Javed Ali

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..As per guidelines provided by the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use and the World Health Organization, the formulation was found to be stable...

..are also conferred...

..The present review describes the involvement of autoimmune responses in periodontal diseases. The mechanisms underlying these responses are also discussed...

..The results suggested that microemulsion gel is a potential vehicle for improved topical delivery of psoralen and that microemulsion gels are potential vehicles for improved topical delivery of babchi oil...

..Gamma imaging was performed in rabbits to assess the buoyancy of the optimized formulation. The optimized formulation remained buoyant during 5 hours of gamma scintigraphic studies in rabbits...

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..The correlation coefficient (R2 value) was obtained upon fitting the data to Higuchi equation, which signifies that the mechanism of release of celecoxib from the microspheres was diffusion rate-limited...

..The article explores the major differences in between the two systems and highlights the need of using appropriate terminology for these individual and distinct systems catering different needs...

..There was an increase in AUC in optimized HBS capsules of metformin when compared with immediate release formulation...

..These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of aceclofenac...

..The mechanism of drug release was found to be non-Fickian diffusion and followed by first-order kinetics. Thus, BW of N could be an alternative route to bypass the hepatic first-pass metabolism and to improve the bioavailability of N...

..The present study showed that the nanoemulsion being a versatile technology has the potential to improve the biopharmaceutics properties of silymarin...

..The shelf life of the nanoemulsion was found to be 5.94 years at room temperature. The present study established nanoemulsion to be a possible alternative for minimizing variation in bioavailability of ezetimibe...

..05) in inhibition after 24 h compared to CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of CXB...

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..From this study it can be concluded that celecoxib can be formulated into a patch for transdermal delivery. Therefore, celecoxib can be recommended for further pharmacokinetic and pharmacodynamic studies in suitable animal models...

..The results indicate an excellent potential of the nanoemulsion formulation for the reversal of CCl(4)-induced liver toxicity in rats as compared to standard silymarin...

..Overall, these findings indicated that nanoemulsions can be successfully used for the enhancement of skin permeation and bioavailability of poorly soluble drugs...

..In order to appreciate the intellectual potential of these delivery systems, this review summarizes the patents governing various applications of these delivery systems...

..Thus, buccal adhesive tablet of ondansetron could be an alternative route to bypass the hepatic first-pass metabolism and to improve the bioavailability of (OH)...

..The shelf life of the nanoemulsion was estimated to be 18.53 months. The present study corroborated nanoemulsion to be a promising choice to improve the bioavailability of ezetimibe...

..These results suggest that CS-RHT NPs have better brain targeting efficiency and are a promising approach for i.n. delivery of RHT for the treatment and prevention of Alzheimer's disease (AD)...

..The use of multiparticulate dosage forms as a promising system for the oral delivery of many therapeutic agents has also been examined in the current review...

..The status of patents for oral, topical and parenteral delivery has been discussed and the commercialized technology of nanoparticles for medical application has also been compiled...

..This article summarizes various drug delivery technologies for herbal actives, which are gaining more attention for better therapeutic response...

..94 years at room temperature. The present study established nanoemulsion formulation to be one of the possible alternatives to traditional oral formulations of ezetimibe to improve its bioavailability...

..It is guaranteed that oral nanoemulsions can act as a potential tool for the delivery of poorly water-soluble therapeutic moieties in a very efficient manner...

..Furthermore, the different patents highlighting the applications of solid dispersions have also been comprehensively discussed in the present review...

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..The present article provides a good patent review regarding the Site Specific Chronotherapeutic Drug Delivery Systems...

..topical, oral, pulmonary, ocular and parenteral administration and its future perspective as a pharmaceutical carrier...

..2% at the end of 12 h. This indicated the enhancement of solubility of curcumin in aqueous solution which is the rate limiting step in the absorption of curcumin in the intestine...

..The intranasal DLX-NLC demonstrated higher concentration in brain compared with DLX solution. Thus, intranasal DLX-NLC was found to be a promising formulation for the treatment of depression...

..Therefore, a number of nanostructured drug delivery carriers have been developed and explored over the past couple of years to transport the drugs to brain...

..The concept of late has given birth to another field of research worth exploring: multiple-pulse drug delivery...

..It can be considered that NBAS is a superior, novel system that overcomes the drawback associated with the conventional buccal adhesive tablet...

..We provide a detailed analysis of prominent research in the field of curcumin drug delivery with special emphasis on bioavailability-enhancement approaches and novel drug-delivery system approaches...

..These systems are useful to several problems encountered during the development of a pharmaceutical dosage form...

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..The main obstacles derive from the limited absorption area and from the barrier properties of the mucosa that have to be overcome for successful delivery drug molecules to the systemic circulation by this route...

..This manuscript deals with various patented herbal formulations with their therapeutic application against various diseases...

..abstract:..

..have also been reviewed in detail...

..These treatments are subjected for undesired side effects whereas some herbal and natural treatments act against the immune system with no side effects...

..The method proposed was also used to investigate the kinetics of acidic and alkaline degradation processes by quantification of drug at different temperature to calculate the activation energy and half-life for silymarin degradation...

..Clinical use of BD is restricted to some extent due to its poor permeability across the skin. So to increase its permeation across the skin, microemulsion-based gel formulations were prepared and characterised...

..Stimulation of these receptors may be possible with a new non-oral drug delivery system, with the aim of achieving long-lasting and less fluctuating drug levels, minimization of peak levels and thereby reduction of side effects...

..The method was validated for accuracy, repeatability, reproducibility and robustness. Linearity, limit of detection and limit of quantitation were established for atorvastatin and ezetimibe...

..Animal models that have been employed to explore the pathology at the different stages of periodontitis and to evaluate its treatment modalities are enlightened in this proposed review...

..The article provides a review of the patents obtained on herbal remedies for the treatment of periodontal diseases. In addition, it also provides an overall view of potent herbal remedies widely used for periodontal diseases...

..Eugenol has also been used as a penetration enhancer. The compound is a very promising candidate for versatile applications, and the design of new drugs based on the pharmacological effects of eugenol could be beneficial...

..CDs, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes...