Small-cell lung cancer presenting as diabetes insipidus and Cushing's syndromeAmar Agha
Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Pituitary 8:105-7. 2005
..This case is a remarkable example of the complex metabolic endocrine manifestations of small-cell lung cancer...
- Target blood pressure for patients with type 2 diabetes is difficult to achieve in the setting of a busy diabetes clinic
A Agha
Department of Endocrinology and Diabetes Mellitus, James Connolly Memorial Hospital, Dublin, Ireland
Ir J Med Sci 172:168-70. 2003
..Target blood pressure control in patients with type 2 diabetes should be 130/85 mmHg or less; however, it is not clear how achievable this target is in clinical practice...
- Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults
Amar Agha
Department of Endocrinology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland
J Clin Endocrinol Metab 90:6355-60. 2005
....
- Acromegaly secondary to growth hormone releasing hormone secretion
- Agha
Department of Endocrinology, James Connolly Memorial Hospital, Dublin, Ireland
Ir J Med Sci 173:215-6. 2004
..Acromegaly secondary to growth hormone releasing hormone (GHRH) secretion is exceptionally rare...
- The natural history of post-traumatic hypopituitarism: implications for assessment and treatment
Amar Agha
Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Am J Med 118:1416. 2005
..We attempted to define the natural history of post-traumatic hypopituitarism to devise guidelines for the optimal timing of patients' assessment and hormone replacement...
- Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity
A Agha
Departments of Endocrinology, St Bartholomew s Hospital, William Harvey Research Institute, Queen Mary University of London, London, UK
J Endocrinol Invest 30:145-9. 2007
..In this report, we describe two further cases of parathyroid carcinoma presenting in MEN1 syndrome...
- Anterior pituitary dysfunction following traumatic brain injury (TBI)
Amar Agha
Department of Endocrinology, Division of Endocrinology and Diabetes, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Clin Endocrinol (Oxf) 64:481-8. 2006
....
- Anterior pituitary dysfunction in survivors of traumatic brain injury
Amar Agha
Academic Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland
J Clin Endocrinol Metab 89:4929-36. 2004
..Hypopituitarism is a treatable cause of morbidity after TBI. In addition to conventional pituitary hormone replacement, the potential of GH treatment to enhance recovery needs to be examined in a prospective study...
A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive protein (hsCRP) as a marker for insulin resistanceEoin P O'Sullivan
Department of Diabetes and Endocrinology, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, Dublin 9, Ireland
Metabolism 62:34-8. 2013
..We aimed to compare the ability of serum OPG with adiponectin and hsCRP to act as a marker for IR in individuals with normal and abnormal glucose tolerance...
- Optimizing glucocorticoid replacement therapy in severely adrenocorticotropin-deficient hypopituitary male patients
Lucy Ann Behan
Division of Endocrinology, Beaumont Hospital and RCSI Medical School, Dublin, Ireland
Clin Endocrinol (Oxf) 75:505-13. 2011
..Management strategies vary from treatment with 15-30 mg or higher in daily divided doses, reflecting the paucity of prospective data on the adequacy of different glucocorticoid regimens...
- Posterior pituitary dysfunction after traumatic brain injury
Amar Agha
Academic Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland
J Clin Endocrinol Metab 89:5987-92. 2004
..Identification of patients with partial posttraumatic DI is important because appropriate treatment may reduce morbidity and optimize the potential for recovery...
- The natural history of surgically treated but radiotherapy-naïve nonfunctioning pituitary adenomas
Eoin P O'Sullivan
Division of Neuro endocrinology, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Clin Endocrinol (Oxf) 71:709-14. 2009
..We aimed to define the natural history of a large, mainly unselected cohort with surgically treated, radiotherapy (RT)-naïve NFPAs and to try to identify predictors of recurrence/regrowth...
- Spontaneous recovery from posttraumatic hypopituitarism
Amar Agha
From the Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Am J Phys Med Rehabil 84:381-5. 2005
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- The natural history of post-traumatic neurohypophysial dysfunction
Amar Agha
Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Eur J Endocrinol 152:371-7. 2005
..Most cases recover completely but there is an appreciable frequency of long-term DI which can be subtle and should be recognized and managed appropriately...
- The interaction between growth hormone and the thyroid axis in hypopituitary patients
Lucy Ann Behan
Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Clin Endocrinol (Oxf) 74:281-8. 2011
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- Neuroendocrine dysfunction in the acute phase of traumatic brain injury
Amar Agha
Academic Department of Endocrinology, Beaumount Hospital, Dublin, Ireland
Clin Endocrinol (Oxf) 60:584-91. 2004
..CONCLUSION: Our data show that post-traumatic neuroendocrine abnormalities occur early and with high frequency, which may have significant implications for recovery and rehabilitation of TBI patients...
- Identifying coronary artery disease in men with type 2 diabetes: osteoprotegerin, pulse wave velocity, and other biomarkers of cardiovascular risk
Colin Davenport
Department of Diabetes and Endocrinology, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, Dublin, Ireland
J Hypertens 29:2469-75. 2011
..The second aim was to compare OPG levels in patients with microvascular complications (microalbuminuria) against those with established CAD...
- The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)
Colin Davenport
RCSI, Beaumont Endocrinology, Beaumont Hospital, Co Dublin, Ireland
Clin Transplant 23:616-20. 2009
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- Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status
Eoin P O'Sullivan
Department of Diabetes, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, and Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin 9, Ireland
Thromb Res 126:e423-7. 2010
..The recently identified Osteoprotegerin(OPG)/RANKL/TRAIL pathway has been implicated in vascular calcification, but data on levels in PAD and effect of co-existent DM are lacking...
- Endocrine consequences of adult traumatic brain injury
Lucy Ann Behan
Division of Endocrinology, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Horm Res 68:18-21. 2007
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- The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage
Mark Sherlock
Department of Academic Endocrinology, National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland
Clin Endocrinol (Oxf) 64:250-4. 2006
..Clipping and coiling of aneurysms are associated with higher rates of hyponatraemia. SIADH is the commonest cause of hyponatraemia after SAH. Delayed hyponatraemia is common, and has implications for early discharge strategies...
- Conventional glucocorticoid replacement overtreats adult hypopituitary patients with partial ACTH deficiency
Amar Agha
Department of Endocrinology, Beaumont Hospital, Dublin, Ireland
Clin Endocrinol (Oxf) 60:688-93. 2004
..The results suggest that current conventional glucocorticoid replacement overtreats patients with partial ACTH deficiency under normal unstressed physiological conditions...
- Modulation of glucocorticoid metabolism by the growth hormone - IGF-1 axis
Amar Agha
Department of Endocrinology, St Bartholomew s Hospital William Harvey Research Institute, Queen Mary University of London, UK
Clin Endocrinol (Oxf) 66:459-65. 2007
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- Clinical review: Disorders of water homeostasis in neurosurgical patients
Mark J Hannon
Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Dublin 9, Ireland
J Clin Endocrinol Metab 97:1423-33. 2012
..They are most commonly seen after subarachnoid hemorrhage, traumatic brain injury, with intracranial tumors, and after pituitary surgery...
- The prevalence of adrenal incidentaloma in routine clinical practice
Colin Davenport
Department of Diabetes and Endocrinology, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, Dublin 9, Ireland
Endocrine 40:80-3. 2011
..Twenty-two were diagnosed by CT abdomen (22/2,227) and 12 by CT thorax (12/1,478), a prevalence of 0.98 and 0.81% with CT abdomen and thorax, respectively, for AI in routine clinical practice...
- Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes
Eoin P O'Sullivan
Department of Diabetes, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, Dublin, Ireland
Diabetes Metab Res Rev 26:496-502. 2010
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- Attenuation of vasopressin-induced antidiuresis in poorly controlled type 2 diabetes
Amar Agha
Academic Department of Endocrinology, Endocrine Unit, Beaumont Hospital, Dublin 9, Ireland
Am J Physiol Endocrinol Metab 287:E1100-6. 2004
..Under conditions of chronic hyperglycemia, these abnormalities may significantly contribute to the development of dehydration in PCDS...
- Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients
Amar Agha
William Harvey Research Institute, Queen Mary University of London, London, UK
Clin Endocrinol (Oxf) 66:72-7. 2007
..The effect of GH replacement on thyroid function in hypopituitary patients has hitherto been studied in small groups of children and adults with conflicting results...
- Central pontine myelinolysis complicating treatment of the hyperglycaemic hyperosmolar state
Grainne O'Malley
Division of Endocrinology and Diabetes, Beaumont Hospital, Dublin, Ireland
Ann Clin Biochem 45:440-3. 2008
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- Clinical insights into the safety and utility of the insulin tolerance test (ITT) in the assessment of the hypothalamo-pituitary-adrenal axis
Francis M Finucane
Academic Department of Endocrinology, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Clin Endocrinol (Oxf) 69:603-7. 2008
..Whether basal cortisol concentration can reliably predict an adequate adrenal response to hypoglycaemia remains to be determined...
- Hypopituitarism following traumatic brain injury (TBI)
Amar Agha
Divisions of Endocrinology and Neurosurgery, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Br J Neurosurg 21:210-6. 2007
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- High risk of hypogonadism after traumatic brain injury: clinical implications
Amar Agha
Academic Division of Endocrinology and Diabetes, Beaumont Hospital and RCSI Medical School, Dublin, Ireland
Pituitary 8:245-9. 2005
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- The role of menin in parathyroid tumorigenesis
Colin Davenport
Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland
Adv Exp Med Biol 668:79-86. 2009
..This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis...
- Which patient requires neuroendocrine assessment following traumatic brain injury, when and how?
Nigel Glynn
Division of Neuro endocrinology, Beaumont Hospital and the RCSI Medical School, Dublin, Ireland
Clin Endocrinol (Oxf) 78:17-20. 2013
..Patients who suffer milder forms of TBI should also be considered for endocrine evaluation if they exhibit any clinical features of pituitary hormone deficiencies...
Diagnosing growth hormone deficiency in adultsNigel Glynn
Department of Endocrinology, Beaumont Hospital, RCSI Medical School, Dublin 9, Ireland
Int J Endocrinol 2012:972617. 2012
..In addition, there is considerable analytical variation in the biochemical measurements of GH and IGF-1 which must be considered before making a diagnosis of GHD in adulthood...
- A case of Resistance to Thyroid Hormone without mutation in the thyroid hormone receptor beta
J H McDermott
Depts of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin, Ireland
Ir J Med Sci 174:60-4. 2005
..RTH should be considered in patients with elevated thyroid hormone levels and normal TSH so that unnecessary and potentially harmful treatment can be avoided...
- An intensive nurse-led, multi-interventional clinic is more successful in achieving vascular risk reduction targets than standard diabetes care
J MacMahon Tone
Academic Department of Diabetes and Endocrinology, Beaumont Hospital RCSI Medical School, Beaumont Road, Dublin 9, Ireland
Ir J Med Sci 178:179-86. 2009
..The aim of this research was to determine whether an intensive, nurse-led clinic could achieve recommended vascular risk reduction targets in patients with type 2 diabetes as compared to standard diabetes management...
- Neuroendocrine disorders after traumatic brain injury
L A Behan
Academic Department of Endocrinology, Beaumont Hospital and RCSI Medical School, Dublin, Ireland
J Neurol Neurosurg Psychiatry 79:753-9. 2008
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- Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review
Harald Jorn Schneider
Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
JAMA 298:1429-38. 2007
..This sequela is a potentially serious but treatable complication of brain injury...
- Aneurysmal subarachnoid hemorrhage
Mark Sherlock
N Engl J Med 354:1755-7; author reply 1755-7. 2006
- The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis
Amar Agha
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
J Clin Endocrinol Metab 91:43-7. 2006
..The high-dose short Synacthen (corticotropin) test (SST) is widely used to investigate suspected secondary adrenal insufficiency, but concern remains about falsely reassuring results...
