Jing Ai

Summary

Publications

  1. pmc Gadd45α: a novel diabetes-associated gene potentially linking diabetic cardiomyopathy and baroreflex dysfunction
    Ning Wang
    Department of Pharmacology, Harbin Medical University, State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, People s Republic of China
    PLoS ONE 7:e49077. 2012
  2. ncbi request reprint MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats
    Jing Ai
    Department of Pharmacology, Harbin Medical University, Harbin, Heilongjiang Province, People s Republic of China, 150081
    J Neurosci 33:3989-4001. 2013
  3. doi request reprint Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly
    Jing Ai
    Department of Pharmacology, Harbin Medical University, No 157 Baojian Road, Nangang District, Harbin, China
    Cardiovasc Res 95:385-93. 2012
  4. pmc Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia
    Jing Ai
    Department of Pharmacology, and State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, Harbin 150081, PR China
    BMC Complement Altern Med 10:80. 2010
  5. doi request reprint Neuropeptide Y reverses chronic stress-induced baroreflex hypersensitivity in rats
    Fang Xie
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, China
    Cell Physiol Biochem 29:463-74. 2012
  6. doi request reprint Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats
    Jing Liu
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province, China
    Cell Physiol Biochem 31:421-31. 2013
  7. doi request reprint Long-term neuropeptide Y administration in the periphery induces abnormal baroreflex sensitivity and obesity in rats
    Fang Xie
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, China
    Cell Physiol Biochem 29:111-20. 2012
  8. pmc MiR-106a is an independent prognostic marker in patients with glioblastoma
    Shiguang Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, People s Republic of China
    Neuro Oncol 15:707-17. 2013
  9. doi request reprint miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells
    Shiguang Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, People s Republic of China
    Cancer Lett 333:253-60. 2013
  10. doi request reprint Mechanism of impaired baroreflex sensitivity in Wistar rats fed a high-fat and -carbohydrate diet
    Jing Ai
    Department of Pharmacology, and the State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, Harbin 150081, China
    Br J Nutr 104:291-7. 2010

Collaborators

Detail Information

Publications31

  1. pmc Gadd45α: a novel diabetes-associated gene potentially linking diabetic cardiomyopathy and baroreflex dysfunction
    Ning Wang
    Department of Pharmacology, Harbin Medical University, State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, People s Republic of China
    PLoS ONE 7:e49077. 2012
    ..Collectively, reduced Gadd45α protein expression by forced miR-499 expression indicated it's a diabetes-associated gene which might potentially be involved in both DCM and DM-induced baroreflex dysfunction...
  2. ncbi request reprint MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats
    Jing Ai
    Department of Pharmacology, Harbin Medical University, Harbin, Heilongjiang Province, People s Republic of China, 150081
    J Neurosci 33:3989-4001. 2013
    ....
  3. doi request reprint Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly
    Jing Ai
    Department of Pharmacology, Harbin Medical University, No 157 Baojian Road, Nangang District, Harbin, China
    Cardiovasc Res 95:385-93. 2012
    ..The purpose of the present study was to evaluate the effects of overexpression of microRNA-1 (miR-1) on cardiac contractile function and the potential molecular mechanisms...
  4. pmc Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia
    Jing Ai
    Department of Pharmacology, and State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, Harbin 150081, PR China
    BMC Complement Altern Med 10:80. 2010
    ..This study was designed to elucidate the effects of DMC on baroreflexes in streptozocin (STZ)-induced diabetic rats with hyperlipoidemia...
  5. doi request reprint Neuropeptide Y reverses chronic stress-induced baroreflex hypersensitivity in rats
    Fang Xie
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, China
    Cell Physiol Biochem 29:463-74. 2012
    ..We conclude that chronic stress-induced baroreflex hypersensitivity could be blocked by NPY pretreatment. Furthermore, the altered expressions of neurotransmitters and receptors in the brainstem might contribute to this process...
  6. doi request reprint Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats
    Jing Liu
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province, China
    Cell Physiol Biochem 31:421-31. 2013
    ..The present study was conducted to determine whether NPY Y1 receptor (Y1R) and NPY Y2 receptor (Y2R) contribute to the regulatin of BRS in diabetic rats...
  7. doi request reprint Long-term neuropeptide Y administration in the periphery induces abnormal baroreflex sensitivity and obesity in rats
    Fang Xie
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, China
    Cell Physiol Biochem 29:111-20. 2012
    ..Furthermore, long-term NPY administration results in abdominal obesity and dyslipidemia...
  8. pmc MiR-106a is an independent prognostic marker in patients with glioblastoma
    Shiguang Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, People s Republic of China
    Neuro Oncol 15:707-17. 2013
    ..This study determined whether miR-106a could be used as an independent prognostic biomarker in those patients...
  9. doi request reprint miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells
    Shiguang Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, People s Republic of China
    Cancer Lett 333:253-60. 2013
    ..We also show that a combination of miR-143 and 2-DG, a widely used glycolysis inhibitor, has synergistic effects against GSLCs. miR-143 is a potential therapeutic target for glioblastoma treatment...
  10. doi request reprint Mechanism of impaired baroreflex sensitivity in Wistar rats fed a high-fat and -carbohydrate diet
    Jing Ai
    Department of Pharmacology, and the State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, Harbin 150081, China
    Br J Nutr 104:291-7. 2010
    ..Remodelled morphology and decreased neurotransmitters and receptors in the domains of the nucleus tractus solitarii and nucleus ambiguus are participating in this process...
  11. doi request reprint Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats
    Fang Xie
    Department of Pharmacology, State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, China
    Acta Pharmacol Sin 32:321-8. 2011
    ..To investigate whether fluvastatin is able to ameliorate the impaired cardiac function or baroreflex sensitivity (BRS) in rats with type 1 diabetes...
  12. doi request reprint Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling
    Lihua Sun
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, China
    Cell Physiol Biochem 26:421-30. 2010
    ..2 and PLB, down-regulating SERCA2a and NCX, subsequently leading to Ca2+ overload by the enhancement of Ca2+ influx and inhibition of intracellular Ca2+ extrusion and cerebral ischemia-induced myocardial dysfunction...
  13. pmc Daming capsule restores endothelial dysfunction induced by high-fat diet
    Rong Zhang
    Department of Pharmacology, the State Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin, Peoples Republic of China
    BMC Complement Altern Med 12:21. 2012
    ..Importantly, we also investigate possible mechanisms involved in mediating the effects of DMC on vascular reactivity...
  14. ncbi request reprint MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IκBα both in vitro and in vivo
    Guang Yang
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 15001, China G Y, D H, X C, D Z, W Z, C L, X C, H L, D Z, J K, F P, Z L, S Z Institute of Brain Science, Harbin Medical University, Harbin, China G Y, D H, X C, D Z, W Z, C L, X C, H L, D Z, J K, F P, Z L, S Z Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin
    Neuro Oncol 16:652-61. 2014
    ..Recent studies have revealed that miR-196a is upregulated in glioblastoma multiforme (GBM) and that it correlates with the clinical outcome of patients with GBM. However, its potential regulatory mechanisms in GBM have never been reported...
  15. doi request reprint Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat
    Hui Che
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province, China
    Cell Physiol Biochem 33:11-22. 2014
    ..2014 S. Karger AG, Basel. ..
  16. ncbi request reprint The protective effect of Daming capsule on heart function in streptozocin-induced diabetic rats with hyperlipidemia
    Jing Ai
    Department of Pharmacology, Harbin Medical University, Harbin Medical University, Nangang District, Harbin, China
    Biol Pharm Bull 32:1354-8. 2009
    ..This protective effect may partially be mediated through affecting the mRNA and protein expression of Kv4.2 and alpha(1c) as well as preventing cardiomyocyte morphological remodeling...
  17. ncbi request reprint Development of Wistar rat model of insulin resistance
    Jing Ai
    Department of Pharmacology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    World J Gastroenterol 11:3675-9. 2005
    ..To establish a simplified and reliable animal model of insulin resistance with low cost in Wistar rats...
  18. ncbi request reprint Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma
    Huailei Liu
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, People s Republic of China
    J Neurooncol 112:39-48. 2013
    ..Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment...
  19. doi request reprint microRNA-124 regulates cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells via targeting STAT3 signaling
    Benzhi Cai
    Department of Pharmacology, the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin, Heilongjiang Province, China
    Stem Cells 30:1746-55. 2012
    ..In summary, we found that miR-124 regulated myogenic differentiation of BMSCs via targeting STAT3 mRNA, which provides new insights into molecular mechanisms of cardiomyogenesis of BMSCs...
  20. doi request reprint Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction
    Jing Ai
    The Department of Pharmacology, Harbin Medical University, Harbin 150081, PR China
    Biochem Biophys Res Commun 391:73-7. 2010
    ..8522 for separation AMI patients under hospitalization and discharge. Collectively, our results revealed that circulating miR-1 may be a novel, independent biomarker for diagnosis of AMI...
  21. ncbi request reprint Inhibition of peripheral NPY Y1 and Y2 receptors ameliorates the aberrant baroreceptor reflex sensitivity in streptozotocin induced diabetic rats
    Hui Fang Niu
    Department of Pharmacology, Harbin Medical University, the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin 150081, China E mail
    Sheng Li Xue Bao 65:370-80. 2013
    ..In addition, BIIE 0246 alleviated the bradycardia, but further impaired cardiac contractility in the STZ rats. These results suggest that peripheral Y1R and Y2R play different roles in STZ-induced impairment of BRS. ..
  22. doi request reprint MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status
    Guang Yang
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, People s Republic of China
    J Mol Med (Berl) 89:1037-50. 2011
    ..Further investigations will focus on the therapeutic use of miR-106a-mediated antitumor effects in glioma...
  23. doi request reprint Advance in research of microRNA in Caenorhabditis elegans
    Jing Liu
    Department of Pharmacology the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education Harbin Medical University, No 157 Baojian Road, Nangang District, Harbin, 150081, China
    J Cell Biochem 114:994-1000. 2013
    ..elegans. In this review, we revisit the research progress of miRNAs in C. elegans related with development, aging, cancer, and neurodegenerative diseases and compared the function of miRNAs between C. elegans and human...
  24. doi request reprint MicroRNA transport: a new way in cell communication
    Ling Xu
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province, China
    J Cell Physiol 228:1713-9. 2013
    ..Studies about miRNA transporters and the transport mechanism are new and developing. With the progress of the research, new functions of extracellular miRNAs may be uncovered in the future...
  25. doi request reprint Homocysteine modulates sodium channel currents in human atrial myocytes
    Benzhi Cai
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin 150081, PR China
    Toxicology 256:201-6. 2009
    ....
  26. ncbi request reprint [Inhibitory effects of chloride channel blockers NPPB on proliferation of human glomerular mesangial cells]
    Jun Dong Jiao
    Department of Pharmacology, Harbin Medical University, Bio pharmaceutical Key Laboratory of Heilongjiang Province, China
    Yao Xue Xue Bao 40:686-9. 2005
    ..To investigate the effects of NPPB, a chloride channel blocker, on proliferation of mesangial cells...
  27. ncbi request reprint SOMG-833, a Novel Selective c-MET Inhibitor, Blocks c-MET-Dependent Neoplastic Effects and Exerts Antitumor Activity
    Hao Tian Zhang
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, People s Republic of China H t Z, J y Y Division of Anti tumor Pharmacology, State Key Laboratory of Drug Research L W, J A, Y C, C X H, Y c J, M H, J D, M y G and CAS Key Laboratory of Receptor Research and Synthetic Organic and Medicinal Chemistry Laboratory A Z, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Pharmacol Exp Ther 350:36-45. 2014
    ..Collectively, our results suggested SOMG-833 as a promising candidate for highly selective c-MET inhibition and a powerful tool to investigate the sole role of MET kinase in cancer. ..
  28. ncbi request reprint [Relationship between muscarinic acetylcholine receptor subtypes]
    Hai Long Yu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    Yi Chuan 29:1280-8. 2007
    ..From protein-protein interaction aspect, we found that the subtypes of the first subclass have indirect interactions with the subtypes of the second subclass, which indicates cooperation relationships...
  29. ncbi request reprint Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms
    Jing Ai
    Department of Pharmacology, Harbin Medical University, Bio pharmaceutical Key Laboratory of Heilongjiang Province Incubator of State Key Laboratory, Harbin 150086, Heilongjiang Province, China
    World J Gastroenterol 10:3612-5. 2004
    ..To investigate the inhibitory effects of sodium orthovanadate on small-intestinal glucose and maltose absorption in rats and its mechanism...
  30. pmc A novel method to quantify gene set functional association based on gene ontology
    Sali Lv
    College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin, People s Republic of China
    J R Soc Interface 9:1063-72. 2012
    ....
  31. doi request reprint Arsenic trioxide induces the apoptosis in bone marrow mesenchymal stem cells by intracellular calcium signal and caspase-3 pathways
    Ben zhi Cai
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin 150081, China
    Toxicol Lett 193:173-8. 2010
    ..Taken together, arsenic trioxide could inhibit the proliferation and induce the apoptosis of BMSCs by modulating intracellular [Ca(2+)](i), and activating the caspase-3 activity...