Oluwatosin Adekunle Adaramoye

Summary

Publications

  1. request reprint
    Adaramoye O, Odunewu A, Farombi E. Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity. Afr J Med Med Sci. 2010;39 Suppl:27-34 pubmed
    ..The results suggest that the hepatoprotective effect of CLME in GNH2 induced liver injury may be related to its antioxidant activity...
  2. request reprint
    Adaramoye O. Protective effect of kolaviron, a biflavonoid from Garcinia kola seeds, in brain of Wistar albino rats exposed to gamma-radiation. Biol Pharm Bull. 2010;33:260-6 pubmed
    ..The antioxidant indices were significantly ameliorated in KV-treated animals. These data suggest that kolaviron may protect against gamma-radiation-induced oxidative stress in brain of exposed rats...
  3. request reprint
    Popoola B, Ashefor O, Akanni O, Adaramoye O. Biochemical, Hormonal and Histological Changes in Prostate of Wistar Rats Following Long Term Streptozotocin-induced Diabetes Mellitus. Niger J Physiol Sci. 2017;32:75-84 pubmed
    ..Histology revealedhyperplasia, intra-luminal budding of epithelia, mild expressions of Bcl2 and Ki67 in 3- and 5-months DM. Overall, prostate health was compromised and may increase infertility in diabetic animals...
  4. request reprint
    Adaramoye O, Kehinde A, Adefisan A, Adeyemi O, Oyinlola I, Akanni O. Ameliorative Effects of Kolaviron, a Biflavonoid Fraction from Garcinia Kola Seed, on Hepato-renal Toxicity of Anti-tuberculosis Drugs in Wistar Rats. Tokai J Exp Clin Med. 2016;41:14-21 pubmed
    ..The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern...
  5. Adaramoye O. Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats. Afr Health Sci. 2012;12:498-506 pubmed
    ..Hypoglycaemic effect of kolaviron (KV), (biflavonoid from Garcinia kola) in streptozotocin (STZ)-diabetic rats has been established...
  6. Adaramoye O, Adedara I, Farombi E. Possible ameliorative effects of kolaviron against reproductive toxicity in sub-lethally whole body gamma-irradiated rats. Exp Toxicol Pathol. 2012;64:379-85 pubmed publisher
    ..Taken together, γ-irradiation caused reproductive dysfunction by depleting the antioxidant defence system in the rats, while administration of KV or VC ameliorated the radiation-induced testicular toxicity...
  7. Adaramoye O, Popoola B, Farombi E. Effects of Xylopia aethiopica (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats. Acta Biol Hung. 2010;61:250-61 pubmed publisher
    ..Treatment with XA and VC ameliorated the radiation-induced decreases in antioxidant status of the animals. These suggest that XA could have beneficial effect by inhibiting oxidative damage in brain of exposed rats...
  8. request reprint
    Adaramoye O, Nwaneri V, Anyanwu K, Farombi E, Emerole G. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol. 2005;32:40-6 pubmed
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  9. Adaramoye O, Awogbindin I, Okusaga J. Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult wistar rats. J Med Food. 2009;12:584-90 pubmed publisher
    ..These findings demonstrated that KV could have a beneficial effect by inhibiting the oxidative damage in liver of Wistar rats caused by chronic ethanol administration...
  10. request reprint
    Adaramoye O, Medeiros I. Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries. J Smooth Muscle Res. 2009;45:39-53 pubmed
    ....

Locale

Detail Information

Publications17

  1. request reprint
    Adaramoye O, Odunewu A, Farombi E. Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity. Afr J Med Med Sci. 2010;39 Suppl:27-34 pubmed
    ..The results suggest that the hepatoprotective effect of CLME in GNH2 induced liver injury may be related to its antioxidant activity...
  2. request reprint
    Adaramoye O. Protective effect of kolaviron, a biflavonoid from Garcinia kola seeds, in brain of Wistar albino rats exposed to gamma-radiation. Biol Pharm Bull. 2010;33:260-6 pubmed
    ..The antioxidant indices were significantly ameliorated in KV-treated animals. These data suggest that kolaviron may protect against gamma-radiation-induced oxidative stress in brain of exposed rats...
  3. request reprint
    Popoola B, Ashefor O, Akanni O, Adaramoye O. Biochemical, Hormonal and Histological Changes in Prostate of Wistar Rats Following Long Term Streptozotocin-induced Diabetes Mellitus. Niger J Physiol Sci. 2017;32:75-84 pubmed
    ..Histology revealedhyperplasia, intra-luminal budding of epithelia, mild expressions of Bcl2 and Ki67 in 3- and 5-months DM. Overall, prostate health was compromised and may increase infertility in diabetic animals...
  4. request reprint
    Adaramoye O, Kehinde A, Adefisan A, Adeyemi O, Oyinlola I, Akanni O. Ameliorative Effects of Kolaviron, a Biflavonoid Fraction from Garcinia Kola Seed, on Hepato-renal Toxicity of Anti-tuberculosis Drugs in Wistar Rats. Tokai J Exp Clin Med. 2016;41:14-21 pubmed
    ..The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern...
  5. Adaramoye O. Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats. Afr Health Sci. 2012;12:498-506 pubmed
    ..Hypoglycaemic effect of kolaviron (KV), (biflavonoid from Garcinia kola) in streptozotocin (STZ)-diabetic rats has been established...
  6. Adaramoye O, Adedara I, Farombi E. Possible ameliorative effects of kolaviron against reproductive toxicity in sub-lethally whole body gamma-irradiated rats. Exp Toxicol Pathol. 2012;64:379-85 pubmed publisher
    ..Taken together, γ-irradiation caused reproductive dysfunction by depleting the antioxidant defence system in the rats, while administration of KV or VC ameliorated the radiation-induced testicular toxicity...
  7. Adaramoye O, Popoola B, Farombi E. Effects of Xylopia aethiopica (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats. Acta Biol Hung. 2010;61:250-61 pubmed publisher
    ..Treatment with XA and VC ameliorated the radiation-induced decreases in antioxidant status of the animals. These suggest that XA could have beneficial effect by inhibiting oxidative damage in brain of exposed rats...
  8. request reprint
    Adaramoye O, Nwaneri V, Anyanwu K, Farombi E, Emerole G. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol. 2005;32:40-6 pubmed
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  9. Adaramoye O, Awogbindin I, Okusaga J. Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult wistar rats. J Med Food. 2009;12:584-90 pubmed publisher
    ..These findings demonstrated that KV could have a beneficial effect by inhibiting the oxidative damage in liver of Wistar rats caused by chronic ethanol administration...
  10. request reprint
    Adaramoye O, Medeiros I. Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries. J Smooth Muscle Res. 2009;45:39-53 pubmed
    ....
  11. Adaramoye O, Farombi E, Nssien M, Idowu S, Ademowo O, Adeyemi E. Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride. J Med Food. 2008;11:544-50 pubmed publisher
    ..These fractions are responsible for the observed antihepatotoxic effect of KV...
  12. request reprint
    Adaramoye O, Ogungbenro B, Anyaegbu O, Fafunso M. Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. J Radiat Res. 2008;49:123-31 pubmed
    ..Taken together, the results suggest that the extracts of VA and HS, and VIT C could increase the antioxidant defense systems and may probably protect animals from radiation-induced liver damage...
  13. request reprint
    Adaramoye O, Adeyemi E. Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds. Basic Clin Pharmacol Toxicol. 2006;98:135-41 pubmed
    ..This protection may be due to the ability of these extracts to induce the expression of phase II drug metabolizing enzymes...
  14. request reprint
    Adaramoye O, Adeyemi E. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol. 2006;58:121-8 pubmed
    ..This study confirms the anti-diabetic and hypolipidaemic effects of KV in STZ-diabetic rats. These observed effects of KV are attributed to two of its fractions, FI and FII, with RF values of 0.48 and 0.71, respectively...
  15. Adaramoye O, Akintayo O, Achem J, Fafunso M. Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet. Vasc Health Risk Manag. 2008;4:235-41 pubmed
    ..Taken together, these results suggest the lipid-lowering effects of VA and, probably serve as a new potential natural product for the treatment of hyperlipidemia...
  16. Adaramoye O, Erguen B, Nitzsche B, Hopfner M, Jung K, Rabien A. Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells. Chem Biol Interact. 2017;274:100-106 pubmed publisher
    ..Moreso, PN increased the expressions of caspases-3 and -8 in PC-3. Overall, PN exerts anti-proliferative activity in PCa cells via induction of apoptosis and anti-angiogenic effect. ..
  17. Adaramoye O, Akanni O, Abiola O, Owumi S, Akinloye O, Olapade Olaopa E. Methyl jasmonate reduces testosterone-induced benign prostatic hyperplasia through regulation of inflammatory and apoptotic processes in rats. Biomed Pharmacother. 2017;95:1493-1503 pubmed publisher
    ..MeJA protects against TP-induced BPH via mechanisms that involve anti-inflammation, induction of apoptosis and inhibition of phase I drug metabolizing enzyme. ..