Jessica Alföldi

Summary

Publications

  1. pmc Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
    Walter L Eckalbar
    School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287 4501, USA
    BMC Genomics 14:49. 2013
  2. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
  3. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
  4. pmc Genome-wide synteny through highly sensitive sequence alignment: Satsuma
    Manfred G Grabherr
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioinformatics 26:1145-51. 2010
  5. pmc Comparative genomics as a tool to understand evolution and disease
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 23:1063-8. 2013

Detail Information

Publications5

  1. pmc Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
    Walter L Eckalbar
    School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287 4501, USA
    BMC Genomics 14:49. 2013
    ..A second generation annotation based on tissue-specific transcriptomes would provide a valuable resource for molecular studies...
  2. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
    ..Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations...
  3. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  4. pmc Genome-wide synteny through highly sensitive sequence alignment: Satsuma
    Manfred G Grabherr
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioinformatics 26:1145-51. 2010
    ..From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes)...
  5. pmc Comparative genomics as a tool to understand evolution and disease
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 23:1063-8. 2013
    ..Furthermore, we anticipate discoveries related to evolutionary mechanisms, adaptation, and disease to quickly accelerate in the coming years. ..