Necrotizing fasciitis caused by Pseudomonas aeruginosaMorikazu Akamine
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, University of the Ryukyus, Okinawa
Intern Med 47:553-6. 2008
..aeruginosa. This is a rare case and its clinical presentation was atypical. The clinical diagnosis of this infection may be difficult, and therefore such cases warrant the careful attention of physicians...
Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cellsHiromitsu Teruya
Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
BMC Microbiol 7:102. 2007
..We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines...
Legionella pneumonia caused by Legionella pneumophila serogroup 2: second case report in JapanMakoto Furugen
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
J Infect Chemother 14:161-5. 2008
..This was considered to be the causative organism. In our literature search, this was only the second case of Legionella pneumonia caused by Legionella pneumophila serogroup 2 in Japan...
- Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone
Makoto Furugen
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara Town, Okinawa 903 0215, Japan
Respir Res 9:39. 2008
..In this study, we investigated the precise mechanism by which A549 alveolar epithelial cells induced by L. pneumophila undergo apoptosis. We also studied the effect of methyl prednisolone on apoptosis in these cells...
- Detection of Legionella pneumophila serogroup 1 antigen in respiratory samples using an immunochromatographic membrane test
Futoshi Higa
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, University of the Ryukyus, Okinawa 903 0215, Japan
J Microbiol Methods 74:121-2. 2008
..The ICT results using respiratory samples agreed well with isolation of L. pneumophila SG1 and ICT using urines...
- Hepatocyte growth factor levels in Legionella pneumonia: a retrospective study
Futoshi Higa
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
BMC Infect Dis 11:74. 2011
..Legionella pneumonia is sometimes complicated by acute lung injury. Our study aimed to determine the role of serum HGF levels in Legionella pneumonia...
- Intravenous ciprofloxacin versus erythromycin in the treatment of Legionella pneumonia
Shusaku Haranaga
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
Intern Med 46:353-7. 2007
..In this study, we compared the evolution of patients with Legionella pneumonia treated with CPFX to those treated with EM...
- [A-DROP system might result in underestimation of severity of cases with Legionnaires' disease]
Shusaku Haranaga
Department of Medicine and Therapeutics, Control and Prevention of Infectious Disease First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Nihon Kokyuki Gakkai Zasshi 46:351-5. 2008
..However all the fatal cases were ranked as severe in the IDSA guidelines. This study suggested that the A-DROP system might underestimate the severity of pneumonia in cases with legionella pneumonia...
- Interferon-gamma reverses the evasion of Birc1e/Naip5 gene mediated murine macrophage immunity by Legionella pneumophila mutant lacking flagellin
Morikazu Akamine
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Microbiol Immunol 51:279-87. 2007
..These findings suggested that IFN-gamma activated macrophages to restrict the intracellular growth of the L. pneumophila flaA mutant by a NO independent pathway...
- In vitro activity of sitafloxacin against clinical strains of Streptococcus pneumoniae with defined amino acid substitutions in QRDRs of gyrase A and topoisomerase IV
Masato Touyama
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan
J Antimicrob Chemother 58:1279-82. 2006
..016-0.5 mg/L. CONCLUSIONS: These findings warrant further studies to evaluate the usefulness of sitafloxacin in the treatment of levofloxacin-resistant S. pneumoniae infection...
