Miroslav Adzic

Summary

Publications

  1. doi request reprint Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers
    Jelena Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
    Neuropsychobiology 66:112-9. 2012
  2. doi request reprint The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β
    Miroslav Adzic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Serbia Electronic address
    Behav Brain Res 291:130-9. 2015
  3. doi request reprint Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism
    Miroslav Adzic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Serbia Electronic address
    Psychoneuroendocrinology 38:2914-24. 2013
  4. pmc The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats
    Miroslav Adzic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001 Belgrade, Serbia
    Int J Biochem Cell Biol 41:2181-8. 2009
  5. doi request reprint Chronic social isolation suppresses proplastic response and promotes proapoptotic signalling in prefrontal cortex of Wistar rats
    Ana Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    J Neurosci Res 88:2524-33. 2010
  6. doi request reprint Chronic social isolation compromises the activity of both glutathione peroxidase and catalase in hippocampus of male wistar rats
    Jelena Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001, Belgrade, Serbia
    Cell Mol Neurobiol 30:693-700. 2010
  7. doi request reprint Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats
    Milos Mitic
    Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, PO Box 522 MBE090, 11001 Belgrade, Serbia
    Neuropharmacology 70:100-11. 2013
  8. doi request reprint Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex
    Ana Djordjevic
    Department of Biochemistry, Institute for Biological Research Sinisa Stankovic, University of Belgrade, 142 Despot Stefan Blvd, 11000 Belgrade, Serbia
    Eur J Pharmacol 693:37-44. 2012
  9. doi request reprint Chronic social isolation is related to both upregulation of plasticity genes and initiation of proapoptotic signaling in Wistar rat hippocampus
    Ana Djordjevic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522, MBE090, 11001 Belgrade, Serbia
    J Neural Transm (Vienna) 116:1579-89. 2009
  10. doi request reprint A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
    Iva Simic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, Belgrade 11001, Serbia
    Psychiatry Res 209:658-64. 2013

Collaborators

  • Jelena Djordjevic
  • Marija Krstic-Demonacos
  • Jelena Radulovic
  • Danka Savić
  • Milos Mitic
  • Ana Djordjevic
  • Marija B Radojcic
  • Iva Lukic
  • Iva Simic
  • Ivan Soldatovic
  • Marija Radojcic
  • Nadja P Maric
  • Zorana Pavlović
  • Marina Mihaljevic
  • Ivana Elaković
  • Milica Jovicić
  • Gordana Matić
  • Ana Niciforovic
  • Milica J Jovicic
  • Natalija Bozovic
  • Sanja Andric
  • Nadja Maric
  • Natasa Popovic
  • Nikola Tatalovic
  • Miroslava Jasovic-Gasic
  • Sabera Ruzdijic
  • Dusan T Kanazir
  • Constantinos Demonacos
  • Elissavet Paraskevopoulou
  • Constantia Pantelidou
  • Vesna Vucic
  • Petar M Mitrasinovic

Detail Information

Publications26

  1. doi request reprint Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers
    Jelena Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
    Neuropsychobiology 66:112-9. 2012
    ..Together with our previous results, the current observations suggest that a chronic social isolation model may potentially be used to study molecular mechanisms that underlie depressive symptomatology...
  2. doi request reprint The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β
    Miroslav Adzic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Serbia Electronic address
    Behav Brain Res 291:130-9. 2015
    ..Sex-dependent mechanisms by which inflammation alters hypothalamic processes and cause pathological behaviour in animals, could be operative in the treatment of depression-related brain inflammation...
  3. doi request reprint Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism
    Miroslav Adzic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Serbia Electronic address
    Psychoneuroendocrinology 38:2914-24. 2013
    ....
  4. pmc The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats
    Miroslav Adzic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001 Belgrade, Serbia
    Int J Biochem Cell Biol 41:2181-8. 2009
    ..Therefore, prolonged social isolation may cause susceptibility to mitochondria triggered proapototic signalling, which at least in part may be mediated by the glucocorticoid receptor dependent mechanism...
  5. doi request reprint Chronic social isolation suppresses proplastic response and promotes proapoptotic signalling in prefrontal cortex of Wistar rats
    Ana Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    J Neurosci Res 88:2524-33. 2010
    ..Such conditions in the PFC are likely to compromise its ability to interact with other CNS structures, such as the hippocampus, which is necessary for successful adaptation to stress...
  6. doi request reprint Chronic social isolation compromises the activity of both glutathione peroxidase and catalase in hippocampus of male wistar rats
    Jelena Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001, Belgrade, Serbia
    Cell Mol Neurobiol 30:693-700. 2010
    ..Such conditions may cause functional decline of CNS structures, such as HIPPO, and are likely to promote state linked to onset of many mood disorders...
  7. doi request reprint Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats
    Milos Mitic
    Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, PO Box 522 MBE090, 11001 Belgrade, Serbia
    Neuropharmacology 70:100-11. 2013
    ....
  8. doi request reprint Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex
    Ana Djordjevic
    Department of Biochemistry, Institute for Biological Research Sinisa Stankovic, University of Belgrade, 142 Despot Stefan Blvd, 11000 Belgrade, Serbia
    Eur J Pharmacol 693:37-44. 2012
    ..The results imply that fluoxetine influences plasticity in the prefrontal cortex of chronically isolated rats and fails to prevent stress-induced initiation of apoptosis in this brain structure...
  9. doi request reprint Chronic social isolation is related to both upregulation of plasticity genes and initiation of proapoptotic signaling in Wistar rat hippocampus
    Ana Djordjevic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522, MBE090, 11001 Belgrade, Serbia
    J Neural Transm (Vienna) 116:1579-89. 2009
    ....
  10. doi request reprint A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
    Iva Simic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, Belgrade 11001, Serbia
    Psychiatry Res 209:658-64. 2013
    ..These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. ..
  11. pmc Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain
    Miroslav Adzic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    J Endocrinol 202:87-97. 2009
    ..Our study suggests that this nuclear isoform of hippocampal and cortical GR may be related to hypocorticism i.e. HPA axis hypoactivity under chronic isolation stress...
  12. doi request reprint Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats
    Ana Djordjevic
    Department of Biochemistry, Institute for Biological Research Sinisa Stankovic, University of Belgrade, 142 Despot Stefan Blvd, 11000 Belgrade, Serbia
    Prog Neuropsychopharmacol Biol Psychiatry 36:92-100. 2012
    ..The observed alterations at the molecular level were accompanied by normalization of stress-induced behavioral changes by fluoxetine...
  13. doi request reprint Stress type dependence of expression and cytoplasmic-nuclear partitioning of glucocorticoid receptor, hsp90 and hsp70 in Wistar rat brain
    Ana Djordjevic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    Neuropsychobiology 59:213-21. 2009
    ..The observed alterations in protein expression and cytoplasmic-nuclear partitioning of the GR, Hsp90 and Hsp70 proteins may be related to maladaptive response of the HPA axis under chronic stress...
  14. doi request reprint The role of glucocorticoid receptor phosphorylation in the model of negative affective states
    Milica Jovicić
    School of Medicine, University of Belgrade, Belgrade, Serbia
    World J Biol Psychiatry 16:301-11. 2015
    ..To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events...
  15. doi request reprint Lymphocyte levels of redox-sensitive transcription factors and antioxidative enzymes as indicators of pro-oxidative state in depressive patients
    Iva Lukic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    Neuropsychobiology 70:1-9. 2014
    ..However, molecular data on the principal cellular redox-sensitive transcriptional factors and the levels of their downstream-regulated antioxidant enzymes in MDD are scarce...
  16. doi request reprint Gender-specific response of brain corticosteroid receptors to stress and fluoxetine
    Ivana Elaković
    University of Belgrade, Institute for Biological Research Sinisa Stankovic, Department of Biochemistry, 142 Despot Stefan Blvd, 11060 Belgrade, Serbia
    Brain Res 1384:61-8. 2011
    ....
  17. pmc Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae
    Natasa Popovic
    Vinca Institute of Nuclear Sciences, P O Box 522, 11001 Belgrade, Serbia
    Steroids 75:457-65. 2010
    ..Our results suggest that GR phosphorylation at specific residues affects its transcriptional functions in a site selective manner and these effects were directly linked to GR dosage...
  18. doi request reprint Alterations in the Nrf2-Keap1 signaling pathway and its downstream target genes in rat brain under stress
    Jelena Djordjevic
    Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia Electronic address
    Brain Res 1602:20-31. 2015
    ..Our results reveal maladaptive character of chronic stress at Nrf2/Keap1 level followed by pro-inflammatory conditions, and suggest a possible role of these alterations in pathogenesis of depressive/anxiety disorders. ..
  19. doi request reprint Fluoxetine affects antioxidant system and promotes apoptotic signaling in Wistar rat liver
    Jelena Djordjevic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001 Belgrade, Serbia
    Eur J Pharmacol 659:61-6. 2011
    ..However, apoptotic alterations were more pronounced in stressed animals, suggesting that stress related oxidative damage could have primed apoptotic effects of fluoxetine. ..
  20. doi request reprint Chronic stress decreases availability of heat shock proteins to glucocorticoid receptor in response to novel acute stress in Wistar rat hypothalamus
    Iva Simic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    Cell Mol Neurobiol 32:625-32. 2012
    ..Thus, our data indicated reduced availability of HSPs to GR in both cytosol and nucleus of the HT under acute stress of CPSI animals, and therefore, pointed out to potentially negative effects of CPSI on GR function in the HT...
  21. doi request reprint Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder
    Iva Simic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, 11001 Belgrade, Serbia
    Prog Neuropsychopharmacol Biol Psychiatry 40:281-5. 2013
    ..There was no difference in the levels of tGR between MDD and control subjects. The study showed that altered phosphorylation of GR could contribute to impaired GR function related to the pathophysiology of depression...
  22. doi request reprint Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner
    Milos Mitic
    Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, 11001, Belgrade, Serbia
    J Mol Neurosci 55:335-46. 2015
    ....
  23. doi request reprint Accumulation of cytoplasmic glucocorticoid receptor is related to elevation of FKBP5 in lymphocytes of depressed patients
    Iva Lukic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, 11001, Belgrade, Serbia
    J Mol Neurosci 55:951-8. 2015
    ..Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients. ..
  24. doi request reprint Modulation of c-Jun N-terminal kinase signaling and specific glucocorticoid receptor phosphorylation in the treatment of major depression
    Milica J Jovicic
    School of Medicine, University of Belgrade, Serbia
    Med Hypotheses 85:291-4. 2015
    ..We also discuss the potential challenges in targeting JNK signaling pathway in depression. ..
  25. doi request reprint Cell culture conditions potentiate differences in the response to ionising radiation of peripheral blood leukocytes isolated from breast cancer patients and healthy subjects
    Miroslav Adzic
    Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    Redox Rep 13:17-22. 2008
    ..The data presented in this current study indicate that brief ex vivo culture of peripheral blood leukocytes potentiates oxidative stress imposed by a breast cancer tumour...
  26. doi request reprint Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells
    Ana Niciforovic
    Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, PO Box 522 090, 11000 Belgrade, Serbia
    Ann Biomed Eng 36:831-8. 2008
    ..The radioresistance of PC-3 cells is suggested to be associated with the positive, feed-forward vicious circle established between the H(2)O(2)-mediated elevation of MnSOD expression...