Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovaryChantel Samardzija
Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Vic, 3052, Australia
J Ovarian Res 5:37. 2012
..Overall, we highlight why ovarian cancer patients, who initially respond to conventional chemotherapy subsequently relapse with recurrent chemoresistant disease that is essentially incurable...
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistanceNuzhat Ahmed
Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
J Cell Biochem 114:21-34. 2013
..We also propose the molecular targeting of CSCs and suggest ways that may improve the efficacy of current chemotherapeutic regimens needed for the management of this disease...
- Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
Nuzhat Ahmed
Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia
J Ovarian Res 3:17. 2010
..The expression of Brn-3a(l) was also evaluated in normal ovarian and cancer cell lines and tumor cells isolated from the ascites of advanced-stage ovarian cancer patients...
Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancerNuzhat Ahmed
Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
Curr Cancer Drug Targets 10:268-78. 2010
..We propose the molecular targeting of distinct 'EMT transformed cancer stem-like cells' and suggest ways that may improve the efficacy of current chemotherapeutic regimens much needed for the management of this disease...
- Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
Nuzhat Ahmed
Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
J Cell Physiol 213:581-8. 2007
..Finally, emphasis is placed on the clinical implications of EMT and potential therapeutic opportunities that may arise from these observations have been proposed...
- Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
Ratana Lim
Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
Int J Cancer 120:2426-34. 2007
..These data indicate that NGAL may be a good marker to monitor changes of benign to premalignant and malignant ovarian tumors and that the molecule may be involved in the progression of epithelial ovarian malignancies...
- Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Clin Cancer Res 10:2415-20. 2004
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- Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
Am J Physiol Cell Physiol 290:C1532-42. 2006
..Failure to do so may lead to the formation of epithelium-derived inclusion cysts, which are known preferential sites of malignant transformation...
- Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Department of Obstetrics and Gynaecology, Baker Heart Research Institute, Royal Women s Hospital, The University of Melbourne, Carlton, Victoria, 3053, Australia
Clin Exp Metastasis 22:391-402. 2005
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- Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile
Ardian Latifi
Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
J Cell Biochem 112:2850-64. 2011
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- Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin
Michelle Colomiere
Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
Int J Biochem Cell Biol 41:1034-45. 2009
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- 2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients
Ratana Lim
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Biochem Biophys Res Commun 406:408-13. 2011
..These proteins are associated with cytoskeleton rearrangement, cell metabolism, tumour suppression function, apoptosis and induction of host response...
- Expression and localization of alphavbeta6 integrin in extraplacental fetal membranes: possible role in human parturition
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
Mol Hum Reprod 10:173-9. 2004
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- An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
Proteomics 3:1980-7. 2003
..In conclusion, treatment of serum samples with Affi-Gel Blue or Aurum kit before 2-DE analysis can be used to remove high abundance proteins in order to increase the detection sensitivity of proteins present in low abundance...
- Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
Ratana Lim
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia
J Ovarian Res 6:5. 2013
..abstract:..
- Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid
Nuzhat Ahmed
Gynaecological Cancer Research Centre, The Department of Obstetrics and Gynaecology, Royal Women s Hospital, The University of Melbourne, Victoria, Australia
J Pathol 201:229-37. 2003
..Suppression of ILK expression may therefore represent a novel and an efficient mechanism for controlling ovarian tumour growth...
- Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors
Ardian Latifi
Women s Cancer Research Centre, Royal Women s Hospital, Victoria, Australia
PLoS ONE 7:e46858. 2012
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- Multicellular spheroids in ovarian cancer metastases: Biology and pathology
Kristy Shield
Center for Cellular and Molecular Biology, Deakin University, Melbourne, Australia
Gynecol Oncol 113:143-8. 2009
..This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality...
- Strategies for revealing lower abundance proteins in two-dimensional protein maps
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital, Department of Obstetrics and Gynaecology, The University of Melbourne, 132 Grattan Street, Carlton, VIC 3053, Australia
J Chromatogr B Analyt Technol Biomed Life Sci 815:39-50. 2005
..The potential use of these strategies, as a means of developing diagnostic tools for early screening of diseases and identification of drug targets for therapeutic intervention, will also be discussed...
- Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach
Nuzhat Ahmed
Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Australia
Proteomics 3:288-98. 2003
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