The endothelium in diabetic nephropathyAndrew Advani
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Semin Nephrol 32:199-207. 2012
..Such advances likely will lead not only to improved tissue oxygenation and reduced fibrosis, but also to improved long-term renal function...
Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanismAndrew Advani
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Am J Pathol 178:2205-14. 2011
..These observations illustrate the therapeutic efficacy of long-term HDAC inhibition in diabetic nephropathy and emphasize the importance of the interplay between eNOS activity and oxidative stress in mediating these effects...
- Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature
Andrew Advani
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
PLoS ONE 6:e24695. 2011
..FMA is an uncomplicated technique for evaluating the renal microvasculature that circumvents many of the limitations imposed by conventional analysis of two-dimensional tissue sections...
- Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy
Andrew Advani
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Nephrology (Carlton) 16:573-81. 2011
..In the present study we sought to investigate the effects of long-term inhibition of the EGFR tyrosine kinase in an experimental model of diabetes that is characterized by angiotensin II dependent hypertension...
- Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor
Richard E Gilbert
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Kidney Int 79:1312-21. 2011
..Thus, early renal changes in diabetes are amenable to epigenetic intervention. Attenuating effects of HDAC inhibition, although multifactorial, are likely to be mediated in part through downregulation of the EGFR...
- Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes
Yanling Zhang
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Diabetes 61:2114-25. 2012
..The similarly beneficial effects of cells from healthy and diabetic donors highlight the potential of autologous cell therapy in the related clinical setting...
- Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy
Kim A Connelly
Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
Circ Heart Fail 2:129-37. 2009
..One such target is the beta-isoform of protein kinase C (PKC), implicated in both the complications of diabetes and in cardiac dysfunction in the nondiabetic setting...
- eNOS deficiency predisposes podocytes to injury in diabetes
Darren A Yuen
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
J Am Soc Nephrol 23:1810-23. 2012
..Identifying mediators of this communication may lead to the future development of therapies targeting endothelial dysfunction in albuminuric individuals with diabetes...
- Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism
Darren A Yuen
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 5:e9543. 2010
..In exploring the therapeutic potential of bone marrow derived cells in chronic cardio-renal disease, we examined the anti-fibrotic effects of bone marrow-derived culture modified cells (CMCs) and stromal cells (SCs)...
- Expression, localization, and function of the thioredoxin system in diabetic nephropathy
Andrew Advani
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
J Am Soc Nephrol 20:730-41. 2009
..Taken together, these findings suggest that impaired thiol reductive capacity contributes to the generation of reactive oxygen species in diabetes in a site- and cell-specific manner...
- The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
Andrew Advani
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, 61 Queen St East, Toronto, Ontario, Canada M5C 2T2
Hypertension 54:261-9. 2009
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- Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions
Andrew Advani
Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, ON, Canada M5C 2T2
Proc Natl Acad Sci U S A 104:14448-53. 2007
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- Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation
Darren A Yuen
Department of Medicine, St Michael s Hospital, Ontario, Canada
Stem Cells Transl Med 1:921-6. 2012
..These findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms...
- Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy
Li Hao Chen
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ont, Canada
Nephron Extra 2:115-24. 2012
..Accordingly, in the present study, we combined streptozotocin-induced diabetes with surgical ablation of 5/6 of the kidney mass with the aim of evaluating their additive effects on renal function and glomerular morphology...
- The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy
Kim A Connelly
Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, Canada
J Hypertens 29:1175-84. 2011
..While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart...
- The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
Tania N Petruzziello-Pellegrini
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
J Clin Invest 122:759-76. 2012
..Collectively, these data implicate the CXCR4/CXCR7/SDF-1 pathway in Stx-mediated pathogenesis and suggest novel therapeutic strategies for prevention and/or treatment of complications associated with E. coli O157:H7 infection...
