TOM ALBERT

Summary

Publications

  1. ncbi request reprint Microarray-based genomic selection for high-throughput resequencing
    David T Okou
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia 30322, USA
    Nat Methods 4:907-9. 2007
  2. pmc Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays
    Petra Matejkov√°
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
    BMC Microbiol 8:76. 2008
  3. pmc Light-directed 5'-->3' synthesis of complex oligonucleotide microarrays
    Thomas J Albert
    NimbleGen Systems Inc, One Science Court, Madison, WI 53711, USA
    Nucleic Acids Res 31:e35. 2003
  4. ncbi request reprint Direct selection of human genomic loci by microarray hybridization
    Thomas J Albert
    NimbleGen Systems Inc, 1 Science Court, Madison, Wisconsin 53711, USA
    Nat Methods 4:903-5. 2007
  5. ncbi request reprint Mutation discovery in bacterial genomes: metronidazole resistance in Helicobacter pylori
    Thomas J Albert
    NimbleGen Systems Inc, One Science Court, Madison, Wisconsin 53711, USA
    Nat Methods 2:951-3. 2005
  6. ncbi request reprint Interrogating genomic diversity of E. coli O157:H7 using DNA tiling arrays
    Scott A Jackson
    Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, MD 20708, USA
    Forensic Sci Int 168:183-99. 2007
  7. ncbi request reprint Genome-wide in situ exon capture for selective resequencing
    Emily Hodges
    Howard Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Genet 39:1522-7. 2007
  8. pmc Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
    Ujjini H Manjunatha
    Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook II, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:431-6. 2006
  9. ncbi request reprint Nucleotide sequence changes between Streptococcus pneumoniae R6 and D39 strains determined by an oligonucleotide hybridization DNA sequencing technology
    Suzanne P Williams
    Translational Biomarkers and DNA Sequencing, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, United States
    J Microbiol Methods 70:65-74. 2007
  10. pmc SNP-specific array-based allele-specific expression analysis
    Hans T Bjornsson
    Department of Medicine and Center for Epigenetics, Institute of Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 18:771-9. 2008

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Microarray-based genomic selection for high-throughput resequencing
    David T Okou
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia 30322, USA
    Nat Methods 4:907-9. 2007
    ..MGS, when combined with a next-generation resequencing technology, can enable large-scale resequencing in single-investigator laboratories...
  2. pmc Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays
    Petra Matejkov√°
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
    BMC Microbiol 8:76. 2008
    ..pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood. Increasing rates of new syphilis cases per year have been observed recently...
  3. pmc Light-directed 5'-->3' synthesis of complex oligonucleotide microarrays
    Thomas J Albert
    NimbleGen Systems Inc, One Science Court, Madison, WI 53711, USA
    Nucleic Acids Res 31:e35. 2003
    ..998). We have also shown that the 3' ends of array probes are available for sequence-specific primer extension and ligation reactions...
  4. ncbi request reprint Direct selection of human genomic loci by microarray hybridization
    Thomas J Albert
    NimbleGen Systems Inc, 1 Science Court, Madison, Wisconsin 53711, USA
    Nat Methods 4:903-5. 2007
    ..These direct selection methods supersede multiplex PCR for the large-scale analysis of genomic regions...
  5. ncbi request reprint Mutation discovery in bacterial genomes: metronidazole resistance in Helicobacter pylori
    Thomas J Albert
    NimbleGen Systems Inc, One Science Court, Madison, Wisconsin 53711, USA
    Nat Methods 2:951-3. 2005
    ..We conclude that CGS identifies mutations in bacterial genomes efficiently, should enrich understanding of systems biology and genome evolution, and help track pathogens during outbreaks...
  6. ncbi request reprint Interrogating genomic diversity of E. coli O157:H7 using DNA tiling arrays
    Scott A Jackson
    Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, MD 20708, USA
    Forensic Sci Int 168:183-99. 2007
    ..coli O157:H7. The tiling DNA microarray system would be useful for the tracking and identification of individual strains of E. coli O157:H7 needed for forensic investigations...
  7. ncbi request reprint Genome-wide in situ exon capture for selective resequencing
    Emily Hodges
    Howard Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Genet 39:1522-7. 2007
    ..This methodology provides an adaptable route toward rapid and efficient resequencing of any sizeable, non-repeat portion of the human genome...
  8. pmc Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
    Ujjini H Manjunatha
    Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook II, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:431-6. 2006
    ..These results suggest that the sensitivity of Mtb to PA-824 and related compounds is mediated by a protein that is highly specific for subtle structural variations in these bicyclic nitroimidazoles...
  9. ncbi request reprint Nucleotide sequence changes between Streptococcus pneumoniae R6 and D39 strains determined by an oligonucleotide hybridization DNA sequencing technology
    Suzanne P Williams
    Translational Biomarkers and DNA Sequencing, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, United States
    J Microbiol Methods 70:65-74. 2007
    ..We also discuss the potential impact of some of the amino acid changes found between these two widely used strains of pneumococci...
  10. pmc SNP-specific array-based allele-specific expression analysis
    Hans T Bjornsson
    Department of Medicine and Center for Epigenetics, Institute of Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 18:771-9. 2008
    ..The approach is scalable to the whole genome and can be used for discovery of functional epigenetic modifications in patient samples...
  11. pmc The UBX-regulated network in the haltere imaginal disc of D. melanogaster
    Bradley M Hersh
    Howard Hughes Medical Institute and University of Wisconsin Madison, 1525 Linden Drive, Madison, WI 53703, USA
    Dev Biol 302:717-27. 2007
    ..The evolution of haltere morphology involved changes in UBX-regulated target genes, both positive and negative, throughout the wing genetic regulatory network...
  12. ncbi request reprint Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale
    Christopher D Herring
    Department of Bioengineering, University of California, San Diego, California 92093, USA
    Nat Genet 38:1406-12. 2006
    ..The success of this new genome-scale approach indicates that real-time evolution studies will now be practical in a wide variety of contexts...
  13. pmc Probing genomic diversity and evolution of Escherichia coli O157 by single nucleotide polymorphisms
    Wei Zhang
    Foodborne and Diarrheal Diseases Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genome Res 16:757-67. 2006
    ..Functional characterization of nucleotide polymorphisms should shed new insights on the evolution, epidemiology, and pathogenesis of STEC O157 and related pathogens...
  14. pmc Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays
    Christopher W Wong
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Genome Res 14:398-405. 2004
    ....
  15. pmc Gene expression analysis using oligonucleotide arrays produced by maskless photolithography
    Emile F Nuwaysir
    NimbleGen Systems, Inc, Madison, Wisconsin 53711, USA
    Genome Res 12:1749-55. 2002
    ..Custom gene expression arrays were manufactured and hybridized to Drosophila melanogaster and mouse samples. Quantitative PCR was used to validate the gene expression data from the mouse arrays...

Research Grants3

  1. Development of a genotyping assay using MAS technology
    Thomas Albert; Fiscal Year: 2002
    ..This system will have very high throughput, a low cost per SNP, and have accuracy >99 percent. ..
  2. DNA Array-Based Exon Detection and Linkage Mapping
    TOM ALBERT; Fiscal Year: 2005
    ....
  3. Large-Scale Selection of Genomic Loci
    Thomas Albert; Fiscal Year: 2007
    ..This proposal, if successful, would revolutionize or ability to discover and track these mutations. ..