Andrew Advani

Summary

Publications

  1. pmc Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy
    Li Hao Chen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ont, Canada
    Nephron Extra 2:115-24. 2012
  2. ncbi request reprint Dipeptidyl peptidase-4 inhibition improves left ventricular function in chronic kidney disease
    Kim A Connelly
    Clin Invest Med 37:E172. 2014
  3. ncbi request reprint The endothelium in diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Semin Nephrol 32:199-207. 2012
  4. pmc Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism
    Andrew Advani
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Pathol 178:2205-14. 2011
  5. ncbi request reprint Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Nephrology (Carlton) 16:573-81. 2011
  6. pmc Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e24695. 2011
  7. ncbi request reprint Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor
    Richard E Gilbert
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Kidney Int 79:1312-21. 2011
  8. pmc Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes
    Yanling Zhang
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes 61:2114-25. 2012
  9. ncbi request reprint Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy
    Kim A Connelly
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circ Heart Fail 2:129-37. 2009
  10. pmc Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, 6 151, 61 Queen Street East, Toronto, ON, Canada M5C 2T2
    Biomed Res Int 2013:201475. 2013

Collaborators

Detail Information

Publications27

  1. pmc Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy
    Li Hao Chen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ont, Canada
    Nephron Extra 2:115-24. 2012
    ..Accordingly, in the present study, we combined streptozotocin-induced diabetes with surgical ablation of 5/6 of the kidney mass with the aim of evaluating their additive effects on renal function and glomerular morphology...
  2. ncbi request reprint Dipeptidyl peptidase-4 inhibition improves left ventricular function in chronic kidney disease
    Kim A Connelly
    Clin Invest Med 37:E172. 2014
    ..In the present study, the actions of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of incretin-based therapy in preventing HFpEF induced by chronic renal impairment were investigated...
  3. ncbi request reprint The endothelium in diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Semin Nephrol 32:199-207. 2012
    ..Such advances likely will lead not only to improved tissue oxygenation and reduced fibrosis, but also to improved long-term renal function...
  4. pmc Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism
    Andrew Advani
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Pathol 178:2205-14. 2011
    ..These observations illustrate the therapeutic efficacy of long-term HDAC inhibition in diabetic nephropathy and emphasize the importance of the interplay between eNOS activity and oxidative stress in mediating these effects...
  5. ncbi request reprint Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Nephrology (Carlton) 16:573-81. 2011
    ..In the present study we sought to investigate the effects of long-term inhibition of the EGFR tyrosine kinase in an experimental model of diabetes that is characterized by angiotensin II dependent hypertension...
  6. pmc Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e24695. 2011
    ..FMA is an uncomplicated technique for evaluating the renal microvasculature that circumvents many of the limitations imposed by conventional analysis of two-dimensional tissue sections...
  7. ncbi request reprint Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor
    Richard E Gilbert
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Kidney Int 79:1312-21. 2011
    ..Thus, early renal changes in diabetes are amenable to epigenetic intervention. Attenuating effects of HDAC inhibition, although multifactorial, are likely to be mediated in part through downregulation of the EGFR...
  8. pmc Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes
    Yanling Zhang
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes 61:2114-25. 2012
    ..The similarly beneficial effects of cells from healthy and diabetic donors highlight the potential of autologous cell therapy in the related clinical setting...
  9. ncbi request reprint Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy
    Kim A Connelly
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circ Heart Fail 2:129-37. 2009
    ..One such target is the beta-isoform of protein kinase C (PKC), implicated in both the complications of diabetes and in cardiac dysfunction in the nondiabetic setting...
  10. pmc Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, 6 151, 61 Queen Street East, Toronto, ON, Canada M5C 2T2
    Biomed Res Int 2013:201475. 2013
    ..These observations highlight the pivotal role that the eNOS-NO system plays in regulating the biologic response to VEGF within the glomerulus. ..
  11. pmc eNOS deficiency predisposes podocytes to injury in diabetes
    Darren A Yuen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 23:1810-23. 2012
    ..Identifying mediators of this communication may lead to the future development of therapies targeting endothelial dysfunction in albuminuric individuals with diabetes...
  12. pmc Expression, localization, and function of the thioredoxin system in diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 20:730-41. 2009
    ..Taken together, these findings suggest that impaired thiol reductive capacity contributes to the generation of reactive oxygen species in diabetes in a site- and cell-specific manner...
  13. pmc Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism
    Darren A Yuen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9543. 2010
    ..In exploring the therapeutic potential of bone marrow derived cells in chronic cardio-renal disease, we examined the anti-fibrotic effects of bone marrow-derived culture modified cells (CMCs) and stromal cells (SCs)...
  14. ncbi request reprint The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, 61 Queen St East, Toronto, Ontario, Canada M5C 2T2
    Hypertension 54:261-9. 2009
    ....
  15. ncbi request reprint Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies
    Kim A Connelly
    Keenan Research Centre for Biomedical Science, St Michael s Hospital, 30 Bond St, 209 Victoria Street, Room 7 052, Toronto, ON, M5B 1W8, Canada
    Acta Diabetol 51:771-82. 2014
    ..High glucose reduces thioredoxin activity and increases ROS via TxnIP overexpression. These findings suggest that impaired thiol reductive capacity, through altered TxnIP expression, contributes to increased ROS in the diabetic heart. ..
  16. pmc Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions
    Andrew Advani
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, ON, Canada M5C 2T2
    Proc Natl Acad Sci U S A 104:14448-53. 2007
    ....
  17. pmc SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease
    Li Hao Chen
    Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 9:e92227. 2014
    ..Augmentation of this pathway, either purposefully or serendipitously with either novel or existing therapies, may attenuate renal decline in CKD. ..
  18. pmc High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
    Antoinette Bugyei-Twum
    Keenan Research Centre for Biomedical Science, St, Michael s Hospital, 209 Victoria Street, Toronto, ON M5B 1T8, Canada
    Cardiovasc Diabetol 13:89. 2014
    ....
  19. ncbi request reprint DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes
    Kim Alexander Connelly
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Cardiovasc Ther 31:259-67. 2013
    ..Accordingly, we hypothesized that inhibiting this enzyme may confer benefit following myocardial infarction in the diabetic setting beyond its effect on glycemia...
  20. ncbi request reprint Early outgrowth cells release soluble endocrine antifibrotic factors that reduce progressive organ fibrosis
    Darren A Yuen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Stem Cells 31:2408-19. 2013
    ..Together, these findings suggest that an endocrine mode of action may underlie the effectiveness of cell therapy in certain settings and portend the possibility for systemic delivery of cell-free therapy...
  21. pmc Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation
    Darren A Yuen
    Department of Medicine, St Michael s Hospital, Ontario, Canada
    Stem Cells Transl Med 1:921-6. 2012
    ..These findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms...
  22. ncbi request reprint The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy
    Kim A Connelly
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, Canada
    J Hypertens 29:1175-84. 2011
    ..While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart...
  23. ncbi request reprint Diabetes induces lysine acetylation of intermediary metabolism enzymes in the kidney
    Hari Kosanam
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes 63:2432-9. 2014
    ..Current drug discovery efforts to develop small molecule inhibitors and activators of various lysine acetylases and deacetylases offer a new potential strategy to reduce the likelihood of diabetes complications. ..
  24. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Collectively, these data implicate the CXCR4/CXCR7/SDF-1 pathway in Stx-mediated pathogenesis and suggest novel therapeutic strategies for prevention and/or treatment of complications associated with E. coli O157:H7 infection...
  25. ncbi request reprint Vascular endothelial growth factor and the kidney: something of the marvellous
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Curr Opin Nephrol Hypertens 23:87-92. 2014
    ..Here, we review recent advances that highlight the subtle nature of the renal VEGF system and its influencers...
  26. pmc Endothelial-podocyte crosstalk: the missing link between endothelial dysfunction and albuminuria in diabetes
    Ferhan S Siddiqi
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes 62:3647-55. 2013
    ..Identification of novel mediators of endothelial-podocyte crosstalk may lead to the development of more effective treatments for diabetic nephropathy and its sequelae. ..
  27. ncbi request reprint Cardiovascular effects of incretins in diabetes
    Andrew Advani
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Ontario, Canada
    Can J Diabetes 37:309-14. 2013
    ..Whether these collective functions will act to reduce cardiovascular events in patients remains to be determined. ..