Gjumrakch Aliev

Summary

Publications

  1. ncbi request reprint Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases
    Gjumrakch Aliev
    School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, Georgia 30360, USA
    Recent Pat Cardiovasc Drug Discov 6:222-41. 2011
  2. ncbi request reprint Pathogenesis of Alzheimer disease: role of oxidative stress, amyloid-β peptides, systemic ammonia and erythrocyte energy metabolism
    Elena A Kosenko
    GALLY International Biomedical Research Institute Inc, 7733 Louis Pasteur Drive, 328, San Antonio, TX, 78229, USA
    CNS Neurol Disord Drug Targets 13:112-9. 2014
  3. pmc Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion
    Gjumrakch Aliev
    GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive, No 328, San Antonio, TX 78229, USA
    Oxid Med Cell Longev 2013:962984. 2013
  4. doi request reprint Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease
    Gjumrakch Aliev
    Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Int J Biochem Cell Biol 41:1989-2004. 2009
  5. doi request reprint Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease
    Gjumrakch Aliev
    Department of Biology and Electron Microscopy Research Center, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Neurotox Res 16:293-305. 2009
  6. pmc Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, 78249, USA
    J Cell Mol Med 13:320-33. 2009
  7. pmc The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease
    Justin C Shenk
    Department of Biology and Electron Microscopy Research Center, University of Texas at San Antonio, San Antonio, TX 78249, USA
    J Neurol Sci 283:199-206. 2009
  8. ncbi request reprint Antioxidant status and energy state of erythrocytes in Alzheimer dementia: probing for markers
    Elena A Kosenko
    GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive No 328, San Antonio, TX 78229 USA
    CNS Neurol Disord Drug Targets 11:926-32. 2012
  9. pmc Antioxidant therapy in Alzheimer's disease: theory and practice
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA
    Mini Rev Med Chem 8:1395-406. 2008
  10. ncbi request reprint Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
    Hector H Palacios
    Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
    CNS Neurol Disord Drug Targets 10:149-62. 2011

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases
    Gjumrakch Aliev
    School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, Georgia 30360, USA
    Recent Pat Cardiovasc Drug Discov 6:222-41. 2011
    ..Future potential exploration using mtDNA markers can be considered more accurate hallmarks for diagnosis and monitoring treatment of human diseases. The present article discusses some of the patents regarding the oxidative stress...
  2. ncbi request reprint Pathogenesis of Alzheimer disease: role of oxidative stress, amyloid-β peptides, systemic ammonia and erythrocyte energy metabolism
    Elena A Kosenko
    GALLY International Biomedical Research Institute Inc, 7733 Louis Pasteur Drive, 328, San Antonio, TX, 78229, USA
    CNS Neurol Disord Drug Targets 13:112-9. 2014
    ....
  3. pmc Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion
    Gjumrakch Aliev
    GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive, No 328, San Antonio, TX 78229, USA
    Oxid Med Cell Longev 2013:962984. 2013
    ....
  4. doi request reprint Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease
    Gjumrakch Aliev
    Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Int J Biochem Cell Biol 41:1989-2004. 2009
    ....
  5. doi request reprint Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease
    Gjumrakch Aliev
    Department of Biology and Electron Microscopy Research Center, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Neurotox Res 16:293-305. 2009
    ....
  6. pmc Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, 78249, USA
    J Cell Mol Med 13:320-33. 2009
    ..001) in the hippocampus. These results suggest that feeding ALCAR with LA may ameliorate age-associated mitochondrial ultrastructural decay and are consistent with previous studies showing improved brain function...
  7. pmc The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease
    Justin C Shenk
    Department of Biology and Electron Microscopy Research Center, University of Texas at San Antonio, San Antonio, TX 78249, USA
    J Neurol Sci 283:199-206. 2009
    ..Our findings indicate that ApoE4 genotype-induced mitochondrial changes and associated structural damage may explain age-dependent pathology seen in AD, indicating potential for novel treatment strategies in the near future...
  8. ncbi request reprint Antioxidant status and energy state of erythrocytes in Alzheimer dementia: probing for markers
    Elena A Kosenko
    GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive No 328, San Antonio, TX 78229 USA
    CNS Neurol Disord Drug Targets 11:926-32. 2012
    ..Decreased glutathione peroxidase activity in RBC may be considered as a new peripheral marker for AD...
  9. pmc Antioxidant therapy in Alzheimer's disease: theory and practice
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA
    Mini Rev Med Chem 8:1395-406. 2008
    ..Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease...
  10. ncbi request reprint Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
    Hector H Palacios
    Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
    CNS Neurol Disord Drug Targets 10:149-62. 2011
    ....
  11. ncbi request reprint Antioxidants in health, disease and aging
    Mark E Obrenovich
    Department of Chemistry, Cleveland State University, 2121 Euclid Ave SR 397B, Cleveland, OH 44115, USA
    CNS Neurol Disord Drug Targets 10:192-207. 2011
    ....
  12. ncbi request reprint Effects of coenzyme Q and creatine supplementation on brain energy metabolism in rats exposed to chronic cerebral hypoperfusion
    Jaromír Horecký
    Surgical Pathophysiology and Tissue Engineering Center, Slovak Medical University, Bratislava, Slovak Republic
    Curr Alzheimer Res 8:868-75. 2011
    ..05) and γ-tocopherol in plasma. This suggests that coenzyme Q10 therapy involves resistance to oxidative stress and improved brain bioenergetics, when supplemented during reperfusion after ischemic brain injury...
  13. pmc Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249 1664, USA
    Vasc Health Risk Manag 4:721-30. 2008
    ..Therefore, pharmacological interventions, directed at correcting the chronic hypoperfusion state, may change the natural course of the development of dementing neurodegeneration...
  14. doi request reprint Implication of the nutritional and nonnutritional factors in the context of preservation of cognitive performance in patients with dementia/depression and Alzheimer disease
    Gjumrakch Aliev
    1GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA
    Am J Alzheimers Dis Other Demen 28:660-70. 2013
    ....