Khaled K Abu-Amero

Summary

Publications

  1. Abu Amero K, Hellani A, Gonzalez A, Larruga J, Cabrera V, Underhill P. Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions. BMC Genet. 2009;10:59 pubmed publisher
    ..Although rare deep rooting lineages for Y-chromosome haplogroups E and J have been detected, the presence of more basal clades supportive of the southern exit route of modern humans to Eurasian, were not found. ..
  2. Kondkar A, Mousa A, Azad T, Sultan T, Alawad A, Altuwaijri S, et al. Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort. J Negat Results Biomed. 2016;15:17 pubmed
    ....
  3. Kondkar A, Edward N, Kalantan H, Al Kharashi A, Altuwaijri S, Mohamed G, et al. Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients. J Negat Results Biomed. 2017;16:3 pubmed publisher
    ..Polymorphism rs540782 is not a risk factor for POAG in the Saudi cohort. ..
  4. Abu Amero K, Khan A, Oystreck D, Kondkar A, Bosley T. The genetics of nonsyndromic bilateral Duane retraction syndrome. J AAPOS. 2016;20:396-400.e2 pubmed publisher
    ..Current evidence suggests other factors such as epigenetic and/or teratogenic abnormalities may be a potential cause of bilateral nsDRS. ..
  5. Abu Amero K, Kondkar A, Chalam K. Resveratrol and Ophthalmic Diseases. Nutrients. 2016;8:200 pubmed publisher
    ....
  6. Ennafaa H, Cabrera V, Abu Amero K, Gonzalez A, Amor M, Bouhaha R, et al. Mitochondrial DNA haplogroup H structure in North Africa. BMC Genet. 2009;10:8 pubmed publisher
    ..Based on this new information, it seems that the Strait of Gibraltar barrier affected both male and female gene flow in a similar fashion. ..
  7. Abu Amero K, Kondkar A, Khan A. A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles. BMC Res Notes. 2017;10:562 pubmed publisher
    ..We speculate that GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the CFEOM1 phenotype in these two children. ..
  8. Abu Amero K, Milcarek B, Bosley T. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Br J Ophthalmol. 2009;93:1101-4 pubmed publisher
    ..It is possible that these GST polymorphisms are risk factors for the types of optic neuropathies investigated here. ..
  9. Abu Amero K, Osman E, Dewedar A, Schmidt S, Allingham R, Al Obeidan S. Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma. Mol Vis. 2010;16:2805-10 pubmed
    ..126 and 0.994 respectively). Similar to almost all non-African populations tested thus far, the "G" allele of both rs1048661 and rs3825942 SNPs were associated with the risk of PEG in the Saudi Arab population. ..
  10. Abu Amero K, Kalantan H, Al Muammar A. Analysis of the VSX1 gene in keratoconus patients from Saudi Arabia. Mol Vis. 2011;17:667-72 pubmed
    ..5053 G>T and g.8222 A>G). All five sequence changes were benign polymorphisms with no apparent clinical significance. In our keratoconus cohort, no pathogenic VSX1 mutation(s) were identified. ..

Locale

Detail Information

Publications22

  1. Abu Amero K, Hellani A, Gonzalez A, Larruga J, Cabrera V, Underhill P. Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions. BMC Genet. 2009;10:59 pubmed publisher
    ..Although rare deep rooting lineages for Y-chromosome haplogroups E and J have been detected, the presence of more basal clades supportive of the southern exit route of modern humans to Eurasian, were not found. ..
  2. Kondkar A, Mousa A, Azad T, Sultan T, Alawad A, Altuwaijri S, et al. Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort. J Negat Results Biomed. 2016;15:17 pubmed
    ....
  3. Kondkar A, Edward N, Kalantan H, Al Kharashi A, Altuwaijri S, Mohamed G, et al. Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients. J Negat Results Biomed. 2017;16:3 pubmed publisher
    ..Polymorphism rs540782 is not a risk factor for POAG in the Saudi cohort. ..
  4. Abu Amero K, Khan A, Oystreck D, Kondkar A, Bosley T. The genetics of nonsyndromic bilateral Duane retraction syndrome. J AAPOS. 2016;20:396-400.e2 pubmed publisher
    ..Current evidence suggests other factors such as epigenetic and/or teratogenic abnormalities may be a potential cause of bilateral nsDRS. ..
  5. Abu Amero K, Kondkar A, Chalam K. Resveratrol and Ophthalmic Diseases. Nutrients. 2016;8:200 pubmed publisher
    ....
  6. Ennafaa H, Cabrera V, Abu Amero K, Gonzalez A, Amor M, Bouhaha R, et al. Mitochondrial DNA haplogroup H structure in North Africa. BMC Genet. 2009;10:8 pubmed publisher
    ..Based on this new information, it seems that the Strait of Gibraltar barrier affected both male and female gene flow in a similar fashion. ..
  7. Abu Amero K, Kondkar A, Khan A. A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles. BMC Res Notes. 2017;10:562 pubmed publisher
    ..We speculate that GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the CFEOM1 phenotype in these two children. ..
  8. Abu Amero K, Milcarek B, Bosley T. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Br J Ophthalmol. 2009;93:1101-4 pubmed publisher
    ..It is possible that these GST polymorphisms are risk factors for the types of optic neuropathies investigated here. ..
  9. Abu Amero K, Osman E, Dewedar A, Schmidt S, Allingham R, Al Obeidan S. Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma. Mol Vis. 2010;16:2805-10 pubmed
    ..126 and 0.994 respectively). Similar to almost all non-African populations tested thus far, the "G" allele of both rs1048661 and rs3825942 SNPs were associated with the risk of PEG in the Saudi Arab population. ..
  10. Abu Amero K, Kalantan H, Al Muammar A. Analysis of the VSX1 gene in keratoconus patients from Saudi Arabia. Mol Vis. 2011;17:667-72 pubmed
    ..5053 G>T and g.8222 A>G). All five sequence changes were benign polymorphisms with no apparent clinical significance. In our keratoconus cohort, no pathogenic VSX1 mutation(s) were identified. ..
  11. Abu Amero K, Gonzalez A, Osman E, Larruga J, Cabrera V, Al Obeidan S. Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients. Mol Vis. 2011;17:1468-72 pubmed
    ..Saudi individuals with mtDNA of African origin are at higher risk of developing POAG. In addition, the mtDNA Eurasian haplogroup N1 may play a mild protective effect to this illness. ..
  12. Abu Amero K, Kapoor S, Hellani A, Monga S, Bosley T. Horizontal gaze palsy and progressive scoliosis due to a deleterious mutation in ROBO3. Ophthalmic Genet. 2011;32:231-6 pubmed publisher
    ..Family members in general were severely affected, but comparison of this family to other families with ROBO3 mutations did not yield a definitive phenotype-genotype correlation. ..
  13. Kalantan H, Kondkar A, Sultan T, Azad T, Alsabaani N, AlQahtani M, et al. Polymorphism rs13334190 in zinc finger protein 469 (ZNF469) is not a risk factor for keratoconus in a Saudi cohort. BMC Res Notes. 2017;10:652 pubmed publisher
    ..018) of developing keratoconus. The genotype frequencies did not differ between the sporadic or familial keratoconus cases. Polymorphism rs13334190 is not an independent risk factor for keratoconus in the Saudi cohort. ..
  14. Abu Amero K, Osman E, Azad M, Allingham R, Hauser M, Al Obeidan S. Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population. Ophthalmic Genet. 2012;33:130-3 pubmed publisher
    ..176). The Saudi Arabian POAG population, similar to all other populations studied to date, demonstrates no association with SNPs associated with pseudoexfoliation glaucoma. ..
  15. Abu Amero K, Hellani A, Salih M, Al Hussain A, al Obailan M, Zidan G, et al. Ophthalmologic abnormalities in a de novo terminal 6q deletion. Ophthalmic Genet. 2010;31:1-11 pubmed publisher
    ..Deleted genes in this area of chromosome 6 may contribute to ophthalmic abnormalities in addition to mental retardation. ..
  16. Abu Amero K, Al Dhalaan H, Al Zayed Z, Hellani A, Bosley T. Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations. J Neurol Sci. 2009;276:22-6 pubmed publisher
    ..The ROBO3 gene does not appear to have an obvious hot spot area for mutations; therefore, we recommend sequencing all exons and exon-intron boundaries in patients with clinical and/or radiologic features of HGPPS. ..
  17. Abu Amero K, Larruga J, Cabrera V, Gonzalez A. Mitochondrial DNA structure in the Arabian Peninsula. BMC Evol Biol. 2008;8:45 pubmed publisher
    ....
  18. Abu Amero K, Kondkar A, Salih M, Alorainy I, Khan A, Oystreck D, et al. Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder. Ophthalmic Genet. 2013;34:90-6 pubmed publisher
    ....
  19. Abu Amero K, Azad T, Mousa A, Osman E, Sultan T, Al Obeidan S. A catalase promoter variant rs1001179 is associated with visual acuity but not with primary angle closure glaucoma in Saudi patients. BMC Med Genet. 2013;14:84 pubmed publisher
    ..022, 0.031 and 0.039) when compared to controls. This variant is possibly associated with visual acuity in PACG patients and thus had the potential to be used as a parameter for assessing PACG severity. ..
  20. Abu Amero K, Al Mohanna F, Al Boudari O, Mohamed G, Dzimiri N. The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. BMC Med Genet. 2007;8:35 pubmed
    ..11; p = < 0.001). Our findings indicate therefore that the risk of acquiring CAD in patients with DM2 increases significantly in the presence of the 128R mutant allele of the E-selectin gene. ..
  21. Abu Amero K, Faletra F, Gasparini P, Parentin F, Pensiero S, Alorainy I, et al. Horizontal gaze palsy and progressive scoliosis without ROBO3 mutations. Ophthalmic Genet. 2011;32:212-6 pubmed publisher
    ....
  22. Azad T, Edward N, Kondkar A, Kalantan H, Altuwaijri S, Sultan T, et al. Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort. J Negat Results Biomed. 2017;16:12 pubmed publisher
    ..Polymorphism rs547984 is neither associated with any clinical indices important for POAG such as IOP and cup/disc ratio nor is a risk factor for POAG in the Saudi cohort. ..