Nuzhat Ahmed

Summary

Publications

  1. ncbi request reprint Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Curr Cancer Drug Targets 10:268-78. 2010
  2. pmc Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    M Colomiere
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 100:134-44. 2009
  3. pmc Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary
    Chantel Samardzija
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Vic, 3052, Australia
    J Ovarian Res 5:37. 2012
  4. doi request reprint Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    J Cell Biochem 114:21-34. 2013
  5. pmc Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia
    J Ovarian Res 3:17. 2010
  6. pmc Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden
    Khalid Abubaker
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
    Mol Cancer 12:24. 2013
  7. pmc Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors
    Ardian Latifi
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria, Australia
    PLoS ONE 7:e46858. 2012
  8. ncbi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
    Ratana Lim
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Int J Cancer 120:2426-34. 2007
  9. ncbi request reprint Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    J Cell Physiol 213:581-8. 2007
  10. ncbi request reprint Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Clin Cancer Res 10:2415-20. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Curr Cancer Drug Targets 10:268-78. 2010
    ..We propose the molecular targeting of distinct 'EMT transformed cancer stem-like cells' and suggest ways that may improve the efficacy of current chemotherapeutic regimens much needed for the management of this disease...
  2. pmc Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    M Colomiere
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 100:134-44. 2009
    ..Such activation of STAT3 suggests a rationale for a combination of anti-STAT3 and EGFR/IL-6R therapy to suppress the peritoneal spread of ovarian cancer...
  3. pmc Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary
    Chantel Samardzija
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Vic, 3052, Australia
    J Ovarian Res 5:37. 2012
    ..Overall, we highlight why ovarian cancer patients, who initially respond to conventional chemotherapy subsequently relapse with recurrent chemoresistant disease that is essentially incurable...
  4. doi request reprint Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    J Cell Biochem 114:21-34. 2013
    ..We also propose the molecular targeting of CSCs and suggest ways that may improve the efficacy of current chemotherapeutic regimens needed for the management of this disease...
  5. pmc Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia
    J Ovarian Res 3:17. 2010
    ..The expression of Brn-3a(l) was also evaluated in normal ovarian and cancer cell lines and tumor cells isolated from the ascites of advanced-stage ovarian cancer patients...
  6. pmc Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden
    Khalid Abubaker
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
    Mol Cancer 12:24. 2013
    ..The novel findings in this study are important in understanding the early molecular mechanisms by which chemoresistance and subsequent relapse may be triggered after the first line of chemotherapy treatment...
  7. pmc Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors
    Ardian Latifi
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria, Australia
    PLoS ONE 7:e46858. 2012
    ....
  8. ncbi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
    Ratana Lim
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Int J Cancer 120:2426-34. 2007
    ..These data indicate that NGAL may be a good marker to monitor changes of benign to premalignant and malignant ovarian tumors and that the molecule may be involved in the progression of epithelial ovarian malignancies...
  9. ncbi request reprint Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    J Cell Physiol 213:581-8. 2007
    ..Finally, emphasis is placed on the clinical implications of EMT and potential therapeutic opportunities that may arise from these observations have been proposed...
  10. ncbi request reprint Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Clin Cancer Res 10:2415-20. 2004
    ....
  11. ncbi request reprint Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
    Am J Physiol Cell Physiol 290:C1532-42. 2006
    ..Failure to do so may lead to the formation of epithelium-derived inclusion cysts, which are known preferential sites of malignant transformation...
  12. ncbi request reprint Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Department of Obstetrics and Gynaecology, Baker Heart Research Institute, Royal Women s Hospital, The University of Melbourne, Carlton, Victoria, 3053, Australia
    Clin Exp Metastasis 22:391-402. 2005
    ....
  13. doi request reprint Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile
    Ardian Latifi
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
    J Cell Biochem 112:2850-64. 2011
    ....
  14. doi request reprint Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin
    Michelle Colomiere
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Int J Biochem Cell Biol 41:1034-45. 2009
    ....
  15. doi request reprint 2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Biochem Biophys Res Commun 406:408-13. 2011
    ..These proteins are associated with cytoskeleton rearrangement, cell metabolism, tumour suppression function, apoptosis and induction of host response...
  16. ncbi request reprint An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
    Proteomics 3:1980-7. 2003
    ..In conclusion, treatment of serum samples with Affi-Gel Blue or Aurum kit before 2-DE analysis can be used to remove high abundance proteins in order to increase the detection sensitivity of proteins present in low abundance...
  17. ncbi request reprint Expression and localization of alphavbeta6 integrin in extraplacental fetal membranes: possible role in human parturition
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Mol Hum Reprod 10:173-9. 2004
    ....
  18. pmc Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia
    J Ovarian Res 6:5. 2013
    ..abstract:..
  19. ncbi request reprint Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Department of Obstetrics and Gynaecology, Royal Women s Hospital, The University of Melbourne, Victoria, Australia
    J Pathol 201:229-37. 2003
    ..Suppression of ILK expression may therefore represent a novel and an efficient mechanism for controlling ovarian tumour growth...
  20. doi request reprint Multicellular spheroids in ovarian cancer metastases: Biology and pathology
    Kristy Shield
    Center for Cellular and Molecular Biology, Deakin University, Melbourne, Australia
    Gynecol Oncol 113:143-8. 2009
    ..This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality...
  21. ncbi request reprint Strategies for revealing lower abundance proteins in two-dimensional protein maps
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Department of Obstetrics and Gynaecology, The University of Melbourne, 132 Grattan Street, Carlton, VIC 3053, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 815:39-50. 2005
    ..The potential use of these strategies, as a means of developing diagnostic tools for early screening of diseases and identification of drug targets for therapeutic intervention, will also be discussed...
  22. ncbi request reprint Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Australia
    Proteomics 3:288-98. 2003
    ....