Jessica Alföldi

Summary

The genome of the green anole lizard and a comparative analysis with birds and mammals
Jessica Alföldi
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nature 477:587-91. 2011
A high-resolution map of human evolutionary constraint using 29 mammals
Kerstin Lindblad-Toh
Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 478:476-82. 2011
Genome-wide synteny through highly sensitive sequence alignment: Satsuma
Manfred G Grabherr
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
Bioinformatics 26:1145-51. 2010

The genome of the green anole lizard and a comparative analysis with birds and mammals
Jessica Alföldi
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nature 477:587-91. 2011
..Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations...
A high-resolution map of human evolutionary constraint using 29 mammals
Kerstin Lindblad-Toh
Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 478:476-82. 2011
..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
Genome-wide synteny through highly sensitive sequence alignment: Satsuma
Manfred G Grabherr
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
Bioinformatics 26:1145-51. 2010
..From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes)...