The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar ratsMiroslav Adzic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001 Belgrade, Serbia
Int J Biochem Cell Biol 41:2181-8. 2009
..Therefore, prolonged social isolation may cause susceptibility to mitochondria triggered proapototic signalling, which at least in part may be mediated by the glucocorticoid receptor dependent mechanism...
Chronic social isolation suppresses proplastic response and promotes proapoptotic signalling in prefrontal cortex of Wistar ratsAna Djordjevic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
J Neurosci Res 88:2524-33. 2010
..Such conditions in the PFC are likely to compromise its ability to interact with other CNS structures, such as the hippocampus, which is necessary for successful adaptation to stress...
- Chronic social isolation is related to both upregulation of plasticity genes and initiation of proapoptotic signaling in Wistar rat hippocampus
Ana Djordjevic
Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522, MBE090, 11001 Belgrade, Serbia
J Neural Transm 116:1579-89. 2009
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- Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers
Jelena Djordjevic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
Neuropsychobiology 66:112-9. 2012
..Together with our previous results, the current observations suggest that a chronic social isolation model may potentially be used to study molecular mechanisms that underlie depressive symptomatology...
- Chronic social isolation compromises the activity of both glutathione peroxidase and catalase in hippocampus of male wistar rats
Jelena Djordjevic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, P O Box 522 MBE090, 11001, Belgrade, Serbia
Cell Mol Neurobiol 30:693-700. 2010
..Such conditions may cause functional decline of CNS structures, such as HIPPO, and are likely to promote state linked to onset of many mood disorders...
- Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain
Miroslav Adzic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
J Endocrinol 202:87-97. 2009
..Our study suggests that this nuclear isoform of hippocampal and cortical GR may be related to hypocorticism i.e. HPA axis hypoactivity under chronic isolation stress...
- Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae
Natasa Popovic
Vinca Institute of Nuclear Sciences, P O Box 522, 11001 Belgrade, Serbia
Steroids 75:457-65. 2010
..Our results suggest that GR phosphorylation at specific residues affects its transcriptional functions in a site selective manner and these effects were directly linked to GR dosage...
- Stress type dependence of expression and cytoplasmic-nuclear partitioning of glucocorticoid receptor, hsp90 and hsp70 in Wistar rat brain
Ana Djordjevic
Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
Neuropsychobiology 59:213-21. 2009
..The observed alterations in protein expression and cytoplasmic-nuclear partitioning of the GR, Hsp90 and Hsp70 proteins may be related to maladaptive response of the HPA axis under chronic stress...
- Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder
Iva Simic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, P O Box 522 MBE090, 11001 Belgrade, Serbia
Prog Neuropsychopharmacol Biol Psychiatry 40:281-5. 2013
..There was no difference in the levels of tGR between MDD and control subjects. The study showed that altered phosphorylation of GR could contribute to impaired GR function related to the pathophysiology of depression...
- Chronic stress decreases availability of heat shock proteins to glucocorticoid receptor in response to novel acute stress in Wistar rat hypothalamus
Iva Simic
Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, Belgrade, Serbia
Cell Mol Neurobiol 32:625-32. 2012
..Thus, our data indicated reduced availability of HSPs to GR in both cytosol and nucleus of the HT under acute stress of CPSI animals, and therefore, pointed out to potentially negative effects of CPSI on GR function in the HT...
