Arpana Agrawal

Summary

Publications

  1. ncbi request reprint Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
    A Agrawal
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1 154, Richmond, VA 23298 0003, USA
    Addict Behav 30:1043-8. 2005
  2. ncbi request reprint The differential impact of risk factors on illicit drug involvement in females
    Arpana Agrawal
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Dept of Human Genetics, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 40:454-66. 2005
  3. ncbi request reprint A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs
    Arpana Agrawal
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
    Psychol Med 34:1227-37. 2004
  4. ncbi request reprint Forms of cannabis and cocaine: a twin study
    Arpana Agrawal
    Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Am J Med Genet B Neuropsychiatr Genet 129:125-8. 2004
  5. ncbi request reprint A twin study of personality and illicit drug use and abuse/dependence
    Arpana Agrawal
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Depts Of Human Genetics and Psychiatry, Richmond, USA
    Twin Res 7:72-81. 2004
  6. ncbi request reprint A population based twin study of sex differences in depressive symptoms
    Arpana Agrawal
    Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Twin Res 7:176-81. 2004
  7. ncbi request reprint Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females
    Arpana Agrawal
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 34:217-28. 2004
  8. doi request reprint The AVPR1A gene and substance use disorders: association, replication, and functional evidence
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Psychiatry 70:519-27. 2011
  9. pmc How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity
    Danielle M Dick
    Department of Psychiatry, Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 16:661-9. 2013
  10. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008

Detail Information

Publications31

  1. ncbi request reprint Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
    A Agrawal
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1 154, Richmond, VA 23298 0003, USA
    Addict Behav 30:1043-8. 2005
    ..Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences...
  2. ncbi request reprint The differential impact of risk factors on illicit drug involvement in females
    Arpana Agrawal
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Dept of Human Genetics, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 40:454-66. 2005
    ..Are there risk factors that associate with illicit drug use or illicit drug abuse/dependence? Is the magnitude of the association the same for use and abuse/dependence? Does this pattern of association differ across categories of drugs?..
  3. ncbi request reprint A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs
    Arpana Agrawal
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
    Psychol Med 34:1227-37. 2004
    ..Gateway and common liabilities models have been employed to explain this relationship. We sought to examine this association using a combination of the discordant twin design and modeling methods...
  4. ncbi request reprint Forms of cannabis and cocaine: a twin study
    Arpana Agrawal
    Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Am J Med Genet B Neuropsychiatr Genet 129:125-8. 2004
    ..These findings also reinforce the validity of composite variables in epidemiological and genetic research...
  5. ncbi request reprint A twin study of personality and illicit drug use and abuse/dependence
    Arpana Agrawal
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Depts Of Human Genetics and Psychiatry, Richmond, USA
    Twin Res 7:72-81. 2004
    ..NS was most closely related to cannabis use while N showed significant genetic overlap with sedative use. NS in males appears to be a good indicator of risk for cannabis use. This result may be useful for candidate gene studies...
  6. ncbi request reprint A population based twin study of sex differences in depressive symptoms
    Arpana Agrawal
    Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Twin Res 7:176-81. 2004
    ..Our analyses suggest that while there may be mean differences in the levels of depressive symptoms across sexes, the genetic and environmental factors that predispose males and females to depressive symptoms are not different...
  7. ncbi request reprint Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females
    Arpana Agrawal
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 34:217-28. 2004
    ..Overall, our results suggest that the use and abuse/dependence of cannabis and other illicit drugs are strongly linked via common risk factors that jointly influence their individual liabilities...
  8. doi request reprint The AVPR1A gene and substance use disorders: association, replication, and functional evidence
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Psychiatry 70:519-27. 2011
    ..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms...
  9. pmc How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity
    Danielle M Dick
    Department of Psychiatry, Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 16:661-9. 2013
    ..Phenotypic measurement has been offered as one explanation, although most of this discussion has focused on problems with binary diagnoses...
  10. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  11. pmc Transitions to regular smoking and to nicotine dependence in women using cannabis
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:107-14. 2008
    ..If there is evidence in its favor, the increased rates of cigarette smoking in cannabis users may prove to be the most significant public health problem associated with cannabis use...
  12. ncbi request reprint The genetic epidemiology of cannabis use, abuse and dependence
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 101:801-12. 2006
    ..The genetic etiology of cannabis use, abuse and dependence has elicited significant interest from genetic epidemiologists...
  13. pmc Genetic and environmental influences on the rate of progression to alcohol dependence in young women
    Carolyn E Sartor
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:632-8. 2008
    ....
  14. ncbi request reprint Clustering of eating disorder symptoms in a general population female twin sample: a latent class analysis
    Alexis E Duncan
    Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychol Med 37:1097-107. 2007
    ..The objective of the current study was to examine the clustering of ED symptoms in a general population sample using latent class analysis (LCA)...
  15. doi request reprint Are there genetic influences on addiction: evidence from family, adoption and twin studies
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1069-81. 2008
    ..With a focus on the classical twin design that utilizes data on monozygotic and dizygotic twins, we discuss support in favor of heritable influences on alcohol, nicotine, cannabis and other illicit drug dependence...
  16. doi request reprint Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Nicotine Tob Res 10:567-78. 2008
    ....
  17. doi request reprint Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions?
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Addict 17:199-208. 2008
    ..Evidence from this and prior studies demonstrating withdrawal strongly suggest that future editions of DSM need to reconsider the exclusion of withdrawal from criteria for cannabis dependence...
  18. doi request reprint Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence
    Narelle K Hansell
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland, 4029, Australia
    Twin Res Hum Genet 11:287-305. 2008
    ..42 to .51 for dependence and from .31 to .51 for consumption. Consumption was significantly less heritable in the younger Phase 2 cohort (23-39 years) compared to the older Phase 1 cohort (28-90 years)...
  19. doi request reprint An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 65:713-21. 2008
    ..Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors...
  20. ncbi request reprint Correlates of regular cigarette smoking in a population-based sample of Australian twins
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63108, USA
    Addiction 100:1709-19. 2005
    ..Design Members of monozygotic and dizygotic, including unlike-sex twin pairs (n = 6257) from a young adult cohort from the Australian Twin Registry...
  21. doi request reprint Drinking expectancies and motives: a genetic study of young adult women
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 103:194-204. 2008
    ..However, little is known of the extent to which genetic and environmental influences contribute to individual differences in expectancies and motives...
  22. ncbi request reprint Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, Box 8134, 660 South Euclid Ave, St Louis, MO 63130, USA
    J Stud Alcohol 67:185-94. 2006
    ..This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence...
  23. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  24. ncbi request reprint Risk for initiation of substance use as a function of age of onset of cigarette, alcohol and cannabis use: findings in a Midwestern female twin cohort
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Prev Med 43:125-8. 2006
    ..We investigated whether use and early-onset use of cigarettes, alcohol and cannabis contributed an increase in risk for initiation of subsequent psychoactive substances in women (N = 3729, mean age = 21.7)...
  25. ncbi request reprint Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America
    Twin Res Hum Genet 9:523-30. 2006
    ..Aggregation of population-level data may obscure important subgroup differences in patterns of illicit drug use and psychiatric comorbidity. Further exploration of a 'self-medicating' subgroup is needed...
  26. pmc Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Drug Alcohol Depend 88:300-7. 2007
    ..We conclude that the criteria that serve as indicators of DSM-IV cannabis abuse and dependence do not function identically in men and women and that certain criteria (e.g. hazardous use) require further refinement...
  27. ncbi request reprint The implications of simultaneous smoking initiation for inferences about the genetics of smoking behavior from twin data
    Michele L Pergadia
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63100, USA
    Behav Genet 36:567-76. 2006
    ..68%). These results indicate the important social influences that may occur for smoking initiation do not appear to seriously bias estimates of genetic effects on later stages of smoking...
  28. ncbi request reprint Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects?
    Julia D Grant
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 31:717-28. 2007
    ..The primary goal of the present analyses is to test hypotheses about the source(s) and magnitude of spousal associations for AD using a twin-spouse design...
  29. pmc Correlates of cannabis initiation in a longitudinal sample of young women: the importance of peer influences
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Prev Med 45:31-4. 2007
    ..In adolescent girls especially, rates of cannabis use have increased over the last decade, urging the need to characterize the potential correlates of onset of cannabis use during emerging adulthood...
  30. ncbi request reprint Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk
    Danielle M Dick
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Addiction 102:1131-9. 2007
    ....
  31. ncbi request reprint A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 102:94-104. 2007
    ..We examine the co-occurrence of abuse/dependence across different illicit drugs and test associations between these classes and major psychiatric disorders...