Research Topics
Genomes and Genes
| Kristian AlmstrupSummaryAffiliation: Growth and Reproduction, Rigshospitalet Location: Copenhagen, Denmark Publications
| Collaborators
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Detail Information
Publications
Gene expression profiles of mouse spermatogenesis during recovery from irradiationFozia J Shah
University Department of Growth and Reproduction GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
Reprod Biol Endocrinol 7:130. 2009....
A fast method for measurement of branching enzyme activity using a thin-layer chromatography-based phosphorylase a stimulation assayK Almstrup
Danisco Cultor Innovation Copenhagen, Langebrogade 1, Copenhagen, DK 1001, Denmark
Anal Biochem 286:297-300. 2000- CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumoursSi B Sonne
University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
APMIS 114:549-58. 2006..In conclusion, despite high mRNA levels, the CDH1 protein is not expressed in CIS, suggesting translational suppression of CDH1 protein expression. CDH1 serum levels may be a serological marker for staging of TGCT patients... - Improved gene expression signature of testicular carcinoma in situKristian Almstrup
University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Int J Androl 30:292-302; discussion 303. 2007..The merged CIS data from two different microarray platforms, to our knowledge, provide the most precise CIS gene expression signature to date... - Current approaches for detection of carcinoma in situ testisChristina E Hoei-Hansen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 30:398-404; discussion 404-5. 2007..In conclusion, one difficulty is to determine in which males CIS should be suspected; secondly, there does not as yet exist an optimal noninvasive method of diagnosis that is more acceptable than an open surgical biopsy... 
Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic developmentDavid Møbjerg Kristensen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Mol Cell Endocrinol 288:111-8. 2008....- Re: Niels J. van Casteren, Hans Stoop, Gert R. Dohle, Ronald de Wit, J. Wolter Oosterhuis, Leendert H.J. Looijenga. Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. Eur Urol 2008;54:153-60Christina E Hoei-Hansen
Eur Urol 55:e67-8. 2009 - Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyteSi Brask Sonne
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Cancer Res 69:5241-50. 2009..The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells... - Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasmsJ E Nielsen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 33:e207-15. 2010..A high expression of EL and abundance of lipid in tubules with CIS may have a diagnostic value... - Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cellsK Almstrup
Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Br J Cancer 103:1269-76. 2010..The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells... - Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experienceLise Aksglaede
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Acta Paediatr 100:793-806. 2011..We aimed at describing the phenotypic characteristics throughout life from clinical follow-up of our large cohort of patients with KS... - A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samplesJ E Nielsen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Andrologia 44:78-85. 2012..Combining the immunohistochemical nuclear markers with a rapid cytochemical alkaline phosphatase reaction for detection of CIS cells in ejaculates may provide a more reliable diagnostic method... - Estrogenic effect of soy isoflavones on mammary gland morphogenesis and gene expression profileAnni R Thomsen
Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, , , Denmark
Toxicol Sci 93:357-68. 2006..e., more and larger TEBs and ducts. The results suggest an estrogenic response of physiological doses of isoflavones on mammary gland development at both the morphological and molecular level, which resembled that induced by puberty... - Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumoursSi Brask Sonne
University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Virchows Arch 449:200-6. 2006..Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells... - Identification and expression profiling of 10 novel spermatid expressed CYPT genesMartin A Hansen
Department Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, GR5064, Blegdamsvej 9, DK 2100, Denmark
Mol Reprod Dev 73:568-79. 2006..The CYPT family may function in the remodeling of the spermatid nucleus before condensation of the DNA... 
Dual effects of phytoestrogens result in u-shaped dose-response curvesKristian Almstrup
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Environ Health Perspect 110:743-8. 2002..Aromatase inhibition may play an important role in the protective effects of phytoestrogens against breast cancer...- Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testisJ E Nielsen
Dept of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Eur J Histochem 47:215-22. 2003..LANCL1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse... - Analysis of cell-type-specific gene expression during mouse spermatogenesisKristian Almstrup
University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Biol Reprod 70:1751-61. 2004..Finally, a group of genes was downregulated during spermatogenesis and probably expressed in nongerm cells. We believe that expression of most genes can be described by a combination of these cell-type-specific expression patterns... - Identification of genes differentially expressed in testes containing carcinoma in situC E Hoei-Hansen
University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Mol Hum Reprod 10:423-31. 2004..g. DCN, IGFBP6, SFRP1, SALL1), supporting our hypothesis that the origin of CIS is probably associated with disturbances of the fetal development of the testis... - Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profilingKristian Almstrup
University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Cancer Res 64:4736-43. 2004..Finally, some of the highly expressed genes identified in this study are promising candidates for new diagnostic markers for CIS and/or TGCTs... - Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumorsChristina E Hoei-Hansen
University Department of Growth and Reproduction, Rigshospitalet, Denmark
Clin Cancer Res 10:8521-30. 2004..In this study we aimed to investigate the expression pattern of AP-2gamma and to shed light on this factor in germ cell differentiation and the pathogenesis of germ cell neoplasia... - A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2gamma in semen samples: case reportC E Hoei-Hansen
University Department of Growth and Reproduction GR 5064, Rigshospitalet Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Hum Reprod 20:579-82. 2005..The value of this method for diagnostic use in the clinic requires further careful validation in a large series of patients and controls, but the preliminary results are promising... - Genomic and gene expression signature of the pre-invasive testicular carcinoma in situKristian Almstrup
University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Cell Tissue Res 322:159-65. 2005..The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular germ cell cancer... - Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumoursK Almstrup
University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, Copenhagen DK 2100, Denmark
Br J Cancer 92:1934-41. 2005.... - Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumoursC E Hoei-Hansen
University Department of Growth and Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark
Histopathology 47:48-56. 2005..In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens... - From embryonic stem cells to testicular germ cell cancer-- should we be concerned?Kristian Almstrup
University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Int J Androl 29:211-8. 2006.... - Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotypeDina G Kristensen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Cancer Genet 205:425-31. 2012.... - Screening of subfertile men for testicular carcinoma in situ by an automated image analysis-based cytological test of the ejaculateK Almstrup
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 34:e21-30; discussion e30-1. 2011..On the basis of the results, we propose that the assay could be offered to subfertile men and other patients who are at increased risk of TC...