Jessica Alföldi

Summary

Publications

  1. pmc Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
    Walter L Eckalbar
    School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287 4501, USA
    BMC Genomics 14:49. 2013
  2. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
  3. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
  4. ncbi request reprint Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes
    Y Q Shirleen Soh
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 159:800-13. 2014
  5. pmc Genome-wide synteny through highly sensitive sequence alignment: Satsuma
    Manfred G Grabherr
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioinformatics 26:1145-51. 2010
  6. pmc Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
    Daniel W Bellott
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 508:494-9. 2014
  7. ncbi request reprint The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations
    Michael Keane
    Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Department of Biology, University of Rochester, NY, USA, Vertebrate and Health Genomics, The Genome Analysis Center, Norwich, UK, Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden and Department of Genetics, Harvard Medical School, Boston, MA, USA
    Bioinformatics 30:3558-60. 2014
  8. pmc Comparative genomics as a tool to understand evolution and disease
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 23:1063-8. 2013

Detail Information

Publications8

  1. pmc Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
    Walter L Eckalbar
    School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287 4501, USA
    BMC Genomics 14:49. 2013
    ..A second generation annotation based on tissue-specific transcriptomes would provide a valuable resource for molecular studies...
  2. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
    ..Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations...
  3. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  4. ncbi request reprint Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes
    Y Q Shirleen Soh
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 159:800-13. 2014
    ..The mouse MSY sequence presents opportunities for experimental studies of a sex-specific chromosome in its entirety, in a genetically tractable model organism. ..
  5. pmc Genome-wide synteny through highly sensitive sequence alignment: Satsuma
    Manfred G Grabherr
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioinformatics 26:1145-51. 2010
    ..From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes)...
  6. pmc Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
    Daniel W Bellott
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 508:494-9. 2014
    ....
  7. ncbi request reprint The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations
    Michael Keane
    Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Department of Biology, University of Rochester, NY, USA, Vertebrate and Health Genomics, The Genome Analysis Center, Norwich, UK, Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden and Department of Genetics, Harvard Medical School, Boston, MA, USA
    Bioinformatics 30:3558-60. 2014
    ..Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher N50 values for scaffolds and contigs...
  8. pmc Comparative genomics as a tool to understand evolution and disease
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 23:1063-8. 2013
    ..Furthermore, we anticipate discoveries related to evolutionary mechanisms, adaptation, and disease to quickly accelerate in the coming years. ..