Richard P Allen

Summary

Publications

  1. doi request reprint Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 10:1097-100. 2009
  2. ncbi request reprint Improving RLS diagnosis and severity assessment: polysomnography, actigraphy and RLS-sleep log
    Richard P Allen
    Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 8:S13-8. 2007
  3. doi request reprint Psychometric evaluation and tests of validity of the Medical Outcomes Study 12-item Sleep Scale (MOS sleep)
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 10:531-9. 2009
  4. ncbi request reprint Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire
    Richard Allen
    Johns Hopkins University, Baltimore, MD, USA Electronic address
    Sleep Med 14:1375-80. 2013
  5. pmc Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease
    Stephanie M Patton
    Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA
    Fluids Barriers CNS 10:20. 2013
  6. pmc Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 80:2028-34. 2013
  7. doi request reprint The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia
    Richard P Allen
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hematol 88:261-4. 2013
  8. doi request reprint Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 12:906-13. 2011
  9. doi request reprint Physician-diagnosed restless legs syndrome in a large sample of primary medical care patients in western Europe: Prevalence and characteristics
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 11:31-7. 2010
  10. ncbi request reprint Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Med 120:S13-21. 2007

Detail Information

Publications84

  1. doi request reprint Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 10:1097-100. 2009
    ..This validation study sought to determine the sensitivity and specificity of the RLS diagnosis based on this questionnaire...
  2. ncbi request reprint Improving RLS diagnosis and severity assessment: polysomnography, actigraphy and RLS-sleep log
    Richard P Allen
    Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 8:S13-8. 2007
    ..These methods need to be developed and evaluated in both our research and clinical trials of RLS because they may enhance accuracy of diagnosis and reduce the placebo response to treatments...
  3. doi request reprint Psychometric evaluation and tests of validity of the Medical Outcomes Study 12-item Sleep Scale (MOS sleep)
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 10:531-9. 2009
    ..To validate the psychometric properties of the Medical Outcomes Study (MOS) Sleep Scale in subjects with restless legs syndrome (RLS)...
  4. ncbi request reprint Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire
    Richard Allen
    Johns Hopkins University, Baltimore, MD, USA Electronic address
    Sleep Med 14:1375-80. 2013
    ..To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL...
  5. pmc Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease
    Stephanie M Patton
    Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA
    Fluids Barriers CNS 10:20. 2013
    ..The purpose of this study was to determine if biomarkers in the cerebrospinal fluid can distinguish RLS/WED patients from neurological controls...
  6. pmc Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 80:2028-34. 2013
    ..To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep...
  7. doi request reprint The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia
    Richard P Allen
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hematol 88:261-4. 2013
    ..This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both...
  8. doi request reprint Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 12:906-13. 2011
    ..This study evaluates efficacy and safety of a new IV iron formulation (ferric carboxymaltose, FCM) with molecular properties that may make iron more available for uptake to the brain than iron sucrose does...
  9. doi request reprint Physician-diagnosed restless legs syndrome in a large sample of primary medical care patients in western Europe: Prevalence and characteristics
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 11:31-7. 2010
    ..This study therefore aimed to determine its prevalence, morbidity and adequacy of diagnosis based on physician evaluations of their own patients in primary care practice...
  10. ncbi request reprint Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Med 120:S13-21. 2007
    ..However, 4 different diagnostic criteria have been established. Familiarity with diagnostic criteria and clinical characteristics are essential for diagnosis and appropriate treatment, if required...
  11. doi request reprint Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample
    Richard P Allen
    Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 12:431-9. 2011
    ....
  12. pmc Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis
    Richard P Allen
    Johns Hopkins University, School of Medicine, Department of Neurology, Asthma and Allergy Building, 1B76B 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 10:123-8. 2009
    ..It would then also reflect both the more severe iron insufficiency pathology of RLS and greater clinical severity, shown by the objective measure of PLMS/hr...
  13. ncbi request reprint Clinical efficacy of ropinirole for restless legs syndrome is not affected by age at symptom onset
    Richard P Allen
    Johns Hopkins Bayview Medical Center, Neurology and Sleep Medicine, Baltimore, MD 21224, USA
    Sleep Med 9:899-902. 2008
    ..To determine whether clinical response to the dopamine agonist, ropinirole, in the treatment of primary restless legs syndrome (RLS), depends upon the age-at-onset of RLS symptoms...
  14. ncbi request reprint The role of iron in restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    Mov Disord 22:S440-8. 2007
    ..Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder...
  15. ncbi request reprint Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States
    Wayne A Hening
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Mov Disord 25:1675-83. 2010
    ..Rotigotine transdermal patches releasing 2 to 3 mg/24 hr significantly reduced the severity of RLS symptoms. Treatment efficacy was maintained throughout the 6-month double-blind period...
  16. pmc A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, AAC 1B 82, Baltimore, MD 21224, USA
    Sleep Med 10:206-11. 2009
    ..The aim of this study was to ascertain whether high-dose intravenous (IV) iron sucrose could improve symptoms and change brain iron concentrations in idiopathic RLS...
  17. pmc Increased synaptic dopamine in the putamen in restless legs syndrome
    Christopher J Earley
    Departments of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep 36:51-7. 2013
    ..Thus, differences in D2R-BP reflect changes in these primary factors. PET techniques are currently available to estimate D2R β(max) and K(d)...
  18. ncbi request reprint Restless legs syndrome prevalence and impact: REST general population study
    Richard P Allen
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21224, USA
    Arch Intern Med 165:1286-92. 2005
    ..Previous epidemiological studies, however, have failed to determine the prevalence of those with clinically significant RLS symptoms and to examine the life effects and medical experiences of this group...
  19. ncbi request reprint Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movements
    Paul V Birinyi
    Department of Neuroscience, Baltimore, The Johns Hopkins University School of Art and Sciences, MD, USA
    Sleep Med 7:480-5. 2006
    ..To evaluate periodic limb movements during sleep (PLMS) in first-degree relatives of both restless legs syndrome (RLS) patients and matched controls without RLS in order to analyze patterns of this motor sign of RLS...
  20. pmc A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS)
    Charlene E Gamaldo
    Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, Baltimore, MD 21224, United States
    Sleep Med 9:500-5. 2008
    ..In this study, we compared the cognitive function of RLS patients who were off treatment to sleep-restricted control subjects...
  21. ncbi request reprint Validation of the Hopkins telephone diagnostic interview for restless legs syndrome
    Wayne A Hening
    RLS Center, Asthma and Allergy, SBTBLJH Bayview, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Sleep Med 9:283-9. 2008
    ..A previous validation was performed on a patient group. In the current report, we have extended that validation to a non-patient group drawn from on ongoing family study...
  22. pmc Evaluating daytime alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controls
    Charlene Gamaldo
    Department of Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Building 1B 75A, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 10:134-8. 2009
    ..In this study we used more objective measures of alertness and compared RLS subjects who are off treatments and chronically sleep restricted to chronic sleep-restricted controls...
  23. ncbi request reprint Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Sleep Med 6:301-5. 2005
    ..To evaluate in RLS patients the efficacy and safety of repeated infusions of iron in order to maintain symptomatic improvements achieved with a prior single 1000 mg infusion of iron...
  24. pmc Pregnancy accounts for most of the gender difference in prevalence of familial RLS
    Nicholas P Pantaleo
    Dept of Psychology and Brain Science, Johns Hopkins Univ, Baltimore, MD, USA
    Sleep Med 11:310-3. 2010
    ..This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS...
  25. ncbi request reprint Cognitive deficits associated with restless legs syndrome (RLS)
    Virginia E Pearson
    Dept of Psychology and Brain Sciences, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:25-30. 2006
    ..e. involving mostly pre-frontal cortical (PFC) functioning...
  26. ncbi request reprint Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 6:429-34. 2005
    ..This study uses the SIT at different times of the day and analyzes time-of-day and duration-of-rest effects and their interaction on the PLMW...
  27. ncbi request reprint Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community
    Hochang B Lee
    Division of Geriatric Psychiatry and Neuropsychiartry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 20:101-5. 2008
    ..9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder...
  28. ncbi request reprint Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria - history, rationale, description, and significance
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 15:860-73. 2014
    ..However, extensive review of accumulating literature based on the 2003 NIH/IRLSSG criteria led to efforts to improve the diagnostic criteria further...
  29. ncbi request reprint Race and restless legs syndrome symptoms in an adult community sample in east Baltimore
    Hochang B Lee
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Sleep Med 7:642-5. 2006
    ..We compared the prevalence of RLS in African-Americans and Caucasians in a biracial community sample as part of Wave IV of the Baltimore Health and Mental Health Study...
  30. pmc Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 11:882-9. 2010
    ..Few studies have used polysomnography (PSG) to characterize changes in sleep architecture during abrupt abstinence from heavy MJ use...
  31. pmc The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome
    Christopher J Earley
    Department of Neurology, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
    Sleep 34:341-7. 2011
    ..The current studies assessed real-time DAT binding potentials (BP) in striatum of RLS patients using (11)C-methylphenidate and PET techniques...
  32. ncbi request reprint Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Hum Hered 62:157-64. 2006
    ..The objective of this study was to ascertain the most likely inheritance pattern of restless legs syndrome (RLS) using segregation analysis...
  33. ncbi request reprint MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:458-61. 2006
    ..In this study our primary hypothesis was that substantia nigra (SN) iron index would be decreased in early-onset RLS compared to controls...
  34. doi request reprint Assessing health-related quality of life in patients with restless legs syndrome in Korea: comparison with other chronic medical diseases
    Yong Won Cho
    Department of Neurology, Dongsan Medical Center, Keimyung University, School of Medicine, Daegu, South Korea
    Sleep Med 13:1158-63. 2012
    ..We studied the QoL of patients with RLS and compared it to normal controls and patients with hypertension, type 2 diabetes, or osteoarthritis in Korea...
  35. ncbi request reprint An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder
    Wayne A Hening
    Johns Hopkins Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Sleep 27:560-83. 2004
    ..This paper reviews the literature on levodopa, dopaminergic agonists (pergolide, pramipexole, ropinirole, talipexole, cabergoline, piribidel, DHEC), and other dopaminergic agents (amantadine, selegiline)...
  36. doi request reprint A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome
    Nathan Silver
    Dept of Psychology and Brain Sciences, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21216, USA
    Sleep Med 12:440-4. 2011
    ..The primary aim of this study was to determine the long-term efficacy (10-year) for commonly used RLS medication types: dopaminergic agonists and opioids...
  37. ncbi request reprint Circadian changes in CSF dopaminergic measures in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:263-8. 2006
    ..The dopaminergic (DAergic) system, which plays a role in RLS, entails circadian changes that parallel RLS symptom changes. The aim of this study was to look for relative and diurnal differences in DAergic activity...
  38. pmc The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 10:1155-7. 2009
    ..Changes at the cellular level in dopaminergic metabolism or at the distal synapse with changes in receptors or transporters were not evaluated in this study...
  39. ncbi request reprint Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study
    Wayne Hening
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
    Sleep Med 5:237-46. 2004
    ..To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population...
  40. ncbi request reprint Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 28:1069-75. 2005
    ....
  41. ncbi request reprint Dissociative changes in the Bmax and KD of dopamine D2/D3 receptors with aging observed in functional subdivisions of the striatum: a revisit with an improved data analysis method
    Hiroto Kuwabara
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 53:805-12. 2012
    ..However, existing methods have limited applications to the whole striatum, putamen, or caudate nucleus. Improved methods are required to examine B(max) and K(D) in detailed functional striatal subdivisions that are becoming widely used...
  42. doi request reprint Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States
    Richard P Allen
    Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    Mov Disord 26:114-20. 2011
    ..Even this very conservative approach finds RLS in this cohort to be common, under-diagnosed, and carried a significant personal and social burden...
  43. doi request reprint Update in restless legs syndrome
    Rachel E Salas
    Department of Neurology, Division of Pulmonary Critical Care, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Curr Opin Neurol 23:401-6. 2010
    ....
  44. pmc Altered iron metabolism in lymphocytes from subjects with restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep 31:847-52. 2008
    ..Thus the study aim was to determine whether patients with RLS and control subjects show differences in lymphocyte iron regulator proteins...
  45. ncbi request reprint An algorithm for the management of restless legs syndrome
    Michael H Silber
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:916-22. 2004
    ..The role of carbidopa/levodopa, dopamine agonists, opioids, benzodiazepines, and anticonvulsants for the different types of the disorder is delineated...
  46. ncbi request reprint Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis
    Charlene E Gamaldo
    Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, 21224 Baltimore, MD, USA
    Sleep Med 8:716-22. 2007
    ..RLS appears to be caused by a complex interaction of genetic and environmental factors. This study sought to identify some environmental risk factors significantly associated with the occurrence of RLS...
  47. ncbi request reprint The treatment of restless legs syndrome with intravenous iron dextran
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 5:231-5. 2004
    ..To evaluate the safety and efficacy of a single 1000 mg iron infusion in treating Restless Legs Syndrome (RLS)...
  48. ncbi request reprint The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population
    Wayne A Hening
    Department of Neurology, University of Medicine and Dentistry of New Jersey RW Johnson Medical School, New Brunswick, NJ, USA
    Sleep Med 4:137-41. 2003
    ..To develop and validate a telephone diagnostic interview (the Johns Hopkins telephone diagnostic interview for restless legs, abbreviated TDI) for diagnosis of the restless legs syndrome (RLS)...
  49. pmc Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording
    Myung Sung Yang
    Johns Hopkins University, 5501 Hopkins Bayview Circle, 1B 70, Baltimore, MD 21224, USA
    Sleep Med 15:132-7. 2014
    ..In our study, we assessed the validity of the measurements of PLM during wakefulness (PLMW) in the SIT for PAM-RL using both default and custom detection threshold parameters compared to AT EMG...
  50. ncbi request reprint Investigation into the correlation between sensation and leg movement in restless legs syndrome
    Paul V Birinyi
    The Johns Hopkins School of Arts and Sciences, Department of Neuroscience, Baltimore, MD 21224, USA
    Mov Disord 20:1097-103. 2005
    ..The temporal dissociation between sensory and motor events supports viewing these motor and sensory events as separate but loosely linked manifestations of RLS...
  51. ncbi request reprint Factor analysis of the International Restless Legs Syndrome Study Group's scale for restless legs severity
    Richard P Allen
    Department of Neurology and Sleep Medicine, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 4:133-5. 2003
    ..This study uses a factor analytic approach to evaluate the IRLS for possibly useful subscales...
  52. ncbi request reprint Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Richard P Allen
    Department of Neurology, Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Building 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 4:101-19. 2003
    ..Modification of the criteria is now necessary to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria...
  53. pmc Increased use-dependent plasticity in chronic insomnia
    Rachel E Salas
    Department of Neurology, Johns Hopkins Medical Institution, Baltimore, MD
    Sleep 37:535-44. 2014
    ..Protocols testing use-dependent plasticity (UDP), one of the mechanisms underlying formation of motor memories traces, provide a sensitive measure to assess neuroplasticity in the context of motor training...
  54. ncbi request reprint Restless legs syndrome and periodic leg movements in sleep
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Handb Clin Neurol 99:913-48. 2011
    ..Finally, recent family studies and gene-wide association studies have identified several candidate genes; this may help to focus future research endeavors into the pathophysiology of RLS...
  55. ncbi request reprint Restless legs syndrome: demographics, presentation, and differential diagnosis
    Wayne Hening
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, USA
    Geriatrics 62:26-9. 2007
    ..Primary RLS is familial and likely to be genetic. Important causes of secondary RLS are end-stage renal disease, pregnancy, and iron deficiency. Every patient should be checked for iron status with a serum ferritin measurement...
  56. pmc Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells
    Seema Gulyani
    Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 215:236-42. 2009
    ..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system...
  57. ncbi request reprint Validation of the Restless Legs Syndrome Quality of Life questionnaire
    Linda Abetz
    Mapi Values Ltd, Macclesfield, Cheshire, UK
    Value Health 8:157-67. 2005
    ..The Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) assesses the impact of RLS on daily life, emotional well-being, social life, and work life. This study investigates its validity and reliability...
  58. ncbi request reprint Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome
    Arthur S Walters
    New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08818, USA
    Sleep Med 4:121-32. 2003
    ..Moreover, RLS is primarily a subjective disorder. Therefore, a subjective scale is at present the optimal instrument to meet this need...
  59. pmc The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population
    Linda Abetz
    Mapi Values, Adelphi Mill, Bollington, Macclesfield, SK10 5JB, UK
    Health Qual Life Outcomes 3:79. 2005
    ..The aim of this study was to determine the reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a clinical trial setting...
  60. ncbi request reprint Restless legs syndrome (RLS): the continuing development of diagnostic standards and severity measures
    Wayne A Hening
    Sleep Med 4:95-7. 2003
  61. ncbi request reprint The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical-trial setting
    Linda Abetz
    Mapi Values, Adelphi Mill, Grimshaw Lane, Bollington, Cheshire SK10 5JB, UK
    Sleep Med 7:340-9. 2006
    ..0), using pooled data from two matching, placebo-controlled studies of ropinirole for treating Restless Legs Syndrome (RLS)...
  62. ncbi request reprint The effects of dietary iron deprivation on murine circadian sleep architecture
    Terry Dean
    The University of Pennsylvania School of Medicine, Department of Neuroscience, USA
    Sleep Med 7:634-40. 2006
    ..To this end, we hypothesized that the iron-deprived mice would exhibit a sleep-wake circadian pattern characteristic of the human syndrome: increased wakefulness during the hours immediately preceding the sleep-predominant period...
  63. ncbi request reprint Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Sleep Med 8:520-30. 2007
    ..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification...
  64. ncbi request reprint Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
    Diego Garcia-Borreguero
    Fundacion Jimenez Diaz, Madrid, Spain
    Sleep Med 8:455-63. 2007
    ..The changes in each dimension are summed to give an ASRS total score...
  65. ncbi request reprint Restless legs syndrome augmentation associated with tramadol
    Christopher J Earley
    Sleep Med 7:592-3. 2006
  66. ncbi request reprint Modeling the causal relationships between symptoms associated with restless legs syndrome and the patient-reported impact of RLS
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305 5730, USA
    Sleep Med 5:485-8. 2004
    ..A primary treatment goal should be the reduction of the sleep disturbance of RLS, both to decrease the RLS-related nocturnal distress and to improve daytime functioning...
  67. ncbi request reprint Clinical significance of RLS
    Wayne A Hening
    UMDNJ RW Johnson Medical School, New Brunswick, New Jersey, USA
    Mov Disord 22:S395-400. 2007
    ..In dialysis patients, RLS has been found to be a risk factor for mortality. Therefore, those with RLS who have clinically significant symptoms suffer increased morbidity and are at risk for impaired long-term medical outcomes...
  68. ncbi request reprint Iron, RLS and blood donations
    Richard P Allen
    Sleep Med 5:113-4. 2004
  69. ncbi request reprint Restless legs syndrome: nonpharmacologic and pharmacologic treatments
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Geriatrics 62:13-6. 2007
    ..Dopamine agonists are considered first-line treatment when daily treatment for primary RLS is indicated. Gabapentin and opioids may be of value for refractory cases. Initial treatment of secondary RLS should address the underlying cause...
  70. ncbi request reprint Restless legs syndrome: prevalence and impact in children and adolescents--the Peds REST study
    Daniel Picchietti
    University of Illinois School of Medicine and Carle Clinic Association, Department of Pediatrics, 602 W University Ave, Urbana, IL 61801, USA
    Pediatrics 120:253-66. 2007
    ..In this first population-based study to use specific pediatric diagnostic criteria, we examined the prevalence and impact of restless legs syndrome in 2 age groups: 8 to 11 and 12 to 17 years...
  71. ncbi request reprint The scoring of movements in sleep
    Arthur S Walters
    Seton Hall University School of Graduate Medical Education, New Jersey Neuroscience Institute at JFK Medical Center, Edison, NJ 08818, USA
    J Clin Sleep Med 3:155-67. 2007
    ..Because of limited or absent evidence for reliability and/or validity, a standardized RAND/UCLA consensus process was employed for recommendation of specific rules for the scoring of sleep-associated movements...
  72. ncbi request reprint Augmentation as a treatment complication of restless legs syndrome: concept and management
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Mov Disord 22:S476-84. 2007
    ..The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition...
  73. ncbi request reprint Definition of restless legs syndrome, how to diagnose it, and how to differentiate it from RLS mimics
    Heike Benes
    Somni Bene Institute for Medical Research and Sleep Medicine, Schwerin, Germany
    Mov Disord 22:S401-8. 2007
    ..Standardized methods to assess a RLS diagnosis are presented which might improve differential diagnosis and in general the reliability and validity of RLS diagnosis...
  74. ncbi request reprint An item response analysis of the international restless legs syndrome study group rating scale for restless legs syndrome
    Glen R Wunderlich
    Boehringer Ingelheim Canada Ltd, Burlington, Ont, Canada
    Sleep Med 6:131-9. 2005
    ..In order to further demonstrate the validity of the IRLS, the present study examined the relationship between scores on individual IRLS items and overall RLS severity...
  75. ncbi request reprint Is ferroportin-hepcidin signaling altered in restless legs syndrome?
    Stacey L Clardy
    Department of Neurosurgery, M S Hershey Medical Center, 500 University Drive, H110, Hershey, PA 17033, USA
    J Neurol Sci 247:173-9. 2006
    ..Nonetheless, these data support the mounting evidence that there is a biological basis for RLS and the underlying mechanism involves iron management...
  76. ncbi request reprint Predictors of health-related quality of life in sufferers with restless legs syndrome: a multi-national study
    Louise McCrink
    RTI Health Solutions, Williams House, Manchester Science Park, Manchester, Lancashire M15 6SE, UK
    Sleep Med 8:73-83. 2007
    ..To explore aspects of restless legs syndrome (RLS) associated with detrimental impact on health-related quality of life (HRQoL)...
  77. ncbi request reprint Systems genetic analysis of peripheral iron parameters in the mouse
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
    Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007
    ..The results show that iron homeostasis is a complex trait and is influenced by multiple genes...
  78. ncbi request reprint Restless legs syndrome symptoms in primary care: a prevalence study
    Deborah A Nichols
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA 94304, USA
    Arch Intern Med 163:2323-9. 2003
    ....
  79. ncbi request reprint Is one night enough for measurement of periodic limb movements in sleep of restless legs patients?
    Richard P Allen
    Sleep 28:296-7. 2005
  80. pmc Epidemiology of restless legs syndrome in Korean adults
    Yong Won Cho
    Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, Korea
    Sleep 31:219-23. 2008
    ..To investigate the prevalence of restless legs syndrome (RLS) in Korea...
  81. ncbi request reprint The resurrection of periodic limb movements (PLM): leg activity monitoring and the restless legs syndrome (RLS)
    Richard P Allen
    Sleep Med 6:385-7. 2005
  82. ncbi request reprint Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
    Mov Disord 22:S495-504. 2007
    ..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols...
  83. ncbi request reprint Assessment of restless legs syndrome--methodological approaches for use in practice and clinical trials
    Ralf Kohnen
    IMEREM Institute for Medical Research Management, Biometrics Ltd, University of Erlangen Nuremberg, Nuremberg, Germany
    Mov Disord 22:S485-94. 2007
    ....
  84. ncbi request reprint Ferritin subunits in CSF are decreased in restless legs syndrome
    Stacey L Clardy
    Department of Neurosurgery, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Lab Clin Med 147:67-73. 2006
    ..These data suggest that CSF ferritin levels may provide a biomarker for assisting in the diagnosis of RLS...