Oluwatosin Adekunle Adaramoye

Summary

Publications

  1. ncbi request reprint Hypolipidemic effect of Telfairia occidentalis (fluted pumpkin) in rats fed a cholesterol-rich diet
    O A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Med Food 10:330-6. 2007
  2. ncbi request reprint Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Afr J Med Med Sci 39:27-34. 2010
  3. ncbi request reprint Ameliorative Effects of Kolaviron, a Biflavonoid Fraction from Garcinia Kola Seed, on Hepato-renal Toxicity of Anti-tuberculosis Drugs in Wistar Rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo, State, Nigeria
    Tokai J Exp Clin Med 41:14-21. 2016
  4. doi request reprint Modulatory effects of methanol extract of Artocarpus altilis (Moraceae) on cadmium-induced hepatic and renal toxicity in male Wistar rats
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria Electronic address
    Pathophysiology 23:1-9. 2016
  5. ncbi request reprint Lopinavir/Ritonavir, an Antiretroviral Drug, Lowers Sperm Quality and Induces Testicular Oxidative Damage in Rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Tokai J Exp Clin Med 40:51-7. 2015
  6. pmc A Comparative In Vitro Study on the Antioxidant and Anti-acetylcholinesterase Properties of Aerial Parts of Strophanthus preusii Engl & Pax
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    West Indian Med J 63:408-15. 2014
  7. pmc Sub-acute effect of N(G)-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices in rats: Protective effects of Kolaviron and extract of Curcuma longa L
    Oluwatosin A Adaramoye
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Pharmacognosy Res 4:127-33. 2012
  8. doi request reprint Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice
    Adaramoye Oluwatosin
    Biochemistry Department, University of Ibadan, University Way, Oyo Ojoo, Road, Ibadan, Ibadan, Oyo South West 20005, Nigeria Electronic address
    Asian Pac J Trop Med 7:97-104. 2014
  9. ncbi request reprint Kolaviron, a biflavonoid complex from Garcinia kola seeds, ameliorates ethanol-induced reproductive toxicity in male wistar rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 28:9-15. 2013
  10. ncbi request reprint Evaluation of toxic effects of metformin hydrochloride and glibenclamide on some organs of male rats
    Oluwatosin Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 27:137-44. 2012

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Hypolipidemic effect of Telfairia occidentalis (fluted pumpkin) in rats fed a cholesterol-rich diet
    O A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Med Food 10:330-6. 2007
    ..This study demonstrates that T. occidentalis may be a useful therapy for hypercholesterolemia through reducing oxidative stress and cholesterol levels...
  2. ncbi request reprint Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Afr J Med Med Sci 39:27-34. 2010
    ..The results suggest that the hepatoprotective effect of CLME in GNH2 induced liver injury may be related to its antioxidant activity...
  3. ncbi request reprint Ameliorative Effects of Kolaviron, a Biflavonoid Fraction from Garcinia Kola Seed, on Hepato-renal Toxicity of Anti-tuberculosis Drugs in Wistar Rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo, State, Nigeria
    Tokai J Exp Clin Med 41:14-21. 2016
    ..The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern...
  4. doi request reprint Modulatory effects of methanol extract of Artocarpus altilis (Moraceae) on cadmium-induced hepatic and renal toxicity in male Wistar rats
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria Electronic address
    Pathophysiology 23:1-9. 2016
    ..The study was designed to investigate the modulatory effects of methanol extract of Artocarpus altilis (AA) on oxidant-antioxidant balance and lipid profile in liver and kidney of Cd-exposed rats while quercetin (QE) served as standard...
  5. ncbi request reprint Lopinavir/Ritonavir, an Antiretroviral Drug, Lowers Sperm Quality and Induces Testicular Oxidative Damage in Rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Tokai J Exp Clin Med 40:51-7. 2015
    ..Lopinavir/Ritonavir (Kaletra®) is a protease inhibitor used in the management of HIV infection. The increased incidence of toxicity of antiretroviral therapy (ART) has necessitated proper evaluation of their effects on reproductive health...
  6. pmc A Comparative In Vitro Study on the Antioxidant and Anti-acetylcholinesterase Properties of Aerial Parts of Strophanthus preusii Engl & Pax
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    West Indian Med J 63:408-15. 2014
    ..To evaluate and compare the antioxidant and acetylcholinestrase (AChE)-inhibitory properties of aerial parts of Strophanthus preussii (leaves, stem and root named as SPL, SPS and SPR, respectively) while catechin served as standard...
  7. pmc Sub-acute effect of N(G)-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices in rats: Protective effects of Kolaviron and extract of Curcuma longa L
    Oluwatosin A Adaramoye
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Pharmacognosy Res 4:127-33. 2012
    ..N(G)- nitro- l- arginine methyl- ester (L- NAME) is L- arginine analogue, which by binding to Nitric Oxide Synthase (NOS) may induce hypertension partly due to increase in tissues oxidative stress...
  8. doi request reprint Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice
    Adaramoye Oluwatosin
    Biochemistry Department, University of Ibadan, University Way, Oyo Ojoo, Road, Ibadan, Ibadan, Oyo South West 20005, Nigeria Electronic address
    Asian Pac J Trop Med 7:97-104. 2014
    ..To investigate the antimalarial potential of kolaviron (KV), a biflavonoid fraction from Garcinia kola seeds, against Plasmodium berghei (P. berghei) infection in Swiss albino mice...
  9. ncbi request reprint Kolaviron, a biflavonoid complex from Garcinia kola seeds, ameliorates ethanol-induced reproductive toxicity in male wistar rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 28:9-15. 2013
    ..Overall, KV ameliorates ethanol-induced toxic assault on testis and improves seminal qualities of the rats. ..
  10. ncbi request reprint Evaluation of toxic effects of metformin hydrochloride and glibenclamide on some organs of male rats
    Oluwatosin Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 27:137-44. 2012
    ..Taken together, MET and GB induced lipid peroxidation, affected seminal qualities and decreased antioxidant status. These drugs may interfere with normal biochemical processes in testis and liver of the rats...
  11. pmc Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Afr Health Sci 12:498-506. 2012
    ..Hypoglycaemic effect of kolaviron (KV), (biflavonoid from Garcinia kola) in streptozotocin (STZ)-diabetic rats has been established...
  12. doi request reprint Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Basic Clin Physiol Pharmacol 23:69-75. 2012
    ..We studied the effect of TFR administered to Wistar rats on hepatic and renal function markers and the possible modulatory role of vitamin E (Vit E)...
  13. doi request reprint Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 31:676-85. 2012
    ..NVP induced oxidative stress with corresponding decrease in antioxidant status of the rats. The changes in sperm parameters and, elevation of liver marker enzymes suggest an interference of NVP2 with these organs...
  14. ncbi request reprint Effect of moderate ethanol administration on biochemical indices in streptozotocin-diabetic Wistar rats
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria
    West Indian Med J 61:3-9. 2012
    ..This study was designed to evaluate the effect of moderate ethanol administration on the biochemical indices in streptozotocin (STZ)-diabetic rats...
  15. doi request reprint Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats
    Oluwatosin Adaramoye
    Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Asian Pac J Trop Med 5:427-33. 2012
    ..To justify the use of African mistletoe (AM) Viscum album (V. album) in folkoric medicine to treat diabetes...
  16. doi request reprint Possible ameliorative effects of kolaviron against reproductive toxicity in sub-lethally whole body gamma-irradiated rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Exp Toxicol Pathol 64:379-85. 2012
    ..Taken together, ╬│-irradiation caused reproductive dysfunction by depleting the antioxidant defence system in the rats, while administration of KV or VC ameliorated the radiation-induced testicular toxicity...
  17. doi request reprint Methanolic extract of Cnidoscolus aconitifolius attenuates renal dysfunction induced by chronic ethanol administration in Wistar rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Alcohol Alcohol 46:4-9. 2011
    ..The present work studied the modulatory role of methanolic extract of Cnidoscolus aconitifolius leaf (MECA) in rat model of renal dysfunction induced by chronic ethanol administration...
  18. ncbi request reprint Extract of Xylopia aethiopica (Annonaceae) protects against gamma-radiation induced testicular damage in Wistar rats
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism Research Laboratory, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    J Basic Clin Physiol Pharmacol 21:295-313. 2010
    ..These findings demonstrated that Xylopia aethiopica has a protective effect by inhibiting oxidative damage in testes of irradiated rats...
  19. ncbi request reprint Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries
    Oluwatosin A Adaramoye
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Joao Pessoa, Paraiba, Brazil
    J Smooth Muscle Res 45:39-53. 2009
    ....
  20. ncbi request reprint Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:40-6. 2005
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  21. ncbi request reprint Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    J Pharm Pharmacol 58:121-8. 2006
    ..This study confirms the anti-diabetic and hypolipidaemic effects of KV in STZ-diabetic rats. These observed effects of KV are attributed to two of its fractions, FI and FII, with RF values of 0.48 and 0.71, respectively...
  22. ncbi request reprint Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 98:135-41. 2006
    ..This protection may be due to the ability of these extracts to induce the expression of phase II drug metabolizing enzymes...
  23. ncbi request reprint Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats
    Oluwatosin Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Radiat Res 49:123-31. 2008
    ..Taken together, the results suggest that the extracts of VA and HS, and VIT C could increase the antioxidant defense systems and may probably protect animals from radiation-induced liver damage...
  24. pmc Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet
    Oluwatosin A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Vasc Health Risk Manag 4:235-41. 2008
    ..Taken together, these results suggest the lipid-lowering effects of VA and, probably serve as a new potential natural product for the treatment of hyperlipidemia...
  25. doi request reprint Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Med Food 11:544-50. 2008
    ..These fractions are responsible for the observed antihepatotoxic effect of KV...
  26. ncbi request reprint Involvement of Na(+)-Ca (2+) exchanger in the endothelium-independent vasorelaxation induced by Curcuma longa L. in isolated rat superior mesenteric arteries
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    J Smooth Muscle Res 44:151-8. 2008
    ..The results provide indirect evidence that the stimulation of the forward mode of Na(+)-Ca (2+) exchanger may probably contribute to the vasorelaxation induced by CLME in endothelium-denuded arterial rings...
  27. ncbi request reprint Vasorelaxation induced by amodiaquine in rat superior mesenteric arteries: in vivo and in vitro studies
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Acta Pol Pharm 67:529-36. 2010
    ....
  28. doi request reprint Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Curcuma longa L. in rats
    Oluwatosin A Adaramoye
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Brazil
    J Ethnopharmacol 124:457-62. 2009
    ..Curcuma longa L. (CL) is a yellow rhizome that is used in African traditional medicine to treat palpitation, hypertension or other related blood circulation disorders...
  29. doi request reprint Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult wistar rats
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Nigeria
    J Med Food 12:584-90. 2009
    ..These findings demonstrated that KV could have a beneficial effect by inhibiting the oxidative damage in liver of Wistar rats caused by chronic ethanol administration...
  30. ncbi request reprint Protective effect of kolaviron, a biflavonoid from Garcinia kola seeds, in brain of Wistar albino rats exposed to gamma-radiation
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan 20005, Nigeria
    Biol Pharm Bull 33:260-6. 2010
    ..The antioxidant indices were significantly ameliorated in KV-treated animals. These data suggest that kolaviron may protect against gamma-radiation-induced oxidative stress in brain of exposed rats...
  31. doi request reprint Dried fruit extract from Xylopia aethiopica (Annonaceae) protects Wistar albino rats from adverse effects of whole body radiation
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Exp Toxicol Pathol 63:635-43. 2011
    ..These results suggest that XA and VC could increase the antioxidant defence systems in the liver and kidney of irradiated animals, and may protect from adverse effects of whole body radiation...
  32. doi request reprint Effects of Xylopia aethiopica (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Acta Biol Hung 61:250-61. 2010
    ..Treatment with XA and VC ameliorated the radiation-induced decreases in antioxidant status of the animals. These suggest that XA could have beneficial effect by inhibiting oxidative damage in brain of exposed rats...
  33. pmc Trace elements and vitamin E status in Nigerian patients with prostate cancer
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Nigeria
    Afr Health Sci 10:2-8. 2010
    ..Prostate cancer is the most common type of cancer among men...
  34. pmc Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats
    Samuel Babafemi Olaleye
    Gastrointestinal Research Unit, Department of Physiology, University of Ibadan, Ibadan, Nigeria
    World J Gastroenterol 13:5121-6. 2007
    ..To investigate the role of reactive oxygen species in the ulcer-aggravating effect of lead in albino rats...
  35. doi request reprint Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats
    Oluwatosin A Adaramoye
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 102:412-8. 2008
    ..These data indicate that oral administration of artemether, coartem and halofantrine has adverse effects on both enzymic and non-enzymatic antioxidant status of the animals...
  36. doi request reprint Hypolipidemic and antioxidant potentials of Xylopia aethiopica seed extract in hypercholesterolemic rats
    Sarah O Nwozo
    Biochemistry Department, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Med Food 14:114-9. 2011
    ..This study has shown that intake of X. aethiopica reduced the composition of lipids and produced a favorable lipid profile in the serum and PMF of visceral organs in experimental hypercholesterolemia...
  37. ncbi request reprint Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants
    E Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Pharmacol Toxicol 91:129-34. 2002
    ....
  38. doi request reprint Cnidoscolus aconitifolius leaf extract protects against hepatic damage induced by chronic ethanol administration in Wistar rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Alcohol Alcohol 46:451-8. 2011
    ..This study focused on the possible protective effect of Cnidoscolus aconitifolius leaf extract (CA) against hepatic damage induced by chronic ethanol administration in rats...