Badreldin H Ali

Summary

Publications

  1. ncbi request reprint Motor and behavioral changes in mice with cisplatin-induced acute renal failure
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    Physiol Res 63:35-45. 2014
  2. doi request reprint Some physiological and histological aspects of the gastrointestinal tract in a mouse model of chronic renal failure
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman Electronic address
    J Pharmacol Toxicol Methods 69:162-6. 2014
  3. doi request reprint New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: comparison with rats
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman Electronic address
    J Pharmacol Toxicol Methods 68:384-93. 2013
  4. ncbi request reprint Comparative efficacy of three brands of gum acacia on adenine-induced chronic renal failure in rats
    B H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Physiol Res 62:47-56. 2013
  5. ncbi request reprint Effect of Hibiscus sabdariffa and its anthocyanins on some reproductive aspects in rats
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Nat Prod Commun 7:41-4. 2012
  6. doi request reprint Effect of Acacia gum on blood pressure in rats with adenine-induced chronic renal failure
    Badreldin H Ali
    Department of Pharmacology, Sultan Qaboos University, Al Khod, Oman
    Phytomedicine 18:1176-80. 2011
  7. doi request reprint Ontogenic aspects of cisplatin-induced nephrotoxicity in rats
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, Sultan Qaboos University, P O Box 35, Al Khod, Postal Code 123, Oman
    Food Chem Toxicol 46:3355-9. 2008
  8. ncbi request reprint Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs: a mini-review
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem Branch 81999, Saudi Arabia
    Acta Vet Hung 52:339-47. 2004
  9. ncbi request reprint Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats
    Badreldin H Ali
    Department of Veterinary Medicine, King Saud University, Burydah, Saudi Arabia
    Basic Clin Pharmacol Toxicol 95:20-3. 2004
  10. ncbi request reprint Stress associated with road transportation in desert sheep and goats, and the effect of pretreatment with xylazine or sodium betaine
    B H Ali
    Department of Veterinary Medicine, Al Gaseem University, P O Box 10158, Burydha, Al Gaseem, Saudi Arabia
    Res Vet Sci 80:343-8. 2006

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Motor and behavioral changes in mice with cisplatin-induced acute renal failure
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    Physiol Res 63:35-45. 2014
    ..CP, given at a nephrotoxic dose, induced several adverse motor and behavioral alterations in mice. Further behavioral tests and molecular and biochemical investigations in the brains of mice with CP-induced ARF are warranted. ..
  2. doi request reprint Some physiological and histological aspects of the gastrointestinal tract in a mouse model of chronic renal failure
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman Electronic address
    J Pharmacol Toxicol Methods 69:162-6. 2014
    ..2%, w/w) to mice can be used as a model of CRF. Here, we investigated the possible effects of adenine-induced CRF on several in vivo and in vitro aspects of GIT physiology and histology of the stomach, duodenum, ileum and colon in mice...
  3. doi request reprint New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: comparison with rats
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman Electronic address
    J Pharmacol Toxicol Methods 68:384-93. 2013
    ..This study aimed at comparing the effects of feeding mice and rats with adenine to induce a state of chronic renal failure (CRF), and to assess the effect of treatment with gum acacia (GA) thereon...
  4. ncbi request reprint Comparative efficacy of three brands of gum acacia on adenine-induced chronic renal failure in rats
    B H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Physiol Res 62:47-56. 2013
    ..However, to enable standardization of different brands between laboratories, the use of the chemically well-characterized GA preparation (such as Supergum) is recommended...
  5. ncbi request reprint Effect of Hibiscus sabdariffa and its anthocyanins on some reproductive aspects in rats
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Nat Prod Commun 7:41-4. 2012
    ..These results suggest that H. sabdariffa exerts no adverse effect on the male reproductive system. Consumption of H. sabdariffa aqueous extract inhibited the growth of the rats compared with the controls...
  6. doi request reprint Effect of Acacia gum on blood pressure in rats with adenine-induced chronic renal failure
    Badreldin H Ali
    Department of Pharmacology, Sultan Qaboos University, Al Khod, Oman
    Phytomedicine 18:1176-80. 2011
    ..In conclusion, adenine-induced CRF in rats significantly increased BP, and this was significantly mitigated by administration of AG. Possible mechanisms of these changes and the protective effect of AG will be investigated...
  7. doi request reprint Ontogenic aspects of cisplatin-induced nephrotoxicity in rats
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, Sultan Qaboos University, P O Box 35, Al Khod, Postal Code 123, Oman
    Food Chem Toxicol 46:3355-9. 2008
    ..This study showed that the vulnerability profile of each age group was different, suggesting that a multi-age pediatric/geriatric animal model is appropriate to assess, more completely, age-dependent changes in drug toxicity...
  8. ncbi request reprint Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs: a mini-review
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem Branch 81999, Saudi Arabia
    Acta Vet Hung 52:339-47. 2004
    ..Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times...
  9. ncbi request reprint Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats
    Badreldin H Ali
    Department of Veterinary Medicine, King Saud University, Burydah, Saudi Arabia
    Basic Clin Pharmacol Toxicol 95:20-3. 2004
    ..The present results indicate that spironolactone aggravates gentamicin-induced nephrotoxicity in the rat...
  10. ncbi request reprint Stress associated with road transportation in desert sheep and goats, and the effect of pretreatment with xylazine or sodium betaine
    B H Ali
    Department of Veterinary Medicine, Al Gaseem University, P O Box 10158, Burydha, Al Gaseem, Saudi Arabia
    Res Vet Sci 80:343-8. 2006
    ..01 mg/kg by the intravenous route significantly ameliorated the effects induced by the stressful stimulus. The effects of pretreatment of the two species with sodium betaine (10 mg/kg) produced variable and insignificant effects...
  11. ncbi request reprint Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, P O Box 35, Al Khod, Muscat 123, Oman
    Food Chem Toxicol 44:1173-83. 2006
    ..Those agents that have been shown to augment cisplatin nephrotoxicity include nitric oxide synthase inhibitors, spironolactone, gemcitabine and others. Combining these agents with cisplatin should be avoided...
  12. ncbi request reprint Tissue and intracellular distribution of rhodanese and mercaptopyruvate sulphurtransferase in ruminants and birds
    A A Al-Qarawi
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Vet Res 32:63-70. 2001
    ..The enzyme activity was equally distributed between the mitochondrial and cytosolic fractions in the liver and kidneys of camels, cattle and sheep...
  13. ncbi request reprint Hormonal replacement therapy in an animal model with chronic renal failure and gonadectomy: biochemical and hematological study
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman
    Ren Fail 28:331-5. 2006
    ..All these signs were significantly and partially reversed by estradiol and testosterone therapy equally in female and male rats, respectively...
  14. ncbi request reprint The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, Sultan Qaboos University, PO Box 35, Al Khod 123, Oman
    Fundam Clin Pharmacol 21:547-53. 2007
    ..The results suggested that OTC had ameliorated the histopathological and biochemical indices of nephrotoxicity in rats. Pending further pharmacological and toxicological studies, OTC may potentially be useful as a nephroprotective agent...
  15. ncbi request reprint Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Oman
    Food Chem Toxicol 46:409-20. 2008
    ..More studies are required in animals and humans on the kinetics of ginger and its constituents and on the effects of their consumption over a long period of time...
  16. doi request reprint Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literature
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, Sultanate of Oman
    Basic Clin Pharmacol Toxicol 106:272-9. 2010
    ..None of these drugs have been proven to be effective in large, controlled, clinical trials...
  17. doi request reprint Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Al Khod, Postal Code 123, Oman
    Exp Biol Med (Maywood) 233:891-6. 2008
    ..Pending further pharmacological and toxicological studies, TMP may potentially be useful as a nephroprotective agent...
  18. doi request reprint Biological effects of gum arabic: a review of some recent research
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Oman
    Food Chem Toxicol 47:1-8. 2009
    ..GA has been shown to have an adverse effect on electrolyte balance and vitamin D in mice, and to cause hypersensitivity in humans. More studies are needed before the pharmacological properties of GA can be utilized in therapy...
  19. ncbi request reprint The effect of Nigella sativa oil on gentamicin nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem Branch, Saudi Arabia
    Am J Chin Med 32:49-55. 2004
    ..The results suggest that N. sativa may be useful in ameliorating signs of GM nephrotoxicity in rats, and pending further experimentation to determine safety and efficacy, may be useful clinically...
  20. ncbi request reprint Does treatment with gum Arabic affect experimental chronic renal failure in rats?
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Buryadah, Saudi Arabia
    Fundam Clin Pharmacol 18:327-9. 2004
    ..Treatment with gum Arabic at the two doses did not significantly reverse the decrease in body weight in CRF rats...
  21. ncbi request reprint Tyrosine ameliorates some of the clinical, biochemical and haematological effects of acute stress associated with transportation of desert sheep
    B H Ali
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Al Gaseem, Saudi Arabia
    Vet Res Commun 25:503-10. 2001
    ..Pretreatment of sheep with tyrosine at a dose of 100 mg/kg by the intravenous route significantly ameliorated the stress-induced clinical, biochemical and haematological changes. The treatment caused no overt adverse effects...
  22. ncbi request reprint Effect of the traditional medicinal plants Rhazya stricta, Balanitis aegyptiaca and Haplophylum tuberculatum on paracetamol-induced hepatotoxicity in mice
    B H Ali
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Phytother Res 15:598-603. 2001
    ..stricta or silymarin protected about 57% and 92% of the treated mice, respectively, against the lethal effect of paracetamol (1 g/kg). B. aegyptiaca and H. tuberculatum protected only 27% and 16% of the animals, respectively...
  23. ncbi request reprint Effect of grapefruit juice on plasma chloroquine kinetics in mice
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Clin Exp Pharmacol Physiol 29:704-6. 2002
    ..The clinical significance of this interaction in patients with malaria needs to be investigated...
  24. ncbi request reprint The effect of treatment with the medicinal plant Rhazya stricta decne on gentamicin nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Buraydah, Saudi Arabia
    Phytomedicine 9:385-9. 2002
    ..These results suggest that R. stricta water extract may contain compounds that could potentially ameliorate GM nephrotoxicity in rats...
  25. ncbi request reprint The effect of calcium load and the calcium channel blocker verapamil on gentamicin nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Buraydah, Saudi Arabia
    Food Chem Toxicol 40:1843-7. 2002
    ..This dose also exacerbated the GM-induced histological necrosis. The above interactions may be clinically relevant in patients treated concurrently with these agents...
  26. ncbi request reprint The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats
    B H Ali
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Al Gaseem, Saudi Arabia
    Phytother Res 17:56-9. 2003
    ..Lower does were ineffective. Pending more evaluation for safety and efficacy, the HAs can potentially be used in mitigating paracetamol-induced hepatotoxicity...
  27. ncbi request reprint The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Saudi Arabia
    Ren Fail 25:15-20. 2003
    ..Further work is warranted on the effect of the treatments on renal functional aspects in models of chronic renal failure, and on the mechanism(s) involved...
  28. doi request reprint Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity
    B H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    J Appl Toxicol 29:302-7. 2009
    ..The mechanism by which NAC and, to a lesser extent TMP, protected against GM-induced nephrotoxicity may be related, at least in part, to the decrease in oxidative stress in renal cortex...
  29. ncbi request reprint Does gum Arabic have an antioxidant action in rat kidney?
    B H Ali
    Department of Veterinary Medicine, King Saudi University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Ren Fail 26:1-3. 2004
    ..It seems highly unlikely that gum Arabic has a palliative effect on renal failure through an antioxidant mechanism...
  30. ncbi request reprint Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Buraydah, Saudi Arabia
    Vet Res Commun 27:475-83. 2003
    ..Plasma enzyme activities and metabolites indicative of hepatic and renal functions measured 1, 2, 4 and 7 days following the drug treatment were within the normal range, indicating that the drug is safe at the dose used...
  31. ncbi request reprint Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research
    B H Ali
    Department of Veterinary Medicine, King Saud University, PO Box 10158 Buraydah, Al Gaseem 81999, Saudi Arabia
    Food Chem Toxicol 41:1447-52. 2003
    ..g. garlic). Other ameliorating agents include antibiotics (e.g. ceftriaxone), antiplatelet drugs (e.g. trapidil) and Ca++ agents that may augment GM nephrotoxicity include cyclosporin and the Ca++-channel blocker verapamil...
  32. doi request reprint Abrogation of cisplatin-induced nephrotoxicity by emodin in rats
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod, Oman
    Fundam Clin Pharmacol 27:192-200. 2013
    ..The results suggested that emodin had ameliorated CP nephrotoxicity in rats. Pending further pharmacological and toxicological studies emodin may be considered a potentially useful nephroprotective agent...
  33. doi request reprint Long-term ingestion of Hibiscus sabdariffa calyx extract enhances myocardial capillarization in the spontaneously hypertensive rat
    Ibrahim Inuwa
    Department of Human Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Al Khod, Muscat 123, Oman
    Exp Biol Med (Maywood) 237:563-9. 2012
    ..It is proposed that these effects might be beneficial in restoring myocyte normal nutritional status compromised by the hypertrophic state of hypertension...
  34. doi request reprint The effect of sildenafil on cisplatin nephrotoxicity in rats
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Sultanate of Oman
    Basic Clin Pharmacol Toxicol 109:300-8. 2011
    ..However, sildenafil (10 mg/kg/day, s.c. for 5 days) did not affect CP nephrotoxicity, suggesting the importance of dose and route selection of sildenafil as a nephroprotectant...
  35. doi request reprint Effects of Gum Arabic in rats with adenine-induced chronic renal failure
    Badreldin H Ali
    Department of Pharmacology, Sultan Qaboos University, Al Khod, Sultanate of Oman
    Exp Biol Med (Maywood) 235:373-82. 2010
    ..The mechanism(s) of this nephroprotection is uncertain but may involve anti-oxidant and/or anti-inflammatory actions...
  36. doi request reprint Effect of curcumin on cisplatin- and oxaliplatin-induced oxidative stress in human embryonic kidney (HEK) 293 cells
    Mostafa I Waly
    Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman
    Ren Fail 33:518-23. 2011
    ..Our findings provide evidence that curcumin significantly ameliorates oxidative stress induced by both cisplatin and oxaliplatin in HEK cells...
  37. ncbi request reprint Effect of dimethyl sulfoxide on gentamicin-induced nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Hum Exp Toxicol 20:199-203. 2001
    ..However, the efficacy and safety of DMSO require further studies. It is suggested that DMSO has potential protective effect against GM nephrotoxicity in rats...
  38. doi request reprint Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells
    Mostafa I Waly
    Department of Food Sciences and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman
    J Appl Toxicol 33:626-30. 2013
    ..These results suggest that emodin has the potential to be used as an adjunct therapeutic agent in patients receiving cisplatin treatment...
  39. doi request reprint Interaction of nimesulide, a cyclooxygenase-2 inhibitor, with cisplatin in normotensive and spontaneously hypertensive rats
    Yousuf M Al Suleimani
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Food Chem Toxicol 48:139-44. 2010
    ..However, nimesulide aggravated CP-induced renal tissue damage in SHRs, but not in WKY rats. The results show that administration nimesulide augmented the histopathological indices of nephrotoxicity in SHRs, but not in WKY rats...
  40. doi request reprint Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Basic Clin Pharmacol Toxicol 109:225-32. 2011
    ..Most of the nephroprotective agents mentioned here have not been tested in large controlled clinical trials. Because of their relative safety and effectiveness, antioxidant agents seem to be good candidates for testing in humans...
  41. pmc The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies
    Mansour S Al Moundhri
    Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Med Toxicol 9:25-33. 2013
    ..Larger experiments using a wider dose range of oxaliplatin, cisplatin, and curcumin are required to fully elucidate the possible protective role of curcumin in platinum-induced neurotoxicity...
  42. doi request reprint Motor and behavioral changes in rats with adenine-induced chronic renal failure: influence of acacia gum treatment
    Badreldin H Ali
    Department of Pharmacology, Sultan Qaboos University, Al Khod, Oman
    Exp Biol Med (Maywood) 236:107-12. 2011
    ..The results of the tests for neuromuscular coordination were inconclusive. In conclusion, adenine-induced CRF caused motor and behavioral alterations, and these were significantly mitigated by administration of AG...
  43. pmc Effect of gum arabic on oxidative stress and inflammation in adenine-induced chronic renal failure in rats
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Muscat, Sultanate of Oman
    PLoS ONE 8:e55242. 2013
    ..Treatment with GA significantly ameliorated these actions. The mechanism of the reported salutary effect of GA in adenine-induced CRF is associated with mitigation of the adenine-induced inflammation and generation of free radicals...
  44. doi request reprint N-acetylcysteine improves renal hemodynamics in rats with cisplatin-induced nephrotoxicity
    Aly M Abdelrahman
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Muscat 123, Sultanate of Oman
    J Appl Toxicol 30:15-21. 2010
    ..The results show that administration of i.p. NAC (500 mg kg(-1) per day for 9 days) reversed the renal hemodynamic changes as well as the biochemical and histopathological indices of CP-induced nephrotoxicity in WKY rats...
  45. ncbi request reprint Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review
    Badreldin H Ali
    Department of Veterinary Medicine, Al Gaseem University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 19:369-75. 2005
    ..sabdariffa and compounds isolated from it (for example, anthocyanins and Hibiscus protocatechuic acid) could be a source of therapeutically useful products...
  46. doi request reprint The effect of activated charcoal on adenine-induced chronic renal failure in rats
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman
    Food Chem Toxicol 65:321-8. 2014
    ..The results suggest that charcoal is a useful sorbent agent in dietary adenine-induced CRF in rats and that its usability as a nephroprotective agent in human kidney disease should be studied. ..
  47. ncbi request reprint Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Sultanate of Oman
    Am J Physiol Lung Cell Mol Physiol 292:L664-70. 2007
    ..We conclude that the presence of DEP in the systemic circulation leads not only to cardiovascular and haemostatic changes but it also triggers pulmonary inflammation...
  48. ncbi request reprint Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
    H A Elsheikh
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    J Vet Med A Physiol Pathol Clin Med 48:581-6. 2001
    ..5 +/- 8.6 and 122.3 +/- 6.7 min in goats and camels, respectively. The mean bioavailability (T) in both goats and camels was 0.9 +/- 0.2. The above data suggest that camels eliminate theophylline at a slower rate than goats...
  49. ncbi request reprint Pharmacological and toxicological properties of Nigella sativa
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 17:299-305. 2003
    ..It would appear that the beneficial effects of the use of the seeds and thymoquinone might be related to their cytoprotective and antioxidant actions, and to their effect on some mediators of inflammation...
  50. ncbi request reprint Isolation stress in desert sheep and goats and the influence of pretreatment with xylazine or sodium betaine
    A A Al-Qarawi
    Department of Veterinary Medicine, King Saud University, PO Box 10158, Buryadah, Al Gaseem, Saudi Arabia
    Vet Res Commun 29:81-90. 2005
    ..There were no significant differences between sheep and goats in the responses to the isolation stress, except in vocalization, which was greater in sheep than in goats...
  51. ncbi request reprint Variations in the normal activity of esterases in plasma and liver of camels (Camelus dromedarius), cattle (Bos indicus), sheep (Ovis aries) and goats (Capra hircus)
    A A Al-Qarawi
    Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    J Vet Med A Physiol Pathol Clin Med 50:201-3. 2003
    ..Gender had no statistically significant effect, although males exhibited about 5-8% more enzyme activity in each of the four species, than females...
  52. ncbi request reprint Antioxidant levels in tissues of young and adult camels (Camelus dromedarius)
    H M Mousa
    Department of Food Science and Human Nutrition, Gassim University, P O Box 1482, Buraydah, Al Gassim 81999, Saudi Arabia
    J Physiol Biochem 62:213-8. 2006
    ..The liver has the highest contents of antioxidants and antioxidant enzymes indicating that it plays an important role in pro-oxidants detoxification. Age has a variable effect on the antioxidant system in camels...
  53. ncbi request reprint Effect of lead exposure on the erythrocytic antioxidant levels in goats
    H M Mousa
    Department of Veterinary Medicine, College of Agriculture and Veterinary, King Saud University, Al Qaseem, Saudi Arabia
    J Vet Med A Physiol Pathol Clin Med 49:531-4. 2002
    ..Lipid peroxide level increased significantly (P < 0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity...
  54. doi request reprint Interaction of diesel exhaust particles with human, rat and mouse erythrocytes in vitro
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Cell Physiol Biochem 29:163-70. 2012
    ..Human erythrocytes showed the highest resistance to the observed effects. These species difference should be noted when using rats and mice blood as models for humans...
  55. ncbi request reprint A short review of some pharmacological, therapeutic and toxicological properties of praziquantel in man and animals
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, P O Box 35, Al Khod, Postal Code 123, Sultanate of Oman
    Pak J Pharm Sci 19:170-5. 2006
    ....
  56. ncbi request reprint Comparative pharmacokinetics of salicylate in camels, sheep and goats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Al Gaseem Branch, Buraydah, Saudi Arabia
    Eur J Drug Metab Pharmacokinet 28:125-8. 2003
    ..The drug bioavailability (F) in camels, sheep and goats were 71.3, 78.4 and 79.4% respectively. These findings suggest that the rate of absorption and elimination of the salicylate is slower in camels than in sheep and goats...
  57. ncbi request reprint Gastrointestinal transit in mice treated with various extracts of date (Phoenix dactylifera L.)
    A A Al-Qarawi
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Saudi Arabia
    Food Chem Toxicol 41:37-9. 2003
    ..Clonidine exerted a significant decrease (68%), and yohimbine a significant increase (30%) in the GIT. Depending on the method of extraction, the date extracts may exert an increase or a decrease in GIT...
  58. ncbi request reprint Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, Al Gaseem University, Burydah, Saudi Arabia
    Fundam Clin Pharmacol 19:473-7. 2005
    ..The results suggested that curcumin had ameliorated the histopathological and biochemical indices of nephrotoxicity in rats. Pending further studies, curcumin may potentially be useful as a nephroprotectant agent...
  59. doi request reprint Acute effects of diesel exhaust particles and cisplatin on oxidative stress in cultured human kidney (HEK 293) cells, and the influence of curcumin thereon
    Mostafa I Waly
    Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, P O Box 35 Al Khod, Oman
    Toxicol In Vitro 27:2299-304. 2013
    ..These findings suggest that DEP augmented the CP-induced toxicity in HEK-293 cells. Curcumin exhibited a strong potential for protection against DEP and CP-induced cytotoxicity. ..
  60. ncbi request reprint The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats
    A A Al-Qarawi
    Department of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine, King Saud University, Al Gaseem Branch, P O 10158, Buraydah, Al Gaseem 81999, Saudi Arabia
    J Ethnopharmacol 98:313-7. 2005
    ..The ethanolic undialyzed extract was more effective than the rest of the other extracts used. It is postulated that the basis of the gastroprotective action of date extracts may be multi-factorial, and may include an anti-oxidant action...
  61. doi request reprint The acute proinflammatory and prothrombotic effects of pulmonary exposure to rutile TiO2 nanorods in rats
    Abderrahim Nemmar
    Faculty of Medicine and Health Sciences, Department of Physiology, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Biol Med (Maywood) 233:610-9. 2008
    ..Rutile TiO2 nanorods also triggered platelet aggregation in vivo and in vitro...