Comparison of the effects of unfractionated heparin and the low-molecular-weight heparins dalteparin and enoxaparin on spontaneous platelet aggregation and adenosine diphosphate activity in platelets during the third trimester of pregnancyA A Ajayi
Department of Medicine Division of Therapeutics, University Hospital, Queen s Medical Center, Nottingham, England
Methods Find Exp Clin Pharmacol 29:539-45. 2007
..The reversal of the heparin-induced platelet activation by apyrase grade II suggests that the mechanism is, at least in part, mediated by copious ADP release from platelets or red cells by heparin but not LMWHs...
- The effect of flutamide on systemic and renal hemodynamics in Zucker diabetic rats: paradoxic renal vasodilator response to endothelin-1 and TXA2 receptor activation in female sex
Adesuyi A Leslie Ajayi
Center for Cardiovascular Diseases, Texas Southern University, Houston, Texas, USA
J Cardiovasc Pharmacol 48:191-8. 2006
..It is, however, unclear whether endogenous testosterone affects renal and systemic microcirculatory responses in the female sex, especially in type 2 diabetes...
- Castration reduces platelet thromboxane A2 receptor density and aggregability
A A L Ajayi
Department of Pharmacology, Division of Clinical Pharmacology, Medical University of South Carolina, Charleston, USA
QJM 98:349-56. 2005
..However, the biological impact of endogenous testosterone on platelet TXA2 receptor expression, especially in older men at risk of coronary artery disease, is unclear...
- Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching
A A Ajayi
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Int J Dermatol 43:972-7. 2004
..The aim of our present study was to assess and compare the antipruritic efficacy of the micro-opiate receptor antagonist, naltrexone, and the antihistamine, promethazine, in chloroquine treated patients with malaria fever...
- Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: studies in gonadectomized and sham-operated Zucker diabetic rats
A A Ajayi
Center for Cardiovascular Diseases, Texas Southern University, Houston, Texas 77004, USA
Eur J Clin Invest 34:349-57. 2004
..The plasma concentrations of both thromboxanes and endothelins are elevated in diabetes, and the receptor cross-talk between TXA(2) and ET-1 receptors may be enhanced in type-2 diabetic Zucker rats...
- Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats
A A Ajayi
Center for Cardiovascular Diseases, Texas Southern University, 3100 Cleburne Avenue, Houston, TX 77004, USA
Diabetes Res Clin Pract 63:155-69. 2004
..We examined the hypothesis that there is an alteration in the ET-A/ET-B receptor subtype sensitivity, and/or the interaction or cross-talk between ET-1 and TXA(2) in type-2 diabetes, using Zucker diabetic rats and their lean littermates...
- Endothelin-like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague Dawley rats
A A Ajayi
Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston 77004, USA
Methods Find Exp Clin Pharmacol 25:817-22. 2003
..These findings suggest a strong possibility of post-receptor cross-talk between alpha2-adrenoceptors and endothelin, as well as a direct effect of alpha2-adrenoceptors on renal NO production...
- Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive heart failure: a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal reflex activity
Adesuyi A Leslie Ajayi
Department of Medicine, Division of Clinical Pharmacology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
Ethn Dis 13:71-9. 2003
..The aims of the present study were to examine and compare the cardiovascular, autonomic, and clinical effects of additional alpha-1, or beta-1 blockade in ACE-inhibitor treated Black patients with moderate to severe CHF...
- Gender difference in vascular and platelet reactivity to thromboxane A(2)-mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hypertensive, hyperinsulinemic) diabetic rats
A A Ajayi
Center for Cardiovascular Diseases, Texas Southern University, 3100 Cleburne Avenue, Houston, TX 77004, USA
Diabetes Res Clin Pract 59:11-24. 2003
..The male gender may therefore be associated with the greater prothrombotic activity and a worse impairment of endothelial reactivity in the type-2 diabetic state...
- Interactions of the renin-angiotensin system and alpha-1 adrenoceptors on renal hemodynamics in healthy and acute renal failure rats: the role of nitric oxide
- Ajayi AAL
Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston 77004, USA
Blood Press 10:238-46. 2001
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- Anthropometric evaluation of cachexia in chronic congestive heart failure: the role of tricuspid regurgitation
A A Ajayi
Department of Medicine and Institute of Public Health, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
Int J Cardiol 71:79-84. 1999
..Tricuspid regurgitation may be an accentuating and accelerating risk factor for cardiac cachexia, on account of a greater hypoalbuminemia and hyponatremia, which, presumably, results from the associated protein-losing enteropathy...
- The effects of enalapril-digoxin-diuretic combination therapy on nutritional and anthropometric indices in chronic congestive heart failure: preliminary findings in cardiac cachexia
A Q Adigun
Department of Medicine, Clinical Pharmacology and Cardiology Units, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
Eur J Heart Fail 3:359-63. 2001
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- Cardiac autonomic function in Blacks with congestive heart failure: vagomimetic action, alteration in sympathovagal balance, and the effect of ACE inhibition on central and peripheral vagal tone
A Q Adigun
Department of Medicine, Cardiology Unit, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
Cell Mol Biol (Noisy-le-grand) 47:1063-7. 2001
..Current treatment reverses autonomic dysfunction to values seen in healthy age matched controls, mainly through augmentation of cardiac parasympathetic activity...
Plasma lipids, lipoproteins, and apolipoproteins in Nigerian diabetes mellitus, essential hypertension, and hypertensive-diabetic patientsO O Oyelola
Department of Chemical Pathology, College of Medical Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
J Natl Med Assoc 87:113-8. 1995
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- The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with essential hypertension
A A Ajayi
Department of Medicine, Faculty of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
J Natl Med Assoc 87:485-8. 1995
..Amlodipine induced no change in plasma potassium, but hydrochlorothiazide caused hypokalemia. Both agents were well tolerated, and Amlodipine should undergo further study in the treatment of hypertension in blacks...
- Shifting trends in the pharmacologic treatment of hypertension in a Nigerian tertiary hospital: a real-world evaluation of the efficacy, safety, rationality and pharmaco-economics of old and newer antihypertensive drugs
A Q Adigun
Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, USA
J Hum Hypertens 17:277-85. 2003
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- For the patient. New treatments for heart failure in Black people. Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive heart failure: a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal re
Adesuyi A Leslie Ajayi
Ethn Dis 13:150. 2003
