Development of square-wave adsorptive stripping voltammetric method for determination of acebutolol in pharmaceutical formulations and biological fluidsAli F Al-Ghamdi
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P, O, Box 2457, Riyadh 11451, Saudi Arabia
Chem Cent J 6:15. 2012
..6 ± 0.64%. Results of the developed square-wave adsorptive stripping voltammetry (SW-AdSV) method were comparable with those obtained by reference analytical method...
A direct HPLC method for the resolution and quantitation of the R-(-)- and S-(+)-enantiomers of vigabatrin (gamma-vinyl-GABA) in pharmaceutical dosage forms using teicoplanin aglycone chiral stationary phaseAbdulrahman A Al-Majed
Department of Pharmaceutical Chemistry, King Saud University, Riyadh, Saudi Arabia
J Pharm Biomed Anal 50:96-9. 2009
..3-99.8% with %RSD ranged from 0.48 to 0.52%. The limit of quantification (LOQ) and limit of detection (LOD) for each enantiomer were 100 and 25microg/ml, respectively. No interferences were found from commonly co-formulated excipients...
Spectrophotometric estimation of D-penicillamine in bulk and dosage forms using 2,6-dichloroquinone-4-chlorimide (DCQ)A A Al-Majed
King Saud University, College of Pharmacy, Pharmaceutical Chemistry Department, Riyadh, Saudi Arabia
J Pharm Biomed Anal 21:827-33. 1999
..57%. The results obtained were sufficiently accurate, reproducible and in accordance with those given by the official method. The method is specific for the intact drug, and can be adopted in the presence of some interfering substances...
- Voltammetric determination of parthenolide in spiked human plasma and urine
F Belal
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 2457, PO Box 11451, Saudi Arabia
Phytochem Anal 12:250-4. 2001
..The described analytical method was applied to the determination of parthenolide in spiked human urine and plasma; the percentage recoveries were 95.72 +/- 0.22 and 94.0 +/- 0.13 (+/- standard deviation; n = 9), respectively...
- Use of 7-fluoro-4-nitrobenzo-2-oxo-1,3-diazole (NBD-F) for the determination of ramipril in tablets and spiked human plasma
A A Al-Majed
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Farmaco 56:291-6. 2001
..08+/-1.11%. The results obtained are in good agreement with those obtained by the reference method. No interference could be observed from the co-administered drug (hydrochlorothiazines)...
- Use of mixed anhydrides for the determination of terfenadine in dosage forms and spiked human plasma
A A Al-Majed
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
J Pharm Biomed Anal 23:281-9. 2000
..The percentage recovery was 99.35 +/- 2.19. The method is highly sensitive and specific. No interference was noticed from co-formulated drugs, such as pseudoephedrine and ibuprofen...
- Kinetic spectrophotometric determination of josamycin in formulations and spiked human plasma using 3-methylbenzothiazolin-2-one hydrazone/Fe+3 system
Abdulrahman A Al-Majed
King Saud University, Department of Pharmaceutical Chemistry, College of Pharmacy, PO Box 2457, Riyadh-11451, Saudi Arabia
J AOAC Int 87:352-9. 2004
..The recovery (n = 8) was 100.76 +/- 3.43%. The stoichiometry of the reaction between the drug and the reagent was studied by adopting the limiting logarithmic method, and a proposal of the reaction pathway was presented...
- New nonextractive and highly sensitive high-performance liquid chromatographic method for determination of paroxetine in plasma after offline precolumn derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
Ibrahim A Darwish
King Saud University, College of Pharmacy, Department of Pharmaceutical Chemistry, PO Box 2457, Riyadh 11451, Saudi Arabia
J AOAC Int 92:1349-55. 2009
..The results demonstrated that the method would have a great value when it is applied in the therapeutic monitoring of PXT...
- Kinetic spectrophotometric determination of the macrolide antibiotic josamycin in formulations
Abdulrahman A Al-Majed
King Saud University, College of Pharmacy, Department of Pharmaceutical Chemistry, PO Box 2457, Riyadh, Saudi Arabia
J AOAC Int 86:484-9. 2003
..The effect of sensitizers and surfactants on the performance of the proposed method was also studied. A proposal of the reaction pathway was presented...
- Spectrofluorometric determination of nimodipine in dosage forms and human urine
F Belal
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Pharmazie 58:874-6. 2003
..The method was further extended to the in vitro determination of NDP in spiked human urine samples. The % recovery was 102.1 +/- 2.54 (n = 4). A proposal of the reduction reaction pathway was postulated...
