Rakesh Aggarwal

Summary

Publications

  1. pmc T-cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis E virus
    R Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Viral Hepat 14:283-92. 2007
  2. doi request reprint Hepatitis E: Historical, contemporary and future perspectives
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 26:72-82. 2011
  3. doi request reprint Hepatitis E: clinical presentation in disease-endemic areas and diagnosis
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Semin Liver Dis 33:30-40. 2013
  4. ncbi request reprint Effect of maternal education on choice of location for delivery among Indian women
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Natl Med J India 24:328-34. 2011
  5. doi request reprint Diagnosis of hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Nat Rev Gastroenterol Hepatol 10:24-33. 2013
  6. pmc Plasma peptidome profiling of acute hepatitis E patients by MALDI-TOF/TOF
    Shikha Taneja
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Proteome Sci 9:5. 2011
  7. doi request reprint Clinical presentation of hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Virus Res 161:15-22. 2011
  8. doi request reprint Hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Hepatology 54:2218-26. 2011
  9. doi request reprint Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
  10. pmc A comparison of online versus on-site training in health research methodology: a randomized study
    Rakesh Aggarwal
    Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    BMC Med Educ 11:37. 2011

Collaborators

Detail Information

Publications77

  1. pmc T-cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis E virus
    R Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Viral Hepat 14:283-92. 2007
    ..These data on mapping of T-cell epitopes in HEV proteins may prove useful for designing HEV vaccines and for studying the immunopathogenesis of hepatitis E...
  2. doi request reprint Hepatitis E: Historical, contemporary and future perspectives
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 26:72-82. 2011
    ..These vaccines should be of particular use in groups that are at high risk of HEV infection and/or of poor outcome...
  3. doi request reprint Hepatitis E: clinical presentation in disease-endemic areas and diagnosis
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Semin Liver Dis 33:30-40. 2013
    ..Assays for these too have low concordance, making comparisons of seroprevalence rates using different assays difficult to interpret. There is an urgent need to develop better assays for markers of HEV infection and exposure...
  4. ncbi request reprint Effect of maternal education on choice of location for delivery among Indian women
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Natl Med J India 24:328-34. 2011
    ..However, in India, a large proportion of deliveries take place outside health facilities. We studied the effect of maternal education on the choice of location for delivery in the Indian population...
  5. doi request reprint Diagnosis of hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Nat Rev Gastroenterol Hepatol 10:24-33. 2013
    ..Improved validation of existing anti-HEV antibody assays or development of new assays with superior performance characteristics is urgently needed...
  6. pmc Plasma peptidome profiling of acute hepatitis E patients by MALDI-TOF/TOF
    Shikha Taneja
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Proteome Sci 9:5. 2011
    ..abstract:..
  7. doi request reprint Clinical presentation of hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Virus Res 161:15-22. 2011
    ..The pathogenesis of these manifestations remains unclear...
  8. doi request reprint Hepatitis E
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Hepatology 54:2218-26. 2011
    ..Two recombinant protein vaccines have undergone successful human trials, but are not yet commercially available. Recent development of cell-culture methods for HEV should allow a better understanding of this enigmatic agent...
  9. doi request reprint Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
    ..Our understanding of hepatitis E epidemiology has undergone major changes in recent years, and the future may hold even more surprises...
  10. pmc A comparison of online versus on-site training in health research methodology: a randomized study
    Rakesh Aggarwal
    Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    BMC Med Educ 11:37. 2011
    ..Our objective was to determine whether on-line courses in Biostatistics and Research Ethics could achieve similar improvements in knowledge, as traditional on-site, classroom-based courses...
  11. doi request reprint Adaptive immune responses during acute uncomplicated and fulminant hepatitis E
    Ratika Srivastava
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 26:306-11. 2011
    ..We therefore studied adaptive immune responses to HEV antigens in patients with hepatitis E of varying disease severity and healthy controls...
  12. ncbi request reprint Hepatitis B virus genotype A is more often associated with severe liver disease in northern India than is genotype D
    Ashish Kumar
    Departments of Gastroenterology and Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 24:19-22. 2005
    ..The clinical outcome of chronic hepatitis B may depend on hepatitis B virus (HBV) genotype. Data from India on this aspect are limited and contradictory. We studied the frequency of HBV genotypes and their clinical significance...
  13. ncbi request reprint Hepatitis E virus is responsible for decompensation of chronic liver disease in an endemic region
    Arvind Kumar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014
    Indian J Gastroenterol 23:59-62. 2004
    ..Hepatitis A virus infection in patients with previously stable chronic liver disease is associated with liver decompensation. Whether infection with hepatitis E virus (HEV) also does so is not known...
  14. doi request reprint Non-organ-specific autoantibodies in Indian patients with chronic liver disease
    Sunilbaran Daschakraborty
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India
    Indian J Gastroenterol 31:237-42. 2012
    ..However, various autoantibodies are often detectable in patients with CLD due to other causes too. Since data on autoantibody prevalence in Indian patients with CLD are limited, we decided to undertake the current study...
  15. pmc Spectrum of malabsorption syndrome among adults & factors differentiating celiac disease & tropical malabsorption
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 136:451-9. 2012
    ..This study was undertaken to investigate the spectrum of MAS among Indian adults and to find out the features that may help to differentiate between TM and celiac disease...
  16. doi request reprint Evidence of hepatitis E virus exposure among seronegative healthy residents of an endemic area
    Mohammad Mushtaq Husain
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Intervirology 54:139-43. 2011
    ..Detection of serum anti-HEV IgG has traditionally been used to determine prior exposure to this virus. We studied HEV-specific recall immune responses in healthy subjects with and without detectable anti-HEV IgG...
  17. doi request reprint Clinical features and predictors of outcome in acute hepatitis A and hepatitis E virus hepatitis on cirrhosis
    Yellapu Radha Krishna
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Liver Int 29:392-8. 2009
    ..Our study aimed to evaluate the clinical profile and predictors of 3-month mortality in patients with this distinctive form of liver failure...
  18. ncbi request reprint Role of IgG anti-beta-lactoglobulin antibody in the diagnosis of cow's milk protein intolerance in India
    Ujjal Poddar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Gastroenterol 27:190-4. 2008
    ..Little is known about cow's milk protein intolerance (CMPI) in India. This study was aimed at finding CMPI cases and determining the role of IgG anti-beta-lactoglobulin antibody in the diagnosis of this condition in India...
  19. ncbi request reprint Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 18:540-7. 2003
    ..In tropical sprue (TS), response to antibiotics may suggest a role for bacterial contamination of the small bowel, which is known in diseases with prolonged orocecal transit time (OCTT)...
  20. ncbi request reprint Etiological spectrum of sporadic malabsorption syndrome in northern Indian adults at a tertiary hospital
    Piyush Ranjan
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 23:94-8. 2004
    ..CONCLUSIONS: Tropical sprue, celiac disease and Crohn's disease are common causes of MAS in Indian adults. Inappropriate anti-tubercular treatment is common in them and needs to be discouraged...
  21. ncbi request reprint Occult hepatitis B virus infection as a cause of cirrhosis of liver in a region with intermediate endemicity
    Neeti Agarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014
    Indian J Gastroenterol 22:127-31. 2003
    ..The frequency of such occult infection in regions with intermediate HBV endemicity is not known. Such cases may be diagnosed by incremental testing for IgG anti-HBc, serum HBV DNA, and HBV DNA in liver tissue...
  22. ncbi request reprint Assessment of cost-effectiveness of universal hepatitis B immunization in a low-income country with intermediate endemicity using a Markov model
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    J Hepatol 38:215-22. 2003
    ..We performed a cost-effectiveness analysis of universal childhood HB immunization in such countries using India as an example, since available data on this aspect are limited...
  23. ncbi request reprint Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India
    Sanjay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 25:236-9. 2006
    ..The cause of thrombosis in these patients remains unclear. We studied the frequency of mutations in genes for coagulation factors V and II (prothrombin) in 61 Indian patients with PVT and 49 healthy control subjects...
  24. ncbi request reprint Profile of liver involvement in dengue virus infection
    Srivenu Itha
    Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh, India
    Natl Med J India 18:127-30. 2005
    ..Data are scarce on liver involvement in adult patients with dengue virus infection...
  25. ncbi request reprint Hepatitis B virus carriers; natural course, diagnostic approach and treatment
    Piyush Ranjan
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Trop Gastroenterol 26:58-65. 2005
  26. pmc Cellular immune responses in acute hepatitis E virus infection to the viral open reading frame 2 protein
    Ruchi Srivastava
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Viral Immunol 20:56-65. 2007
    ..Further, the limited immune reactivity we detected in peripheral blood cells may be related to the sequestration of immune events to the intrahepatic compartment, which is the major disease site...
  27. ncbi request reprint Does co-infection with multiple viruses adversely influence the course and outcome of sporadic acute viral hepatitis in children?
    Arvind Kumar
    Department of Gastroenterology Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 21:1533-7. 2006
    ..This study looked at the frequency of co-infection with multiple hepatotropic viruses and the effect of such infection on the course and outcome of acute sporadic viral hepatitis (AVH) and fulminant hepatic failure (FHF) in children...
  28. ncbi request reprint Antibody testing in Indian children with celiac disease
    Surender Kumar Yachha
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 25:132-5. 2006
    ....
  29. ncbi request reprint Immunological alterations in pregnant women with acute hepatitis E
    Rekha Pal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 20:1094-101. 2005
    ..Although usually self-limiting and benign, the disease is particularly severe among pregnant women, with mortality rates reaching 15-20%...
  30. ncbi request reprint Low frequency of factor V Leiden and prothrombin G20210A mutations in patients with hepatic venous outflow tract obstruction in northern India: a case-control study
    Sirish I Kumar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 24:211-5. 2005
    ..We studied the prevalence of these mutations among patients with HVOTO in northern India in comparison with healthy population...
  31. doi request reprint Histological and immunohistochemical features in fatal acute fulminant hepatitis E
    Vinita Agrawal
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Indian J Pathol Microbiol 55:22-7. 2012
    ..Hepatitis E is being increasingly recognized as an emerging infection in developed countries. Data on histological findings and nature of inflammatory cell infiltrate in liver in this disease are quite sparse...
  32. ncbi request reprint Treatment of chronic hepatitis B with interferon-alpha: cost-effectiveness in developing countries
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
    Natl Med J India 15:320-7. 2002
    ..Treatment with interferon-alpha (IFN) has been shown to be cost-effective in developed countries. However, cost-effectiveness In developing countries such as India has not been studied...
  33. ncbi request reprint Role of travel as a risk factor for hepatitis E virus infection in a disease-endemic area
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 21:14-8. 2002
    ..We undertook epidemiologic and laboratory studies during an epidemic of acute hepatitis in Sindri town, in District Dhanbad, Bihar in 1998...
  34. ncbi request reprint Effect of a gluten-free diet on growth and small-bowel histology in children with celiac disease in India
    Surender K Yachha
    Department of Gastroenterology Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 22:1300-5. 2007
    ..Follow-up studies on growth and histological recovery of children with celiac disease (CD) while on a gluten-free diet (GFD) are lacking from Asia. We therefore assessed the effects of this diet...
  35. ncbi request reprint Prediction of large esophageal varices in patients with cirrhosis of the liver using clinical, laboratory and imaging parameters
    Sanjay Kumar Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 22:1909-15. 2007
    ..This approach leads to unnecessary UGIE in those without LEVx. We tried to identify clinical, laboratory and imaging parameters that may predict the presence of LEVx and help select patients for UGIE...
  36. pmc Preventing and treating hepatitis B infection
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    BMJ 329:1080-6. 2004
  37. ncbi request reprint Severe ulcerative colitis: prospective study of parameters determining outcome
    Sanjay Kumar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 19:1247-52. 2004
    ..Although several studies have reported parameters associated with failure of medical treatment, studies using multivariate analysis of various predictors are scanty...
  38. ncbi request reprint Presence of hepatitis E virus in sewage in Northern India: frequency and seasonal pattern
    Sirish Kumar Ippagunta
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Med Virol 79:1827-31. 2007
    ..The study suggests that HEV infection and fecal viral excretion may be common in HEV-endemic regions throughout the year even during non-epidemic periods...
  39. ncbi request reprint A boost to hepatitis B vaccine: no need for boosters
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
    Natl Med J India 18:313-4. 2005
  40. ncbi request reprint Abernethy malformation with portal vein aneurysm
    Atin Kumar
    Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
    Diagn Interv Radiol 14:143-6. 2008
    ..Etiology, clinical significance, and management strategies with regard to these abnormalities are discussed...
  41. doi request reprint Validation of video-based skill assessment in carotid artery stenting
    I Van Herzeele
    Department of Thoracic and Vascular Surgery, Ghent University Hospital, Gent, Belgium
    Eur J Vasc Endovasc Surg 38:1-9. 2009
    ..To develop weighted error-based, generic and procedure-specific rating scales, to validate these scales for video-based assessment during virtual carotid artery stent (CAS) procedures and correlate them with simulator-derived metrics...
  42. doi request reprint Vestibular schwannoma: role of conservative management
    R Suryanarayanan
    Department of Otolaryngology, Manchester Royal Infirmary and Hope Hospital, Salford, UK
    J Laryngol Otol 124:251-7. 2010
    ..To assess the outcome of conservative management of vestibular schwannoma...
  43. doi request reprint Experienced endovascular interventionalists objectively improve their skills by attending carotid artery stent training courses
    I Van Herzeele
    Department of Biosurgery and Surgical Technology, Imperial College London, UK Regional Vascular Unit, St Mary s Hospital, London, UK
    Eur J Vasc Endovasc Surg 35:541-50. 2008
    ..Carotid artery stenting (CAS) is an advanced endovascular intervention with a steep learning curve. Virtual reality (VR) simulation has been proposed as a means to train and objectively assess technical performance...
  44. ncbi request reprint Training with simulation versus operative room attendance
    L M Desender
    Department of Thoracic and Vascular Surgery, University Hospital Ghent, Ghent, Belgium
    J Cardiovasc Surg (Torino) 52:17-37. 2011
    ..This article reviews the evidence and the limitations for this adjunctive tool, the implementation in current training programmes and future applications to maintain the highest standards of care for treatment of vascular disease...
  45. ncbi request reprint Evidence for activation of cellular immune responses in patients with acute hepatitis E
    Sita Naik
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 21:149-52. 2002
    ..We looked for evidence of lymphocyte sensitization to HEV peptides in patients with acute HEV infection...
  46. ncbi request reprint Superior sagittal sinus thrombosis and Budd-Chiari syndrome due to paroxysmal nocturnal hemoglobinuria managed with transjugular intrahepatic portosystemic shunt: a case report
    Abhinav Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Trop Gastroenterol 26:146-8. 2005
    ..We report a patient with PNH complicated by intracranial venous thrombosis and Budd-Chiari syndrome, who was managed with transjugular intrahepatic portosystemic shunt...
  47. ncbi request reprint HFE, hepcidin and ferroportin gene mutations are not present in Indian patients with primary haemochromatosis
    Priyanka Shukla
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Natl Med J India 19:20-3. 2006
    ..In India, the disease is uncommon and the genetic defects associated with it are unknown. We therefore looked for mutations in the HFE and other genes involved in iron metabolism in Indian patients with primary haemochromatosis...
  48. ncbi request reprint Alterations in natural killer cells and natural killer T cells during acute viral hepatitis E
    R Srivastava
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Viral Hepat 15:910-6. 2008
    ..During convalescence, all the parameters normalized. In conclusion, reversible alterations in NK and NKT cell number and activation status during acute hepatitis E suggest a role of these cells in the pathogenesis of this disease...
  49. ncbi request reprint Gut microbiota and liver disease
    Amit Goel
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 29:1139-48. 2014
    ....
  50. ncbi request reprint Prediction of essential proteins in prokaryotes by incorporating various physico-chemical features into the general form of Chou's pseudo amino acid composition
    Aditya Narayan Sarangi
    Biomedical Informatics Centre, School of Telemedicine and Biomedical Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
    Protein Pept Lett 20:781-95. 2013
    ..7% in external validation set and of 91.8% and 88.1% using a different yeast protein dataset. Our result indicates that this classification model can be used for identification of novel prokaryotic essential proteins...
  51. pmc Hepatitis E vaccine
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences SGPGIMS, Rae Bareilly Road, Lucknow, 226 014, India
    Hepatol Int 2:308-15. 2008
    ..However, significant progress has been made in developing and testing recombinant subunit vaccines based on the viral capsid protein. This review summarizes these efforts...
  52. ncbi request reprint Recurrent duodenal ulcer haemorrhage: a pharmacoeconomic comparison of various management strategies
    Uday Chand Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
    Expert Opin Pharmacother 4:1593-603. 2003
    ..Prevention of recurrence is, therefore, an important goal. Eradication of Helicobacter pylori or maintenance treatment with a proton pump inhibitor (PPI) may reduce recurrent DU bleeding. Economic comparison of these options is sparse...
  53. pmc Piperacillin induced bone marrow suppression: a case report
    Ashish Kumar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    BMC Clin Pharmacol 3:2. 2003
    ..Piperacillin (and piperacillin/tazobactam) is a commonly prescribed antibiotic and is generally considered safe. We report a case of piperacillin induced bone marrow suppression...
  54. ncbi request reprint Strongyloides stercoralis infestation associated with septicemia due to intestinal transmural migration of bacteria
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, India
    J Gastroenterol Hepatol 17:1331-3. 2002
    ..This supports the hypothesis of migration of bacteria from the intestinal lumen as a cause of septicemia in patients with fulminant S. stercoralis infestation...
  55. ncbi request reprint Hepatitis A vaccine versus immunoglobulin for post-exposure prophylaxis
    Anshu Srivastava
    Department of Paediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
    Natl Med J India 20:302-3. 2007
  56. ncbi request reprint Plasmodium falciparum and hepatitis E virus co-infection in fulminant hepatic failure
    U C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 20:111. 2001
    ..Peripheral smear was positive for Plasmodium falciparum, and IgM anti-HEV was positive. She died despite antimalarial drugs and supportive management. Postmortem liver tissue showed changes suggestive of acute viral hepatitis...
  57. ncbi request reprint Hepatitis E virus infection among animals in northern India: an unlikely source of human disease
    P Shukla
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Viral Hepat 14:310-7. 2007
    ..However, the swine HEV in India differs genetically from human HEV isolates, indicating that pigs may not play an important role in the spread of human hepatitis E in endemic regions...
  58. ncbi request reprint Hepatitis E virus RNA detection in serum and feces specimens with the use of microspin columns
    R Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Virol Methods 74:209-13. 1998
    ..Use of this method may allow better assessment of viremia and fecal excretion in patients and experimental animals infected with HEV...
  59. ncbi request reprint A serological study of intrafamilial spread from patients with sporadic hepatitis E virus infection
    S K Somani
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    J Viral Hepat 10:446-9. 2003
    ..This suggests that person-to-person transmission is uncommon in sporadic hepatitis E...
  60. ncbi request reprint High frequency of hepatitis B virus infection in patients with beta-thalassemia receiving multiple transfusions
    H Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Vox Sang 84:292-9. 2003
    ..g. G587A) in a region critical for reactivity to antibody to hepatitis B surface antigen (anti-HBs). The true prevalence of HBV in individuals with beta-thalassemia has not been studied previously...
  61. pmc A large waterborne viral hepatitis E epidemic in Kanpur, India
    S R Naik
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Bull World Health Organ 70:597-604. 1992
    ..The first peak was probably caused by faecal contamination of river water, indicated by water analysis data, and the second, by inadequate chlorination of water in a reservoir. There was no evidence of secondary intrafamilial spread...
  62. ncbi request reprint Virtual reality simulation training can improve inexperienced surgeons' endovascular skills
    R Aggarwal
    Department of Biosurgery and Surgical Technology, Imperial College London, London, UK
    Eur J Vasc Endovasc Surg 31:588-93. 2006
    ..The aim of this study was to evaluate virtual reality (VR) simulation for endovascular training of surgeons inexperienced in this technique...
  63. ncbi request reprint Identification of skills common to renal and iliac endovascular procedures performed on a virtual reality simulator
    S K Neequaye
    Department of Biosurgery and Surgical Technology, Imperial College, London, UK
    Eur J Vasc Endovasc Surg 33:525-32. 2007
    ..The aim of this study was to determine the nature of skills acquisition on the renal and iliac modules of a commercially-available VR simulator...
  64. ncbi request reprint Objective assessment of gynecologic laparoscopic skills using the LapSimGyn virtual reality simulator
    C R Larsen
    Department of Gynecology and Obstetrics, The Juliane Marie Centre for Children, woman, and Reproduction, Copenhagen University Hospital, Blegdamsvej 3, Rigshospitalet, DK 2100 Ø, Denmark
    Surg Endosc 20:1460-6. 2006
    ..This study aimed to investigate the construct validity of the LapSimGyn VR simulator, and to determine the learning curves of gynecologists with different levels of experience...
  65. ncbi request reprint Systematic review of randomized controlled trials on the effectiveness of virtual reality training for laparoscopic surgery
    K Gurusamy
    Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, University College London and Royal Free Hospital NHS Trust, London NW32QG, UK
    Br J Surg 95:1088-97. 2008
    ..The aim of this review was to determine whether virtual reality (VR) training can supplement and/or replace conventional laparoscopic training in surgical trainees with limited or no laparoscopic experience...
  66. ncbi request reprint Skills training in telerobotic surgery
    J Hance
    Department of Surgical Oncology and Technology, Imperial College, London, UK
    Int J Med Robot 1:7-12. 2005
    ..Only when the standard of practice is firmly established, should the proliferation of robotic practitioners be encouraged thus ensuring patient safety is not compromised...
  67. ncbi request reprint Motion tracking systems for assessment of surgical skill
    R Aggarwal
    Surg Endosc 21:339. 2007
  68. doi request reprint Validation of orthopaedic bench models for trauma surgery
    J J H Leong
    St Mary s Hospital, London, England
    J Bone Joint Surg Br 90:958-65. 2008
    ..The availability of valid objective tools of assessment of surgical skills allows further studies into improving methods of training...
  69. ncbi request reprint Global epidemiology and medical aspects of hepatitis E
    K Krawczynski
    Division of Viral Hepatitis, NCID, Centers for Disease Control and Prevention Atlanta, GA 30333, USA
    Forum (Genova) 11:166-79. 2001
    ..Recombinant vaccines are being developed that may be particularly useful for travellers to the disease-endemic areas and for pregnant women...
  70. ncbi request reprint Endovascular simulation-based training
    R Aggarwal
    Surgeon 6:196-7. 2008
  71. ncbi request reprint Consensus guidelines for validation of virtual reality surgical simulators
    F J Carter
    The Cuschieri Skills Centre, Ninewells Hospital, University of Dundee, Dundee, Scotland
    Surg Endosc 19:1523-32. 2005
    ..The work group intends to update these consensus guidelines on a regular basis, with the resulting article available on the EAES website (http://www.eaes-eur.org )...
  72. ncbi request reprint Virtual reality simulation training can improve technical skills during laparoscopic salpingectomy for ectopic pregnancy
    R Aggarwal
    Department of Biosurgery and Surgical Technology, Imperial College London, London, UK
    BJOG 113:1382-7. 2006
    ..To assess the first commercially available virtual reality (VR) simulator to incorporate procedural modules for training of inexperienced gynaecological surgeons to perform laparoscopic salpingectomy for ectopic pregnancy...
  73. ncbi request reprint Technical skills examination for general surgical trainees
    V Datta
    Department of Surgical Oncology and Technology, 10th Floor, Queen Elizabeth the Queen Mother Building, St Mary s Hospital, London W2 1NY, UK
    Br J Surg 93:1139-46. 2006
    ..The technical skills of surgical trainees are difficult to assess and compare objectively. This study involved a structured, multistation, technical skills examination that enables the stratification of surgical trainees...
  74. pmc The simulated operating theatre: comprehensive training for surgical teams
    R Aggarwal
    Department of Surgical Oncology and Technology, Imperial College London, 10th Floor, QEQM Building, St Mary s Hospital, Praed Street, London, W2 1NY UK
    Qual Saf Health Care 13:i27-32. 2004
    ..The effect of external influences such as distractions, new technology, or a crisis scenario can also be defined, with the ultimate aim of reducing the number of adverse events arising in the real operating room...
  75. pmc Training in the operating theatre: is it safe?
    R Aggarwal
    Thorax 61:278-9. 2006
  76. ncbi request reprint Laparoscopic skills training and assessment
    R Aggarwal
    Department of Surgical Oncology and Technology, Imperial College, London, UK
    Br J Surg 91:1549-58. 2004
    ..This article reviews the tools currently available for training and assessment in laparoscopic surgery...
  77. ncbi request reprint Robotic prostatectomy: the first UK experience
    E K Mayer
    Imperial Robotic Urological Surgery Group, Department of Urology, St Mary s Hospital, London, UK
    Int J Med Robot 2:321-8. 2006
    ..We describe a teamwork approach to setting up the UK's first clinical programme for robotically assisted laparoscopic radical prostatectomy...