profiling of 10 novel spermatid expressed CYPT genes
    Martin A Hansen
    Department Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, GR5064, Blegdamsvej 9, DK 2100, Denmark
    Mol Reprod Dev 73:568-79. 2006
    ..The CYPT family may function in the remodeling of the spermatid nucleus before condensation of the DNA...
  16. pmc Dual effects of phytoestrogens result in u-shaped dose-response curves
    Kristian Almstrup
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 110:743-8. 2002
    ..Aromatase inhibition may play an important role in the protective effects of phytoestrogens against breast cancer...
  17. ncbi request reprint Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis
    J E Nielsen
    Dept of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Eur J Histochem 47:215-22. 2003
    ..LANCL1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse...
  18. ncbi request reprint Analysis of cell-type-specific gene expression during mouse spermatogenesis
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Biol Reprod 70:1751-61. 2004
    ..Finally, a group of genes was downregulated during spermatogenesis and probably expressed in nongerm cells. We believe that expression of most genes can be described by a combination of these cell-type-specific expression patterns...
  19. ncbi request reprint Identification of genes differentially expressed in testes containing carcinoma in situ
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Hum Reprod 10:423-31. 2004
    ..g. DCN, IGFBP6, SFRP1, SALL1), supporting our hypothesis that the origin of CIS is probably associated with disturbances of the fetal development of the testis...
  20. ncbi request reprint Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
    ..Finally, some of the highly expressed genes identified in this study are promising candidates for new diagnostic markers for CIS and/or TGCTs...
  21. ncbi request reprint Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
    ..In this study we aimed to investigate the expression pattern of AP-2gamma and to shed light on this factor in germ cell differentiation and the pathogenesis of germ cell neoplasia...
  22. ncbi request reprint A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2gamma in semen samples: case report
    C E Hoei-Hansen
    University Department of Growth and Reproduction GR 5064, Rigshospitalet Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 20:579-82. 2005
    ..The value of this method for diagnostic use in the clinic requires further careful validation in a large series of patients and controls, but the preliminary results are promising...
  23. ncbi request reprint Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cell Tissue Res 322:159-65. 2005
    ..The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular germ cell cancer...
  24. pmc Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours
    K Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Br J Cancer 92:1934-41. 2005
    ....
  25. ncbi request reprint Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours
    C E Hoei-Hansen
    University Department of Growth and Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark
    Histopathology 47:48-56. 2005
    ..In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens...
  26. ncbi request reprint From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
    Kristian Almstrup
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Androl 29:211-8. 2006
    ....
  27. doi request reprint Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells
    Dina G Kristensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Int J Dev Biol 57:309-17. 2013
    ....
  28. doi request reprint Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype
    Dina G Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Genet 205:425-31. 2012
    ....
  29. doi request reprint Screening of subfertile men for testicular carcinoma in situ by an automated image analysis-based cytological test of the ejaculate
    K Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 34:e21-30; discussion e30-1. 2011
    ..On the basis of the results, we propose that the assay could be offered to subfertile men and other patients who are at increased risk of TC...